Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

Science

Volumn 339, Issue 6125, 2013, Pages 1323-1328

  Ben Sahra, Issam ^a   Howell, Jessica J ^a   Asara, John M ^b   Manning, Brendan D ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE CARBAMOYLTRANSFERASE; CARBAMOYL PHOSPHATE SYNTHETASE 2; DIHYDROOROTASE; GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PENTOSE PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PYRIMIDINE; RAPAMYCIN; RIBOSOMAL S6 PROTEIN KINASE 1; S6 KINASE; SYNTHETASE; UNCLASSIFIED DRUG;

CATALYSIS; CELL ORGANELLE; ENZYME ACTIVITY; GROWTH RATE; METABOLISM; PROTEIN; SIGNAL;

AMINO ACID SYNTHESIS; ARTICLE; CATALYSIS; CELL CYCLE PROGRESSION; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; ENZYME ACTIVITY; EPITHELIUM CELL; FIBROBLAST; HUMAN; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 84874995247     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1228792     Document Type: Article

References (18)

1. M. Laplante, D. M. Sabatini, Cell 149, 274 (2012).
2. V. Iadevaia, Y. Huo, Z. Zhang, L. J. Foster, C. G. Proud, Biochem. Soc. Trans. 40, 168 (2012).
3. T. Porstmann et al., Cell Metab. 8, 224 (2008).
4. K. Düvel et al., Mol. Cell 39, 171 (2010).
5. J. Huang, B. D. Manning, Biochem. J. 412, 179 (2008).
6. S. Menon, B. D. Manning, Oncogene 27, (Suppl 2), S43 (2008).
7. A. Radu, V. Neubauer, T. Akagi, H. Hanafusa, M. M. Georgescu, Mol. Cell. Biol. 23, 6139 (2003).
8. M. Mori, M. Tatibana, Methods Enzymol. 51, 111 (1978).
9. R. A. Williamson et al ., Transplant. Proc. 28, 3088 (1996).
10. E. A. Carrey, D. G. Campbell, D. G. Hardie, EMBO J. 4, 3735 (1985).
11. P. P. Hsu et al., Science 332, 1317 (2011).
12. Y. Yu et al., Science 332, 1322 (2011).
13. H. Flotow, G. Thomas, J. Biol. Chem. 267, 3074 (1992).
14. D. R. Alessi, F. B. Caudwell, M. Andjelkovic, B. A. Hemmings, P. Cohen, FEBS Lett. 399, 333 (1996).
15. L. R. Pearce et al., Biochem. J. 431, 245 (2010).
16. C. C. Dibble, J. M. Asara, B. D. Manning, Mol. Cell. Biol. 29, 5657 (2009).
17. L. M. Graves et al., Nature 403, 328 (2000).
18. L. A. Musmanno, R. S. Jamison, R. S. Barnett, E. Buford, J. N. Davidson, Somat. Cell Mol. Genet. 18, 309 (1992).