Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

Metabolomics

Volumn 11, Issue 5, 2015, Pages 1157-1174

  Perl, Andras ^a   Hanczko, Robert ^a   Lai, Zhi Wei ^a   Oaks, Zachary ^a   Kelly, Ryan ^a   Borsuk, Rebecca ^a   Asara, John M ^b   Phillips, Paul E ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Kynurenine; mTOR; N acetylcysteine; Oxidative stress; Pentose phosphate pathway

Indexed keywords

ACETYLCYSTEINE; KYNURENINE; MAMMALIAN TARGET OF RAPAMYCIN; PLACEBO;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING;

EID: 84941022225     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-015-0772-0     Document Type: Article

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