PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

Nature Medicine

Volumn 11, Issue 9, 2005, Pages 933-935

  Barber, Domingo F ^a   Bartolomé, Almira ^a   Hernandez, Carmen ^a   Flores, Juana M ^b   Redondo, Clara ^c   Fernandez Arias, Cristina ^a   Camps, Montserrat ^d   Rückle, Thomas ^d   Schwarz, Matthias K ^d   Rodríguez, Santiago ^a   Martinez A, Carlos ^a   Balomenos, Dimitrios ^a   Rommel, Christian ^d   Carrera, Ana C ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

^d SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AS 605240; DEXAMETHASONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 QUINOXALIN 6 YLMETHYLENETHIAZOLIDINE 2,4 DIONE; 5-QUINOXALIN-6-YLMETHYLENETHIAZOLIDINE-2,4-DIONE; ENZYME INHIBITOR; QUINOXALINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; FEMALE; GLOMERULONEPHRITIS; INFLAMMATION; LIFESPAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SYSTEMIC LUPUS ERYTHEMATOSUS; TREATMENT OUTCOME; ANIMAL; DRUG ANTAGONISM; EVALUATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE MUTANT;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; MICE; MICE, MUTANT STRAINS; QUINOXALINES; THIAZOLIDINEDIONES;

EID: 24744449495     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1291     Document Type: Article

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