Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus

Science Translational Medicine

Volumn 6, Issue 246, 2014, Pages

  Wu, Xiang Ni ^a   Ye, Yan Xia ^a   Niu, Jing Wen ^a   Li, Yang ^a   Li, Xin ^a   You, Xin ^a   Chen, Hua ^a   Zhao, Li Dan ^a   Zeng, Xiao Feng ^a   Zhang, Feng Chun ^a   Tang, Fu Lin ^a   He, Wei ^b   Cao, Xue Tao ^b   Zhang, Xuan ^a   Lipsky, Peter E ^a,c  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGOMIR; CD40 LIGAND; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 21; MESSENGER RNA; MICRORNA; MICRORNA 21; MICRORNA 22; MICRORNA 7; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN; PROTEIN KINASE B; STAT3 PROTEIN; UNCLASSIFIED DRUG; CD38 ANTIGEN; INTERLEUKIN DERIVATIVE; MIRN7 MICRORNA, HUMAN; PTEN PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE HYPERRESPONSIVENESS; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPLICATION; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHOSPHORYLATION; PLASMA CELL; PROTEINURIA; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIGENS, CD38; B-LYMPHOCYTES; BASE SEQUENCE; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MALE; MICRORNAS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PLASMA CELLS; PROTEINURIA; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; UP-REGULATION; YOUNG ADULT;

EID: 84927152610     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3009131     Document Type: Article

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