mTOR inhibition rescues osteopenia in mice with systemic sclerosis

Journal of Experimental Medicine

Volumn 212, Issue 1, 2015, Pages 73-91

  Chen, Chider ^a,b   Akiyama, Kentaro ^a,c   Wang, Dandan ^d   Xu, Xingtian ^a,e   Li, Bei ^a,f   Moshaverinia, Alireza ^a   Brombacher, Frank ^g   Sun, Lingyun ^d   Shi, Songtao ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c OKAYAMA UNIVERSITY   (Japan)

^d THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^e TONGJI UNIVERSITY   (China)

^f FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^g UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRILLIN 1; INTERLEUKIN 4 RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; RAPAMYCIN; S6 KINASE; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA; ACTIN BINDING PROTEIN; CELL SURFACE RECEPTOR; FIBRILLIN; IL4RA PROTEIN, MOUSE; IMMUNOSUPPRESSIVE AGENT; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE MASS; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; GENE MUTATION; MOUSE; NONHUMAN; OSTEOPENIA; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; SYSTEMIC SCLEROSIS; TREATMENT OUTCOME; UPREGULATION; 129 MOUSE; ADIPOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE DEVELOPMENT; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOBLOTTING; KNOCKOUT MOUSE; MALE; MESENCHYMAL STROMA CELL; METABOLIC BONE DISEASE; METABOLISM; RNA INTERFERENCE; TRANSGENIC MOUSE;

ADIPOGENESIS; ANIMALS; BONE DISEASES, METABOLIC; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOSUPPRESSIVE AGENTS; MALE; MESENCHYMAL STROMAL CELLS; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MICROSCOPY, FLUORESCENCE; OSTEOGENESIS; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84921413874     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20140643     Document Type: Article

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