Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Molecular Cell

Volumn 49, Issue 1, 2013, Pages 172-185

  Kim, Sang Gyun ^a   Hoffman, Gregory R ^a,f   Poulogiannis, George ^b   Buel, Gwen R ^a   Jang, Young Jin ^a,c   Lee, Ki Won ^c   Kim, Bo Yeon ^d   Erikson, Raymond L ^e   Cantley, Lewis C ^b   Choo, Andrew Y ^a   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Seoul National University   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^e HARVARD UNIVERSITY   (United States)

^f NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CARBON; GLUCOSE; GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; TEL2 TTI1 TTI2 RUVBL1 COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL STRESS; CELLULAR DISTRIBUTION; CITRIC ACID CYCLE; DIMERIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYSOSOME; METABOLIC STRESS; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; ANIMALS; BREAST NEOPLASMS; CARCINOMA; CARRIER PROTEINS; CELLS, CULTURED; CITRIC ACID CYCLE; DNA HELICASES; ENERGY METABOLISM; FEMALE; GLUCOSE; GLUTAMINE; HUMANS; LYSOSOMES; MICE; MICE, KNOCKOUT; MONOMERIC GTP-BINDING PROTEINS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; STRESS, PHYSIOLOGICAL; TELOMERE-BINDING PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84872272443     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.10.003     Document Type: Article

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