메뉴 건너뛰기




Volumn 16, Issue 2, 2015, Pages 188-196

Control of PI(3) kinase in Tregcells maintains homeostasis and lineage stability

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR FOXP3;

EID: 84922917657     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3077     Document Type: Article
Times cited : (331)

References (50)
  • 1
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory t cell development by the transcription factor foxp3
    • Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 2
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of cd4+cd25+ regulatory t cells
    • Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330-336 (2003
    • (2003) Nat. Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 3
    • 84893576757 scopus 로고    scopus 로고
    • Signals and pathways controlling regulatory t cells
    • Huynh, A., Zhang, R. & Turka, L.A. Signals and pathways controlling regulatory T cells. Immunol. Rev. 258, 117-131 (2014
    • (2014) Immunol. Rev , vol.258 , pp. 117-131
    • Huynh, A.1    Zhang, R.2    Turka, L.A.3
  • 4
    • 65549091509 scopus 로고    scopus 로고
    • Vivo expansion of t reg cells with il-2-mab complexes: Induction of resistance to eae and long-Term acceptance of islet allografts without immunosuppression
    • Webster, K.E., et al. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-Term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206, 751-760 (2009
    • (2009) J. Exp. Med , vol.206 , pp. 751-760
    • Webster, K.E.1
  • 5
    • 33845935950 scopus 로고    scopus 로고
    • Il-2 receptor β-dependent stat5 activation is required for the development of foxp3+ regulatory t cells
    • Burchill, M.A., Yang, J., Vogtenhuber, C., Blazar, B.R. & Farrar, M.A. IL-2 receptor β-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J. Immunol. 178, 280-290 (2007
    • (2007) J. Immunol , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 6
    • 0026502874 scopus 로고
    • Regulation of d-3 phosphoinositides during t cell activation via the t cell antigen receptor/cd3 complex and cd2 antigens
    • Ward, S.G., Ley, S.C., MacPhee, C. & Cantrell, D.A. Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens. Eur. J. Immunol. 22, 45-49 (1992
    • (1992) Eur. J. Immunol , vol.22 , pp. 45-49
    • Ward, S.G.1    Ley, S.C.2    MacPhee, C.3    Cantrell, D.A.4
  • 7
    • 0032843540 scopus 로고    scopus 로고
    • Impaired fas response and autoimmunity in pten+/- mice
    • Di Cristofano, A., et al. Impaired Fas response and autoimmunity in Pten+/- mice. Science 285, 2122-2125 (1999
    • (1999) Science , vol.285 , pp. 2122-2125
    • Di Cristofano, A.1
  • 8
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of pkb/akt-dependent cell survival by the tumor suppressor pten
    • Stambolic, V., et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39 (1998
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1
  • 9
    • 0034995242 scopus 로고    scopus 로고
    • T cell-specific loss of pten leads to defects in central and peripheral tolerance
    • Suzuki, A., et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14, 523-534 (2001
    • (2001) Immunity , vol.14 , pp. 523-534
    • Suzuki, A.1
  • 10
    • 77954981351 scopus 로고    scopus 로고
    • Distinct roles for pten in prevention of t cell lymphoma and autoimmunity in mice
    • Liu, X., et al. Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J. Clin. Invest. 120, 2497-2507 (2010
    • (2010) J. Clin. Invest , vol.120 , pp. 2497-2507
    • Liu, X.1
  • 11
    • 11144357191 scopus 로고    scopus 로고
    • Distinct il-2 receptor signaling pattern in cd4+cd25+ regulatory t cells
    • Bensinger, S.J., et al. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J. Immunol. 172, 5287-5296 (2004
    • (2004) J. Immunol , vol.172 , pp. 5287-5296
    • Bensinger, S.J.1
  • 12
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on cd4+cd25+foxp3+ regulatory t cells compared with conventional cd4+ t cells
    • Zeiser, R., et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 111, 453-462 (2008
    • (2008) Blood , vol.111 , pp. 453-462
    • Zeiser, R.1
  • 13
    • 84863133195 scopus 로고    scopus 로고
    • Scaffold protein disc large homolog 1 is required for t-cell receptor-induced activation of regulatory t-cell function
    • Zanin-Zhorov, A., et al. Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proc. Natl. Acad. Sci. USA 109, 1625-1630 (2012
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 1625-1630
    • Zanin-Zhorov, A.1
  • 14
    • 45549098562 scopus 로고    scopus 로고
    • T cell receptor signaling controls foxp3 expression via pi3k akt, and mtor
    • Sauer, S., et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 105, 7797-7802 (2008
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7797-7802
    • Sauer, S.1
  • 15
    • 84881192927 scopus 로고    scopus 로고
    • Mtorc1 couples immune signals and metabolic programming to establish treg-cell function
    • Zeng, H., et al. mTORC1 couples immune signals and metabolic programming to establish Treg-cell function. Nature 499, 485-490 (2013
    • (2013) Nature , vol.499 , pp. 485-490
    • Zeng, H.1
  • 16
    • 41149113441 scopus 로고    scopus 로고
    • The akt-mtor axis regulates de novo differentiation of cd4+foxp3+ cells
    • Haxhinasto, S., Mathis, D. & Benoist, C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J. Exp. Med. 205, 565-574 (2008
    • (2008) J. Exp. Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 17
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of foxp3+ regulatory t cells
    • Ouyang, W., et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat. Immunol. 11, 618-627 (2010
    • (2010) Nat. Immunol , vol.11 , pp. 618-627
    • Ouyang, W.1
  • 18
    • 84869872964 scopus 로고    scopus 로고
    • Novel foxo1-dependent transcriptional programs control treg cell function
    • Ouyang, W., et al. Novel Foxo1-dependent transcriptional programs control Treg cell function. Nature 491, 554-559 (2012
    • (2012) Nature , vol.491 , pp. 554-559
    • Ouyang, W.1
  • 19
    • 33748335576 scopus 로고    scopus 로고
    • Pten inhibits il-2 receptor-mediated expansion of cd4+ cd25+ tregs
    • Walsh, P.T., et al. PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J. Clin. Invest. 116, 2521-2531 (2006
    • (2006) J. Clin. Invest , vol.116 , pp. 2521-2531
    • Walsh, P.T.1
  • 20
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor t-bet controls regulatory t cell homeostasis and function during type 1 inflammation
    • Koch, M.A., et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009
    • (2009) Nat. Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1
  • 21
    • 0030936323 scopus 로고    scopus 로고
    • Pten, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li, J., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275, 1943-1947 (1997
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1
  • 22
    • 84893525871 scopus 로고    scopus 로고
    • Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the notch ligand dll4 on t cells
    • Xiong, H., et al. Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells. PLoS ONE 8, e84841 (2013
    • (2013) PLoS ONE , vol.8 , pp. e84841
    • Xiong, H.1
  • 23
    • 84873337168 scopus 로고    scopus 로고
    • An obligate cell-intrinsic function for cd28 in tregs
    • Zhang, R., et al. An obligate cell-intrinsic function for CD28 in Tregs. J. Clin. Invest. 123, 580-593 (2013
    • (2013) J. Clin. Invest , vol.123 , pp. 580-593
    • Zhang, R.1
  • 24
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of pten in mouse brain causes seizures, ataxia and defects in soma size resembling lhermitte-duclos disease
    • Backman, S.A., et al. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396-403 (2001
    • (2001) Nat. Genet , vol.29 , pp. 396-403
    • Backman, S.A.1
  • 25
    • 23844478869 scopus 로고    scopus 로고
    • Natural recovery and protection from autoimmune encephalomyelitis: Contribution of cd4+cd25+ regulatory cells within the central nervous system
    • McGeachy, M.J., Stephens, L.A. & Anderton, S.M. Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J. Immunol. 175, 3025-3032 (2005
    • (2005) J. Immunol , vol.175 , pp. 3025-3032
    • McGeachy, M.J.1    Stephens, L.A.2    Anderton, S.M.3
  • 26
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory t cell transcriptional signature
    • Hill, J.A., et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27, 786-800 (2007
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1
  • 27
    • 84866562625 scopus 로고    scopus 로고
    • Metabolic checkpoints in activated t cells
    • Wang, R. & Green, D.R. Metabolic checkpoints in activated T cells. Nat. Immunol. 13, 907-915 (2012
    • (2012) Nat. Immunol , vol.13 , pp. 907-915
    • Wang, R.1    Green, D.R.2
  • 28
    • 0036069699 scopus 로고    scopus 로고
    • The cd28 signaling pathway regulates glucose metabolism
    • Frauwirth, K.A., et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769-777 (2002
    • (2002) Immunity , vol.16 , pp. 769-777
    • Frauwirth, K.A.1
  • 29
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory cd4+ t cell subsets
    • Michalek, R.D., et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011
    • (2011) J. Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1
  • 30
    • 49649107703 scopus 로고    scopus 로고
    • Dna methylation controls foxp3 gene expression
    • Polansky, J.K., et al. DNA methylation controls Foxp3 gene expression. Eur. J. Immunol. 38, 1654-1663 (2008
    • (2008) Eur. J. Immunol , vol.38 , pp. 1654-1663
    • Polansky, J.K.1
  • 31
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of foxp3+ t cells reflects promiscuous foxp3 expression in conventional t cells but not reprogramming of regulatory t cells
    • Miyao, T., et al. Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36, 262-275 (2012
    • (2012) Immunity , vol.36 , pp. 262-275
    • Miyao, T.1
  • 32
    • 84891838421 scopus 로고    scopus 로고
    • Pathogenic conversion of foxp3+ t cells into th17 cells in autoimmune arthritis
    • Komatsu, N., et al. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat. Med. 20, 62-68 (2014
    • (2014) Nat. Med , vol.20 , pp. 62-68
    • Komatsu, N.1
  • 33
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory t-cell functions are subverted and converted owing to attenuated foxp3 expression
    • Wan, Y.Y. & Flavell, R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445, 766-770 (2007
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 34
    • 77957371028 scopus 로고    scopus 로고
    • Stability of the regulatory t cell lineage in vivo
    • Rubtsov, Y.P., et al. Stability of the regulatory T cell lineage in vivo. Science 329, 1667-1671 (2010
    • (2010) Science , vol.329 , pp. 1667-1671
    • Rubtsov, Y.P.1
  • 35
    • 84922930171 scopus 로고    scopus 로고
    • The pten-mtorc2 axis coordinates treg cell stability and control of th1 and tfh cell flexibility
    • 5 January 2015
    • Shrestha, S., et al. The PTEN-mTORC2 axis coordinates Treg cell stability and control of TH1 and TFH cell flexibility. Nat. Immunol. doi:10.1038/ni.3076 (5 January 2015
    • Nat. Immunol
    • Shrestha, S.1
  • 36
    • 84892502529 scopus 로고    scopus 로고
    • Ccr7 provides localized access to il-2 and defines homeostatically distinct regulatory t cell subsets
    • Smigiel, K.S., et al. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J. Exp. Med. 211, 121-136 (2014
    • (2014) J. Exp. Med , vol.211 , pp. 121-136
    • Smigiel, K.S.1
  • 37
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor foxp3 leads to the generation of pathogenic memory t cells in vivo
    • Zhou, X., et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007 (2009
    • (2009) Nat. Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1
  • 38
    • 84887512828 scopus 로고    scopus 로고
    • Self-Antigen-driven activation induces instability of regulatory t cells during an inflammatory autoimmune response
    • Bailey-Bucktrout, S.L., et al. Self-Antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity 39, 949-962 (2013
    • (2013) Immunity , vol.39 , pp. 949-962
    • Bailey-Bucktrout, S.L.1
  • 39
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory t cell receptor repertoires
    • Hsieh, C.S., Zheng, Y., Liang, Y., Fontenot, J.D. & Rudensky, A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7, 401-410 (2006
    • (2006) Nat. Immunol , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 40
    • 84884206864 scopus 로고    scopus 로고
    • Stability and function of regulatory t cells is maintained by a neuropilin-1-semaphorin-4a axis
    • Delgoffe, G.M., et al. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 501, 252-256 (2013
    • (2013) Nature , vol.501 , pp. 252-256
    • Delgoffe, G.M.1
  • 41
    • 84859215796 scopus 로고    scopus 로고
    • Systemic elevation of pten induces a tumor-suppressive metabolic state
    • Garcia-Cao, I., et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell 149, 49-62 (2012
    • (2012) Cell , vol.149 , pp. 49-62
    • Garcia-Cao, I.1
  • 42
    • 42949139481 scopus 로고    scopus 로고
    • Ampk phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn, D.M., et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226 (2008
    • (2008) Mol. Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1
  • 43
    • 66949173728 scopus 로고    scopus 로고
    • The mtor kinase differentially regulates effector and regulatory t cell lineage commitment
    • Delgoffe, G.M., et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832-844 (2009
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1
  • 44
    • 80052277906 scopus 로고    scopus 로고
    • Control of th17/treg balance by hypoxia-inducible factor 1
    • Dang, E.V., et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1
  • 45
    • 79956221450 scopus 로고    scopus 로고
    • Cutting edge: Phlpp regulates the development, function, and molecular signaling pathways of regulatory t cells
    • Patterson, S.J., et al. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J. Immunol. 186, 5533-5537 (2011
    • (2011) J. Immunol , vol.186 , pp. 5533-5537
    • Patterson, S.J.1
  • 46
    • 84903188335 scopus 로고    scopus 로고
    • Inactivation of pi(3)k p110d breaks regulatory t-cell-mediated immune tolerance to cancer
    • Ali, K., et al. Inactivation of PI(3)K p110d breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510, 407-411 (2014
    • (2014) Nature , vol.510 , pp. 407-411
    • Ali, K.1
  • 47
    • 51049120236 scopus 로고    scopus 로고
    • Selective mirna disruption in t reg cells leads to uncontrolled autoimmunity
    • Zhou, X., et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J. Exp. Med. 205, 1983-1991 (2008
    • (2008) J. Exp. Med , vol.205 , pp. 1983-1991
    • Zhou, X.1
  • 48
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory t cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov, Y.P., et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28, 546-558 (2008
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1
  • 49
    • 0037444638 scopus 로고    scopus 로고
    • A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse
    • Badea, T.C., Wang, Y. & Nathans, J. A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J. Neurosci. 23, 2314-2322 (2003
    • (2003) J. Neurosci , vol.23 , pp. 2314-2322
    • Badea, T.C.1    Wang, Y.2    Nathans, J.3
  • 50
    • 0034904776 scopus 로고    scopus 로고
    • Growth factors can influence cell growth and survival through effects on glucose metabolism
    • Vander Heiden, M.G., et al. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21, 5899-5912 (2001
    • (2001) Mol. Cell. Biol , vol.21 , pp. 5899-5912
    • Vander Heiden, M.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.