-
1
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg O. On respiratory impairment in cancer cells. Science. 1956;124:269-70.
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
2
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860-7.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
4
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, et al. The CD28 signaling pathway regulates glucose metabolism. Immunity. 2002;16:769-77.
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
-
5
-
-
84876514626
-
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
-
Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM, Cantrell DA. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol. 2013;14:500-8.
-
(2013)
Nat Immunol
, vol.14
, pp. 500-508
-
-
Sinclair, L.V.1
Rolf, J.2
Emslie, E.3
Shi, Y.B.4
Taylor, P.M.5
Cantrell, D.A.6
-
6
-
-
0027474296
-
Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes
-
Bental M, Deutsch C. Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes. Magn Reson Med. 1993;29:317-26.
-
(1993)
Magn Reson Med
, vol.29
, pp. 317-326
-
-
Bental, M.1
Deutsch, C.2
-
7
-
-
0037069384
-
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation
-
Kovacs B, Maus MV, Riley JL, Derimanov GS, Koretzky GA, June CH, et al. Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. Proc Natl Acad Sci U S A. 2002;99:15006-11.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15006-15011
-
-
Kovacs, B.1
Maus, M.V.2
Riley, J.L.3
Derimanov, G.S.4
Koretzky, G.A.5
June, C.H.6
-
8
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med. 2011;208:1367-76.
-
(2011)
J Exp Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
-
9
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature. 2009;460:103-7.
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
Walsh, M.C.2
Cejas, P.J.3
Harms, G.M.4
Shen, H.5
Wang, L.S.6
-
10
-
-
79251575592
-
Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia
-
Gaber T, Schellmann S, Erekul KB, Fangradt M, Tykwinska K, Hahne M, et al. Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia. J Immunol. 2011;186:764-74.
-
(2011)
J Immunol
, vol.186
, pp. 764-774
-
-
Gaber, T.1
Schellmann, S.2
Erekul, K.B.3
Fangradt, M.4
Tykwinska, K.5
Hahne, M.6
-
11
-
-
84879477859
-
Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation
-
Gaber T, Tran CL, Schellmann S, Hahne M, Strehl C, Hoff P, et al. Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation. Eur J Immunol. 2013;43:1588-97.
-
(2013)
Eur J Immunol
, vol.43
, pp. 1588-1597
-
-
Gaber, T.1
Tran, C.L.2
Schellmann, S.3
Hahne, M.4
Strehl, C.5
Hoff, P.6
-
13
-
-
84898606445
-
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells
-
Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, et al. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014;192:3626-36.
-
(2014)
J Immunol
, vol.192
, pp. 3626-3636
-
-
Caro-Maldonado, A.1
Wang, R.2
Nichols, A.G.3
Kuraoka, M.4
Milasta, S.5
Sun, L.D.6
-
14
-
-
0027960973
-
Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production
-
Greiner EF, Guppy M, Brand K. Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem. 1994;269:31484-90.
-
(1994)
J Biol Chem
, vol.269
, pp. 31484-31490
-
-
Greiner, E.F.1
Guppy, M.2
Brand, K.3
-
15
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. 2011;35:871-82.
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
Dillon, C.P.2
Shi, L.Z.3
Milasta, S.4
Carter, R.5
Finkelstein, D.6
-
16
-
-
84904057246
-
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
-
Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014;20:61-72.
-
(2014)
Cell Metab
, vol.20
, pp. 61-72
-
-
Macintyre, A.N.1
Gerriets, V.A.2
Nichols, A.G.3
Michalek, R.D.4
Rudolph, M.C.5
Deoliveira, D.6
-
17
-
-
84896785783
-
Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for ATP-citrate lyase in lipopolysaccharide-induced differentiation
-
Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, Scott DA, et al. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for ATP-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem. 2014;289:7011-24.
-
(2014)
J Biol Chem
, vol.289
, pp. 7011-7024
-
-
Dufort, F.J.1
Gumina, M.R.2
Ta, N.L.3
Tao, Y.4
Heyse, S.A.5
Scott, D.A.6
-
18
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang CH, Curtis JD, Maggi Jr LB, Faubert B, Villarino AV, O'Sullivan D, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 2013;153:1239-51.
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.H.1
Curtis, J.D.2
Maggi, L.B.3
Faubert, B.4
Villarino, A.V.5
O'Sullivan, D.6
-
19
-
-
84856183120
-
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
-
van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity. 2012;36:68-78.
-
(2012)
Immunity
, vol.36
, pp. 68-78
-
-
Windt, G.J.1
Everts, B.2
Chang, C.H.3
Curtis, J.D.4
Freitas, T.C.5
Amiel, E.6
-
20
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009;30:832-44.
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
-
21
-
-
67650074206
-
mTOR regulates memory CD8 T-cell differentiation
-
Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature. 2009;460:108-12.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
-
22
-
-
77955475969
-
Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
-
Carr EL, Kelman A, Wu GS, Gopaul R, Senkevitch E, Aghvanyan A, et al. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J Immunol. 2010;185:1037-44.
-
(2010)
J Immunol
, vol.185
, pp. 1037-1044
-
-
Carr, E.L.1
Kelman, A.2
Wu, G.S.3
Gopaul, R.4
Senkevitch, E.5
Aghvanyan, A.6
-
23
-
-
0023870346
-
Glutamine and glucose metabolism in human peripheral lymphocytes
-
Ardawi MS. Glutamine and glucose metabolism in human peripheral lymphocytes. Metabolism. 1988;37:99-103.
-
(1988)
Metabolism
, vol.37
, pp. 99-103
-
-
Ardawi, M.S.1
-
24
-
-
84900440370
-
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
-
Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 2014;40:692-705.
-
(2014)
Immunity
, vol.40
, pp. 692-705
-
-
Nakaya, M.1
Xiao, Y.2
Zhou, X.3
Chang, J.H.4
Chang, M.5
Cheng, X.6
-
25
-
-
37449034854
-
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A. 2007;104:19345-50.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
-
26
-
-
84884153932
-
Fatty acid remodeling in cellular glycerophospholipids following the activation of human T cells
-
Robichaud PP, Boulay K, Munganyiki JE, Surette ME. Fatty acid remodeling in cellular glycerophospholipids following the activation of human T cells. J Lipid Res. 2013;54:2665-77.
-
(2013)
J Lipid Res
, vol.54
, pp. 2665-2677
-
-
Robichaud, P.P.1
Boulay, K.2
Munganyiki, J.E.3
Surette, M.E.4
-
27
-
-
84904392273
-
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
-
O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, et al. Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity. 2014;41:75-88.
-
(2014)
Immunity
, vol.41
, pp. 75-88
-
-
O'Sullivan, D.1
Windt, G.J.2
Huang, S.C.3
Curtis, J.D.4
Chang, C.H.5
Buck, M.D.6
-
28
-
-
0021266843
-
Lymphokine regulation of human lymphocyte proliferation: formation of resting G0 cells by removal of interleukin 2 in cultures of proliferating T lymphocytes
-
Bettens F, Kristensen F, Walker C, Bonnard GD, de Weck AL. Lymphokine regulation of human lymphocyte proliferation: formation of resting G0 cells by removal of interleukin 2 in cultures of proliferating T lymphocytes. Cell Immunol. 1984;86:337-46.
-
(1984)
Cell Immunol
, vol.86
, pp. 337-346
-
-
Bettens, F.1
Kristensen, F.2
Walker, C.3
Bonnard, G.D.4
Weck, A.L.5
-
29
-
-
84897505811
-
Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity
-
Lee J, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol. 2014;192:3190-9.
-
(2014)
J Immunol
, vol.192
, pp. 3190-3199
-
-
Lee, J.1
Walsh, M.C.2
Hoehn, K.L.3
James, D.E.4
Wherry, E.J.5
Choi, Y.6
-
30
-
-
79953190405
-
Primary human CD4+ T cells have diverse levels of membrane lipid order that correlate with their function
-
Miguel L, Owen DM, Lim C, Liebig C, Evans J, Magee AI, et al. Primary human CD4+ T cells have diverse levels of membrane lipid order that correlate with their function. J Immunol. 2011;186:3505-16.
-
(2011)
J Immunol
, vol.186
, pp. 3505-3516
-
-
Miguel, L.1
Owen, D.M.2
Lim, C.3
Liebig, C.4
Evans, J.5
Magee, A.I.6
-
31
-
-
75649131191
-
Developments in the scientific understanding of rheumatoid arthritis
-
Goronzy JJ, Weyand CM. Developments in the scientific understanding of rheumatoid arthritis. Arthritis Res Ther. 2009;11:249.
-
(2009)
Arthritis Res Ther
, vol.11
, pp. 249
-
-
Goronzy, J.J.1
Weyand, C.M.2
-
33
-
-
84863998881
-
Genetics of rheumatoid arthritis: an impressionist perspective
-
Jacob N, Jacob CO. Genetics of rheumatoid arthritis: an impressionist perspective. Rheum Dis Clin North Am. 2012;38:243-57.
-
(2012)
Rheum Dis Clin North Am
, vol.38
, pp. 243-257
-
-
Jacob, N.1
Jacob, C.O.2
-
34
-
-
0034879613
-
Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease
-
Schaller M, Burton DR, Ditzel HJ. Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol. 2001;2:746-53.
-
(2001)
Nat Immunol
, vol.2
, pp. 746-753
-
-
Schaller, M.1
Burton, D.R.2
Ditzel, H.J.3
-
35
-
-
0032960240
-
Serum samples of patients with rheumatoid arthritis contain a specific autoantibody to 'denatured' aldolase A in the osteoblast-like cell line, MG-63
-
Ukaji F, Kitajima I, Kubo T, Shimizu C, Nakajima T, Maruyama I. Serum samples of patients with rheumatoid arthritis contain a specific autoantibody to 'denatured' aldolase A in the osteoblast-like cell line, MG-63. Ann Rheum Dis. 1999;58:169-74.
-
(1999)
Ann Rheum Dis
, vol.58
, pp. 169-174
-
-
Ukaji, F.1
Kitajima, I.2
Kubo, T.3
Shimizu, C.4
Nakajima, T.5
Maruyama, I.6
-
36
-
-
0036095626
-
Presence of autoantibodies to the glycolytic enzyme alpha-enolase in sera from patients with early rheumatoid arthritis
-
Saulot V, Vittecoq O, Charlionet R, Fardellone P, Lange C, Marvin L, et al. Presence of autoantibodies to the glycolytic enzyme alpha-enolase in sera from patients with early rheumatoid arthritis. Arthritis Rheum. 2002;46:1196-201.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1196-1201
-
-
Saulot, V.1
Vittecoq, O.2
Charlionet, R.3
Fardellone, P.4
Lange, C.5
Marvin, L.6
-
37
-
-
84903735770
-
Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients
-
Balakrishnan L, Bhattacharjee M, Ahmad S, Nirujogi RS, Renuse S, Subbannayya Y, et al. Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients. Clin Proteomics. 2014;11:1.
-
(2014)
Clin Proteomics
, vol.11
, pp. 1
-
-
Balakrishnan, L.1
Bhattacharjee, M.2
Ahmad, S.3
Nirujogi, R.S.4
Renuse, S.5
Subbannayya, Y.6
-
38
-
-
84885448124
-
Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
-
Yang Z, Fujii H, Mohan SV, Goronzy JJ, Weyand CM. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J Exp Med. 2013;210:2119-34.
-
(2013)
J Exp Med
, vol.210
, pp. 2119-2134
-
-
Yang, Z.1
Fujii, H.2
Mohan, S.V.3
Goronzy, J.J.4
Weyand, C.M.5
-
39
-
-
79959333447
-
Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b + and Th/Treg cells
-
Lee K, Won HY, Bae MA, Hong JH, Hwang ES. Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b + and Th/Treg cells. Proc Natl Acad Sci U S A. 2011;108:9548-53.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 9548-9553
-
-
Lee, K.1
Won, H.Y.2
Bae, M.A.3
Hong, J.H.4
Hwang, E.S.5
-
40
-
-
34648839997
-
Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies
-
Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A, Olofsson P, et al. Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies. Antioxid Redox Signal. 2007;9:1541-67.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 1541-1567
-
-
Gelderman, K.A.1
Hultqvist, M.2
Olsson, L.M.3
Bauer, K.4
Pizzolla, A.5
Olofsson, P.6
-
41
-
-
84884541598
-
A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement
-
Pizzolla A, Wing K, Holmdahl R. A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. Am J Pathol. 2013;183:1144-55.
-
(2013)
Am J Pathol
, vol.183
, pp. 1144-1155
-
-
Pizzolla, A.1
Wing, K.2
Holmdahl, R.3
-
42
-
-
84894477280
-
The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy
-
Yang Z, Goronzy JJ, Weyand CM. The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy. Autophagy. 2014;10:382-3.
-
(2014)
Autophagy
, vol.10
, pp. 382-383
-
-
Yang, Z.1
Goronzy, J.J.2
Weyand, C.M.3
-
43
-
-
2342527293
-
Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation
-
Goronzy JJ, Weyand CM. Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther. 2003;5:225-34.
-
(2003)
Arthritis Res Ther
, vol.5
, pp. 225-234
-
-
Goronzy, J.J.1
Weyand, C.M.2
-
44
-
-
0043125779
-
Immunosenescence, autoimmunity, and rheumatoid arthritis
-
Weyand CM, Fulbright JW, Goronzy JJ. Immunosenescence, autoimmunity, and rheumatoid arthritis. Exp Gerontol. 2003;38:833-41.
-
(2003)
Exp Gerontol
, vol.38
, pp. 833-841
-
-
Weyand, C.M.1
Fulbright, J.W.2
Goronzy, J.J.3
-
45
-
-
84883815576
-
The janus head of T cell aging - autoimmunity and immunodeficiency
-
Goronzy JJ, Li G, Yang Z, Weyand CM. The janus head of T cell aging - autoimmunity and immunodeficiency. Front Immunol. 2013;4:131.
-
(2013)
Front Immunol
, vol.4
, pp. 131
-
-
Goronzy, J.J.1
Li, G.2
Yang, Z.3
Weyand, C.M.4
-
47
-
-
63149145433
-
Telomerase insufficiency in rheumatoid arthritis
-
Fujii H, Shao L, Colmegna I, Goronzy JJ, Weyand CM. Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009;106:4360-5.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4360-4365
-
-
Fujii, H.1
Shao, L.2
Colmegna, I.3
Goronzy, J.J.4
Weyand, C.M.5
-
48
-
-
67449127107
-
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis
-
Shao L, Fujii H, Colmegna I, Oishi H, Goronzy JJ, Weyand CM. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J Exp Med. 2009;206:1435-49.
-
(2009)
J Exp Med
, vol.206
, pp. 1435-1449
-
-
Shao, L.1
Fujii, H.2
Colmegna, I.3
Oishi, H.4
Goronzy, J.J.5
Weyand, C.M.6
-
49
-
-
0029958821
-
CD4+ CD7-CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity
-
Schmidt D, Goronzy JJ, Weyand CM. CD4+ CD7-CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest. 1996;97:2027-37.
-
(1996)
J Clin Invest
, vol.97
, pp. 2027-2037
-
-
Schmidt, D.1
Goronzy, J.J.2
Weyand, C.M.3
-
50
-
-
84870293512
-
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
-
Li G, Yu M, Lee WW, Tsang M, Krishnan E, Weyand CM, et al. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med. 2012;18:1518-24.
-
(2012)
Nat Med
, vol.18
, pp. 1518-1524
-
-
Li, G.1
Yu, M.2
Lee, W.W.3
Tsang, M.4
Krishnan, E.5
Weyand, C.M.6
-
51
-
-
84859574715
-
Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
-
Yu M, Li G, Lee WW, Yuan M, Cui D, Weyand CM, et al. Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc Natl Acad Sci U S A. 2012;109:E879-88.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E879-E888
-
-
Yu, M.1
Li, G.2
Lee, W.W.3
Yuan, M.4
Cui, D.5
Weyand, C.M.6
-
52
-
-
82555196095
-
Systemic lupus erythematosus
-
Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011;365:2110-21.
-
(2011)
N Engl J Med
, vol.365
, pp. 2110-2121
-
-
Tsokos, G.C.1
-
53
-
-
78649269147
-
Characterization of the metabolic phenotype of chronically activated lymphocytes
-
Wahl DR, Petersen B, Warner R, Richardson BC, Glick GD, Opipari AW. Characterization of the metabolic phenotype of chronically activated lymphocytes. Lupus. 2010;19:1492-501.
-
(2010)
Lupus
, vol.19
, pp. 1492-1501
-
-
Wahl, D.R.1
Petersen, B.2
Warner, R.3
Richardson, B.C.4
Glick, G.D.5
Opipari, A.W.6
-
54
-
-
0036161789
-
Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus
-
Gergely Jr P, Grossman C, Niland B, Puskas F, Neupane H, Allam F, et al. Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arthritis Rheum. 2002;46:175-90.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 175-190
-
-
Gergely, P.1
Grossman, C.2
Niland, B.3
Puskas, F.4
Neupane, H.5
Allam, F.6
-
55
-
-
84887171398
-
Oxidative stress in the pathology and treatment of systemic lupus erythematosus
-
Perl A. Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat Rev Rheumatol. 2013;9:674-86.
-
(2013)
Nat Rev Rheumatol
, vol.9
, pp. 674-686
-
-
Perl, A.1
-
56
-
-
75749113653
-
Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment
-
Perl A. Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment. Autoimmunity. 2010;43:32-47.
-
(2010)
Autoimmunity
, vol.43
, pp. 32-47
-
-
Perl, A.1
-
57
-
-
84902161920
-
Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus
-
Doherty E, Oaks Z, Perl A. Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus. Antioxid Redox Signal. 2014;21:56-65.
-
(2014)
Antioxid Redox Signal
, vol.21
, pp. 56-65
-
-
Doherty, E.1
Oaks, Z.2
Perl, A.3
-
58
-
-
84899562139
-
Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus
-
Kato H, Perl A. Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus. J Immunol. 2014;192:4134-44.
-
(2014)
J Immunol
, vol.192
, pp. 4134-4144
-
-
Kato, H.1
Perl, A.2
-
59
-
-
33749345289
-
Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus
-
Fernandez D, Bonilla E, Mirza N, Niland B, Perl A. Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arthritis Rheum. 2006;54:2983-8.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2983-2988
-
-
Fernandez, D.1
Bonilla, E.2
Mirza, N.3
Niland, B.4
Perl, A.5
-
60
-
-
84865633655
-
N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial
-
Lai ZW, Hanczko R, Bonilla E, Caza TN, Clair B, Bartos A, et al. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2012;64:2937-46.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2937-2946
-
-
Lai, Z.W.1
Hanczko, R.2
Bonilla, E.3
Caza, T.N.4
Clair, B.5
Bartos, A.6
-
61
-
-
84862509819
-
Metabolic disturbances associated with systemic lupus erythematosus
-
Wu T, Xie C, Han J, Ye Y, Weiel J, Li Q, et al. Metabolic disturbances associated with systemic lupus erythematosus. PLoS One. 2012;7:e37210.
-
(2012)
PLoS One
, vol.7
, pp. e37210
-
-
Wu, T.1
Xie, C.2
Han, J.3
Ye, Y.4
Weiel, J.5
Li, Q.6
-
62
-
-
84893835144
-
Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients
-
McDonald G, Deepak S, Miguel L, Hall CJ, Isenberg DA, Magee AI, et al. Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. J Clin Invest. 2014;124:712-24.
-
(2014)
J Clin Invest
, vol.124
, pp. 712-724
-
-
McDonald, G.1
Deepak, S.2
Miguel, L.3
Hall, C.J.4
Isenberg, D.A.5
Magee, A.I.6
-
63
-
-
0043025561
-
Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid
-
Sarchielli P, Greco L, Floridi A, Gallai V. Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid. Arch Neurol. 2003;60:1082-8.
-
(2003)
Arch Neurol
, vol.60
, pp. 1082-1088
-
-
Sarchielli, P.1
Greco, L.2
Floridi, A.3
Gallai, V.4
-
64
-
-
84876271669
-
Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans
-
Tisell A, Leinhard OD, Warntjes JB, Aalto A, Smedby O, Landtblom AM, et al. Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans. PLoS One. 2013;8:e61817.
-
(2013)
PLoS One
, vol.8
-
-
Tisell, A.1
Leinhard, O.D.2
Warntjes, J.B.3
Aalto, A.4
Smedby, O.5
Landtblom, A.M.6
-
65
-
-
0021020593
-
Presence and steroid inducibility of glutamine synthetase in human leukemic cells
-
Marchetti P, Ranelletti FO, Natoli V, Sica G, De Rossi G, Iacobelli S. Presence and steroid inducibility of glutamine synthetase in human leukemic cells. J Steroid Biochem. 1983;19:1665-70.
-
(1983)
J Steroid Biochem
, vol.19
, pp. 1665-1670
-
-
Marchetti, P.1
Ranelletti, F.O.2
Natoli, V.3
Sica, G.4
Rossi, G.5
Iacobelli, S.6
|