Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

Progress in Retinal and Eye Research

Volumn 51, Issue , 2016, Pages 69-89

  Ferrington, Deborah A ^a   Sinha, Debasish ^b   Kaarniranta, Kai ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Age related macular degeneration; Autophagy; Lysosome; Proteasome; Proteostasis; Retinal pigment epithelium

Indexed keywords

HEAT SHOCK PROTEIN 70; LIPOFUSCIN; PROTEASOME; PROTEIN; PROTEIN P62; SEQUESTOSOME 1; UBIQUITIN; UNCLASSIFIED DRUG; UBIQUITIN PROTEIN LIGASE;

AGE RELATED MACULAR DEGENERATION; AUTOPHAGY; CELL DAMAGE; CELL MATURATION; CELLULAR STRESS RESPONSE; CHRONIC INFLAMMATION; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; HUMAN; IMMUNOPROTEASOME; INTRACELLULAR SIGNALING; LYSOSOME; MACROAUTOPHAGY; MITOCHONDRION; MITOPHAGY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHAGOCYTOSIS; PHAGOSOME; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN TARGETING; RETINA NEUROEPITHELIAL LAYER; RETINA ROD OUTER SEGMENT; REVIEW; SELECTIVE AUTOPHAGY; SIGNAL TRANSDUCTION; ANIMAL; MACULAR DEGENERATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINAL PIGMENT EPITHELIUM;

ANIMALS; AUTOPHAGY; HUMANS; LYSOSOMES; MACULAR DEGENERATION; PHAGOCYTOSIS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RETINAL PIGMENT EPITHELIUM; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 84959130952     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2015.09.002     Document Type: Review

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