메뉴 건너뛰기




Volumn 47, Issue 12, 2006, Pages 5385-5394

RPE cells resist bystander killing by CTLs, but are highly susceptible to antigen-dependent CTL killing

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BETA GALACTOSIDASE; CASPASE 3; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEASOME; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

EID: 34248215643     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0636     Document Type: Article
Times cited : (15)

References (47)
  • 1
    • 0035997391 scopus 로고    scopus 로고
    • Experimental autoimmune uveitides: Multiple antigens, diverse diseases
    • Adamus G, Chan CC. Experimental autoimmune uveitides: multiple antigens, diverse diseases. Int Rev Immunol. 2002;21:209-229.
    • (2002) Int Rev Immunol , vol.21 , pp. 209-229
    • Adamus, G.1    Chan, C.C.2
  • 2
    • 33645394595 scopus 로고    scopus 로고
    • Bystander killing of neurons by cytotoxic T cells specific for a glial antigen
    • McPherson SW, Heuss ND, Roehrich H, Gregerson DS. Bystander killing of neurons by cytotoxic T cells specific for a glial antigen. Glia. 2006;53:457-466.
    • (2006) Glia , vol.53 , pp. 457-466
    • McPherson, S.W.1    Heuss, N.D.2    Roehrich, H.3    Gregerson, D.S.4
  • 3
    • 0033565592 scopus 로고    scopus 로고
    • Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic, and creates a target for autoimmune uveoretinitis
    • Gregerson DS, Torseth JW, McPherson SW, Roberts JP, Shinohara T, Zack DJ. Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic, and creates a target for autoimmune uveoretinitis. J Immunol. 1999;163:1073-1080.
    • (1999) J Immunol , vol.163 , pp. 1073-1080
    • Gregerson, D.S.1    Torseth, J.W.2    McPherson, S.W.3    Roberts, J.P.4    Shinohara, T.5    Zack, D.J.6
  • 4
    • 0036730884 scopus 로고    scopus 로고
    • Spontaneous induction of immunoregulation by an endogenous retinal protein
    • Gregerson DS, Dou C. Spontaneous induction of immunoregulation by an endogenous retinal protein. Invest Ophthalmol Vis Sci. 2002;43:2984-2991.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2984-2991
    • Gregerson, D.S.1    Dou, C.2
  • 5
    • 1542637061 scopus 로고    scopus 로고
    • Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter
    • Ham DI, Kim SJ, Chen J, et al. Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter. Invest Ophthalmol Vis Sci. 2004;45:857-862.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 857-862
    • Ham, D.I.1    Kim, S.J.2    Chen, J.3
  • 6
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self-shadow within the thymus by the aire protein
    • Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological self-shadow within the thymus by the aire protein. Science. 2002;298;1395-1401.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3
  • 7
    • 10744232942 scopus 로고    scopus 로고
    • An immunologically privileged retinal antigen elicits tolerance: Major role for central selection mechanisms
    • Avichezer D, Grajewski RS, Chan CC, et al. An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J Exp Med. 203;198:1665-1676.
    • J Exp Med , vol.203 , Issue.198 , pp. 1665-1676
    • Avichezer, D.1    Grajewski, R.S.2    Chan, C.C.3
  • 8
    • 0242491044 scopus 로고    scopus 로고
    • Resting CD8 T cells recognize beta-galactosidase expressed in the immune privileged retina, and mediate autoimmune disease when activated
    • McPherson SW, Yang J, Chan CC, Dou C, Gregerson DS. Resting CD8 T cells recognize beta-galactosidase expressed in the immune privileged retina, and mediate autoimmune disease when activated. Immunology. 2003;110:386-396.
    • (2003) Immunology , vol.110 , pp. 386-396
    • McPherson, S.W.1    Yang, J.2    Chan, C.C.3    Dou, C.4    Gregerson, D.S.5
  • 9
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science. 2002;296:301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 10
    • 0037114135 scopus 로고    scopus 로고
    • Cutting edge: Inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen
    • Vezys V, Lefrancois L. Cutting edge: inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen. J Immunol. 2002;169:6677-6680.
    • (2002) J Immunol , vol.169 , pp. 6677-6680
    • Vezys, V.1    Lefrancois, L.2
  • 11
    • 33746922680 scopus 로고    scopus 로고
    • Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells
    • Ferrington DA, Tran TN, Lew KL, Van Remmen H, Gregerson DS. Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells. Exp Eye Res. 2006;83:638-650.
    • (2006) Exp Eye Res , vol.83 , pp. 638-650
    • Ferrington, D.A.1    Tran, T.N.2    Lew, K.L.3    Van Remmen, H.4    Gregerson, D.S.5
  • 14
    • 33746736392 scopus 로고    scopus 로고
    • Retinal proteins modified by 4-hydroxynonenal: Identification of molecular targets
    • Kapphahn RJ, Giwa BM, Berg KM, et al. Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets. Exp Eye Res. 2006;83:165-175.
    • (2006) Exp Eye Res , vol.83 , pp. 165-175
    • Kapphahn, R.J.1    Giwa, B.M.2    Berg, K.M.3
  • 15
    • 0027433264 scopus 로고
    • Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes
    • Gavin MA, Gilbert MJ, Riddell SR, Greenberg PD, Bevan MJ. Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes. J Immunol. 1993,151:3971-3980.
    • (1993) J Immunol , vol.151 , pp. 3971-3980
    • Gavin, M.A.1    Gilbert, M.J.2    Riddell, S.R.3    Greenberg, P.D.4    Bevan, M.J.5
  • 16
    • 0028214484 scopus 로고
    • Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides
    • Dick LR, Aldrich C, Jameson SC, et al. Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides. J Immunol. 1994;152:3884-3894.
    • (1994) J Immunol , vol.152 , pp. 3884-3894
    • Dick, L.R.1    Aldrich, C.2    Jameson, S.C.3
  • 17
    • 0025179012 scopus 로고
    • Recombinant vaccinia viruses as vectors for studying T lymphocyte specificity and function
    • Bennink JR, Yewdell JW. Recombinant vaccinia viruses as vectors for studying T lymphocyte specificity and function. Curr Topics Microbiol Immunol. 1990;163:153-184.
    • (1990) Curr Topics Microbiol Immunol , vol.163 , pp. 153-184
    • Bennink, J.R.1    Yewdell, J.W.2
  • 18
    • 0036402152 scopus 로고    scopus 로고
    • Proteasome function and protein oxidation in the aged retina
    • Louie J, Kapphahn R, Ferrington DA. Proteasome function and protein oxidation in the aged retina. Exp Eye Res. 2002;75:271-284.
    • (2002) Exp Eye Res , vol.75 , pp. 271-284
    • Louie, J.1    Kapphahn, R.2    Ferrington, D.A.3
  • 19
    • 0242636272 scopus 로고    scopus 로고
    • Measurement of CTL-induced cytotoxicity: The caspase 3 assay
    • Jerome KR, Sloan DD, Aubert M. Measurement of CTL-induced cytotoxicity: the caspase 3 assay. Apoptosis. 2003;8:563-571.
    • (2003) Apoptosis , vol.8 , pp. 563-571
    • Jerome, K.R.1    Sloan, D.D.2    Aubert, M.3
  • 20
    • 0029920469 scopus 로고    scopus 로고
    • Presentation of antigens on MHC class I molecules
    • York I, Rock KL. Presentation of antigens on MHC class I molecules. Ann Rev Immunol. 1996;14:369-396.
    • (1996) Ann Rev Immunol , vol.14 , pp. 369-396
    • York, I.1    Rock, K.L.2
  • 21
    • 0032730872 scopus 로고    scopus 로고
    • Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation
    • Macagno A, Gilliet M, Sallusto F, Lanzavecchia A, Nestle FO, Groettrup M. Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation. Eur J Immunol. 1999;29:4037-4042.
    • (1999) Eur J Immunol , vol.29 , pp. 4037-4042
    • Macagno, A.1    Gilliet, M.2    Sallusto, F.3    Lanzavecchia, A.4    Nestle, F.O.5    Groettrup, M.6
  • 22
    • 0036315596 scopus 로고    scopus 로고
    • Human retinal pigment epithelial cells inhibit proliferation and IL2R expression of activated T cells
    • Kaestel CG, Jorgensen A, Nielsen M, et al. Human retinal pigment epithelial cells inhibit proliferation and IL2R expression of activated T cells. Exp Eye Res. 2002;74:627-637.
    • (2002) Exp Eye Res , vol.74 , pp. 627-637
    • Kaestel, C.G.1    Jorgensen, A.2    Nielsen, M.3
  • 23
    • 0027260894 scopus 로고
    • Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms
    • Liversidge J, McKay D, Mullen G, Forrester JV. Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms. Cell Immunol. 1993;149:315-330.
    • (1993) Cell Immunol , vol.149 , pp. 315-330
    • Liversidge, J.1    McKay, D.2    Mullen, G.3    Forrester, J.V.4
  • 24
    • 0030937833 scopus 로고    scopus 로고
    • Capture and processing of exogenous antigens for presentation on MHC molecules
    • Watts C. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol. 1997;15:821-850.
    • (1997) Annu Rev Immunol , vol.15 , pp. 821-850
    • Watts, C.1
  • 25
    • 0033037628 scopus 로고    scopus 로고
    • Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T-cells in a Fas ligand and PGE2 independent pathway
    • Rezai KA, Semnani RT, Farrokh-Siar L, et al. Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T-cells in a Fas ligand and PGE2 independent pathway. Curr Eye Res. 1999;18:430-439.
    • (1999) Curr Eye Res , vol.18 , pp. 430-439
    • Rezai, K.A.1    Semnani, R.T.2    Farrokh-Siar, L.3
  • 26
    • 0033016275 scopus 로고    scopus 로고
    • Human fetal retinal pigment epithelial cells induce apoptosis in the T-cell line Jurkat
    • Farrokh-Siar L, Rezai KA, Semnani RT, et al. Human fetal retinal pigment epithelial cells induce apoptosis in the T-cell line Jurkat. Invest Ophthalmol Vis Sci. 1999;40:1503-1511.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1503-1511
    • Farrokh-Siar, L.1    Rezai, K.A.2    Semnani, R.T.3
  • 28
    • 17444451425 scopus 로고    scopus 로고
    • Human retinal pigment epithelial cell-induced apoptosis in activated T cells
    • Jorgensen A, Wiencke AK, la Cour M, et al. Human retinal pigment epithelial cell-induced apoptosis in activated T cells. Invest Ophthalmol Vis Sci. 1998;39:1590-1599.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1590-1599
    • Jorgensen, A.1    Wiencke, A.K.2    la Cour, M.3
  • 29
    • 0038238009 scopus 로고    scopus 로고
    • The effect of type I and II interferons on human fetal retinal pigment epithelium-induced apoptosis in Jurkat T cells
    • Rezai KA, Farrokh-Siar L, Gasyna EM, Ernest JT, van Seventer GA. The effect of type I and II interferons on human fetal retinal pigment epithelium-induced apoptosis in Jurkat T cells. Invest Ophthalmol Vis Sci. 2003;44:3130-3134.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3130-3134
    • Rezai, K.A.1    Farrokh-Siar, L.2    Gasyna, E.M.3    Ernest, J.T.4    van Seventer, G.A.5
  • 30
    • 0036896659 scopus 로고    scopus 로고
    • Retinal pigment epithelial cells phagocytosis of T lymphocytes: Possible implication in the immune privilege of the eye
    • Willermain F, Caspers-Velu L, Nowak B, et al. Retinal pigment epithelial cells phagocytosis of T lymphocytes: possible implication in the immune privilege of the eye. Br J Ophthalmol. 2002;86:1417-1421.
    • (2002) Br J Ophthalmol , vol.86 , pp. 1417-1421
    • Willermain, F.1    Caspers-Velu, L.2    Nowak, B.3
  • 31
    • 21344436842 scopus 로고    scopus 로고
    • The immune privilege of the eye: Human retinal pigment epithelial cells selectively modulate T-cell activation in vitro
    • Kaestel CG, Lovato P, Odum N, Nissen MH, Ropke C. The immune privilege of the eye: human retinal pigment epithelial cells selectively modulate T-cell activation in vitro. Curr Eye Res. 2005;30:375-383.
    • (2005) Curr Eye Res , vol.30 , pp. 375-383
    • Kaestel, C.G.1    Lovato, P.2    Odum, N.3    Nissen, M.H.4    Ropke, C.5
  • 32
    • 0037815115 scopus 로고    scopus 로고
    • Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4
    • Sugita S, Streilein JW. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2003;198:161-171.
    • (2003) J Exp Med , vol.198 , pp. 161-171
    • Sugita, S.1    Streilein, J.W.2
  • 33
    • 0347358072 scopus 로고    scopus 로고
    • Vulnerability of allogeneic retinal pigment epithelium to immune T-cell-mediated damage in vivo and in vitro
    • Zamiri P, Zhang Q, Streilein JW. Vulnerability of allogeneic retinal pigment epithelium to immune T-cell-mediated damage in vivo and in vitro. Invest Ophthalmol Vis Sci. 2004;45:177-184.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 177-184
    • Zamiri, P.1    Zhang, Q.2    Streilein, J.W.3
  • 34
    • 0036017391 scopus 로고    scopus 로고
    • Protein degradation and the generation of MHC class I-presented peptides
    • Rock KL, York IA, Saric T, Goldberg AL. Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol. 2002;80:1-70.
    • (2002) Adv Immunol , vol.80 , pp. 1-70
    • Rock, K.L.1    York, I.A.2    Saric, T.3    Goldberg, A.L.4
  • 35
    • 0035806246 scopus 로고    scopus 로고
    • Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
    • Chen W, Norbury CC, Cho Y, Yewdell JW, Bennink JR. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J Exp Med. 2001;193:1319-1326.
    • (2001) J Exp Med , vol.193 , pp. 1319-1326
    • Chen, W.1    Norbury, C.C.2    Cho, Y.3    Yewdell, J.W.4    Bennink, J.R.5
  • 36
    • 0034698738 scopus 로고    scopus 로고
    • Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28
    • van Hall T, Sijts A, Camps M, et al. Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28. J Exp Med. 2000;192:483-494.
    • (2000) J Exp Med , vol.192 , pp. 483-494
    • van Hall, T.1    Sijts, A.2    Camps, M.3
  • 37
    • 0141707939 scopus 로고    scopus 로고
    • ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells
    • Guermonprez P, Saveanu L, Kleijmeer M, Davoust J, Van Endert P, Amigorena S. ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature. 2003;425:397-402.
    • (2003) Nature , vol.425 , pp. 397-402
    • Guermonprez, P.1    Saveanu, L.2    Kleijmeer, M.3    Davoust, J.4    Van Endert, P.5    Amigorena, S.6
  • 38
    • 18344405138 scopus 로고    scopus 로고
    • Phagosomes are competent organelles for antigen cross-presentation
    • Houde M, Bertholet S, Gagnon E, et al. Phagosomes are competent organelles for antigen cross-presentation. Nature. 2003;425:402-406.
    • (2003) Nature , vol.425 , pp. 402-406
    • Houde, M.1    Bertholet, S.2    Gagnon, E.3
  • 39
    • 26244461724 scopus 로고    scopus 로고
    • Quantitative and dynamic assessment of the contribution of the ER to phagosome formation
    • Touret N, Paroutis P, Terebiznik M, et al. Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell. 2005;123:157-170.
    • (2005) Cell , vol.123 , pp. 157-170
    • Touret, N.1    Paroutis, P.2    Terebiznik, M.3
  • 41
    • 17744363648 scopus 로고    scopus 로고
    • Lack of FasL expression in cultured human retinal pigment epithelial cells
    • Kaestel CG, Madsen HO, Prause JU, et al. Lack of FasL expression in cultured human retinal pigment epithelial cells. Exp Clin Immunogenet. 2001;18:34-41.
    • (2001) Exp Clin Immunogenet , vol.18 , pp. 34-41
    • Kaestel, C.G.1    Madsen, H.O.2    Prause, J.U.3
  • 42
    • 0036152088 scopus 로고    scopus 로고
    • Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies
    • Kanuga N, Winton HL, Beauchene L, et al. Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies. Invest Ophthalmol Vis Sci. 2002;43:546-555.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 546-555
    • Kanuga, N.1    Winton, H.L.2    Beauchene, L.3
  • 43
    • 0028978658 scopus 로고
    • CD95 (Fas/APO-1) antibody-mediated apoptosis of human retinal pigment epithelial cells
    • Esser P, Heimann K, Abts H, Fontana A, Weller M. CD95 (Fas/APO-1) antibody-mediated apoptosis of human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1995;213:1026-1034.
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 1026-1034
    • Esser, P.1    Heimann, K.2    Abts, H.3    Fontana, A.4    Weller, M.5
  • 44
    • 0034066522 scopus 로고    scopus 로고
    • Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells
    • Jiang S, Wu MW, Sternberg P, Jones DP. Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells. Invest Ophthalmol Vis Sci. 2000;41:645-655.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 645-655
    • Jiang, S.1    Wu, M.W.2    Sternberg, P.3    Jones, D.P.4
  • 46
    • 2942625603 scopus 로고    scopus 로고
    • Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
    • Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci USA. 2004;101:8491-8496.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8491-8496
    • Mukherjee, P.K.1    Marcheselli, V.L.2    Serhan, C.N.3    Bazan, N.G.4
  • 47
    • 4644284867 scopus 로고    scopus 로고
    • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: A detailed gene expression and cellular analysis
    • Strunnikova N, Zhang C, Teichberg D, et al. Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004;45:3767-3777.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 3767-3777
    • Strunnikova, N.1    Zhang, C.2    Teichberg, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.