Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

FASEB Journal

Volumn 14, Issue 7, 2000, Pages 835-846

  Mullins, Robert F ^a   Russell, Stephen R ^a   Anderson, Don H ^b   Hageman, Gregory S ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyloid; Retina; Retinal pigmented epithelium; Soft drusen; Vitronectin

Indexed keywords

APOLIPOPROTEIN E; BLOOD CLOTTING FACTOR 10; COMPLEMENT COMPONENT C5; COMPLEMENT MEMBRANE ATTACK COMPLEX; IMMUNOGLOBULIN LIGHT CHAIN; VITRONECTIN;

AGING; AMYLOIDOSIS; ARTICLE; ATHEROSCLEROSIS; DISEASE ASSOCIATION; DRUSEN; ELASTOSIS; HUMAN; IMMUNOREACTIVITY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

EID: 0034012166     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.7.835     Document Type: Article

References (106)

1. Gass, J. (1973) Drusen and disciform macular detachment and degeneration. Arch. Ophthalmol. 90, 206-217
2. Klein, M., Mauldin, W., and Stoumbos, V. (1994) Heredity and age-related macular degeneration. Observations in monozygotic twins. Arch. Ophthalmol. 112, 932-937
3. Hyman, L., Lilienfeld, A., Ferris, F., and Fine, S. (1983) Senile macular degeneration: a case-control study. Am. J. Epidemiol. 118, 213-227
4. Stone, E., and Sheffield, V. (1993) Molecular Genetics of Inherited Eye Disorders (Wright, A. F., and Harwood, B. J., eds) Academic Publishers, Chur, Switzerland
5. Heiba, I., Elston, R., Klein, B. K., and Klein, R. (1994) Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genet. Epidemiol. 11, 51-67
6. Silvestri, G., Johnston, P., and Hughes, A. (1994) Is genetic predisposition an important risk factor in age-related macular degeneration? Eye 8, 564-568
7. Seddon, J., Ajani, U., and Mitchell, B. (1997) Familial aggregation of age-related maculopathy. Am. J. Ophthalmol. 123, 199-206
8. Gorin, M., Breitner, J., de Jong, P., Hageman, G., Klaver, C., Kuehn, M., and Seddon, J. (1999) The genetics of macular degeneration. Mol. Vision 5, 29
9. Pauleikhoff, D., Barondes, M., Minassian, D., Chisholm, I., and Bird, A. (1990) Drusen as risk factors in age-related macular disease. Am. J. Ophthalmol. 109, 38-43
10. Sarks, S. (1980) Drusen and their relationship to senile macular degeneration. Aust. J. Ophthalmol. 8, 117-130
11. Bressler, S., Maguire, G., Bressler, N., and Fine, S. (1990) Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. Arch. Ophthalmol. 108, 1442-1447
12. Lewis, H., Straatsma, B., and Foos, R. (1986) Chorioretinal juncture: multiple extramacular drusen. Ophthalmology 93, 1098-1112
13. Bird, A. (1992) Pathophysiology of AMD. In Age-Related Macular Degeneration: Principles and Practice (Hampton, G., and Nelsen, P. T., eds) Chap. 3, Raven Press, New York
14. Frennesson, C., Nilsson, U., and Nilsson, S. (1995) Colour contrast sensitivity in patients with soft drusen, an early stage of ARM. Documenta Ophthalmol. 90, 377-86
15. Holz, F., Gross-Jendroska, M., Eckstein, A., Hogg, C., Arden, G., and Bird, A. (1995) Colour contrast sensitivity in patients with age-related Bruch's membrane changes. German J. Ophthalmol. 4, 336-341
16. Stangos, N., Voutas, S., Topouzis, F., and Karampatakis, V. (1995) Contrast sensitivity evaluation in eyes predisposed to age-related macular degeneration and presenting normal visual acuity. Ophthalmologica 209, 194-198
17. Liem, A., Keunen, J., and van Norren, D. (1992) Foveal densitometry in adult-onset diffuse drusen. Am. J. Ophthalmol. 114, 149-157
18. Midena, F., Segato, T., Blarzino, M., and Angeli, C. (1994) Macular drusen and the sensitivity of the central visual field. Documenta Ophthalmol. 88, 179-185
19. Sigelman, J. (1991) Foveal drusen resorption one year after perifoveal laser photocoagulation. Ophthalmology 98, 1379-1383
20. Figueroa, M., Regueras, A., and Bertrand, J. (1994) Laser photocoagulation to treat macular soft drusen in age-related macular degeneration. Retina 14, 391-396
21. Wetzig, P. (1988) Treatment of drusen-related aging macular degeneration by photocoagulation. Trans. Am. Ophthalmol. Soc. 86, 276-290
22. Duvall, J., and Tso, M. (1985) Cellular mechanisms of resolution of drusen after laser coagulation: an experimental study. Arch. Ophthalmol. 103, 694-703
23. Frennesson, I., and Nilsson, S. (1995) Effects of argon (green) laser treatment of soft drusen in early age-related maculopathy: a 6 month prospective study. Br. J. Ophthalmol. 79, 905-909
24. van der Schaft, T., Mooy, C., de Bruijn, W., Oron, F., Mulder, P., and de Jong, P. (1992) Histological features of age-related macular degeneration. A statistical analysis. Ophthalmology 99, 278-286
25. Farkas, T., Sylvester, V., Archer, D., and Altona, M. (1971) The histochemistry of drusen. Am. J. Ophthalmol. 71, 1206-1215
26. Kliffen, M., Mooy, C., Luider, T., and de Jong, P. (1994) Analysis of carbohydrate structures in basal laminar deposit in aging human macula. Invest. Ophthalmol. Vis. Sci. 35, 2901-2905
27. Kliffen, M., Mooy, C., Luider, T., Huijmans, J., Kerkvliet, S., and de Jong, P. (1996) Identification of glycosaminoglycans in age-related macular deposits. Arch. Ophthalmol 114, 1009-1014
28. Loeffler, K., Edward, D., and Tso, M. (1995) Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest. Ophthalmol. Vis. Sci. 36, 24-31
29. Loeffler, K., and Mangini, M. (1997) Immunolocalization of ubiquitin and related enzymes in human retina and retinal pigment epithelium. Graefe's Arch. Clin. Exp. Ophthalmol. 235, 248-254
30. Newsome, D., Hewitt, A., Huh, W., Robey, P., and Hassell, J. (1987) Detection of specific extracellular matrix molecules in drusen, Bruch's membrane, and ciliary body. Am. J. Ophthalmol. 104, 373-381
31. van der Schaft, T., Mooy, C., de Bruijn, W., and de Jong, P. (1993) Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study. Br. J. Ophthalmol. 77, 657-661
32. Hageman, G., Mullins, R., Russell, S., Johnson, L., and Anderson, D. (1999) Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. FASEB J. 13, 477-484
33. Preissner, K. (1991) Structure and biological role of vitronectin. Annu. Rev. Cell Biol. 7, 275-310
34. Niculescu, F., Rus, H., and Vlaicu, R. (1987) Immunohistochemical localization of C5b-9, S-protein, C3d and apolipoprotein B in human arterial tissues with atherosclerosis. Atherosclerosis 65, 1-11
35. Niculescu, F., Rus, H., Porutiu, D., Ghiurca, V., and Vlaicu, R. (1989) Immunoelectron-microscopic localization of S-protein/vitronectin in human atherosclerotic wall. Atherosclerosis 78, 197-203
36. Dahlback, K., Wulf, H., and Dahlback, B. (1993) Vitronectin in mouse skin: immunohistochemical demonstration of its association with cutaneous amyloid. Invest. Dermatol. 100, 166-170
37. Dahlback, K., Lofberg, H., and Dahlback, B. (1988) Immunohistochemical studies on vitronectin in elastic tissue disorders, cutaneous amyloidosis. Lichen ruberplanus and porphyria. Acta Dermatol. Venereol. 68, 107-115
38. Jansen, J., Hogasen, K., and Mollnes, T. (1993) Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease). Am. J. Pathol. 143, 1356-1365
39. Vingerling, J., Dielemans, I., Bots, M., Hofman, A., Grobbee, D., and de Jong, P. (1995) Age-related macular degeneration is associated with atherosclerosis. The Rotterdam Study. Am. J. Epidemiol. 142, 404-409
40. Blumenkranz, M., Russell, S., Robey, M., Kott-Blumenkranz, R., and Penneys, N. (1986) Risk factors in age-related maculopathy complicated by choroidal neovascularization. Ophthalmology 93, 552-558
41. Mullins, R., Johnson, L., Anderson, D., and Hageman, G. (1997) Characterization of drusen-associated glycoconjugates. Ophthalmology 104, 288-294
42. Hale, I., and Matsumoto, B. (1993) Resolution of subcellular detail in thick tissue sections: immunohistochemical preparation and fluorescence confocal microscopy. Methods Cell Biol. 38, 289-324
43. Luna, L. (1968) Manual of Histological Staining Methods of the Armed Forces Institute of Pathology, McGraw-Hill, New York
44. Hageman, G., and Mullins, R. (1999) Molecular composition of drusen as related to substructural phenotype. Mol. Vision 5, 28
45. Coria, F., Castano, E., Prelli, F., Larrando-Lillo, M., van Duinen, S., Shelanski, M., and Frangione, B. (1988) Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Lab. Invest. 58, 454-458
46. Li, X., Hatanaka, K., Ishibashi-Ueda, H., Yutani, C., and Yamamoto, A. (1995) Characterization of serum amyloid P component from human aortic atherosclerotic lesions. Arteriosclerosis Thromb. Vasc. Biol. 15, 252-257
47. Yang, G., Nieto, R., Stachura, I., and Gallo, G. (1992) Ultrastructural immunohistochemical localization of polyclonal IgG, C3, and amyloid P component on the Congo red-negative amyloid-like fibrils of fibrillar glomerulopathy. Am. J. Pathol. 141, 409-419
48. Babaev, V., Dergunov, A., Chenchik, A., Tararak, E., Yanushevskaya, K., Trakht, I., Sorg, C., and Smirnov, V. (1990) Localization of apolipoprotein E in normal and atherosclerotic human aorta. Atherosclerosis 85, 239-247
49. Kida, F., Golabek, A., Wisniewski, T., and Wisniewski, K. (1994) Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain. Neurosci. Lett. 167, 73-76
50. Mullins, R., and Hageman, G. (1999) Human ocular drusen possess novel core domains with a distinct carbohydrate composition. J. Histochem. Cytochem. 47, 1533-1539
51. Akiyama, H., Kawamata, T., Dedhar, S., and McGreer, P. (1991) Immunohistochemical localization of vitronectin, its receptor, and beta-3 integrin in Alzheimer brain tissue. J. Neuroimmunol. 32, 19-28
52. Puchtler, H., Sweat, F., and Levine, M. (1962) On the binding of Congo red by amyloid. J. Histochem. Cytochem. 10, 355-364
53. Tan, S., and Pepys, M. (1994) Amyloidosis. Histopathology 25, 403-414
54. Strittmatter, W. J., and Roses, A. D. (1995) Apolipoprotein E and Alzheimer disease. Proc. Natl. Acad. Sci. USA 92, 4725-4727
55. Ermilov, V., and Vodovozov, A. (1995) Role of local amyloidosis of the fundus oculi tissues in the pathogenesis of senile maculopathy. Vestnik Oftalmologii 111, 24-27
56. Hintner, H., Booker, J., Ashworth, J., Aubock, J., Pepys, M., and Breathnach, S. (1988) Amyloid P component binds to keratin bodies in human skin and to isolated keratin filament aggregates in vitro. J. Invest. Dermatol. 91, 22-28
57. Li, J., and McAdam, W. (1984) Human amyloid P component: an elastase inhibitor. Scand. J. Immunol. 20, 219-226
58. Kivela, T., Tarkkanen, A., Frangione, B., Ghiso, J., and Haltia, M. (1994) Ocular amyloid deposition in familial amyloidosis, Finnish: an analysis of native and variant gelsolin in Meretoja's syndrome. Invest. Ophthalmol. Vis. Sci. 35, 3759-3769
59. Fariss, R. N., Apte, S. S., Olsen, B. R., Iwata, K., and Milam, A. H. (1997) Tissue inhibitor of metalloproteinases-3 is a component of Bruch's membrane of the eye. Am. J. Pathol. 150, 323-328
60. Jaworowski, A., Fang, Z., Khong, T. F., and Augusteyn, R. C. (1995) Protein synthesis and secretion by cultured retinal pigment epithelia. Biochim. Biophys. Acta 1245, 121-129
61. Ishibashi, T., Patterson, R., Ohnishi, Y., Inomata, H., and Ryan, S. (1986) Formation of drusen in the human eye. Am. J. Ophthalmol. 101, 342-353
62. Kligman, A. (1969) Early destructive effect of sunlight on human skin. J. Am. Med. Assoc. 210, 2377-2380
63. Dahlback, K., Ljungquist, A., Lofberg, H., Dahlback, B., Engvall, E., and Sakai, L. (1990) Fibrillin immunoreactive fibers constitute a unique network in the human dermis: immunohistochemical comparison of the distributions of fibrillin, vitronectin, amyloid P component, and orcein stainable structures in normal skin and elastosis. J. Invest. Dermatol. 94, 284-291
64. Dahlback, K., Lofberg, H., Alumets, J., and Dahlback, B. (1989) Immunohistochemical demonstration of age-related deposition of vitronectin (S-protein of complement) and terminal complement complex on dermal elastic fibers. J. Invest. Dermatol. 92, 727-733
65. Newsome, D., Huh, W., and Green, W. (1987) Bruch's membrane age-related changes vary by region. Curr. Eye Res. 6, 1211-1221
66. Spraul, C., and Grossniklaus, H. (1997) Characteristics of drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration. Arch. Ophthalmol. 115, 267-273
67. Hashimoto, K., and DiBella, R. (1967) Electron microscopic studies of normal and abnormal elastic fibers of the skin. J. Invest. Dermatol. 48, 405-422
68. Mehregan, A., and Hashimoto, K. (1991) Pinkus' Guide to Dermatohistopathology, 5th Ed, pp. 369-382, Prentice Hall, Englewood Cliffs, N.J.
69. Newsome, D. (1988) Angioid streaks and Bruch's membrane degenerations. In Retinal Dystrophies and Degenerations (Newsome, D., ed) pp. 271-283, Raven Press, New York
70. Muda, A., Barsotti, P., and Marinozzi, V. (1988) Ultrastructural histochemical investigations of 'dense deposit disease'. Pathogenetic approach to a special type of mesangiocapillary glomerulonephritis. Virchows Arch. A, Pathol. Anat. Histopathol. 413, 529-537
71. Thorner, P., and Baumal, R. (1982) Extraglomerular dense deposits in dense deposit disease. Arch. Pathol. Lab. Med. 106, 628-631
72. Duvall-Young, J., MacDonald, M., and McKechnie, N. (1989) Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report. Br. J. Ophthalmol. 73, 297-302
73. Leys, A., Vanrenterghem, Y., Van Damme, B., Snyers, B., Pirson, Y., and Leys, M. (1991) Fundus changes in membranoproliferative glomerulonephritis type II. A fluorescein angiographic study of 23 patients. Graefe's Arch. Clin. Exp. Ophthalmol. 229, 406-410
74. Leys, A., Michielsen, B., Leys, M., Vanrenterghem, Y., Missotten, L., and Van Damme, B. (1990) Subretinal neovascular membranes associated with chronic membranoproliferative glomerulonephritis type II. Graefe's Arch. Clin. Exp. Ophthalmol. 228, 499-504
75. Joh, K., Aizawa, S., Matsuyama, N., Yamaguchi, Y., Kitajima, T., Sakai, O., Mochizuki, H., Usui, N., Hamaguchi, K., and Mitarai, T. (1993) Morphologic variations of dense deposit disease: light and election microscopic, immunohistochemical and clinical findings in 10 patients. Acta Pathol. Japon. 43, 552-565
76. van der Schaft, T., Mooy, C., de Bruijn, W., Bosman, F., and de Jong, P. (1994) Immunohistochemical light and electron microscopy of basal laminar deposit. Graefe's Arch. Clin. Exp. Ophthalmol. 232, 40-46
77. Guyton, J., and Klemp, K. (1996) Development of the lipid-rich core in human atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 16, 4-11
78. Reblin, T., Meyer, N., Labeur, C., Henne-Bruns, D., and Beisiegel, U. (1995) Extraction of lipoprotein(a), apo B, and apo E from fresh human arterial wall and atherosclerotic plaques. Atherosclerosis 113, 179-188
79. Stary, U., Chandler, A., Dinsmore, R., Fuster, V., Glagov, S., Insull, W., Rosenfeld, M., Schwartz, C., Wagner, W., and Wissler, R. (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. Circulation 92, 1355-1374
80. Bobryshev, Y., Lord, R., and Warren, B. (1995) Calcified deposit formation in intimal thickenings of the human aorta. Atherosclerosis 118, 9-21
81. Bocan, T., Brown, S., and Guyton, J. (1988) Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A. Arteriosclerosis 8, 499-508
82. Penfold, P., Provis, J., Furby, J., Gatenby, P., and Billson, R. (1990) Autoantibodies to retinal astrocytes associated with age-related macular degeneration. Graefe's Arch. Clin. Exp. Ophthalmol. 228, 270-274
83. Guerne, D., Tso, M., Edward, D., and Ripps, H. (1991) Antiretinal antibodies in serum of patients with age-related macular degeneration. Ophthalmology 98, 602-607
84. Killingsworth, M., Sarks, J., and Sarks, S. (1990) Macrophages related to Bruch's membrane in age-related macular degeneration. Eye 4, 613-621
85. Dastgheib, K., and Green, W. (1994) Granulomatous reaction to Bruch's membrane in age-related macular degeneration. Arch. Ophthalmol. 112, 813-818
86. Penfold, P., Killingsworth, M., and Sarks, S. (1985) Senile macular degeneration: the involvement of immunocompetent cells. Graefe's Arch. Clin. Exp. Ophthalmol. 223, 69-76
87. Penfold, P., Killingsworth, M., and Sarks, S. (1986) Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 27, 364-371
88. Oppenheim, J., and Leonard, E. (1989) Introduction to human monocytes. In Human Monocytes (Zembala, M., and Asherson, G., eds) Academic Press, San Diego, California
89. Kliffen, M., de Jong, P., and Luider, T. (1995) Protein analysis of human maculae in relation to age-related maculopathy. Lab. Invest. 73, 267-272
90. Osusky, R., Dorio, R., Arora, Y., Ryan, S., and Walker, S. (1997) MHC class II positive retinal pigment epithelial (RPE) cells can function as antigen-presenting cells for microbial superantigen. Receptors Signal Transduct. 5, 43-50
91. Ozaki, T., Johnson, L., Mullins, R., Hageman, G., and Anderson, D. (1999) Real-time quantitation of vitronectin transcription in human retina and retinal pigmented epithelium. Biochem. Biophys. Res. Commun. 258, 524-529
92. Anderson, D., Hageman, G., Mullins, R., Neitz, M., Neitz, J., Ozaki, S., Preissner, K., and Johnson, L. (1999) Vitronectin gene expression in the adult human retina. Invest. Ophthalmol. Vis. Sci. In press
93. Penfold, P., Liew, S., Madigan, M., and Provis, J. (1997) Modulation of major histocompatibility complex class II expression in retinas with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 38, 2125-2133
94. Pauleikhoff, D., Zuels, S., Sheraidah, G., Marshall, J., Wessing, A., and Bird, A. (1992) Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane. Ophthalmology 99, 1548-1553
95. Sarks, S., and Sarks, J. (1989) Age-related macular degeneration: atrophic form. In The Retina (Ryan, S., ed) Vol. 2, CV Mosby, St. Louis, Missouri
96. Pepys, M., Rademacher, T., Amatayakul-Chantler, S., Williams, P., Noble, G., Hutchinson, W., Hawkins, P., Nelson, S., Gallimore, J., Herbert, J., et al. (1994) Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure. Proc. Natl. Acad. Sci. USA 91, 5602-5606
97. Castano, E., Prelli, F., Pras, M., and Frangione, B. (1995) Apolipoprotein E carboxyl-terminal fragments are complexed to amyloids A and L Implications for amyloidogenesis and Alzheimer's disease. J. Biol. Chem. 270, 17610-17615
98. Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., and Kawasaki, I. (1991) Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541, 163-166
99. Bradt, B., Kolb, W., and Cooper, N. (1998) Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J. Exp. Med. 188, 431-438
100. Yanaghihara, M., Kato, F., Shikano, Y., Fukushima, N., and Moris, S. (1985) Intimate structural association of amyloid and elastic fibers in systemic and cutaneous amyloidoses. J. Cutaneous Pathol. 12, 110-116
101. 2+ and amyloid P-component. Clin. Exp. Immunol. 94, 189-195
102. Snow, A., Mar, H., Nochlin, D., Kresse, H., and Wight, T. (1992) Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease. J. Histochem. Cytochem. 40, 105-113
103. Hoque, M., Suzuki, S., Shimada, H., Takashima, N., Ueno, M., Nishi, S., Karasawa, R., Inn, H., Kishimoto, H., Takayama, R., et al. (1993) Clinico-pathological studies of amyloid-P component in human glomerulonephropathies. Jpn. J. Nephrol. 35, 365-370
104. Buyukbabani, N., and Droz, D. 1994) Distribution of the extracellular matrix components in human glomerular lesions. J. Pathol. 172, 199-207
105. Tarnawski, R., Tarnawski, R, and Grobelny, J. (1995) Changes in elastin in human atherosclerotic aorta: carbon-13 magic angle sample-spinning NMR studies. Atherosclerosis 115, 27-33
106. Camejo, G., Hurt-Camejo, E., Wiklund, O., and Bondjers, G., (1998) Association of apoB lipoproteins with arterial proteoglycans: pathological significance and molecular basis. Atherosclerosis 139, 205-222