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Volumn 32, Issue 8, 2012, Pages 2657-2666

MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; INTERLEUKIN 6; LACTADHERIN; LIPOPOLYSACCHARIDE; PHOSPHATIDYLSERINE; TUMOR NECROSIS FACTOR ALPHA; VITRONECTIN RECEPTOR;

EID: 84863141913     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4837-11.2012     Document Type: Article
Times cited : (160)

References (50)
  • 2
    • 4344715014 scopus 로고    scopus 로고
    • Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice
    • Asano K, Miwa M, Miwa K, Hanayama R, Nagase H, Nagata S, Tanaka M (2004) Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med 200:459-467.
    • (2004) J Exp Med , vol.200 , pp. 459-467
    • Asano, K.1    Miwa, M.2    Miwa, K.3    Hanayama, R.4    Nagase, H.5    Nagata, S.6    Tanaka, M.7
  • 3
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 5
    • 34247868178 scopus 로고    scopus 로고
    • Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain
    • Choi HB, Ryu JK, Kim SU, McLarnon JG (2007) Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J Neurosci 27:4957-4968.
    • (2007) J Neurosci , vol.27 , pp. 4957-4968
    • Choi, H.B.1    Ryu, J.K.2    Kim, S.U.3    McLarnon, J.G.4
  • 7
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB (2000) Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 74:2213-2216.
    • (2000) J Neurochem , vol.74 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 8
    • 77954396042 scopus 로고    scopus 로고
    • Clearance of apoptotic cells: Implications in health and disease
    • Elliott MR, Ravichandran KS (2010) Clearance of apoptotic cells: implications in health and disease. J Cell Biol 189:1059-1070.
    • (2010) J Cell Biol , vol.189 , pp. 1059-1070
    • Elliott, M.R.1    Ravichandran, K.S.2
  • 9
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    • Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101:890-898.
    • (1998) J Clin Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 10
    • 55049140968 scopus 로고    scopus 로고
    • Erythrocyte programmed cell death
    • Föller M, Huber SM, Lang F (2008) Erythrocyte programmed cell death. IUBMB Life 60:661-668.
    • (2008) IUBMB Life , vol.60 , pp. 661-668
    • Föller, M.1    Huber, S.M.2    Lang, F.3
  • 11
    • 55849085357 scopus 로고    scopus 로고
    • MFG-E8 regulates microglial phagocytosis of apoptotic neurons
    • Fuller AD, Van Eldik LJ (2008) MFG-E8 regulates microglial phagocytosis of apoptotic neurons. J Neuroimmune Pharmacol 3:246-256.
    • (2008) J Neuroimmune Pharmacol , vol.3 , pp. 246-256
    • Fuller, A.D.1    van Eldik, L.J.2
  • 12
    • 0036316772 scopus 로고    scopus 로고
    • Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: Relevance to Parkinson's disease
    • Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B (2002) Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem 81:1285-1297.
    • (2002) J Neurochem , vol.81 , pp. 1285-1297
    • Gao, H.M.1    Jiang, J.2    Wilson, B.3    Zhang, W.4    Hong, J.S.5    Liu, B.6
  • 14
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394.
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 15
    • 0029778085 scopus 로고    scopus 로고
    • Structural and functional aspects of RGD-containing cyclic pentapeptides as highly potent and selective integrin alpha(v)beta(3) antagonists
    • Haubner R, Gratias R, Diefenbach B, Goodman SL, Jonczyk A, Kessler H (1996) Structural and functional aspects of RGD-containing cyclic pentapeptides as highly potent and selective integrin alpha(v)beta(3) antagonists. J Am Chem Soc 118:7461-7472.
    • (1996) J Am Chem Soc , vol.118 , pp. 7461-7472
    • Haubner, R.1    Gratias, R.2    Diefenbach, B.3    Goodman, S.L.4    Jonczyk, A.5    Kessler, H.6
  • 16
    • 0035849895 scopus 로고    scopus 로고
    • Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans
    • Hoeppner DJ, Hengartner MO, Schnabel R (2001) Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 412:202-206.
    • (2001) Nature , vol.412 , pp. 202-206
    • Hoeppner, D.J.1    Hengartner, M.O.2    Schnabel, R.3
  • 17
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162:3749-3752.
    • (1999) J Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 18
    • 34447121852 scopus 로고    scopus 로고
    • MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF
    • Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G (2007) MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF. J Clin Invest 117:1902-1913.
    • (2007) J Clin Invest , vol.117 , pp. 1902-1913
    • Jinushi, M.1    Nakazaki, Y.2    Dougan, M.3    Carrasco, D.R.4    Mihm, M.5    Dranoff, G.6
  • 19
    • 61449208877 scopus 로고    scopus 로고
    • Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: Role in macrophage recognition and engulfment
    • Jitkaew S, Witasp E, Zhang S, Kagan VE, Fadeel B (2009) Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: role in macrophage recognition and engulfment. J Leukoc Biol 85:427-437.
    • (2009) J Leukoc Biol , vol.85 , pp. 427-437
    • Jitkaew, S.1    Witasp, E.2    Zhang, S.3    Kagan, V.E.4    Fadeel, B.5
  • 21
    • 77956938316 scopus 로고    scopus 로고
    • A model to die for: Signaling to apoptotic cell removal in worm, fly and mouse
    • Kinchen JM (2010) A model to die for: signaling to apoptotic cell removal in worm, fly and mouse. Apoptosis 15:998-1006.
    • (2010) Apoptosis , vol.15 , pp. 998-1006
    • Kinchen, J.M.1
  • 22
    • 28244472094 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation
    • Kinsner A, Pilotto V, Deininger S, Brown GC, Coecke S, Hartung T, Bal-Price A (2005) Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation. J Neurochem 95:1132-1143.
    • (2005) J Neurochem , vol.95 , pp. 1132-1143
    • Kinsner, A.1    Pilotto, V.2    Deininger, S.3    Brown, G.C.4    Coecke, S.5    Hartung, T.6    Bal-Price, A.7
  • 23
    • 79952159132 scopus 로고    scopus 로고
    • Emerging inflammasome effector mechanisms
    • Lamkanfi M (2011) Emerging inflammasome effector mechanisms. Nat Rev Immunol 11:213-220.
    • (2011) Nat Rev Immunol , vol.11 , pp. 213-220
    • Lamkanfi, M.1
  • 24
    • 40449097556 scopus 로고    scopus 로고
    • A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS
    • Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, Nitsch R, Weber JR (2008) A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J Neurosci 28:2320-2331.
    • (2008) J Neurosci , vol.28 , pp. 2320-2331
    • Lehnardt, S.1    Schott, E.2    Trimbuch, T.3    Laubisch, D.4    Krueger, C.5    Wulczyn, G.6    Nitsch, R.7    Weber, J.R.8
  • 25
    • 0345374586 scopus 로고    scopus 로고
    • Phosphatidylserine receptor is required for clearance of apoptotic cells
    • Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA (2003) Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 302:1560-1563.
    • (2003) Science , vol.302 , pp. 1560-1563
    • Li, M.O.1    Sarkisian, M.R.2    Mehal, W.Z.3    Rakic, P.4    Flavell, R.A.5
  • 26
    • 35549006420 scopus 로고    scopus 로고
    • Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
    • Lobsiger CS, Cleveland DW (2007) Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci 10:1355-1360.
    • (2007) Nat Neurosci , vol.10 , pp. 1355-1360
    • Lobsiger, C.S.1    Cleveland, D.W.2
  • 30
    • 0037105511 scopus 로고    scopus 로고
    • Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: Role of glucocorticoids and CD14
    • Nadeau S, Rivest S (2002) Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. J Immunol 169:3370-3381.
    • (2002) J Immunol , vol.169 , pp. 3370-3381
    • Nadeau, S.1    Rivest, S.2
  • 31
    • 79955008182 scopus 로고    scopus 로고
    • Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death
    • Neher JJ, Neniskyte U, Zhao JW, Bal-Price A, Tolkovsky AM, Brown GC (2011) Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J Immunol 186:4973-4983.
    • (2011) J Immunol , vol.186 , pp. 4973-4983
    • Neher, J.J.1    Neniskyte, U.2    Zhao, J.W.3    Bal-Price, A.4    Tolkovsky, A.M.5    Brown, G.C.6
  • 32
    • 81155154302 scopus 로고    scopus 로고
    • Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia
    • Neniskyte U, Neher JJ, Brown GC (2011) Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia. J Biol Chem 286:39904-39913.
    • (2011) J Biol Chem , vol.286 , pp. 39904-39913
    • Neniskyte, U.1    Neher, J.J.2    Brown, G.C.3
  • 34
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • Neumann H, Kotter MR, Franklin RJ (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132: 288-295.
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 35
    • 0036178402 scopus 로고    scopus 로고
    • Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles
    • Oshima K, Aoki N, Kato T, Kitajima K, Matsuda T (2002) Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. Eur J Biochem 269:1209-1218.
    • (2002) Eur J Biochem , vol.269 , pp. 1209-1218
    • Oshima, K.1    Aoki, N.2    Kato, T.3    Kitajima, K.4    Matsuda, T.5
  • 36
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E (2004) Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 279:7370-7377.
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6    Abraham, E.7
  • 39
    • 0038723231 scopus 로고    scopus 로고
    • from apoptotic cells: invitation to a quiet meal. Cell
    • Ravichandran KS (2003) "Recruitment signals" from apoptotic cells: invitation to a quiet meal. Cell 113:817-820.
    • (2003) Recruitment Signals , vol.113 , pp. 817-820
    • Ravichandran, K.S.1
  • 40
    • 0035849886 scopus 로고    scopus 로고
    • Phagocytosis promotes programmed cell death in C
    • Reddien PW, Cameron S, Horvitz HR (2001) Phagocytosis promotes programmed cell death in C. elegans. Nature 412:198-202.
    • (2001) Elegans. Nature , vol.412 , pp. 198-202
    • Reddien, P.W.1    Cameron, S.2    Horvitz, H.R.3
  • 41
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • Savill J, Dransfield I, Gregory C, Haslett C (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2:965-975.
    • (2002) Nat Rev Immunol , vol.2 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 42
    • 13844253258 scopus 로고    scopus 로고
    • Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons
    • Schmued LC, Stowers CC, Scallet AC, Xu L (2005) Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 1035:24-31.
    • (2005) Brain Res , vol.1035 , pp. 24-31
    • Schmued, L.C.1    Stowers, C.C.2    Scallet, A.C.3    Xu, L.4
  • 44
    • 0035844225 scopus 로고    scopus 로고
    • Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells
    • Sun YF, Yu LY, Saarma M, Timmusk T, Arumae U (2001) Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells. J Biol Chem 276: 16240-16247.
    • (2001) J Biol Chem , vol.276 , pp. 16240-16247
    • Sun, Y.F.1    Yu, L.Y.2    Saarma, M.3    Timmusk, T.4    Arumae, U.5
  • 45
    • 0033579382 scopus 로고    scopus 로고
    • Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    • Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, MullanM (1999) Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 286:2352-2355.
    • (1999) Science , vol.286 , pp. 2352-2355
    • Tan, J.1    Town, T.2    Paris, D.3    Mori, T.4    Suo, Z.5    Crawford, F.6    Mattson, M.P.7    Flavell, R.A.8
  • 48
    • 3042608198 scopus 로고    scopus 로고
    • Loss of NeuN immunoreactivity after cerebral ischemia does not indicate neuronal cell loss: A cautionary note
    • Unal-Cevik I, Kilinç M, Gürsoy-Ozdemir Y, Gurer G, Dalkara T (2004) Loss of NeuN immunoreactivity after cerebral ischemia does not indicate neuronal cell loss: a cautionary note. Brain Res 1015:169-174.
    • (2004) Brain Res , vol.1015 , pp. 169-174
    • Unal-Cevik, I.1    Kilinç, M.2    Gürsoy-Ozdemir, Y.3    Gurer, G.4    Dalkara, T.5
  • 50
    • 33645845142 scopus 로고    scopus 로고
    • Phosphatidylserine recognition by phagocytes: A view to a kill
    • Wu Y, Tibrewal N, Birge RB (2006) Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol 16:189-197.
    • (2006) Trends Cell Biol , vol.16 , pp. 189-197
    • Wu, Y.1    Tibrewal, N.2    Birge, R.B.3


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