메뉴 건너뛰기




Volumn 12, Issue 4, 2013, Pages 1005-1012

Phagocyte dysfunction, tissue aging and degeneration

Author keywords

Aging; Macrophage; Microglia; Phagocyte dysfunction; Phagocytosis; Retinal pigment epithelium

Indexed keywords

ALPHAVBETA5 INTEGRIN; AMYLOID BETA PROTEIN; CD36 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; COMPLEMENT RECEPTOR; FC RECEPTOR; MEMBRANE RECEPTOR; MER RECEPTOR TYROSINE KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLSERINE; PROTEIN TYROSINE KINASE; SCAVENGER RECEPTOR; SCAVENGER RECEPTOR A; TOLL LIKE RECEPTOR; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

EID: 84888198684     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2013.05.006     Document Type: Review
Times cited : (96)

References (96)
  • 1
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal A., Agrawal S., Cao J.N., Su H., Osann K., Gupta S. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 2007, 178:6912-6922.
    • (2007) J. Immunol. , vol.178 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.N.3    Su, H.4    Osann, K.5    Gupta, S.6
  • 4
    • 43349104959 scopus 로고    scopus 로고
    • Ageing is associated with diminished apoptotic cell clearance in vivo
    • Aprahamian T., Takemura Y., Goukassian D., Walsh K. Ageing is associated with diminished apoptotic cell clearance in vivo. Clin. Exp. Immunol. 2008, 152:448-455.
    • (2008) Clin. Exp. Immunol. , vol.152 , pp. 448-455
    • Aprahamian, T.1    Takemura, Y.2    Goukassian, D.3    Walsh, K.4
  • 5
    • 33847640493 scopus 로고    scopus 로고
    • Immunosenescence: emerging challenges for an ageing population
    • Aw D., Silva A.B., Palmer D.B. Immunosenescence: emerging challenges for an ageing population. Immunology 2007, 120:435-446.
    • (2007) Immunology , vol.120 , pp. 435-446
    • Aw, D.1    Silva, A.B.2    Palmer, D.B.3
  • 7
    • 33646128251 scopus 로고    scopus 로고
    • Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
    • Bazan N.G. Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci. 2006, 29:263-271.
    • (2006) Trends Neurosci. , vol.29 , pp. 263-271
    • Bazan, N.G.1
  • 8
    • 77956460474 scopus 로고    scopus 로고
    • Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1
    • Bazan N.G., Calandria J.M., Serhan C.N. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J. Lipid Res. 2010, 51:2018-2031.
    • (2010) J. Lipid Res. , vol.51 , pp. 2018-2031
    • Bazan, N.G.1    Calandria, J.M.2    Serhan, C.N.3
  • 10
    • 79952506823 scopus 로고    scopus 로고
    • Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination
    • Binder M.D., Xiao J., Kemper D., Ma G.Z., Murray S.S., Kilpatrick T.J. Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination. PLoS One 2011, 6:e17727.
    • (2011) PLoS One , vol.6
    • Binder, M.D.1    Xiao, J.2    Kemper, D.3    Ma, G.Z.4    Murray, S.S.5    Kilpatrick, T.J.6
  • 11
    • 79960671469 scopus 로고    scopus 로고
    • Age related macular degeneration and drusen: neuroinflammation in the retina
    • Buschini E., Piras A., Nuzzi R., Vercelli A. Age related macular degeneration and drusen: neuroinflammation in the retina. Prog. Neurobiol. 2011, 95:14-25.
    • (2011) Prog. Neurobiol. , vol.95 , pp. 14-25
    • Buschini, E.1    Piras, A.2    Nuzzi, R.3    Vercelli, A.4
  • 14
    • 84867143780 scopus 로고    scopus 로고
    • Tubby regulates microglial phagocytosis through MerTK
    • Caberoy N.B., Alvarado G., Li.W. Tubby regulates microglial phagocytosis through MerTK. J. Neuroimmunol. 2012, 252:40-48.
    • (2012) J. Neuroimmunol. , vol.252 , pp. 40-48
    • Caberoy, N.B.1    Alvarado, G.2    Li, W.3
  • 15
    • 70450252025 scopus 로고    scopus 로고
    • Identification of tubby and tubby-like protein 1 as eat-me signals by phage display
    • Caberoy N.B., Maiguel D., Kim Y., Li W. Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. Exp. Cell Res. 2010, 316:245-257.
    • (2010) Exp. Cell Res. , vol.316 , pp. 245-257
    • Caberoy, N.B.1    Maiguel, D.2    Kim, Y.3    Li, W.4
  • 16
    • 78649714537 scopus 로고    scopus 로고
    • Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis
    • Caberoy N.B., Zhou Y., Li W. Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J. 2010, 29:3898-3910.
    • (2010) EMBO J. , vol.29 , pp. 3898-3910
    • Caberoy, N.B.1    Zhou, Y.2    Li, W.3
  • 17
    • 0030045552 scopus 로고    scopus 로고
    • Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease
    • Cataldo A.M., Hamilton D.J., Barnett J.L., Paskevich P.A., Nixon R.A. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J. Neurosci. 1996, 16:186-199.
    • (1996) J. Neurosci. , vol.16 , pp. 186-199
    • Cataldo, A.M.1    Hamilton, D.J.2    Barnett, J.L.3    Paskevich, P.A.4    Nixon, R.A.5
  • 18
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: sensing and reacting to damage
    • Chen G.Y., Nunez G. Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 2010, 10:826-837.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 19
    • 64049111816 scopus 로고    scopus 로고
    • Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity
    • Chen H., Lukas T.J., Du N., Suyeoka G., Neufeld A.H. Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity. Invest. Ophthalmol. Vis. Sci. 2009, 50:1895-1902.
    • (2009) Invest. Ophthalmol. Vis. Sci. , vol.50 , pp. 1895-1902
    • Chen, H.1    Lukas, T.J.2    Du, N.3    Suyeoka, G.4    Neufeld, A.H.5
  • 24
    • 21744437451 scopus 로고    scopus 로고
    • Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence
    • 50 Online Pub:OL683-690
    • de la Fuente M., Hernanz A., Guayerbas N., Alvarez P., Alvarado C. Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell. Mol. Biol. (Noisy-le-grand) 2004, 50 Online Pub:OL683-690.
    • (2004) Cell. Mol. Biol. (Noisy-le-grand)
    • de la Fuente, M.1    Hernanz, A.2    Guayerbas, N.3    Alvarez, P.4    Alvarado, C.5
  • 25
    • 0034307632 scopus 로고    scopus 로고
    • Cell death in early neural development: beyond the neurotrophic theory
    • de la Rosa E.J., de Pablo F. Cell death in early neural development: beyond the neurotrophic theory. Trends Neurosci. 2000, 23:454-458.
    • (2000) Trends Neurosci. , vol.23 , pp. 454-458
    • de la Rosa, E.J.1    de Pablo, F.2
  • 26
    • 59849104241 scopus 로고    scopus 로고
    • Molecular pathology of age-related macular degeneration
    • Ding X., Patel M., Chan C.C. Molecular pathology of age-related macular degeneration. Prog. Retin. Eye Res. 2009, 28:1-18.
    • (2009) Prog. Retin. Eye Res. , vol.28 , pp. 1-18
    • Ding, X.1    Patel, M.2    Chan, C.C.3
  • 27
    • 84925554375 scopus 로고
    • Inherited retinal dystrophy in the rat
    • Dowling J.E., Sidman R.L. Inherited retinal dystrophy in the rat. J. Cell Biol. 1962, 14:73-109.
    • (1962) J. Cell Biol. , vol.14 , pp. 73-109
    • Dowling, J.E.1    Sidman, R.L.2
  • 28
    • 34547656330 scopus 로고    scopus 로고
    • Immunological consequences of apoptotic cell phagocytosis
    • Erwig L.P., Henson P.M. Immunological consequences of apoptotic cell phagocytosis. Am. J. Pathol. 2007, 171:2-8.
    • (2007) Am. J. Pathol. , vol.171 , pp. 2-8
    • Erwig, L.P.1    Henson, P.M.2
  • 30
    • 77951673268 scopus 로고    scopus 로고
    • TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
    • Freeman G.J., Casasnovas J.M., Umetsu D.T., DeKruyff R.H. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 2010, 235:172-189.
    • (2010) Immunol. Rev. , vol.235 , pp. 172-189
    • Freeman, G.J.1    Casasnovas, J.M.2    Umetsu, D.T.3    DeKruyff, R.H.4
  • 31
  • 35
    • 44949216859 scopus 로고    scopus 로고
    • Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases
    • Grillo M.A., Colombatto S. Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases. Amino Acids 2008, 35:29-36.
    • (2008) Amino Acids , vol.35 , pp. 29-36
    • Grillo, M.A.1    Colombatto, S.2
  • 37
    • 0032759729 scopus 로고    scopus 로고
    • Retinal degeneration in tulp1-/- mice: vesicular accumulation in the interphotoreceptor matrix
    • Hagstrom S.A., Duyao M., North M.A., Li T. Retinal degeneration in tulp1-/- mice: vesicular accumulation in the interphotoreceptor matrix. Invest. Ophthalmol. Vis. Sci. 1999, 40:2795-2802.
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 2795-2802
    • Hagstrom, S.A.1    Duyao, M.2    North, M.A.3    Li, T.4
  • 41
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman S.E., Allison E.K., El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J. Neurosci. 2008, 28:8354-8360.
    • (2008) J. Neurosci. , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 45
    • 33745630055 scopus 로고    scopus 로고
    • Human Fc receptors: critical targets in the treatment of autoimmune diseases and transplant rejections
    • Ivan E., Colovai A.I. Human Fc receptors: critical targets in the treatment of autoimmune diseases and transplant rejections. Hum. Immunol. 2006, 67:479-491.
    • (2006) Hum. Immunol. , vol.67 , pp. 479-491
    • Ivan, E.1    Colovai, A.I.2
  • 47
    • 84855859453 scopus 로고    scopus 로고
    • Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages
    • Jiang M., Xiang Y., Wang D., Gao J., Liu D., Liu Y., Liu S., Zheng D. Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages. Aging Cell 2012, 11:29-40.
    • (2012) Aging Cell , vol.11 , pp. 29-40
    • Jiang, M.1    Xiang, Y.2    Wang, D.3    Gao, J.4    Liu, D.5    Liu, Y.6    Liu, S.7    Zheng, D.8
  • 49
    • 0021270648 scopus 로고
    • Age-related changes in the retinal pigment epithelium of pigmented rats
    • Katz M.L., Robison W.G. Age-related changes in the retinal pigment epithelium of pigmented rats. Exp. Eye Res. 1984, 38:137-151.
    • (1984) Exp. Eye Res. , vol.38 , pp. 137-151
    • Katz, M.L.1    Robison, W.G.2
  • 50
    • 84861600073 scopus 로고    scopus 로고
    • Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
    • Kinnunen K., Petrovski G., Moe M.C., Berta A., Kaarniranta K. Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmol. 2012, 90:299-309.
    • (2012) Acta Ophthalmol. , vol.90 , pp. 299-309
    • Kinnunen, K.1    Petrovski, G.2    Moe, M.C.3    Berta, A.4    Kaarniranta, K.5
  • 51
    • 84858259145 scopus 로고    scopus 로고
    • Clearance of amyloid-beta peptides by microglia and macrophages: the issue of what, when and where
    • Lai A.Y., McLaurin J. Clearance of amyloid-beta peptides by microglia and macrophages: the issue of what, when and where. Future Neurol. 2012, 7:165-176.
    • (2012) Future Neurol. , vol.7 , pp. 165-176
    • Lai, A.Y.1    McLaurin, J.2
  • 52
    • 77956955758 scopus 로고    scopus 로고
    • The role of microglia in amyloid clearance from the AD brain
    • Lee C.Y., Landreth G.E. The role of microglia in amyloid clearance from the AD brain. J. Neural. Transm. 2010, 117:949-960.
    • (2010) J. Neural. Transm. , vol.117 , pp. 949-960
    • Lee, C.Y.1    Landreth, G.E.2
  • 53
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke G., Rothlin C.V. Immunobiology of the TAM receptors. Nat. Rev. Immunol. 2008, 8:327-336.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 54
    • 84862968058 scopus 로고    scopus 로고
    • Eat-me signals: Keys to molecular phagocyte biology and "Appetite" control
    • Li W. Eat-me signals: Keys to molecular phagocyte biology and "Appetite" control. J. Cell Physiol. 2012, 227:1291-1297.
    • (2012) J. Cell Physiol. , vol.227 , pp. 1291-1297
    • Li, W.1
  • 55
    • 84868371983 scopus 로고    scopus 로고
    • ORF phage display to identify cellular proteins with different functions
    • Li W. ORF phage display to identify cellular proteins with different functions. Methods 2012, 58:2-9.
    • (2012) Methods , vol.58 , pp. 2-9
    • Li, W.1
  • 56
    • 77950826971 scopus 로고    scopus 로고
    • Microglia in the aging brain: relevance to neurodegeneration
    • Luo X.G., Ding J.Q., Chen S.D. Microglia in the aging brain: relevance to neurodegeneration. Mol. Neurodegener. 2010, 5:12.
    • (2010) Mol. Neurodegener. , vol.5 , pp. 12
    • Luo, X.G.1    Ding, J.Q.2    Chen, S.D.3
  • 57
    • 68249129509 scopus 로고    scopus 로고
    • An empirical analysis of the precision of estimating the numbers of neurons and glia in human neocortex using a fractionator-design with sub-sampling
    • Lyck L., Santamaria I.D., Pakkenberg B., Chemnitz J., Schroder H.D., Finsen B., Gundersen H.J. An empirical analysis of the precision of estimating the numbers of neurons and glia in human neocortex using a fractionator-design with sub-sampling. J. Neurosci. Methods 2009, 182:143-156.
    • (2009) J. Neurosci. Methods , vol.182 , pp. 143-156
    • Lyck, L.1    Santamaria, I.D.2    Pakkenberg, B.3    Chemnitz, J.4    Schroder, H.D.5    Finsen, B.6    Gundersen, H.J.7
  • 58
    • 79951563979 scopus 로고    scopus 로고
    • Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility
    • Ma G.Z., Stankovich J., Kilpatrick T.J., Binder M.D., Field J. Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility. PLoS One 2011, 6:e16964.
    • (2011) PLoS One , vol.6
    • Ma, G.Z.1    Stankovich, J.2    Kilpatrick, T.J.3    Binder, M.D.4    Field, J.5
  • 61
    • 65649098369 scopus 로고    scopus 로고
    • The role of microglia in antibody-mediated clearance of amyloid-beta from the brain
    • Morgan D. The role of microglia in antibody-mediated clearance of amyloid-beta from the brain. CNS Neurol. Disord. Drug Targets 2009, 8:7-15.
    • (2009) CNS Neurol. Disord. Drug Targets , vol.8 , pp. 7-15
    • Morgan, D.1
  • 63
    • 2942625603 scopus 로고    scopus 로고
    • Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
    • Mukherjee P.K., Marcheselli V.L., Serhan C.N., Bazan N.G. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc. Natl. Acad. Sci. USA 2004, 101:8491-8496.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8491-8496
    • Mukherjee, P.K.1    Marcheselli, V.L.2    Serhan, C.N.3    Bazan, N.G.4
  • 64
    • 59349112140 scopus 로고    scopus 로고
    • Microglial clearance function in health and disease
    • Napoli I., Neumann H. Microglial clearance function in health and disease. Neuroscience 2009, 158:1030-1038.
    • (2009) Neuroscience , vol.158 , pp. 1030-1038
    • Napoli, I.1    Neumann, H.2
  • 65
    • 77955661661 scopus 로고    scopus 로고
    • Protective effects of microglia in multiple sclerosis
    • Napoli I., Neumann H. Protective effects of microglia in multiple sclerosis. Exp. Neurol. 2010, 225:24-28.
    • (2010) Exp. Neurol. , vol.225 , pp. 24-28
    • Napoli, I.1    Neumann, H.2
  • 66
    • 84872069366 scopus 로고    scopus 로고
    • Variant TREM2 as risk factor for Alzheimer's disease
    • Neumann H., Daly M.J. Variant TREM2 as risk factor for Alzheimer's disease. N. Engl. J. Med. 2013, 368:182-184.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 182-184
    • Neumann, H.1    Daly, M.J.2
  • 67
    • 33847625914 scopus 로고    scopus 로고
    • Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
    • Neumann H., Takahashi K. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. J. Neuroimmunol. 2007, 184:92-99.
    • (2007) J. Neuroimmunol. , vol.184 , pp. 92-99
    • Neumann, H.1    Takahashi, K.2
  • 68
    • 81355132325 scopus 로고    scopus 로고
    • Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function
    • e191-112
    • Njie E.G., Boelen E., Stassen F.R., Steinbusch H.W., Borchelt D.R., Streit W.J. Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol. Aging 2012, 33(195). e191-112.
    • (2012) Neurobiol. Aging , vol.33 , Issue.195
    • Njie, E.G.1    Boelen, E.2    Stassen, F.R.3    Steinbusch, H.W.4    Borchelt, D.R.5    Streit, W.J.6
  • 75
    • 0029088742 scopus 로고
    • Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes
    • Schmidt A.M., Hori O., Chen J.X., Li J.F., Crandall J., Zhang J., Cao R., Yan S.D., Brett J., Stern D. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J. Clin. Invest. 1995, 96:1395-1403.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1395-1403
    • Schmidt, A.M.1    Hori, O.2    Chen, J.X.3    Li, J.F.4    Crandall, J.5    Zhang, J.6    Cao, R.7    Yan, S.D.8    Brett, J.9    Stern, D.10
  • 76
    • 0034795140 scopus 로고    scopus 로고
    • The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
    • Schmidt A.M., Yan S.D., Yan S.F., Stern D.M. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J. Clin. Invest. 2001, 108:949-955.
    • (2001) J. Clin. Invest. , vol.108 , pp. 949-955
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 78
    • 73949130412 scopus 로고    scopus 로고
    • GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche
    • Shiozawa Y., Pedersen E.A., Taichman R.S. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Experimental hematology 2010, 38:132-140.
    • (2010) Experimental hematology , vol.38 , pp. 132-140
    • Shiozawa, Y.1    Pedersen, E.A.2    Taichman, R.S.3
  • 79
    • 0036549138 scopus 로고    scopus 로고
    • The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
    • Sim F.J., Zhao C., Penderis J., Franklin R.J. The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. J. Neurosci. 2002, 22:2451-2459.
    • (2002) J. Neurosci. , vol.22 , pp. 2451-2459
    • Sim, F.J.1    Zhao, C.2    Penderis, J.3    Franklin, R.J.4
  • 80
    • 79951722208 scopus 로고    scopus 로고
    • Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis
    • Simell B., Vuorela A., Ekstrom N., Palmu A., Reunanen A., Meri S., Kayhty H., Vakevainen M. Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis. Vaccine 2011, 29:1929-1934.
    • (2011) Vaccine , vol.29 , pp. 1929-1934
    • Simell, B.1    Vuorela, A.2    Ekstrom, N.3    Palmu, A.4    Reunanen, A.5    Meri, S.6    Kayhty, H.7    Vakevainen, M.8
  • 83
    • 84868193217 scopus 로고    scopus 로고
    • Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
    • [Epub ahead of print] (PMID: 22560929)
    • Solana R., Tarazona R., Gayoso I., Lesur O., Dupuis G., Fulop T. Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans. Semin. Immunol. 2012, [Epub ahead of print] (PMID: 22560929).
    • (2012) Semin. Immunol.
    • Solana, R.1    Tarazona, R.2    Gayoso, I.3    Lesur, O.4    Dupuis, G.5    Fulop, T.6
  • 84
    • 0028913076 scopus 로고
    • The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    • Stitt T.N., Conn G., Gore M., Lai C., Bruno J., Radziejewski C., Mattsson K., Fisher J., Gies D.R., Jones P.F., et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 1995, 80:661-670.
    • (1995) Cell , vol.80 , pp. 661-670
    • Stitt, T.N.1    Conn, G.2    Gore, M.3    Lai, C.4    Bruno, J.5    Radziejewski, C.6    Mattsson, K.7    Fisher, J.8    Gies, D.R.9    Jones, P.F.10
  • 86
    • 34247500821 scopus 로고    scopus 로고
    • TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
    • Takahashi K., Prinz M., Stagi M., Chechneva O., Neumann H. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med. 2007, 4:e124.
    • (2007) PLoS Med. , vol.4
    • Takahashi, K.1    Prinz, M.2    Stagi, M.3    Chechneva, O.4    Neumann, H.5
  • 87
    • 0034924709 scopus 로고    scopus 로고
    • Influence of aging on Kupffer cell respiratory activity in relation to particle phagocytosis and oxidative stress parameters in mouse liver
    • Videla L.A., Tapia G., Fernandez V. Influence of aging on Kupffer cell respiratory activity in relation to particle phagocytosis and oxidative stress parameters in mouse liver. Redox Rep. 2001, 6:155-159.
    • (2001) Redox Rep. , vol.6 , pp. 155-159
    • Videla, L.A.1    Tapia, G.2    Fernandez, V.3
  • 89
    • 0029366113 scopus 로고
    • Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex
    • Vlassara H., Li Y.M., Imani F., Wojciechowicz D., Yang Z., Liu F.T., Cerami A. Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex. Mol. Med. 1995, 1:634-646.
    • (1995) Mol. Med. , vol.1 , pp. 634-646
    • Vlassara, H.1    Li, Y.M.2    Imani, F.3    Wojciechowicz, D.4    Yang, Z.5    Liu, F.T.6    Cerami, A.7
  • 90
    • 75949127404 scopus 로고    scopus 로고
    • Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders
    • von Bernhardi R., Tichauer J.E., Eugenin J. Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. J. Neurochem. 2010, 112:1099-1114.
    • (2010) J. Neurochem. , vol.112 , pp. 1099-1114
    • von Bernhardi, R.1    Tichauer, J.E.2    Eugenin, J.3
  • 92
    • 67649935007 scopus 로고    scopus 로고
    • Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions
    • Weinger J.G., Omari K.M., Marsden K., Raine C.S., Shafit-Zagardo B. Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. Am. J. Pathol. 2009, 175:283-293.
    • (2009) Am. J. Pathol. , vol.175 , pp. 283-293
    • Weinger, J.G.1    Omari, K.M.2    Marsden, K.3    Raine, C.S.4    Shafit-Zagardo, B.5
  • 95
    • 33644910475 scopus 로고    scopus 로고
    • Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    • Zhao C., Li W.W., Franklin R.J. Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination. Neurobiol. Aging 2006, 27:1298-1307.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1298-1307
    • Zhao, C.1    Li, W.W.2    Franklin, R.J.3
  • 96
    • 34250780586 scopus 로고    scopus 로고
    • Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit
    • Zhao L., Wang Z., Liu Y., Song Y., Li Y., Laties A.M., Wen R. Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit. Mol. Vis. 2007, 13:873-880.
    • (2007) Mol. Vis. , vol.13 , pp. 873-880
    • Zhao, L.1    Wang, Z.2    Liu, Y.3    Song, Y.4    Li, Y.5    Laties, A.M.6    Wen, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.