Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-Implications for age-related macular degeneration (AMD)

Immunology Letters

Volumn 147, Issue 1-2, 2012, Pages 29-33

  Kauppinen, Anu ^a   Niskanen, Henri ^a   Suuronen, Tiina ^a   Kinnunen, Kati ^a,b   Salminen, Antero ^a,b   Kaarniranta, Kai ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Age related macular degeneration (AMD); Aging; Inflammasome; Inflammation; NLRP3; Retinal pigment epithelium (RPE)

Indexed keywords

4 HYDROXYNONENAL; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CRYOPYRIN GENE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; GENE; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RETINA MACULA AGE RELATED DEGENERATION; SIGNAL TRANSDUCTION;

ALDEHYDES; CARRIER PROTEINS; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACULAR DEGENERATION; NF-KAPPA B; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84865369140     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.05.005     Document Type: Article

References (37)

1. Cannizzo E.S., Clement C.C., Sahu R., Follo C., Santambrogio L. Oxidative stress, inflamm-aging and immunosenescence. J Proteomics 2011, 74:2313-2323.
2. Gehrs K.M., Anderson D.H., Johnson L.V., Hageman G.S. Age-related macular degeneration - emerging pathogenetic and therapeutic concepts. Ann Med 2006, 38:450-471.
3. Kaarniranta K., Salminen A., Haapasalo A., Soininen H., Hiltunen M. Age-related macular degeneration (AMD): Alzheimer's disease in the eye?. J Alzheimers Dis 2011, 24:615-631.
4. Kindzelskii A.L., Elner V.M., Elner S.G., Yang D., Hughes B.A., Petty H.R. Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments. J Gen Physiol 2004, 124:139-149.
5. Beatty S., Koh H., Phil M., Henson D., Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000, 45:115-134.
6. Ehrlich R., Harris A., Kheradiya N.S., Winston D.M., Ciulla T.A., Wirostko B. Age-related macular degeneration and the aging eye. Clin Interv Aging 2008, 3:473-482.
7. Nowak J.Z. Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol Rep 2006, 58:353-363.
8. Cassel S.L., Joly S., Sutterwala F.S. The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol 2009, 21:194-198.
9. Jin C., Flavell R.A. Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol 2010, 30:628-631.
10. O'Connor W., Harton J.A., Zhu X., Linhoff M.W., Ting J.P. Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol 2003, 171:6329-6333.
11. Petrilli V., Dostert C., Muruve D.A., Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 2007, 19:615-622.
12. Winer J., Jung C.K., Shackel I., Williams P.M. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 1999, 270:41-49.
13. Paimela T., Ryhanen T., Mannermaa E., Ojala J., Kalesnykas G., Salminen A., et al. The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. Immunol Lett 2007, 110:139-144.
14. Kaarniranta K., Ryhanen T., Karjalainen H.M., Lammi M.J., Suuronen T., Huhtala A., et al. Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells. Neurosci Lett 2005, 382:185-190.
15. Hogquist K.A., Unanue E.R., Chaplin D.D. Release of IL-1 from mononuclear phagocytes. J Immunol 1991, 147:2181-2186.
16. Meylan E., Tschopp J., Karin M. Intracellular pattern recognition receptors in the host response. Nature 2006, 442:39-44.
17. Mattson M.P. Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. Exp Gerontol 2009, 44:625-633.
18. Kaemmerer E., Schutt F., Krohne T.U., Holz F.G., Kopitz J. Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis. Invest Ophthalmol Vis Sci 2007, 48:1342-1347.
19. Krohne T.U., Stratmann N.K., Kopitz J., Holz F.G. Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells. Exp Eye Res 2010, 90:465-471.
20. Schmitz-Valckenberg S., Fleckenstein M., Scholl H.P., Holz F.G. Fundus autofluorescence and progression of age-related macular degeneration. Surv Ophthalmol 2009, 54:96-117.
21. Puren A.J., Fantuzzi G., Dinarello C.A. Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc Natl Acad Sci USA 1999, 96:2256-2261.
22. Dinarello C.A. Interleukin-1beta. Crit Care Med 2005, 33:S460-S462.
23. Miyake K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin Immunol 2007, 19:3-10.
24. Yu M., Wang H., Ding A., Golenbock D.T., Latz E., Czura C.J., et al. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 2006, 26:174-179.
25. Martinon F., Agostini L., Meylan E., Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 2004, 14:1929-1934.
26. Busillo J.M., Azzam K.M., Cidlowski J.A. Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome. J Biol Chem 2011, 286:38703-38713.
27. Chen G., Shaw M.H., Kim Y.G., Nunez G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol 2009, 4:365-398.
28. Martinon F. Signaling by ROS drives inflammasome activation. Eur J Immunol 2010, 40:616-619.
29. Zhou R., Tardivel A., Thorens B., Choi I., Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2010, 11:136-140.
30. Dostert C., Petrilli V., Van Bruggen R., Steele C., Mossman B.T., Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008, 320:674-677.
31. Klein R.J., Zeiss C., Chew E.Y., Tsai J.Y., Sackler R.S., Haynes C., et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005, 308:385-389.
32. Wu Z., Lauer T.W., Sick A., Hackett S.F., Campochiaro P.A. Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. J Biol Chem 2007, 282:22414-22425.
33. Brunk U.T., Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 2002, 33:611-619.
34. Brunk U.T., Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002, 269:1996-2002.
35. Bressler N.M., Bressler S.B., Fine S.L. Age-related macular degeneration. Surv Ophthalmol 1988, 32:375-413.
36. Sola-Villa D., Camacho M., Sola R., Soler M., Diaz J.M., Vila L. IL-1beta induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells. Kidney Int 2006, 70:1935-1941.
37. Melloul D. Role of NF-kappaB in beta-cell death. Biochem Soc Trans 2008, 36:334-339.