Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Autophagy

Volumn 10, Issue 3, 2014, Pages 480-496

  Valapala, Mallika ^a   Wilson, Christine ^a   Hose, Stacey ^a   Bhutto, Imran A ^a   Grebe, Rhonda ^a   Dong, Aling ^a   Greenbaum, Seth ^a   Gu, Limin ^a,b   Sengupta, Samhita ^a   Cano, Marisol ^a   Hackett, Sean ^a   Xu, Guotong ^b   Lutty, Gerard A ^a   Dong, Lijin ^c   Sergeev, Yuri ^c   Handa, James T ^a   Campochiaro, Peter ^a   Wawrousek, Eric ^c   Zigler Jr , J Samuel ^a   Sinha, Debasish ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c NATIONAL EYE INSTITUTE   (United States)

Author keywords

Autophagy; Lysosomes; MTORC1; Phagocytosis; Retinal function; Retinal pigment epithelium; V ATPase; A3 A1 crystallin

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BETA CRYSTALLIN; CATHEPSIN D; CRYSTALLIN; FAT DROPLET; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTON PUMP; ATP6V0A1 PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TARGET OF RAPAMYCIN KINASE;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VACUOLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; ENZYME ACTIVITY; GENE EXPRESSION; GENE LOSS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LYSOSOMAL MEDIATED WASTE CLEARANCE; LYSOSOME; MOUSE; NONHUMAN; OPHTHALMOSCOPY; PH; PHAGOCYTOSIS; PHAGOSOME; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; RETINA; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; RAT;

ANIMALS; AUTOPHAGY; CRYSTALLINS; LYSOSOMES; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; PHAGOCYTOSIS; PHAGOSOMES; RATS; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84896903811     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.27292     Document Type: Article

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