Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

Journal of Cell Science

Volumn 124, Issue 4, 2011, Pages 523-531

  Samuel Zigler Jr , J ^a   Zhang, Cheng ^a   Grebe, Rhonda ^a   Sehrawat, Gitanjali ^a   Hackler Jr , Laszlo ^a   Adhya, Souvonik ^a   Hose, Stacey ^a   McLeod, D Scott ^a   Bhutto, Imran ^a   Barbour, Walid ^a   Parthasarathy, Geetha ^a   Zack, Donald J ^a   Sergeev, Yuri ^b   Lutty, Gerard A ^a   Handa, James T ^a   Sinha, Debasish ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

A3 A1 crystallin; Autophagy; Cathepsin D; Lysosome; Phagocytosis; Photoreceptor outer segment discs; Retinal pigmented epithelium (RPE)

Indexed keywords

BETA CRYSTALLIN; CATHEPSIN D; NUC1 PROTEIN; PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE MUTATION; LENS IMPLANT; NONHUMAN; PHAGOSOME; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; RETINA NEUROEPITHELIAL LAYER; WILD TYPE;

ANIMALS; CRYSTALLINS; MUTATION; PHAGOSOMES; RATS; RATS, SPRAGUE-DAWLEY; RETINAL PIGMENT EPITHELIUM;

RATTUS;

EID: 79951820641     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.078790     Document Type: Article

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