Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration.

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Volumn 18, Issue 3, 2004, Pages 562-564

  Bergmann, M ^a   Schutt F ^a   Holz, F G ^a   Kopitz, J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; 3-METHYLADENINE; A2 E (N RETINYLIDENE N RETINYLETHANOLAMINE); A2-E (N-RETINYLIDENE-N-RETINYLETHANOLAMINE); ADENINE; ADENOSINE TRIPHOSPHATE; DRUG DERIVATIVE; EYE PROTEIN; HYDROLASE; LIPOFUSCIN; PROTON PUMP; RETINOID;

ACTIVE TRANSPORT; ANIMAL; ARTICLE; CELL CULTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; LYSOSOME; METABOLISM; PH; PHAGOCYTOSIS; PIGMENT EPITHELIUM; RETINA MACULA DEGENERATION; RETINA ROD OUTER SEGMENT; SWINE;

ADENINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EYE PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLASES; LIPOFUSCIN; LYSOSOMES; MACULAR DEGENERATION; PHAGOCYTOSIS; PIGMENT EPITHELIUM OF EYE; PROTON PUMPS; RETINOIDS; ROD OUTER SEGMENTS; SWINE;

EID: 2442648066     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.03-0289fje     Document Type: Article

References (0)