Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action

Experimental Eye Research

Volumn 90, Issue 2, 2010, Pages 261-266

  Krohne, Tim U ^a   Kaemmerer, Elke ^b   Holz, Frank G ^a   Kopitz, Jürgen ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Age related macular degeneration; Cathepsin; Cell culture; Lipid peroxidation; Lysosome; Outer segments; Oxidative stress; Retinal pigment epithelium

Indexed keywords

4 HYDROXYNONENAL; CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; LYSOSOME ENZYME; MALONALDEHYDE; PROTEINASE;

ANIMAL TISSUE; ARTICLE; CELL ISOLATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; LIPID PEROXIDATION; MASS SPECTROMETRY; NONHUMAN; PATHOGENESIS; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; REGULATORY MECHANISM; RETINA MACULA AGE RELATED DEGENERATION;

ALDEHYDES; ANIMALS; CATHEPSIN B; CATHEPSIN L; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; LIPID PEROXIDATION; LYSOSOMES; MALONDIALDEHYDE; RETINAL PHOTORECEPTOR CELL OUTER SEGMENT; RETINAL PIGMENT EPITHELIUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE;

EID: 77649168211     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.10.014     Document Type: Article

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