NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: Implications for age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 1, 2013, Pages 110-120

  Tseng, Wen Allen ^a,b   Thein, Thuzar ^a   Kinnunen, Kati ^a,c,d   Lashkari, Kameran ^a,b   Gregory, Meredith S ^a,b   D'Amore, Patricia A ^a,b   Ksander, Bruce R ^a,b  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; LEUCYLLEUCINE METHYL ESTER; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DENSITOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GEOGRAPHIC ATROPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LYSOSOME; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; CELL DEATH; CELL STRAIN HEK293; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; METABOLISM; OPTIC DISK ANOMALY; PATHOLOGY; RETINA MACULA DEGENERATION;

CARRIER PROTEINS; CASPASE 1; CELL DEATH; HEK293 CELLS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LYSOSOMES; MACULAR DEGENERATION; NF-KAPPA B; OPTIC DISK DRUSEN; RETINAL PIGMENT EPITHELIUM; RNA, SMALL INTERFERING;

MLCS; MLOWN;

EID: 84874524481     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10655     Document Type: Article

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