메뉴 건너뛰기




Volumn 5, Issue 4, 2010, Pages

Abundant lipid and protein components of drusen

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID P COMPONENT; APOLIPOPROTEIN E; CHOLESTEROL ESTER; CLUSTERIN; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C6; COMPLEMENT COMPONENT C8; COMPLEMENT COMPONENT C8 ALPHA; COMPLEMENT COMPONENT C8 BETA; COMPLEMENT COMPONENT C8 GAMMA; COMPLEMENT COMPONENT C9; COMPLEMENT FACTOR H; FORKHEAD ASSOCIATED PHOSPHOPEPTIDE BINDING DOMAIN 1; HLA DR ANTIGEN; NEURON SPECIFIC ENOLASE; PHOSPHATIDYLCHOLINE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RETINOL DEHYDROGENASE; RETINOL DEHYDROGENASE 5; SCAVENGER RECEPTOR B; SCAVENGER RECEPTOR B2; SERUM ALBUMIN; SERUM AMYLOID A; SERUM AMYLOID A1; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; VITRONECTIN; APOLIPOPROTEIN; EYE PROTEIN; LIPID;

EID: 77956402099     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010329     Document Type: Article
Times cited : (291)

References (97)
  • 1
    • 0019018431 scopus 로고
    • Council Lecture: Drusen and their relationship to senile macular degeneration
    • Sarks SH (1980) Council Lecture: Drusen and their relationship to senile macular degeneration. Aust J Ophthalmol 8: 117-130.
    • (1980) Aust J Ophthalmol , vol.8 , pp. 117-130
    • Sarks, S.H.1
  • 2
    • 0027452475 scopus 로고
    • Age-related macular degeneration histopathologic studies: The 1992 Lorenz E. Zimmerman Lecture
    • Green WR, Enger C (1993) Age-related macular degeneration histopathologic studies: the 1992 Lorenz E. Zimmerman Lecture. Ophthalmology 100: 1519-1535.
    • (1993) Ophthalmology , vol.100 , pp. 1519-1535
    • Green, W.R.1    Enger, C.2
  • 5
    • 33846472391 scopus 로고    scopus 로고
    • Fifteen-year cumulative incidence of age-related macular degeneration: The Beaver Dam Eye Study
    • Klein R, Klein BE, Knudtson MD, Meuer SM, Swift M, et al. (2007) Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology 114: 253-262.
    • (2007) Ophthalmology , vol.114 , pp. 253-262
    • Klein, R.1    Klein, B.E.2    Knudtson, M.D.3    Meuer, S.M.4    Swift, M.5
  • 6
    • 0032714687 scopus 로고    scopus 로고
    • Human ocular drusen possess novel core domains with a distinct carbohydrate composition
    • Mullins RF, Hageman GS (1999) Human ocular drusen possess novel core domains with a distinct carbohydrate composition. J Histochem Cytochem 47: 1533-1539.
    • (1999) J Histochem Cytochem , vol.47 , pp. 1533-1539
    • Mullins, R.F.1    Hageman, G.S.2
  • 7
    • 0034012166 scopus 로고    scopus 로고
    • Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • Mullins RF, Russell SR, Anderson DH, Hageman GS (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14: 835-846.
    • (2000) FASEB J , vol.14 , pp. 835-846
    • Mullins, R.F.1    Russell, S.R.2    Anderson, D.H.3    Hageman, G.S.4
  • 8
    • 0035008434 scopus 로고    scopus 로고
    • Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: Implications for the process of drusen formation
    • Anderson DH, Ozaki S, Nealon M, Neitz J, Mullins RF, et al. (2001) Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation. Am J Ophthalmol 131: 767-781.
    • (2001) Am J Ophthalmol , vol.131 , pp. 767-781
    • Anderson, D.H.1    Ozaki, S.2    Nealon, M.3    Neitz, J.4    Mullins, R.F.5
  • 9
    • 11144258543 scopus 로고    scopus 로고
    • Drusen proteome analysis: An approach to the etiology of age-related macular degeneration
    • Crabb JW, Miyagi M, Gu X, Shadrach K, West KA, et al. (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A 99: 14682-14687.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14682-14687
    • Crabb, J.W.1    Miyagi, M.2    Gu, X.3    Shadrach, K.4    West, K.A.5
  • 10
    • 0037332052 scopus 로고    scopus 로고
    • Apolipoprotein B in cholesterol-containing drusen and basal deposits in eyes with age-related maculopathy
    • Malek G, Li C-M, Guidry C, Medeiros NE, Curcio CA (2003) Apolipoprotein B in cholesterol-containing drusen and basal deposits in eyes with age-related maculopathy. Am J Pathol 162: 413-425.
    • (2003) Am J Pathol , vol.162 , pp. 413-425
    • Malek, G.1    Li, C.-M.2    Guidry, C.3    Medeiros, N.E.4    Curcio, C.A.5
  • 11
    • 23244467801 scopus 로고    scopus 로고
    • Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: Initial characterization
    • Li C-M, Chung BH, Presley JB, Malek G, Zhang X, et al. (2005) Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization. Invest Ophthalmol Vis Sci 46: 2576-2586.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 2576-2586
    • Li, C.-M.1    Chung, B.H.2    Presley, J.B.3    Malek, G.4    Zhang, X.5
  • 12
    • 33947101484 scopus 로고    scopus 로고
    • High concentration of zinc in sub-retinal pigment epithelial deposits
    • Lengyel I, Flinn JM, Peto T, Linkous DH, Cano K, et al. (2007) High concentration of zinc in sub-retinal pigment epithelial deposits. Exp Eye Res 84: 772-780.
    • (2007) Exp Eye Res , vol.84 , pp. 772-780
    • Lengyel, I.1    Flinn, J.M.2    Peto, T.3    Linkous, D.H.4    Cano, K.5
  • 13
    • 0036741098 scopus 로고    scopus 로고
    • A role for local inflammation in the formation of drusen in the aging eye
    • Anderson DH, Mullins RF, Hageman GS, Johnson LV (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134: 411-431.
    • (2002) Am J Ophthalmol , vol.134 , pp. 411-431
    • Anderson, D.H.1    Mullins, R.F.2    Hageman, G.S.3    Johnson, L.V.4
  • 14
    • 17244379811 scopus 로고    scopus 로고
    • Complement factor H polymorphism and age-related macular degeneration
    • Edwards AO, Ritter R, 3rd, Abel KJ, Manning A, Panhuysen C, et al. (2005) Complement factor H polymorphism and age-related macular degeneration. Science 308: 421-424.
    • (2005) Science , vol.308 , pp. 421-424
    • Edwards, A.O.1    Ritter, R.2    Abel, K.J.3    Manning, A.4    Panhuysen, C.5
  • 15
    • 33645419787 scopus 로고    scopus 로고
    • Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
    • Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, et al. (2006) Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet 38: 458-462.
    • (2006) Nat Genet , vol.38 , pp. 458-462
    • Gold, B.1    Merriam, J.E.2    Zernant, J.3    Hancox, L.S.4    Taiber, A.J.5
  • 18
    • 0026670743 scopus 로고
    • Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane
    • Pauleikhoff D, Zuels S, Sheraidah GS, Marshall J, Wessing A, et al. (1992) Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane. Ophthalmol 99: 1548-1553.
    • (1992) Ophthalmol , vol.99 , pp. 1548-1553
    • Pauleikhoff, D.1    Zuels, S.2    Sheraidah, G.S.3    Marshall, J.4    Wessing, A.5
  • 20
    • 0035018921 scopus 로고    scopus 로고
    • The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing microscopy
    • Haimovici R, Gantz DL, Rumelt S, Freddo TF, Small DM (2001) The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing microscopy. Invest Ophthalmol Vis Sci 42: 1592-1599.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1592-1599
    • Haimovici, R.1    Gantz, D.L.2    Rumelt, S.3    Freddo, T.F.4    Small, D.M.5
  • 21
    • 28444468904 scopus 로고    scopus 로고
    • Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy
    • Curcio CA, Presley JB, Medeiros NE, Malek G, Avery DV, et al. (2005) Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy. Exp Eye Res 81(6): 731-741.
    • (2005) Exp Eye Res , vol.81 , Issue.6 , pp. 731-741
    • Curcio, C.A.1    Presley, J.B.2    Medeiros, N.E.3    Malek, G.4    Avery, D.V.5
  • 22
    • 20444430102 scopus 로고    scopus 로고
    • Basal deposits and drusen in eyes with age-related maculopathy: Evidence for solid lipid particles
    • Curcio CA, Presley JB, Millican CL, Medeiros NE (2005) Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles. Exp Eye Res 80: 761-775.
    • (2005) Exp Eye Res , vol.80 , pp. 761-775
    • Curcio, C.A.1    Presley, J.B.2    Millican, C.L.3    Medeiros, N.E.4
  • 23
    • 0025038027 scopus 로고
    • Aging changes in Bruch's membrane: A histochemical and morphological study
    • Pauleikhoff D, Harper CA, Marshall J, Bird AC (1990) Aging changes in Bruch's membrane: a histochemical and morphological study. Ophthalmology 97: 171-178.
    • (1990) Ophthalmology , vol.97 , pp. 171-178
    • Pauleikhoff, D.1    Harper, C.A.2    Marshall, J.3    Bird, A.C.4
  • 24
    • 77950615514 scopus 로고    scopus 로고
    • Apolipoprotein B-containing Lipoproteins in Retinal Aging and Age-related Maculopathy
    • submitted 7/6/09
    • Curcio CA, Johnson M, Huang J-D, Rudolf M. (2009) Apolipoprotein B-containing Lipoproteins in Retinal Aging and Age-related Maculopathy. J Lipid Res, submitted 7/6/09.
    • (2009) J Lipid Res
    • Curcio, C.A.1    Johnson, M.2    Huang, J.-D.3    Rudolf, M.4
  • 25
    • 70350422838 scopus 로고    scopus 로고
    • Aging, age-related macular degeneration, and the Response-to-Retention of apolipoprotein B-containing lipoproteins
    • Curcio CA, Johnson M, Huang J-D, Rudolf M (2009) Aging, age-related macular degeneration, and the Response-to-Retention of apolipoprotein B-containing lipoproteins. Prog Ret Eye Res 28: 393-422.
    • (2009) Prog Ret Eye Res , vol.28 , pp. 393-422
    • Curcio, C.A.1    Johnson, M.2    Huang, J.-D.3    Rudolf, M.4
  • 26
    • 0344791691 scopus 로고    scopus 로고
    • Basal linear deposit and large drusen are specific for early age-related maculopathy
    • Curcio CA, Millican CL (1999) Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch Ophthalmol 117: 329-339.
    • (1999) Arch Ophthalmol , vol.117 , pp. 329-339
    • Curcio, C.A.1    Millican, C.L.2
  • 27
    • 33746551720 scopus 로고    scopus 로고
    • Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression
    • Li C-M, Clark ME, Chimento MF, Curcio CA (2006) Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression. Invest Ophthalmol Vis Sci 47: 3119-3128.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 3119-3128
    • Li, C.-M.1    Clark, M.E.2    Chimento, M.F.3    Curcio, C.A.4
  • 28
    • 34447635912 scopus 로고    scopus 로고
    • Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen
    • Li C-M, Clark M, Rudolf M, Curcio CA (2007) Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen. Exp Eye Res 85: 192-201.
    • (2007) Exp Eye Res , vol.85 , pp. 192-201
    • Li, C.-M.1    Clark, M.2    Rudolf, M.3    Curcio, C.A.4
  • 29
    • 41949092443 scopus 로고    scopus 로고
    • Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy
    • Rudolf M, Clark ME, Chimento M, Li C-M, Medeiros NE, et al. (2008) Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy. Invest Ophthalmol Vis Sci 49: 1200-1209.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 1200-1209
    • Rudolf, M.1    Clark, M.E.2    Chimento, M.3    Li, C.-M.4    Medeiros, N.E.5
  • 31
    • 4344700940 scopus 로고    scopus 로고
    • Association of drusen deposition with choroidal intercapillary pillars in the aging human eye
    • Lengyel I, Tufail A, Hosaini HA, Luthert P, Bird AC, et al. (2004) Association of drusen deposition with choroidal intercapillary pillars in the aging human eye. Invest Ophthalmol Vis Sci 45: 2886-2892.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2886-2892
    • Lengyel, I.1    Tufail, A.2    Hosaini, H.A.3    Luthert, P.4    Bird, A.C.5
  • 32
    • 33845754932 scopus 로고    scopus 로고
    • Ten-year incidence and progression of age-related maculopathy: The blue Mountains Eye Study
    • Wang JJ, Rochtchina E, Lee AJ, Chia EM, Smith W, et al. (2007) Ten-year incidence and progression of age-related maculopathy: the blue Mountains Eye Study. Ophthalmology 114: 92-98.
    • (2007) Ophthalmology , vol.114 , pp. 92-98
    • Wang, J.J.1    Rochtchina, E.2    Lee, A.J.3    Chia, E.M.4    Smith, W.5
  • 33
    • 0037975774 scopus 로고    scopus 로고
    • Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas
    • Dentchev T, Milam AH, Lee VM, Trojanowski JQ, Dunaief JL (2003) Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol Vis 9: 184-190.
    • (2003) Mol Vis , vol.9 , pp. 184-190
    • Dentchev, T.1    Milam, A.H.2    Lee, V.M.3    Trojanowski, J.Q.4    Dunaief, J.L.5
  • 34
    • 0141790103 scopus 로고    scopus 로고
    • Age-dependent variations in the drusen fluorescence on indocyanine green angiography
    • Chang AA, Guyer DR, Orlock DR, Yannuzzi LA (2003) Age-dependent variations in the drusen fluorescence on indocyanine green angiography. Clin Experiment Ophthalmol 31: 300-304.
    • (2003) Clin Experiment Ophthalmol , vol.31 , pp. 300-304
    • Chang, A.A.1    Guyer, D.R.2    Orlock, D.R.3    Yannuzzi, L.A.4
  • 36
    • 70449158340 scopus 로고
    • A simple method for the purification of total lipids from animal tissues
    • Folch P, Lees M, Sloane-Stanley GH (1957) A simple method for the purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, P.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 37
    • 0023724421 scopus 로고
    • Ultrastructural discrimination of lipid droplets and vesicles in atherosclerosis: Value of osmium-thiocarbohydrazide-osmium and tannic acid-paraphenylenediamine techniques
    • Guyton JR, Klemp KF (1988) Ultrastructural discrimination of lipid droplets and vesicles in atherosclerosis: value of osmium-thiocarbohydrazide-osmium and tannic acid-paraphenylenediamine techniques. J Histochem Cytochem 36: 1319-1328.
    • (1988) J Histochem Cytochem , vol.36 , pp. 1319-1328
    • Guyton, J.R.1    Klemp, K.F.2
  • 38
    • 21744444937 scopus 로고    scopus 로고
    • Retina expresses microsomal triglyceride transfer protein: Implications for age-related maculopathy
    • Li C-M, Presley JB, Zhang X, Dashti N, Chung BH, et al. (2005) Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy. J Lipid Res 46: 628-640.
    • (2005) J Lipid Res , vol.46 , pp. 628-640
    • Li, C.-M.1    Presley, J.B.2    Zhang, X.3    Dashti, N.4    Chung, B.H.5
  • 39
    • 59449093969 scopus 로고    scopus 로고
    • Lipoprotein particles of intra-ocular origin in human Bruch membrane: An unusual lipid profile
    • Wang L, Li C-M, Rudolf M, Belyaeva OV, Chung BH, et al. (2009) Lipoprotein particles of intra-ocular origin in human Bruch membrane: an unusual lipid profile. Invest Ophthalmol Vis Sci 50: 870-877.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 870-877
    • Wang, L.1    Li, C.-M.2    Rudolf, M.3    Belyaeva, O.V.4    Chung, B.H.5
  • 40
    • 0018161396 scopus 로고
    • Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells
    • Gamble W, Vaughan M, Kruth HS, Avigan T (1978) Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells. J Lipid Res 19: 1068-1070.
    • (1978) J Lipid Res , vol.19 , pp. 1068-1070
    • Gamble, W.1    Vaughan, M.2    Kruth, H.S.3    Avigan, T.4
  • 41
    • 48249104648 scopus 로고    scopus 로고
    • Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration
    • Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA (2008) Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci 49: 2848-2855.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 2848-2855
    • Nordgaard, C.L.1    Karunadharma, P.P.2    Feng, X.3    Olsen, T.W.4    Ferrington, D.A.5
  • 42
    • 33645401537 scopus 로고    scopus 로고
    • Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration
    • Nordgaard CL, Berg KM, Kapphahn RJ, Reilly C, Feng X, et al. (2006) Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci 47: 815-822.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 815-822
    • Nordgaard, C.L.1    Berg, K.M.2    Kapphahn, R.J.3    Reilly, C.4    Feng, X.5
  • 43
    • 33750613413 scopus 로고    scopus 로고
    • Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors
    • Tserentsoodol N, Gordiyenko NV, Pascual I, Lee JW, Fliesler SJ, et al. (2006) Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors. Mol Vis 12: 1319-1333.
    • (2006) Mol Vis , vol.12 , pp. 1319-1333
    • Tserentsoodol, N.1    Gordiyenko, N.V.2    Pascual, I.3    Lee, J.W.4    Fliesler, S.J.5
  • 44
    • 0033033364 scopus 로고    scopus 로고
    • Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus
    • Yamamoto H, Simon A, Eriksson U, Harris E, Berson EL, et al. (1999) Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus. Nat Genet 22: 188-191.
    • (1999) Nat Genet , vol.22 , pp. 188-191
    • Yamamoto, H.1    Simon, A.2    Eriksson, U.3    Harris, E.4    Berson, E.L.5
  • 45
    • 0033499606 scopus 로고    scopus 로고
    • Characterization of peroxidized lipids in Bruch's membrane
    • Spaide R, Ho-Spaide W, Browne R, Armstrong D (1999) Characterization of peroxidized lipids in Bruch's membrane. Retina 19: 141-147.
    • (1999) Retina , vol.19 , pp. 141-147
    • Spaide, R.1    Ho-Spaide, W.2    Browne, R.3    Armstrong, D.4
  • 46
    • 34249802348 scopus 로고    scopus 로고
    • Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration
    • Suzuki M, Kamei M, Itabe H, Yoneda K, Bando H, et al. (2007) Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration. Mol Vis 13: 772-778.
    • (2007) Mol Vis , vol.13 , pp. 772-778
    • Suzuki, M.1    Kamei, M.2    Itabe, H.3    Yoneda, K.4    Bando, H.5
  • 47
    • 1842756746 scopus 로고    scopus 로고
    • Functional roles of lipids in membranes
    • In: Vance DE, Vance JE, eds., Amsterdam: Elsevier
    • Dowhan W, Bogdanov M (2002) Functional roles of lipids in membranes. In: Vance DE, Vance JE, eds. Biochemistry of Lipids, Lipoproteins and Membranes. Amsterdam: Elsevier. pp 1-35.
    • (2002) Biochemistry of Lipids, Lipoproteins and Membranes , pp. 1-35
    • Dowhan, W.1    Bogdanov, M.2
  • 48
    • 0032511098 scopus 로고    scopus 로고
    • SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells
    • Webb NR, Connell PM, Graf GA, Smart EJ, de Villiers WJ, et al. (1998) SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. J Biol Chem 273: 15241-15248.
    • (1998) J Biol Chem , vol.273 , pp. 15241-15248
    • Webb, N.R.1    Connell, P.M.2    Graf, G.A.3    Smart, E.J.4    de Villiers, W.J.5
  • 50
    • 0024498088 scopus 로고
    • Retinal pigment epithelium possesses both LDL and scavenger receptor activity
    • Hayes KC, Lindsey S, Stephan ZF, Brecker D (1989) Retinal pigment epithelium possesses both LDL and scavenger receptor activity. Invest Ophthalmol Vis Sci 30: 225-232.
    • (1989) Invest Ophthalmol Vis Sci , vol.30 , pp. 225-232
    • Hayes, K.C.1    Lindsey, S.2    Stephan, Z.F.3    Brecker, D.4
  • 51
  • 52
    • 51449101273 scopus 로고    scopus 로고
    • Xanthophylls are preferentially taken up compared to beta -carotene by retinal cells via a scavenger receptor BI-dependent mechanism
    • During A, Doraiswamy S, Harrison EH (2008) Xanthophylls are preferentially taken up compared to beta -carotene by retinal cells via a scavenger receptor BI-dependent mechanism. J Lipid Res 49: 1715-1724.
    • (2008) J Lipid Res , vol.49 , pp. 1715-1724
    • During, A.1    Doraiswamy, S.2    Harrison, E.H.3
  • 53
    • 38049095535 scopus 로고    scopus 로고
    • Transport and retinal capture of lutein and zeaxanthin with reference to age-related macular degeneration
    • Loane E, Nolan JM, O'Donovan O, Bhosale P, Bernstein PS, et al. (2008) Transport and retinal capture of lutein and zeaxanthin with reference to age-related macular degeneration. Surv Ophthalmol 53: 68-81.
    • (2008) Surv Ophthalmol , vol.53 , pp. 68-81
    • Loane, E.1    Nolan, J.M.2    O'Donovan, O.3    Bhosale, P.4    Bernstein, P.S.5
  • 54
    • 70350034035 scopus 로고    scopus 로고
    • Rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration
    • Zerbib J, Seddon JM, Richard F, Reynolds R, Leveziel N, et al. (2009) Rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS One 4: e7341.
    • (2009) PLoS One , vol.4
    • Zerbib, J.1    Seddon, J.M.2    Richard, F.3    Reynolds, R.4    Leveziel, N.5
  • 56
    • 33847355664 scopus 로고    scopus 로고
    • Proteomic and phototoxic characterization of melanolipofuscin: Correlation to disease and model for its origin
    • Warburton S, Davis WE, Southwick K, Xin H, Woolley AT, et al. (2007) Proteomic and phototoxic characterization of melanolipofuscin: correlation to disease and model for its origin. Mol Vis 13: 318-329.
    • (2007) Mol Vis , vol.13 , pp. 318-329
    • Warburton, S.1    Davis, W.E.2    Southwick, K.3    Xin, H.4    Woolley, A.T.5
  • 60
    • 0345760069 scopus 로고    scopus 로고
    • Characterization of beta amyloid assemblies in drusen: The deposits associated with aging and age-related macular degeneration
    • Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, et al. (2004) Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res 78: 243-256.
    • (2004) Exp Eye Res , vol.78 , pp. 243-256
    • Anderson, D.H.1    Talaga, K.C.2    Rivest, A.J.3    Barron, E.4    Hageman, G.S.5
  • 61
    • 21044453724 scopus 로고    scopus 로고
    • A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    • Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, et al. (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A 102: 7227-7232.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7227-7232
    • Hageman, G.S.1    Anderson, D.H.2    Johnson, L.V.3    Hancox, L.S.4    Taiber, A.J.5
  • 63
    • 32444450909 scopus 로고    scopus 로고
    • Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
    • Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, et al. (2006) Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest 116: 378-385.
    • (2006) J Clin Invest , vol.116 , pp. 378-385
    • Luibl, V.1    Isas, J.M.2    Kayed, R.3    Glabe, C.G.4    Langen, R.5
  • 64
    • 0035699547 scopus 로고    scopus 로고
    • Complement activation and inflammatory processes in drusen formation and age related macular degeneration
    • Johnson LV, Leitner WP, Staples MK, Anderson DH (2001) Complement activation and inflammatory processes in drusen formation and age related macular degeneration. Exp Eye Res 73: 887-896.
    • (2001) Exp Eye Res , vol.73 , pp. 887-896
    • Johnson, L.V.1    Leitner, W.P.2    Staples, M.K.3    Anderson, D.H.4
  • 68
    • 33746551720 scopus 로고    scopus 로고
    • Apolipoprotein Localization in Isolated Drusen and Retinal Apolipoprotein Gene Expression
    • E-Abstract 855
    • Li C-M, Clark ME, Chimento MF, Curcio CA (2006) Apolipoprotein Localization in Isolated Drusen and Retinal Apolipoprotein Gene Expression. Invest Ophthalmol Vis Sci 47: E-Abstract 855.
    • (2006) Invest Ophthalmol Vis Sci , vol.47
    • Li, C.-M.1    Clark, M.E.2    Chimento, M.F.3    Curcio, C.A.4
  • 69
    • 56649102186 scopus 로고    scopus 로고
    • Lipid and fatty acid profile of the retina, retinal pigment epithelium/choroid, and the lacrimal gland, and associations with adipose tissue fatty acids in human subjects
    • Bretillon L, Thuret G, Gregoire S, Acar N, Joffre C, et al. (2008) Lipid and fatty acid profile of the retina, retinal pigment epithelium/choroid, and the lacrimal gland, and associations with adipose tissue fatty acids in human subjects. Exp Eye Res 87: 521-528.
    • (2008) Exp Eye Res , vol.87 , pp. 521-528
    • Bretillon, L.1    Thuret, G.2    Gregoire, S.3    Acar, N.4    Joffre, C.5
  • 71
    • 34447624676 scopus 로고    scopus 로고
    • Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane
    • Lin MY, Kochounian H, Moore RE, Lee TD, Rao N, et al. (2007) Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane. Mol Vis 13: 1203-1214.
    • (2007) Mol Vis , vol.13 , pp. 1203-1214
    • Lin, M.Y.1    Kochounian, H.2    Moore, R.E.3    Lee, T.D.4    Rao, N.5
  • 72
    • 38549166720 scopus 로고    scopus 로고
    • The opsins of the vertebrate retina: Insights from structural, biochemical, and evolutionary studies
    • Nickle B, Robinson PR (2007) The opsins of the vertebrate retina: insights from structural, biochemical, and evolutionary studies. Cell Mol Life Sci 64: 2917-2932.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 2917-2932
    • Nickle, B.1    Robinson, P.R.2
  • 73
    • 42749092828 scopus 로고    scopus 로고
    • Itinerant exosomes: Emerging roles in cell and tissue polarity
    • Lakkaraju A, Rodriguez-Boulan E (2008) Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol 18: 199-209.
    • (2008) Trends Cell Biol , vol.18 , pp. 199-209
    • Lakkaraju, A.1    Rodriguez-Boulan, E.2
  • 74
    • 58349109733 scopus 로고    scopus 로고
    • Autophagy and exosomes in the aged retinal pigment epithelium: Possible relevance to drusen formation and age-related macular degeneration
    • Wang AL, Lukas TJ, Yuan M, Du N, Tso MO, et al. (2009) Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS ONE 4: e4160.
    • (2009) PLoS ONE , vol.e4160 , pp. 4
    • Wang, A.L.1    Lukas, T.J.2    Yuan, M.3    Du, N.4    Tso, M.O.5
  • 75
    • 67651083457 scopus 로고    scopus 로고
    • Bestrophin detected in the basal membrane of the retinal epithelium and drusen of monkeys with drusenoid maculopathy
    • Gouras P, Braun K, Ivert L, Neuringer M, Mattison JA (2009) Bestrophin detected in the basal membrane of the retinal epithelium and drusen of monkeys with drusenoid maculopathy. Graefes Arch Clin Exp Ophthalmol 247: 1051-1056.
    • (2009) Graefes Arch Clin Exp Ophthalmol , vol.247 , pp. 1051-1056
    • Gouras, P.1    Braun, K.2    Ivert, L.3    Neuringer, M.4    Mattison, J.A.5
  • 76
    • 67349274173 scopus 로고    scopus 로고
    • Accumulation of extracellular RGR-d in Bruch's membrane and close association with drusen at intercapillary regions
    • Kochounian H, Johnson LV, Fong HK (2009) Accumulation of extracellular RGR-d in Bruch's membrane and close association with drusen at intercapillary regions. Exp Eye Res 88: 1129-1136.
    • (2009) Exp Eye Res , vol.88 , pp. 1129-1136
    • Kochounian, H.1    Johnson, L.V.2    Fong, H.K.3
  • 78
    • 0024151007 scopus 로고
    • Evolution of geographic atrophy of the retinal pigment epithelium
    • Sarks JP, Sarks SH, Killingsworth MC (1988) Evolution of geographic atrophy of the retinal pigment epithelium. Eye 2: 552-577.
    • (1988) Eye , vol.2 , pp. 552-577
    • Sarks, J.P.1    Sarks, S.H.2    Killingsworth, M.C.3
  • 79
    • 34248325662 scopus 로고    scopus 로고
    • Scavenger receptors for oxidized lipoprotein in age-related macular degeneration
    • Kamei M, Yoneda K, Kume N, Suzuki M, Itabe H, et al. (2007) Scavenger receptors for oxidized lipoprotein in age-related macular degeneration. Invest Ophthalmol Vis Sci 48: 1801-1807.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 1801-1807
    • Kamei, M.1    Yoneda, K.2    Kume, N.3    Suzuki, M.4    Itabe, H.5
  • 80
    • 42549161012 scopus 로고    scopus 로고
    • Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells
    • Yamada Y, Tian J, Yang Y, Cutler RG, Wu T, et al. (2008) Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells. J Neurochem 105: 1187-1197.
    • (2008) J Neurochem , vol.105 , pp. 1187-1197
    • Yamada, Y.1    Tian, J.2    Yang, Y.3    Cutler, R.G.4    Wu, T.5
  • 81
    • 59449093828 scopus 로고    scopus 로고
    • 7-Ketocholesterol is present in lipid deposits in the primate retina: Potential implication in the induction of VEGF and CNV formation
    • Moreira EF, Larrayoz IM, Lee JW, Rodriguez IR (2009) 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. Invest Ophthalmol Vis Sci 50: 523-532.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 523-532
    • Moreira, E.F.1    Larrayoz, I.M.2    Lee, J.W.3    Rodriguez, I.R.4
  • 82
    • 34347215846 scopus 로고    scopus 로고
    • Function and regulation of the complement system in cardiovascular diseases
    • Oksjoki R, Kovanen PT, Meri S, Pentikainen MO (2007) Function and regulation of the complement system in cardiovascular diseases. Front Biosci 12: 4696-4708.
    • (2007) Front Biosci , vol.12 , pp. 4696-4708
    • Oksjoki, R.1    Kovanen, P.T.2    Meri, S.3    Pentikainen, M.O.4
  • 83
    • 42449093343 scopus 로고    scopus 로고
    • Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice
    • Raoul W, Feumi C, Keller N, Lavalette S, Houssier M, et al. (2008) Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice. Ophthalmic Res 40: 115-119.
    • (2008) Ophthalmic Res , vol.40 , pp. 115-119
    • Raoul, W.1    Feumi, C.2    Keller, N.3    Lavalette, S.4    Houssier, M.5
  • 84
    • 73349097249 scopus 로고    scopus 로고
    • The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    • Luhmann UF, Robbie S, Munro PM, Barker SE, Duran Y, et al. (2009) The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest Ophthalmol Vis Sci 50: 5934-5943.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 5934-5943
    • Luhmann, U.F.1    Robbie, S.2    Munro, P.M.3    Barker, S.E.4    Duran, Y.5
  • 85
    • 23844463473 scopus 로고    scopus 로고
    • Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration
    • Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, et al. (2005) Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration. Proc Natl Acad Sci U S A 102: 11900-11905.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11900-11905
    • Malek, G.1    Johnson, L.V.2    Mace, B.E.3    Saloupis, P.4    Schmechel, D.E.5
  • 86
    • 45549102062 scopus 로고    scopus 로고
    • ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina
    • Bretillon L, Acar N, Seeliger MW, Santos M, Maire MA, et al. (2008) ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci 49: 1307-1314.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 1307-1314
    • Bretillon, L.1    Acar, N.2    Seeliger, M.W.3    Santos, M.4    Maire, M.A.5
  • 87
    • 39549108352 scopus 로고    scopus 로고
    • Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection
    • Schmidt-Erfurth U, Rudolf M, Funk M, Hofmann-Rummelt C, Franz-Haas NS, et al. (2008) Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection. Invest Ophthalmol Vis Sci 49: 390-398.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 390-398
    • Schmidt-Erfurth, U.1    Rudolf, M.2    Funk, M.3    Hofmann-Rummelt, C.4    Franz-Haas, N.S.5
  • 88
    • 67349093946 scopus 로고    scopus 로고
    • A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD
    • Fujihara M, Bartels ED, Nielsen LB, Handa JT (2009) A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD. Exp Eye Res 88: 1115-1123.
    • (2009) Exp Eye Res , vol.88 , pp. 1115-1123
    • Fujihara, M.1    Bartels, E.D.2    Nielsen, L.B.3    Handa, J.T.4
  • 89
    • 67650578625 scopus 로고    scopus 로고
    • Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein B-100 genes
    • Sallo FB, Bereczki E, Csont T, Luthert PJ, Munro P, et al. (2009) Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein B-100 genes. Exp Eye Res 89: 178-186.
    • (2009) Exp Eye Res , vol.89 , pp. 178-186
    • Sallo, F.B.1    Bereczki, E.2    Csont, T.3    Luthert, P.J.4    Munro, P.5
  • 90
    • 4344600751 scopus 로고    scopus 로고
    • Reengineering of aged Bruch's membrane to enhance retinal pigment epithelium repopulation
    • Tezel TH, Del Priore LV, Kaplan HJ (2004) Reengineering of aged Bruch's membrane to enhance retinal pigment epithelium repopulation. Invest Ophthalmol Vis Sci 45: 3337-3348.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 3337-3348
    • Tezel, T.H.1    del Priore, L.V.2    Kaplan, H.J.3
  • 91
    • 0031893280 scopus 로고    scopus 로고
    • Reattachment rate of human retinal pigment epithelium to layers of human Bruch's membrane
    • Del Priore LV, Tezel TH (1998) Reattachment rate of human retinal pigment epithelium to layers of human Bruch's membrane. Arch Ophthalmol 116: 335-341.
    • (1998) Arch Ophthalmol , vol.116 , pp. 335-341
    • del Priore, L.V.1    Tezel, T.H.2
  • 92
    • 39149118049 scopus 로고    scopus 로고
    • Culture-induced increase in alpha integrin subunit expression in retinal pigment epithelium is important for improved resurfacing of aged human Bruch's membrane
    • Gullapalli VK, Sugino IK, Zarbin MA (2008) Culture-induced increase in alpha integrin subunit expression in retinal pigment epithelium is important for improved resurfacing of aged human Bruch's membrane. Exp Eye Res 86: 189-200.
    • (2008) Exp Eye Res , vol.86 , pp. 189-200
    • Gullapalli, V.K.1    Sugino, I.K.2    Zarbin, M.A.3
  • 94
    • 0032608438 scopus 로고    scopus 로고
    • Hormone-sensitive lipase and neutral cholesteryl ester lipase
    • Holm C, Osterlund T (1999) Hormone-sensitive lipase and neutral cholesteryl ester lipase. Methods Mol Biol 109: 109-121.
    • (1999) Methods Mol Biol , vol.109 , pp. 109-121
    • Holm, C.1    Osterlund, T.2
  • 95
    • 14644412857 scopus 로고    scopus 로고
    • Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaques
    • Chung BH, Mishra V, Franklin F, Liang P, Doran S, et al. (2005) Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaques. Biochem Biophys Acta Molecular and Cell Biology of Lipids 1733: 76-89.
    • (2005) Biochem Biophys Acta Molecular and Cell Biology of Lipids , vol.1733 , pp. 76-89
    • Chung, B.H.1    Mishra, V.2    Franklin, F.3    Liang, P.4    Doran, S.5
  • 96
    • 70350370344 scopus 로고    scopus 로고
    • Vasculoprotective effects of apolipoprotein mimetic peptides: An evolving paradigm in HDL therapy
    • White CR, Datta G, Mochon P, Zhang Z, Kelly O, et al. (2009) Vasculoprotective effects of apolipoprotein mimetic peptides: an evolving paradigm in HDL therapy. Vascular Disease Prevention 6: 122-130.
    • (2009) Vascular Disease Prevention , vol.6 , pp. 122-130
    • White, C.R.1    Datta, G.2    Mochon, P.3    Zhang, Z.4    Kelly, O.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.