Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

Autophagy

Volumn 10, Issue 11, 2014, Pages 1989-2005

  Mitter, Sayak K ^a,b   Song, Chunjuan ^b   Qi, Xiaoping ^a   Mao, Haoyu ^b   Rao, Haripriya ^b   Akin, Debra ^b   Lewin, Alfred ^b   Grant, Maria ^a   Dunn, William ^b   Ding, Jindong ^c   Rickman, Catherine Bowes ^c   Boulton, Michael ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Age related macular degeneration; Aging; Autophagy; Oxidative stress; RPE

Indexed keywords

3 METHYLADENINE; BECLIN 1; HYDROGEN PEROXIDE; LIPOFUSCIN; MEMBRANE PROTEIN; PROTEIN ATG7; PROTEIN ATG9; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; APOLIPOPROTEIN E4; GLUTATHIONE;

AGE RELATED MACULAR DEGENERATION; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LONG TERM EXPOSURE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; MACULAR DEGENERATION; MEMBRANE POTENTIAL; METABOLISM; PATHOLOGY; RETINA;

ANIMALIA; MUS;

ADENINE; ANIMALS; APOLIPOPROTEIN E4; AUTOPHAGY; CELL SURVIVAL; GENE EXPRESSION REGULATION; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; LIPOFUSCIN; MACULAR DEGENERATION; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RETINA; RETINAL PIGMENT EPITHELIUM;

EID: 84919740196     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.36184     Document Type: Article

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