The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

Progress in Retinal and Eye Research

Volumn 29, Issue 2, 2010, Pages 95-112

  Anderson, Don H ^a   Radeke, Monte J ^a   Gallo, Natasha B ^a   Chapin, Ethan A ^a   Johnson, Patrick T ^a   Curletti, Christy R ^a   Hancox, Lisa S ^b   Hu, Jane ^c   Ebright, Jessica N ^e   Malek, Goldis ^e   Hauser, Michael A ^e   Bowes Rickman, Catherine ^e,g   Bok, Dean ^c,d   Hageman, Gregory S ^f   Johnson, Lincoln V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c JULES STEIN EYE INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Complement; Drusen; Factor H; Gene expression; Macular degeneration; Retinal pigment epithelium; SNP discovery

Indexed keywords

ADIPSIN; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C7; COMPLEMENT FACTOR H; LECTIN; MONOCYTE CHEMOTACTIC PROTEIN;

AGING; CHOROID; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT LECTIN PATHWAY; COMPLEMENT SYSTEM; DRUSEN; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; IMMUNOPATHOGENESIS; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEUROEPITHELIAL LAYER; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

AGING; CHOROID; COMPLEMENT SYSTEM PROTEINS; GENE EXPRESSION; HUMANS; MACULAR DEGENERATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RETINAL PIGMENT EPITHELIUM;

EID: 77249147331     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2009.11.003     Document Type: Review

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