A potential role for immune complex pathogenesis in drusen formation

Experimental Eye Research

Volumn 70, Issue 4, 2000, Pages 441-449

  Johnson, Lincoln V ^a   Ozaki, Shiro ^a   Staples, Michelle K ^a   Erickson, Page A ^b   Anderson, Don H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b QualTek Molecular Laboratories   (United States)

Author keywords

Antibody; Autoimmune response; Complement activation; Macular degeneration; Retinal pigmented epithelium

Indexed keywords

ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNE DISEASE; COMPLEMENT ACTIVATION; DRUSEN; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

EID: 0033842370     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1999.0798     Document Type: Article

References (53)

1. Drusen in age-related macular degeneration: Pathogenesis, natural course, and laser photocoagulation-induced regression
2. Local cellular sources of drusen-associated molecules
3. Vitronectin receptor expression and distribution at the photoreceptor-retinal pigment epithelial interface
4. Epitope retrieval (unmasking) in immunohisto-chemistry
5. Bruch's membrane change with age
6. Immunolocalization of integrins in the human retina
7. Age-related macular degeneration
8. Clinico-morphologic correlations of drusen of Bruch's membrane
9. Autoimmunity in hereditary retinal degeneration. I. Basic studies
10. Granulomatous reaction to Bruch's membrane in age-related macular degeneration
11. Beitrage zur pathologischen Anatomie des Auges
12. Tissue inhibitor of metalloproteinases-3 is a component of Bruch's membrane of the eye
13. Familial and secondary drusen: Histologic and functional correlations
14. The ultrastructure of drusen
15. The histochemistry of drusen
16. Age-related changes in the ultrastructure of Bruch's membrane
17. Lipoidal degeneration of the retinal pigment epithelium
18. Drusen and disciform macular detachment and degeneration
19. Antiretinal antibodies in serum of patients with age-related macular degeneration
20. Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells
21. Increase in the advanced glycation end product pentosidine in Bruch's membrane with age
22. Detection of specific polymerase chain reaction product by utilizing the 5'3' exonuclease activity of Thermus aquaticus DNA polymerase
23. Advanced glycation end products in age-related macular degeneration
24. Formation of drusen in the human eye
25. TIMP-3 accumulation in Bruch's membrane and drusen in eyes from normal and age-related macular degeneration donors
26. The immune complex pathogenesis of experimental membranous glomerulopathy (Heymann nephritis) and its significance in human glomerular disease
27. Age-related components of Bruch's membrane in the human eye
28. Macrophages related to Bruch's membrane in age-related macular degeneration
29. Genetic association of apolipoprotein E with age-related macular degeneration
30. Integrin αvβ5 participates in the binding of photoreceptor rod outer segments during phagocytosis by cultured human retinal pigment epithelium
31. Immunolocalization of ubiquitin and related enzymes in human retina and retinal pigment epithelium
32. Immuno-reactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina
33. Macular function impairment in eyes with early age-related macular degeneration
34. Macular drusen and the sensitivity of the central visual field
35. Effects of the membrane attack complex of complement on nucleated cells
36. Physiology and pathophysiology of complement: Progress and trends
37. Extrahepatic complement biosynthesis: Where, when and why?
38. Anatomische beitrage zur ophthalmologie
39. Histochemical comparison of ocular 'drusen' in monkey and human
40. Characterization of drusen-associated glycoconjugates
41. Drusen associated with aging and age-related macular degeneration contain molecular constituents common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
42. Detection of specific extracellular matrix molecules in drusen, Bruch's membrane, and ciliary body
43. The human retina and retinal pigment epithelium are abundant sources of vitronectin mRNA
44. Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane
45. An ultrastructural study of the role of leucocytes and fibroblasts in the breakdown of Bruch's membrane
46. Senile macular degeneration: The involvement of immunocompetent cells
47. Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium
48. Autoantibodies to retinal astrocytes associated with age-related macular degeneration
49. Ageing and degeneration in the macular region: A clinico-pathological study
50. Retinal sensitivity measurement over drusen using scanning laser ophthalmoscope microperimetry
51. Basal laminar deposit in the aging peripheral human retina
52. Pathophysiology of age-related macular degeneration
53. Age-related macular degeneration: Review of pathogenesis