Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 7, 2008, Pages 2838-2847

  Rózanowski, Bartosz ^a   Burke, Janice M ^b   Boulton, Michael E ^c   Sarna, Tadeusz ^d   Rózanowska, Małgorzata ^d,e  

^a PEDAGOGICAL UNIVERSITY   (Poland)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d JAGIELLONIAN UNIVERSITY   (Poland)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CATION; HISTIDINE; IRON; LINOLEIC ACID; LIPOFUSCIN; MELANIN; MELANOLIPOFUSCIN; PORPHYRIN; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; OXIDIZING AGENT; PHOTOSENSITIZING AGENT; PIGMENT; TETRA(4 N TRIMETHYLANILINIUM)PORPHINE; TETRA(4-N-TRIMETHYLANILINIUM)PORPHINE;

ADULT; AGED; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLUE LIGHT; CELL ISOLATION; CONTROLLED STUDY; COW; DONOR; ELECTRON SPIN RESONANCE; EYE; GRANULE CELL; HUMAN; HUMAN TISSUE; IRRADIATION; LIGHT EXPOSURE; MELANOSOME; NONHUMAN; OXIDATION; OXIMETRY; PHOTODEGRADATION; PHOTOSENSITIZATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; SUSPENSION; AGING; ANIMAL; BIOSYNTHESIS; CATTLE; DRUG EFFECT; IN VITRO STUDY; LIGHT; METABOLISM; MIDDLE AGED; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; PHYSIOLOGY; RADIATION EXPOSURE;

AGED; AGED, 80 AND OVER; AGING; ANILINE COMPOUNDS; ANIMALS; ASCORBIC ACID; CATIONS; CATTLE; HUMANS; IRON; LIGHT; LINOLEIC ACID; MELANINS; MELANOSOMES; MIDDLE AGED; OXIDANTS; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PHOTOSENSITIZING AGENTS; PIGMENT EPITHELIUM OF EYE; PIGMENTS, BIOLOGICAL; PORPHYRINS;

EID: 48249123789     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-1700     Document Type: Article

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