The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells

Journal of Biological Chemistry

Volumn 283, Issue 36, 2008, Pages 24770-24780

  Vives Bauza, Cristofol ^a   Anand, Monika ^a   Shirazi, Arash K ^a   Magrane, Jordi ^a   Gao, Junping ^b   Vollmer Snarr, Heidi R ^b   Manfredi, Giovanni ^a   Finnemann, Silvia C ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; ANTIGEN-ANTIBODY REACTIONS; CELL DEATH; CELL MEMBRANES; DNA; GLUCOSE; IMMUNOLOGY; NUCLEIC ACIDS; OPHTHALMOLOGY; ORGANIC ACIDS; PHOSPHORYLATION; TOXIC MATERIALS;

AGERELATED MACULAR DEGENERATIONS; ANTI-OXIDANTS; ATP SYNTHESIS; CARBON ENERGIES; CELLULAR MODELS; HUMAN EYES; MITOCHONDRIAL DYSFUNCTIONS; MITOCHONDRIAL ENERGIES; MITOCHONDRIAL MEMBRANE POTENTIALS; OXIDATIVE PHOSPHORYLATIONS; OXIDATIVE PROCESSES; PHAGOCYTIC ACTIVITIES; PHYSIOLOGICAL CONCENTRATIONS; PHYSIOLOGICAL LEVELS; POINT MUTATIONS; PYRUVATE; RETINAL DISEASES; RETINAL PIGMENT EPITHELIAL; RETINAL PIGMENT EPITHELIAL CELLS; RPE CELLS; TOXIC LEVELS;

ANIMAL CELL CULTURE;

ADENOSINE TRIPHOSPHATE; GLUCOSE; LIPOFUSCIN; PYRUVIC ACID; RETINOID; A2E COMPOUND; ANTIOXIDANT; MITOCHONDRIAL DNA; PYRIDINIUM DERIVATIVE;

ARTICLE; BINDING AFFINITY; CELL DEATH; CELL FUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MERRF SYNDROME; MITOCHONDRION; NARP SYNDROME; NONHUMAN; PHAGOCYTOSIS; PIGMENT EPITHELIUM; POINT MUTATION; PRIORITY JOURNAL; RAT; AGING; ANIMAL; CELL LINE; DRUG EFFECT; EPITHELIUM CELL; GENETICS; LONG EVANS RAT; LYSOSOME; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS; OXIDATIVE PHOSPHORYLATION; PATHOLOGY; RETINA MACULA DEGENERATION;

ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; ANTIOXIDANTS; CELL DEATH; CELL LINE; DNA, MITOCHONDRIAL; EPITHELIAL CELLS; GLUCOSE; HUMANS; LIPOFUSCIN; LYSOSOMES; MACULAR DEGENERATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOSIS; OXIDATIVE PHOSPHORYLATION; PHAGOCYTOSIS; PIGMENT EPITHELIUM OF EYE; POINT MUTATION; PYRIDINIUM COMPOUNDS; PYRUVIC ACID; RATS; RATS, LONG-EVANS; RETINOIDS;

EID: 54049085790     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800706200     Document Type: Article

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