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Volumn 87, Issue 2, 2009, Pages 117-123

Age-related macular degeneration: Activation of innate immunity system via pattern recognition receptors

Author keywords

AMD; CFH; Inflammasome; Inflammation; Innate immunity; Macular degeneration

Indexed keywords

NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; SCAVENGER RECEPTOR; TOLL LIKE RECEPTOR;

EID: 58549098926     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0418-z     Document Type: Review
Times cited : (73)

References (75)
  • 1
    • 0034832029 scopus 로고    scopus 로고
    • An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    • GS Hageman PJ Luthert NHV Chong LV Johnson DH Anderson RF Mullins 2001 An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration Prog Retin Eye Res 20 705 732
    • (2001) Prog Retin Eye Res , vol.20 , pp. 705-732
    • Hageman, G.S.1    Luthert, P.J.2    Chong, N.H.V.3    Johnson, L.V.4    Anderson, D.H.5    Mullins, R.F.6
  • 2
    • 33144459399 scopus 로고    scopus 로고
    • The role of inflammation in the pathogenesis of age-related macular degeneration
    • LA Donoso D Kim A Frost A Callahan G Hageman 2006 The role of inflammation in the pathogenesis of age-related macular degeneration Surv Ophthalmol 51 137 152
    • (2006) Surv Ophthalmol , vol.51 , pp. 137-152
    • Donoso, L.A.1    Kim, D.2    Frost, A.3    Callahan, A.4    Hageman, G.5
  • 3
    • 33746373850 scopus 로고    scopus 로고
    • Age-related macular degeneration (AMD): Pathogenesis and therapy
    • JZ Nowak 2006 Age-related macular degeneration (AMD): pathogenesis and therapy Pharmacol Rep 58 353 363
    • (2006) Pharmacol Rep , vol.58 , pp. 353-363
    • Nowak, J.Z.1
  • 4
    • 35448975681 scopus 로고    scopus 로고
    • Progress in defining the molecular biology of age related macular degeneration
    • A Lotery D Trump 2007 Progress in defining the molecular biology of age related macular degeneration Hum Genet 122 219 236
    • (2007) Hum Genet , vol.122 , pp. 219-236
    • Lotery, A.1    Trump, D.2
  • 5
    • 38949176804 scopus 로고    scopus 로고
    • Genetics of age-related macular degeneration
    • AO Edwards 2008 Genetics of age-related macular degeneration Adv Exp Med Biol 613 211 219
    • (2008) Adv Exp Med Biol , vol.613 , pp. 211-219
    • Edwards, A.O.1
  • 6
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • S Akira S Uematsu O Takeuchi 2006 Pathogen recognition and innate immunity Cell 124 783 801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 7
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • ME Bianchi 2007 DAMPs, PAMPs and alarmins: all we need to know about danger J Leukoc Biol 81 1 5
    • (2007) J Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 8
    • 36849045915 scopus 로고    scopus 로고
    • The inflammasome: A danger sensing complex triggering innate immunity
    • V Petrilli C Dostert DA Muruve J Tschopp 2007 The inflammasome: a danger sensing complex triggering innate immunity Curr Opin Immunol 19 615 622
    • (2007) Curr Opin Immunol , vol.19 , pp. 615-622
    • Petrilli, V.1    Dostert, C.2    Muruve, D.A.3    Tschopp, J.4
  • 9
    • 32944477673 scopus 로고    scopus 로고
    • The evolution of adaptive immunity
    • Z Pancer MD Cooper 2006 The evolution of adaptive immunity Annu Rev Immunol 24 497 518
    • (2006) Annu Rev Immunol , vol.24 , pp. 497-518
    • Pancer, Z.1    Cooper, M.D.2
  • 10
    • 84934436897 scopus 로고    scopus 로고
    • Self, non-self, and danger: A complementary view
    • J Kohl 2006 Self, non-self, and danger: a complementary view Adv Exp Med Biol 586 71 94
    • (2006) Adv Exp Med Biol , vol.586 , pp. 71-94
    • Kohl, J.1
  • 12
    • 33947629255 scopus 로고    scopus 로고
    • Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
    • K Miyake 2007 Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors Semin Immunol 19 3 10
    • (2007) Semin Immunol , vol.19 , pp. 3-10
    • Miyake, K.1
  • 13
    • 0037378811 scopus 로고    scopus 로고
    • Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments
    • GT Higgins JH Wang P Dockery PE Cleary HP Redmond 2003 Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments Invest Ophthalmol Vis Sci 44 1775 1782
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 1775-1782
    • Higgins, G.T.1    Wang, J.H.2    Dockery, P.3    Cleary, P.E.4    Redmond, H.P.5
  • 14
    • 2442648066 scopus 로고    scopus 로고
    • Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration
    • M Bergmann F Schutt FG Holz J Kopitz 2004 Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration FASEB J 18 562 564
    • (2004) FASEB J , vol.18 , pp. 562-564
    • Bergmann, M.1    Schutt, F.2    Holz, F.G.3    Kopitz, J.4
  • 15
    • 18044366931 scopus 로고    scopus 로고
    • RPE lipofuscin and its role in retinal pathobiology
    • JR Sparrow M Boulton 2005 RPE lipofuscin and its role in retinal pathobiology Exp Eye Res 80 595 606
    • (2005) Exp Eye Res , vol.80 , pp. 595-606
    • Sparrow, J.R.1    Boulton, M.2
  • 17
    • 21244451958 scopus 로고    scopus 로고
    • The retinal pigment epithelium in visual function
    • O Strauss 2005 The retinal pigment epithelium in visual function Physiol Rev 85 845 881
    • (2005) Physiol Rev , vol.85 , pp. 845-881
    • Strauss, O.1
  • 18
    • 33644788693 scopus 로고    scopus 로고
    • Bruch's membrane and the vascular intima: Is there a common basis for age-related changes and disease?
    • S Sivaprasad TA Bailey VNH Chong 2005 Bruch's membrane and the vascular intima: is there a common basis for age-related changes and disease? Clin Exp Ophthalmol 33 518 523
    • (2005) Clin Exp Ophthalmol , vol.33 , pp. 518-523
    • Sivaprasad, S.1    Bailey, T.A.2    Chong, V.N.H.3
  • 19
    • 5144222255 scopus 로고    scopus 로고
    • Complement: A unique innate immune sensor for danger signals
    • P Gasque 2004 Complement: a unique innate immune sensor for danger signals Mol Immunol 41 1089 1098
    • (2004) Mol Immunol , vol.41 , pp. 1089-1098
    • Gasque, P.1
  • 20
    • 55949096010 scopus 로고    scopus 로고
    • Properdin: New roles in pattern recognition and target clearance
    • C Kemper DE Hourcade 2008 Properdin: new roles in pattern recognition and target clearance Mol Immunol 45 4048 4056
    • (2008) Mol Immunol , vol.45 , pp. 4048-4056
    • Kemper, C.1    Hourcade, D.E.2
  • 21
    • 47249130305 scopus 로고    scopus 로고
    • Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activation
    • W Xu SP Berger LA Trouw H de Boer N Schlagwein C Mutsaers MR Daha C van Kooten 2008 Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activation J Immunol 180 7613 7621
    • (2008) J Immunol , vol.180 , pp. 7613-7621
    • Xu, W.1    Berger, S.P.2    Trouw, L.A.3    De Boer, H.4    Schlagwein, N.5    Mutsaers, C.6    Daha, M.R.7    Van Kooten, C.8
  • 22
    • 38449106206 scopus 로고    scopus 로고
    • Genetic susceptibility to age-related macular degeneration: A paradigm for dissecting complex disease traits
    • A Swaroop KEH Branham W Chen G Abecasis 2007 Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits Hum Mol Genet 16 R174 R182
    • (2007) Hum Mol Genet , vol.16
    • Swaroop, A.1    Branham, K.E.H.2    Chen, W.3    Abecasis, G.4
  • 23
    • 47749126514 scopus 로고    scopus 로고
    • Factor H family proteins and human diseases
    • M Jozsi PF Zipfel 2008 Factor H family proteins and human diseases Trends Immunol 29 380 387
    • (2008) Trends Immunol , vol.29 , pp. 380-387
    • Jozsi, M.1    Zipfel, P.F.2
  • 24
    • 34848886930 scopus 로고    scopus 로고
    • Loss of self-control in the complement system and innate autoreactivity
    • S Meri 2007 Loss of self-control in the complement system and innate autoreactivity Ann N Y Acad Sci 1109 93 105
    • (2007) Ann N y Acad Sci , vol.1109 , pp. 93-105
    • Meri, S.1
  • 25
    • 33749143187 scopus 로고    scopus 로고
    • Complement factor H: Spatial and temporal expression and localization in the eye
    • MNA Mandal R Ayyagari 2006 Complement factor H: spatial and temporal expression and localization in the eye Invest Ophthalmol Vis Sci 47 4091 4097
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 4091-4097
    • Mandal, M.N.A.1    Ayyagari, R.2
  • 26
    • 33751243644 scopus 로고    scopus 로고
    • Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid
    • PT Johnson KE Betts MJ Radeke GS Hageman DH Anderson LV Johnson 2006 Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid Proc Natl Acad Sci USA 103 17456 17461
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17456-17461
    • Johnson, P.T.1    Betts, K.E.2    Radeke, M.J.3    Hageman, G.S.4    Anderson, D.H.5    Johnson, L.V.6
  • 27
    • 33947160639 scopus 로고    scopus 로고
    • Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments
    • M Chen JV Forrester H Xu 2007 Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments Exp Eye Res 84 635 645
    • (2007) Exp Eye Res , vol.84 , pp. 635-645
    • Chen, M.1    Forrester, J.V.2    Xu, H.3
  • 28
    • 34547963062 scopus 로고    scopus 로고
    • Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3
    • Z Wu TW Lauer A Sick SF Hackett PA Campochiaro 2007 Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3 J Biol Chem 282 22414 22425
    • (2007) J Biol Chem , vol.282 , pp. 22414-22425
    • Wu, Z.1    Lauer, T.W.2    Sick, A.3    Hackett, S.F.4    Campochiaro, P.A.5
  • 29
    • 17644423119 scopus 로고    scopus 로고
    • Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    • C Garlanda B Bottazzi A Bastone A Mantovani 2005 Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility Annu Rev Immunol 23 337 366
    • (2005) Annu Rev Immunol , vol.23 , pp. 337-366
    • Garlanda, C.1    Bottazzi, B.2    Bastone, A.3    Mantovani, A.4
  • 31
    • 33745677515 scopus 로고    scopus 로고
    • A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration
    • DA Schaumberg WG Christen P Kozlowski DT Miller PM Ridker RYL Zee 2006 A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration Invest Ophthalmol Vis Sci 47 2336 2340
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 2336-2340
    • Schaumberg, D.A.1    Christen, W.G.2    Kozlowski, P.3    Miller, D.T.4    Ridker, P.M.5    Zee, R.Y.L.6
  • 33
    • 34548459868 scopus 로고    scopus 로고
    • Structure and function of Toll receptors and their ligands
    • NJ Gay M Gangloff 2007 Structure and function of Toll receptors and their ligands Annu Rev Biochem 76 141 165
    • (2007) Annu Rev Biochem , vol.76 , pp. 141-165
    • Gay, N.J.1    Gangloff, M.2
  • 34
    • 33947668943 scopus 로고    scopus 로고
    • Viral recognition by Toll-like receptors
    • GM Barton 2007 Viral recognition by Toll-like receptors Semin Immunol 19 33 40
    • (2007) Semin Immunol , vol.19 , pp. 33-40
    • Barton, G.M.1
  • 36
    • 34548656855 scopus 로고    scopus 로고
    • Signaling pathways downstream of pattern-recognition receptors and their cross talk
    • MS Lee YJ Kim 2007 Signaling pathways downstream of pattern-recognition receptors and their cross talk Annu Rev Biochem 76 447 480
    • (2007) Annu Rev Biochem , vol.76 , pp. 447-480
    • Lee, M.S.1    Kim, Y.J.2
  • 37
    • 3843049059 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4) of retinal pigment epithelium cells participates in transmembrane signaling in response to photoreceptor outer segments
    • AL Kindzelskii VM Elner SG Elner D Yang BA Hughes HR Petty 2004 Toll-like receptor 4 (TLR4) of retinal pigment epithelium cells participates in transmembrane signaling in response to photoreceptor outer segments J Gen Physiol 124 139 149
    • (2004) J Gen Physiol , vol.124 , pp. 139-149
    • Kindzelskii, A.L.1    Elner, V.M.2    Elner, S.G.3    Yang, D.4    Hughes, B.A.5    Petty, H.R.6
  • 38
    • 3242670505 scopus 로고    scopus 로고
    • Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells
    • MV Kumar CN Nagineni MS Chin JJ Hooks B Detrick 2004 Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells J Neuroimmunol 153 7 15
    • (2004) J Neuroimmunol , vol.153 , pp. 7-15
    • Kumar, M.V.1    Nagineni, C.N.2    Chin, M.S.3    Hooks, J.J.4    Detrick, B.5
  • 40
    • 34250850127 scopus 로고    scopus 로고
    • Distinct functions between Toll-like receptors 3 and 9 in retinal pigment epithelial cells
    • N Ebihara L Chen T Tokura H Ushio M Iwatsu A Murakami 2007 Distinct functions between Toll-like receptors 3 and 9 in retinal pigment epithelial cells Ophthalmic Res 39 155 163
    • (2007) Ophthalmic Res , vol.39 , pp. 155-163
    • Ebihara, N.1    Chen, L.2    Tokura, T.3    Ushio, H.4    Iwatsu, M.5    Murakami, A.6
  • 41
    • 34249701359 scopus 로고    scopus 로고
    • The effect of 17β-estradiol on IL-6 secretion and NF-κB DNA-binding activity in human retinal pigment epithelial cells
    • T Paimela T Ryhanen E Mannermaa J Ojala G Kalesnykas A Salminen K Kaarniranta 2007 The effect of 17β-estradiol on IL-6 secretion and NF-κB DNA-binding activity in human retinal pigment epithelial cells Immunol Lett 110 139 144
    • (2007) Immunol Lett , vol.110 , pp. 139-144
    • Paimela, T.1    Ryhanen, T.2    Mannermaa, E.3    Ojala, J.4    Kalesnykas, G.5    Salminen, A.6    Kaarniranta, K.7
  • 43
    • 34948822892 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells
    • D Yang SG Elner ZM Bian GO Till HR Petty VM Elner 2007 Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells Exp Eye Res 85 462 472
    • (2007) Exp Eye Res , vol.85 , pp. 462-472
    • Yang, D.1    Elner, S.G.2    Bian, Z.M.3    Till, G.O.4    Petty, H.R.5    Elner, V.M.6
  • 44
    • 0035219629 scopus 로고    scopus 로고
    • Retinal pigment epithelium system interactions: Cytokine production and cytokine-induced changes
    • GM Holtkamp A Kijlstra R Peek AF de Vos 2001 Retinal pigment epithelium system interactions: cytokine production and cytokine-induced changes Prog Retin Eye Res 20 29 48
    • (2001) Prog Retin Eye Res , vol.20 , pp. 29-48
    • Holtkamp, G.M.1    Kijlstra, A.2    Peek, R.3    De Vos, A.F.4
  • 45
    • 33746807729 scopus 로고    scopus 로고
    • Nitric oxide-induced accumulation of lipofuscin-like materials is caused by inhibition of cathepsin S
    • E Sugano H Tomita S Ishiguro H Isago M Tamai 2006 Nitric oxide-induced accumulation of lipofuscin-like materials is caused by inhibition of cathepsin S Curr Eye Res 31 607 616
    • (2006) Curr Eye Res , vol.31 , pp. 607-616
    • Sugano, E.1    Tomita, H.2    Ishiguro, S.3    Isago, H.4    Tamai, M.5
  • 46
    • 33846234257 scopus 로고    scopus 로고
    • Signalling and phagocytosis in the orchestration of host defence
    • JM Blander 2007 Signalling and phagocytosis in the orchestration of host defence Cell Microbiol 9 290 299
    • (2007) Cell Microbiol , vol.9 , pp. 290-299
    • Blander, J.M.1
  • 48
    • 0030698428 scopus 로고    scopus 로고
    • Hyaluronan localization in tissues of the mouse posterior eye wall: Absence in the interphotoreceptor matrix
    • JG Hollyfield ME Rayborn R Tammi 1997 Hyaluronan localization in tissues of the mouse posterior eye wall: absence in the interphotoreceptor matrix Exp Eye Res 65 603 608
    • (1997) Exp Eye Res , vol.65 , pp. 603-608
    • Hollyfield, J.G.1    Rayborn, M.E.2    Tammi, R.3
  • 49
    • 0023425786 scopus 로고
    • Bruch's membrane age-related changes vary by region
    • DA Newsome W Huh WR Green 1987 Bruch's membrane age-related changes vary by region Curr Eye Res 6 1211 1221
    • (1987) Curr Eye Res , vol.6 , pp. 1211-1221
    • Newsome, D.A.1    Huh, W.2    Green, W.R.3
  • 50
    • 0032786405 scopus 로고    scopus 로고
    • Histologic and morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in postmortem eyes with age-related macular degeneration and histologic examination of surgically excised choroid neovascular membranes
    • Suppl 1
    • CW Spraul GE Lang HE Grossniklaus GK Lang 1999 Histologic and morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in postmortem eyes with age-related macular degeneration and histologic examination of surgically excised choroid neovascular membranes Surv Ophthalmol 44 Suppl 1 S10 S32
    • (1999) Surv Ophthalmol , vol.44
    • Spraul, C.W.1    Lang, G.E.2    Grossniklaus, H.E.3    Lang, G.K.4
  • 54
    • 31644450525 scopus 로고    scopus 로고
    • The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas
    • Y Yamada K Ishibashi K Ishibashi IA Bhutto J Tian GA Lutty JT Handa 2006 The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas Exp Eye Res 82 840 848
    • (2006) Exp Eye Res , vol.82 , pp. 840-848
    • Yamada, Y.1    Ishibashi, K.2    Ishibashi, K.3    Bhutto, I.A.4    Tian, J.5    Lutty, G.A.6    Handa, J.T.7
  • 57
    • 47049100720 scopus 로고    scopus 로고
    • Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity
    • SL Hazen 2008 Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity J Biol Chem 283 15527 15531
    • (2008) J Biol Chem , vol.283 , pp. 15527-15531
    • Hazen, S.L.1
  • 58
    • 0030022233 scopus 로고    scopus 로고
    • CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium
    • SW Ryeom JR Sparrow RL Silverstein 1996 CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium J Cell Sci 109 387 395
    • (1996) J Cell Sci , vol.109 , pp. 387-395
    • Ryeom, S.W.1    Sparrow, J.R.2    Silverstein, R.L.3
  • 59
    • 0035172341 scopus 로고    scopus 로고
    • Differential roles of CD36 and αvβ5 integrin in photoreceptor phagocytosis by retinal pigment epithelium
    • SC Finnemann RL Silverstein 2001 Differential roles of CD36 and αvβ5 integrin in photoreceptor phagocytosis by retinal pigment epithelium J Exp Med 194 1289 1297
    • (2001) J Exp Med , vol.194 , pp. 1289-1297
    • Finnemann, S.C.1    Silverstein, R.L.2
  • 63
    • 0033295671 scopus 로고    scopus 로고
    • Class B scavenger receptors, caveolae and cholesterol homeostasis
    • GA Graf SV Matveev EJ Smart 1999 Class B scavenger receptors, caveolae and cholesterol homeostasis Trends Cardiovasc Med 9 221 225
    • (1999) Trends Cardiovasc Med , vol.9 , pp. 221-225
    • Graf, G.A.1    Matveev, S.V.2    Smart, E.J.3
  • 64
    • 33747191203 scopus 로고    scopus 로고
    • The inflammasome: First line of the immune response to cell stress
    • Y Ogura FS Sutterwala RA Flavell 2006 The inflammasome: first line of the immune response to cell stress Cell 126 659 662
    • (2006) Cell , vol.126 , pp. 659-662
    • Ogura, Y.1    Sutterwala, F.S.2    Flavell, R.A.3
  • 71
    • 33745158932 scopus 로고    scopus 로고
    • Regulation of cysteine cathepsin expression by oxidative stress in the retinal pigment epithelium/choroid of the mouse
    • P Alizadeh Z Smit-McBride SL Oltjen LM Hjelmeland 2006 Regulation of cysteine cathepsin expression by oxidative stress in the retinal pigment epithelium/choroid of the mouse Exp Eye Res 83 679 687
    • (2006) Exp Eye Res , vol.83 , pp. 679-687
    • Alizadeh, P.1    Smit-Mcbride, Z.2    Oltjen, S.L.3    Hjelmeland, L.M.4
  • 72
    • 34548444551 scopus 로고    scopus 로고
    • Liaisons dangereuses: P2X7 and the inflammasome
    • F Di Virgilio 2007 Liaisons dangereuses: P2X7 and the inflammasome Trends Pharmacol Sci 28 465 472
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 465-472
    • Di Virgilio, F.1
  • 73
    • 43649088649 scopus 로고    scopus 로고
    • Purinergic signalling in the subretinal space: A role in the communication between retina and PRE
    • CH Mitchell D Reigada 2008 Purinergic signalling in the subretinal space: a role in the communication between retina and PRE Purinergic Signal 4 101 107
    • (2008) Purinergic Signal , vol.4 , pp. 101-107
    • Mitchell, C.H.1    Reigada, D.2
  • 75
    • 33845235464 scopus 로고    scopus 로고
    • IL-1β induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells
    • D Sola-Villa M Camacho R Sola M Soler JM Diaz L Vila 2006 IL-1β induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells Kidney Int 70 1935 1941
    • (2006) Kidney Int , vol.70 , pp. 1935-1941
    • Sola-Villa, D.1    Camacho, M.2    Sola, R.3    Soler, M.4    Diaz, J.M.5    Vila, L.6


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