Polyphenols: Potential future arsenals in the treatment of Diabetes

Current Pharmaceutical Design

Volumn 22, Issue 5, 2016, Pages 549-565

  Solayman, Md ^a   Ali, Yousuf ^a   Alam, Fahmida ^b   Islam, Md Asiful ^b   Alam, Nadia ^b   Khalil, Md Ibrahim ^a,b   Gan, Siew Hua ^b  

^a JAHANGIRNAGAR UNIVERSITY   (Bangladesh)

^b SCHOOL OF MEDICAL SCIENCES   (Malaysia)

Author keywords

Diabetes mellitus; Gluconeogenesis; Glucose transport; Insulin resistance; Polyphenols

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALDEHYDE REDUCTASE; ANTIDIABETIC AGENT; GALLOCATECHIN; GLUCAGON; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; POLYPHENOL; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2;

ACTIVE TRANSPORT; ANTIDIABETIC ACTIVITY; ARTICLE; AUBERGINE; BLACKBERRY; CACAO; CARBOHYDRATE METABOLISM; CLINICAL TRIAL (TOPIC); COFFEE; DIABETES MELLITUS; ENERGY METABOLISM; GENETIC MARKER; GLUCAGON RELEASE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GRAPE; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TEA; ANIMAL;

ANIMALS; DIABETES MELLITUS; HUMANS; HYPOGLYCEMIC AGENTS; POLYPHENOLS;

EID: 84958245588     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612822666151125001111     Document Type: Article

References (241)

1. Alberti KGMM, Zimmet PF. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetic Med 1998; 15: 539-53.
2. Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract 2014; 103: 137-49.
3. Stolar M. Glycemic control and complications in type 2 diabetes mellitus. Am J Med 2010; 123: S3-11.
4. Van Belle TL, Coppieters KT, Von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 2011; 91: 79-118.
5. WHO Study Group on Diabetes Mellitus, World Health Organization. Diabetes Mellitus: Report of a WHO Study Group [meeting held in Geneva from 11 to 16 February 1985]. Geneva: World Health Organization 1985; pp 113.
6. Vlad A, Timar R. Pathogenesis of Type 1 diabetes mellitus: a brief overview. Romanian J Diabetes Nut Metabol Dis 2012; 19: 67-72.
7. Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37: S81-90.
8. Bastaki A. Diabetes mellitus and its treatment. Int J Diabetes Metabol 2005; 13: 111.
9. Sahra IB, Laurent K, Loubat A, et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27: 3576-86.
10. Inzucchi SE, Maggs DG, Spollett GR, et al. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N Engl J Med 1998; 338: 867-73.
11. Bodmer M, Meier C, Krähenbühl S, Jick SS, Meier CR. Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia A nested case-control analysis. Diabetes Care 2008; 31: 2086-91.
12. Abraham B, Sellin JH. Drug-induced diarrhea. Curr Gastroenterol Reports 2007; 9: 365-72.
13. Levetan C. Oral antidiabetic agents in type 2 diabetes. Curr Med Res Opinion® 2007; 23: 945-52.
14. Fonseca V. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am J Med 2003; 115: 42-48.
15. Patel D, Kumar R, Laloo D, Hemalatha S. Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity. Asian Pacific J Trop Biomed 2012; 2: 411-20.
16. Beckman CH. Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? Physiol Mol Plant Pathol 2000; 57: 101-10.
17. Graf BA, Milbury PE, Blumberg JB. Flavonols, flavones, flavanones, and human health: epidemiological evidence. J Med Food 2005; 8: 281-90.
18. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005; 81: 317S-25.
19. Bahadoran Z, Mirmiran P, Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metabol Disord 2013; 12: 43.
20. Williamson G. Possible effects of dietary polyphenols on sugar absorption and digestion. Mol Nut Food Res 2013; 57: 48-57.
21. McCulloch D, Palmer J. The appropriate use of B cell function testing in the preclinical period of type 1 diabetes. Diabetic Med 1991; 8: 800-4.
22. Smyth DJ, Cooper JD, Bailey R, et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 2006; 38: 617-9.
23. Hakonarson H, Grant SF, Bradfield JP, et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Na- ture 2007; 448: 591-4.
24. Lowe CE, Cooper JD, Brusko T, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007; 39: 1074-82.
25. Wass JA, Stewart PM. Oxford textbook of endocrinology and diabetes. UK: Oxford University Press 2011.
26. Meier JJ, Nauck MA. Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired -cell function? Diabetes 2010; 59: 1117-25.
27. Unger RH, Scherer PE. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metabol 2010; 21: 345-52.
28. Voight BF, Scott LJ, Steinthorsdottir V, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010; 42: 579-89.
29. Herder C, Roden M. Genetics of type 2 diabetes: pathophysiologic and clinical relevance. Eur J ClinInvest 2011; 41: 679-92.
30. Dabelea D, Hanson RL, Lindsay RS, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 2000; 49: 2208-11.
31. Daglia M. Polyphenols as antimicrobial agents. Curr Opin Biotechnol 2012; 23: 174-81.
32. Quideau S, Deffieux D, Douat Casassus C, Pouységu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed 2011; 50: 586-621.
33. Pasinetti GM, Wang J, Ho L, Zhao W, Dubner L. Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment. Biochim Biophys Acta (BBA)-Mol Basis Dis 2015; 1852: 1202-8.
34. Pate KM, Rogers M, Moss M. The ability of polyphenols to reduce A -induced apoptosis associated with Alzheimer's disease. Biophys J 2015; 108: 66a.
35. Wang J, Bi W, Cheng A, Freire D, et al. Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications. Front Aging Neurosci 2014; 6: 42.
36. Chastain SE, Moss M. Green and black tea polyphenols mechanistically inhibit the aggregation of amyloidin Alzheimer's disease. Biophys J 2015; 108: 357a.
37. Yang CS, Chung JY, Yang G-y, Chhabra SK, Lee M-J. Tea and tea polyphenols in cancer prevention. J Nut 2000; 130: 472S-8.
38. Singh M, Bhui K, Singh R, Shukla Y. Tea polyphenols enhance cisplatin chemosensitivity in cervical cancer cells via induction of apoptosis. Life Sci 2013; 93: 7-16.
39. Ramos S. Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 2008; 52: 507-26.
40. Damianaki A, Bakogeorgou E, Kampa M, et al. Potent inhibitory action of red wine polyphenols on human breast cancer cells. J Cell Biochem 2000; 78: 429-41.
41. Khan N, Mukhtar H. Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett 2008; 269: 269-80.
42. Lambert JD, Elias RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arc Biochem Biophys 2010; 501: 65-72.
43. Zamora-Ros R, Knaze V, Rothwell JA, et al. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nut 2015: 1-17.
44. Lall RK, Syed DN, Adhami VM, Khan MI, Mukhtar H. Dietary polyphenols in prevention and treatment of prostate cancer. Int J Mol Sci 2015; 16: 3350-76.
45. Kona FR, Shen M, Chen D, Chan TH, Ping Dou Q. Discovery of polyphenol based drugs for cancer prevention and treatment: the tumor proteasome as a novel target. Rec Adv Polyphenol Res 2014; 4: 209-37.
46. Turrini E, Ferruzzi L, Fimognari C. Potential effects of pomegranate polyphenols in cancer prevention and therapy. Oxidat Med Cell Longev 2015; 2015: 938475.
47. Srichairatanakool S, Fucharoen S. Antioxidants as complementary medication in thalassemia. In: Atroshi F, Ed. Pharmacology and nutritional intervention in the treatment of disease. USA: InTech 2014.
48. Fibach E, Rachmilewitz EA. The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia. Annl NY Acad Sci 2010; 1202: 10-6.
49. Kukreja A, Wadhwa N, Tiwari A. Therapeutic role of natural agents in beta-thalassemia: a review. J Pharm Res 2013; 6: 954-9.
50. Parkar SG, Stevenson DE, Skinner MA. The potential influence of fruit polyphenols on colonic microflora and human gut health. Int J Food Microbiol 2008; 124: 295-8.
51. Dryden GW, Song M, McClain C. Polyphenols and gastrointestinal diseases. Curr Opin Gastroenterol 2006; 22: 165.
52. Shapiro H, Singer P, Halpern Z, Bruck R. Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis. Gut 2007; 56: 426-36.
53. Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, QueipoOrtuño MI. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem 2013; 24: 1415-22.
54. Manach C, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol 2005; 16: 77-84.
55. Quiñones M, Miguel M, Aleixandre A. Beneficial effects of polyphenols on cardiovascular disease. Pharmacol Res 2013; 68: 125-31.
56. Perez-Vizcaino F, Duarte J, Andriantsitohaina R. Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res 2006; 40: 1054-65.
57. Michalska M, Gluba A, Mikhailidis DP, et al. The role of polyphenols in cardiovascular disease. Med Sci Monit Basic Res 2010; 16.
58. Okoro IO, Osagie A, Asibor EO. Antioxidant and antimicrobial activities of polyphenols from ethnomedicinal plants of Nigeria. African J Biotechnol 2010; 9: 2989-93.
59. Moreno S, Scheyer T, Romano CS, Vojnov AA. Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radical Res 2006; 40: 223-31.
60. Fattouch S, Caboni P, Coroneo V, et al. Antimicrobial activity of Tunisian quince (Cydonia oblonga Miller) pulp and peel polyphenolic extracts. J Agric Food Chem 2007; 55: 963-9.
61. Striegel L, Kang B, Pilkenton SJ, Rychlik M, Apostolidis E. Effect of black tea and black tea pomace polyphenols on -glucosidase and -amylase inhibition, relevant to type 2 diabetes prevention. Front Nutr 2015; 2: 3.
62. Xiao J, Hogger P. Dietary polyphenols and type 2 diabetes: current insights and future perspectives. Curr Med Chem 2015; 22: 23-38.
63. Carpéné C, Gomez-Zorita S, Deleruyelle S, Carpéné M. Novel strategies for preventing diabetes and obesity complications with natural polyphenols. Curr Med Chem 2015; 22: 150-64.
64. Kusirisin W, Srichairatanakool S, Lerttrakarnnon P, et al. Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients. Med Chem 2009; 5: 139-47.
65. Quideau S. Plant “polyphenolic” small molecules can induce a calorie restriction mimetic life span extension by activating sir- tuins: will “polyphenols” someday be used as chemotherapeutic drugs in western medicine? ChemBioChem 2004; 5: 427-30.
66. Correia da Silva M, Sousa E, Pinto MM. Emerging sulfated flavonoids and other polyphenols as drugs: Nature as an inspiration. Med Res Rev 2014; 34: 223-79.
67. Terra W, Ferreira C, Jordao B, Dillon R. Digestive enzymes. In: Lehane M, Billingsley P, Eds Biology of the insect midgut. Springer 1996; pp 153-94.
68. Zakowski JJ, Bruns DE. Biochemistry of human alpha amylase isoenzymes. Crit Rev Clin Lab Sci 1985; 21: 283-322.
69. Chiba S. Molecular mechanism inglucosidase and glucoamylase. Biosci Biotechnol Biochem 1997; 61: 1233-9.
70. Levin RJ. Digestion and absorption of carbohydrates-from molecules and membranes to humans. Am J Clin Nutr 1994; 59: 690S-8.
71. Tundis R, Loizzo M, Menichini F. Natural products as –amylase and glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update. Mini Rev Med Chem 2010; 10: 315-31.
72. McDougall GJ, Stewart D. The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 2005; 23: 189-95.
73. Funke I, Melzig M. Effect of different phenolic compounds on amylase activity: Screening by microplate-reader based kinetic assay. Die Pharm-An Int J Pharm Sci 2005; 60: 796-7.
74. Eddouks M, Maghrani M, Lemhadri A, Ouahidi M-L, Jouad H. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J Ethnopharmacol 2002; 82: 97-103.
75. Hussain S, Mahwi T, Aziz T. Quercetin dampens postprandial hyperglycemia in type 2 diabetic patients challenged with carbohydrates load. Int J Diabetes Res 2012; 1: 32-5.
76. Kim J-S, Kwon C-S, Son KH. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci Biotechnol Biochem 2000; 64: 2458-61.
77. Ishikawa A, Yamashita H, Hiemori M, et al. Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum. J Nutr Sci Vitaminol 2007; 53: 166-73.
78. McDougall GJ, Shpiro F, Dobson P, Smith P, Blake A, Stewart D. Different polyphenolic components of soft fruits inhibitamylase and glucosidase. J Agric Food Chem 2005; 53: 2760-6.
79. Mai TT, Thu NN, Tien PG, Van Chuyen N. Alpha-glucosidase inhibitory and antioxidant activities of Vietnamese edible plants and their relationships with polyphenol contents. J Nutr Sci Vita- minol 2007; 53: 267-76.
80. Thorens B. Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. Am J Physiol-Gastrointestinal Liver Physiol 1996; 270: G541-53.
81. Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev 2011; 91: 733-94.
82. Scheepers A, Joost H-G, Schurmann A. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. J Parenteral Enteral Nutr 2004; 28: 364-71.
83. Wright EM. Renal Na+-glucose cotransporters. Am J PhysiolRenal Physiol 2001; 280: F10-8.
84. Bell GI, Kayano T, Buse JB, et al. Molecular biology of mammalian glucose transporters. Diabetes Care 1990; 13: 198-208.
85. Kobayashi Y, Suzuki M, Satsu H, et al. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. J Agric Food Chem 2000; 48: 5618-23.
86. Welsch CA, Lachance PA, Wasserman BP. Dietary phenolic compounds: inhibition of Na+-dependent D-glucose uptake in rat intestinal brush border membrane vesicles. J Nutr 1989; 119: 1698-704.
87. Aguirre L, Arias N, Macarulla MT, Gracia A, Portillo MP. Beneficial effects of quercetin on obesity and diabetes. Open Nutraceuticals J 2011; 4: 189-98.
88. Kwon O, Eck P, Chen S, et al. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J 2007; 21: 366-77.
89. Alvarado F. Hypothesis for the interaction of phlorizin and phloretin with membrane carriers for sugars. Biochim Biophys Acta (BBA)-Biomembr 1967; 135: 483-95.
90. Krook A, Kawano Y, Song XM, et al. Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats. Diabetes 1997; 46: 2110-4.
91. Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R, Leighton F. Myricetin, quercetin and catechingallate inhibit glucose uptake in isolated rat adipocytes. Biochem J 2005; 386: 471-8.
92. Vera JC, Reyes AM, Velásquez FV, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry 2001; 40: 777-90.
93. Vera JC, Reyes AM, Cárcamo JG, et al. Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1. J Biol Chem 1996; 271: 8719-24.
94. Watanabe T, Kondo K, Oishi M. Induction of in vitro differentiation of mouse erythroleukemia cells by genistein, an inhibitor of tyrosine protein kinases. Cancer Res 1991; 51: 764-8.
95. Akiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 1987; 262: 5592-5.
96. Scrutton MC, Utter MF. The regulation of glycolysis and gluconeogenesis in animal tissues. Ann Rev Biochem 1968; 37: 249-302.
97. Hundal RS, Krssak M, Dufour S, et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 2000; 49: 2063-9.
98. Pari L, Srinivasan S. Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocinnicotinamide-induced diabetic rats. Biomed Pharmacotherapy 2010; 64: 477-81.
99. Kanchana G, Shyni WJ, Rajadurai M, Periasamy R. Evaluation of antihyperglycemic effect of sinapic acid in normal and streptozotocin-induced diabetes in albino rats. Global J Pharmacol 2011; 5: 33-9.
100. Ong KW, Hsu A, Song L, Huang D, Tan BKH. Polyphenolsrich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J Ethnopharmacol 2011; 133: 598-607.
101. Collins QF, Liu H-Y, Pi J, Liu Z, Quon MJ, Cao W. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5 -AMP-activated protein kinase. J Biol Chem 2007; 282: 30143-9.
102. Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 2002; 277: 34933-40.
103. Park SA, Choi MS, Cho SY, et al. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci 2006; 79: 1207-13.
104. Choi M, Jung U, Yeo J, Kim M, Lee M. Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non obese diabetic (NOD) mice. Diabetes/Metabol Res Rev 2008; 24: 74-81.
105. Pitchai D, Saravana B, Modilal R. Antihyperglycemic effects of Phyllanthus extracts in alloxan-induced diabetic rats. Int J Pharm Sci 2009; 1: 261-4.
106. Cernea S, Dobreanu M. Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochem Med 2013; 23: 266-80.
107. Kahn CR, White M. The insulin receptor and the molecular mechanism of insulin action. J Clin Invest 1988; 82: 1151.
108. Rutter GA. Nutrient-secretion coupling in the pancreatic islet -cell: recent advances. Mol Aspects Med 2001; 22: 247-84.
109. Rutter G. Visualising insulin secretion. The Minkowski lecture 2004. Diabetologia 2004; 47: 1861-72.
110. Buchanan TA, Xiang AH, Peters RK, et al. Preservation of pancreatic cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women. Diabetes 2002; 51: 2796-803.
111. Rouse M, Younès A, Egan JM. Resveratrol and curcumin enhance pancreatic-cell function by inhibiting phosphodiesterase activity. J Endocrinol 2014; 223: 107-17.
112. Cai EP, Lin J-K. Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic cells. J Agric Food Chem 2009; 57: 9817-27.
113. Chakravarthy B, Gupta S, Gode K. Functional cell regeneration in the islets of pancreas in alloxan induced diabetic rats by (-) epicetechin. J Life Sci 1982; 31: 2693-7.
114. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and -cell damage in rat pancreas. Pharmacol Res 2005; 51: 117-23.
115. Kang Y-J, Jung UJ, Lee M-K, et al. Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic -cell function in type 2 diabetic mice. Diabetes Res Clin Pract 2008; 82: 25-32.
116. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806.
117. Scalbert A, Manach C, Morand C, Rémésy C, Jiménez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 2005; 45: 287-306.
118. Youl E, Bardy G, Magous R, et al. Quercetin potentiates insulin secretion and protects INS 1 pancreatic cells against oxidative damage via the ERK1/2 pathway. Br J Pharmacol 2010; 161: 799-814.
119. Bardy G, Virsolvy A, Quignard J, et al. Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells. Br J Pharmacol 2013; 169: 1102-13.
120. Fu-Liang X, Xiao-Hui S, Lu G, Xiang-Liang Y, Hui-Bi X. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. Eur J Pharmacol 2006; 529: 7.
121. Kamalakkannan N, Prince PSM. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin induced diabetic wistar rats. Basic Clin Pharmacol Toxicol 2006; 98: 97-103.
122. Srinivasan S, Pari L. Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Chem-Biol Interact 2012; 195: 43-51.
123. Lopez-Lazaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 2009; 9: 31-59.
124. Zarzuelo A, Jimenez I, Gamez M, et al. Effects of luteolin 5-O- -rutinoside in streptozotocin-induced diabetic rats. Life Sci 1996; 58: 2311-6.
125. Ding L, Jin D, Chen X. Luteolin enhances insulin sensitivity via activation of PPAR transcriptional activity in adipocytes. J Nutr Biochem 2010; 21: 941-7.
126. Hsu CL, Yen GC. Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. J Agric Food Chem 2007; 55: 1730-6.
127. Huang TH, Peng G, Kota BP, et al. Anti-diabetic action of Punica granatum flower extract: activation of PPAR- and identification of an active component. Toxicol Appl Pharmacol 2005; 207: 160-9.
128. Consortium I. Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study. PLoS One 2012; 7: e36910.
129. Lee C-C, Hsu W-H, Shen S-R, Cheng Y-H, Wu S-C. Fagopyrum tataricum (buckwheat) improved high-glucose-induced insulin resistance in mouse hepatocytes and diabetes in fructose-rich diet- induced mice. Exp Diabetes Res 2012; 2012.
130. Epstein FH, Shepherd PR, Kahn BB. Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341: 248-57.
131. Natella F, Scaccini C. Role of coffee in modulation of diabetes risk. Nutr Rev 2012; 70: 207-17.
132. Prabhakar PK, Doble M. Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine 2009; 16: 1119-26.
133. Park CE, Kim M, Lee JH, et al. Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med 2007; 39: 222.
134. Ward CW, Lawrence MC. Ligand induced activation of the insulin receptor: a multi step process involving structural changes in both the ligand and the receptor. Bioessays 2009; 31: 422-34.
135. Minokoshi Y, Kahn CR, Kahn BB. Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem 2003; 278: 33609-12.
136. Do GM, Jung UJ, Park HJ, et al. Resveratrol ameliorates diabetes related metabolic changes via activation of AMP activated protein kinase and its downstream targets in db/db mice. Mol Nut Food Res 2012; 56: 1282-91.
137. Barger JL, Kayo T, Vann JM, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PloS One 2008; 3: e2264.
138. Ali F, Ismail A, Kersten S. Molecular mechanisms underlying the potential antiobesity related diseases effect of cocoa polyphenols. Mol Nut Food Res 2014; 58: 33-48.
139. Ong KW, Hsu A, Tan B. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PloS One 2012; 7: e32718.
140. Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33: S62-9.
141. Malaguarnera R, Sacco A, Voci C, Pandini G, Vigneri R, Belfiore A. Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway. Endocrinology 2012; 153: 2152-63.
142. Cao H, Polansky MM, Anderson RA. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys 2007; 459: 214-22.
143. Sharma R. Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr Res 1986; 6: 1353-64.
144. Kannappan S, Anuradha C. Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model. Indian J Med Res 2009; 129: 401-8.
145. Basnet P, Kadota S, Shimizu M, Takata Y, Kobayashi M, Namba T. Bellidifolin stimulates glucose uptake in rat 1 fibroblasts and ameliorates hyperglycemia in streptozotocin (STZ)-induced diabetic rats. Planta Med 1995; 61: 402-5.
146. Tian LY, Bai X, Chen XH, Fang JB, Liu SH, Chen JC. Antidiabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism. Phytomedicine 2010; 17: 533-9.
147. Group SRTR. A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Arch Ophthalmol 1990; 108: 1234.
148. Greene D, Arezzo J, Brown M. Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Neurology 1999; 53: 580-0.
149. Dunlop M. Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int 2000; 58: S3-12.
150. Kinoshita JH, Kador P, Catiles M. Aldose reductase in diabetic cataracts. JAMA 1981; 246: 257-61.
151. Matsuda H, Nishida N, Yoshikawa M. Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC.(2): Structures of myrciacitrins III, IV, and V. Chem Pharm Bull 2002; 50: 429-31.
152. Varma SD, Kinoshita JH. Inhibition of lens aldose reductase by flavonoids—their possible role in the prevention of diabetic cataracts. Biochem Pharmacol 1976; 25: 2505-13.
153. Yoshikawa M, Nishida N, Shimoda H, Takada M, Kawahara Y, Matsuda H. Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities. J Pharm Soc Japan 2001; 121: 371-8.
154. Betteridge DJ. What is oxidative stress? Metabolism 2000; 49: 3-8.
155. Jenner P. Oxidative stress in Parkinson's disease. Annl Neurol 2003; 53: S26-38.
156. Christen Y. Oxidative stress and Alzheimer disease. Am J Clin Nutr 2000; 71: 621s-9.
157. Ishii T, Yasuda K, Akatsuka A, Hino O, Hartman PS, Ishii N. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Cancer Res 2005; 65: 203-9.
158. Ha H, Kim KH. Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. Diabetes Res Clin Pract 1999; 45: 147-51.
159. Singh U, Jialal I. Oxidative stress and atherosclerosis. Pathophysiology 2006; 13: 129-42.
160. Kowluru RA. Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes 2003; 52: 818-23.
161. Cai L, Kang YJ. Oxidative stress and diabetic cardiomyopathy. Cardiovasc Toxicol 2001; 1: 181-93.
162. Tak PP, Zvaifler NJ, Green DR, Firestein GS. Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol Today 2000; 21: 78-82.
163. Blomhoff R. Antioxidants and oxidative stress. Tidsskrift for Den Norske Laegeforening: Tidsskrift for Praktisk Medicin, ny Raekke 2004; 124: 1643-5.
164. Urquiaga I, Leighton F. Plant polyphenol antioxidants and oxidative stress. Biol Res 2000; 33: 55-64.
165. Sabu M, Smitha K, Kuttan R. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. J Ethnopharmacol 2002; 83: 109-16.
166. Latif R. Chocolate/cocoa and human health: a review. Netherlands J Med 2013; 71: 63-8.
167. Drel VR, Sybirna N. Protective effects of polyphenolics in red wine on diabetes associated oxidative/nitrative stress in streptozotocin diabetic rats. Cell Biol Int 2010; 34: 1147-53.
168. Guilford JM, Pezzuto JM. Wine and health: a review. Am J Enol Viticult 2011; 62: 471-86.
169. Larocca LM, Teofili L, Sica S, et al. Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-beta 1 in these cells. Blood 1995; 85: 3654-61.
170. Budin SB, Ismail H, Pek LC. Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats. Sains Malaysiana 2013; 42: 707-13.
171. Vessal M, Hemmati M, Vasei M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol 2003; 135: 357-64.
172. Jorge AP, Horst H, de Sousa E, Pizzolatti MG, Silva FRMB. Insulinomimetic effects of kaempferitrin on glycaemia and on 14 C glucose uptake in rat soleus muscle. Chem-Biol Interact 2004; 149: 89-96.
173. Daisy P, Balasubramanian K, Rajalakshmi M, Eliza J, Selvaraj J. Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats. Phytomedicine 2010; 17: 28-36.
174. Jayaprakasam B, Vareed SK, Olson LK, Nair MG. Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem 2005; 53: 28-31.
175. Singh R, Barden A, Mori T, Beilin L. Advanced glycation endproducts: a review. Diabetologia 2001; 44: 129-46.
176. Ahmed N. Advanced glycation endproducts—role in pathology of diabetic complications. Diabetes Res Clin Pract 2005; 67: 3-21.
177. Wu Q, Chen H, Lv Z, et al. Oligomeric procyanidins of lotus seedpod inhibits the formation of advanced glycation end-products by scavenging reactive carbonyls. Food Chem 2013; 138: 1493-502.
178. Wu CH, Yen GC. Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts. J Agric Food Chem 2005; 53: 3167-73.
179. Lee I-S, Kim IS, Lee YM, Lee Y, Kim J-H, Kim JS. 2, 4 -O-diacetylquercitrin, a novel advanced glycation end-product formation and aldose reductase inhibitor from Melastoma sanguineum. Chem Pharm Bull 2013; 61: 662-5.
180. Xie Y, Chen X. Structures required of polyphenols for inhibiting advanced glycation end products formation. Curr Drug Metabol 2013; 14: 414-31.
181. van Summeren-Wesenhagen PV, Marienhagen J. Metabolic engineering of Escherichia coli for the synthesis of the plant polyphenol pinosylvin. Appl Environ Microbiol 2015; 81: 840-9.
182. Beekwilder J, Wolswinkel R, Jonker H, Hall R, de Vos CR, Bovy A. Production of resveratrol in recombinant microorganisms. Appl Environ Microbiol 2006; 72: 5670-2.
183. Hwang EI, Kaneko M, Ohnishi Y, Horinouchi S. Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster. Appl Environ Microbiol 2003; 69: 2699-706.
184. Manivannan A, Soundararajan P, Park YG, Sakkiah S, Jeong BR. Binding mode investigation of polyphenols from scrophularia targeting human aldose reductase using molecular docking and mo- lecular dynamics simulations. J Chem 2015; 2015; Article ID434256.
185. Burdulis D, Ivanauskas L, Dirse V, Kazlauskas S, Razukas A. Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits. Medicina (Kaunas, Lithuania) 2007; 43: 971-7.
186. Einbond LS, Reynertson KA, Luo X-D, Basile MJ, Kennelly EJ. Anthocyanin antioxidants from edible fruits. Food Chem 2004; 84 23-28.
187. Solomon A, Golubowicz S, Yablowicz Z, et al. Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L.). J Agric Food Chem 2006; 54: 7717-23.
188. Sass-Kiss A, Kiss J, Milotay P, Kerek M, Toth-Markus M. Differences in anthocyanin and carotenoid content of fruits and vegetables. Food Res Int 2005; 38: 1023-9.
189. Bowen-Forbes CS, Zhang Y, Nair MG. Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits. J Food Composit Analysis 2010; 23: 554-60.
190. Sun J, Yao J, Huang S, Long X, Wang J, García-García E. Antioxidant activity of polyphenol and anthocyanin extracts from fruits of Kadsura coccinea (Lem.) AC Smith. Food Chem 2009; 117: 276-81.
191. Bureau S, Renard CM, Reich M, Ginies C, Audergon JM. Change in anthocyanin concentrations in red apricot fruits during ripening. LWT-Food Sci Technol 2009; 42: 372-7.
192. Machado TdB, Leal IC, Amaral ACF, Santos K, Silva MGD, Kuster RM. Antimicrobial ellagitannin of Punica granatum fruits. J Brazil Chem Soc 2002; 13: 606-610.
193. Vrhovsek U, Giongo L, Mattivi F, Viola R. A survey of ellagitannin content in raspberry and blackberry cultivars grown in Trentino (Italy). Eur Food Res Technol 2008; 226: 817-24.
194. Bochi VC, Godoy HT, Giusti MM. Anthocyanin and other phenolic compounds in Ceylon gooseberry (Dovyalis hebecarpa) fruits. Food Chem 2015; 176: 234-43.
195. Koponen JM, Happonen AM, Mattila PH, Törrönen AR. Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J Agric Food Chem 2007; 55: 1612-9.
196. Lugasi A, Takács M. Flavonoid aglycons in foods of plant origin II. Fresh and dried fruits. Acta Aliment 2002; 31: 63-71.
197. Fu L, Xu BT, Xu XR, et al. Antioxidant capacities and total phenolic contents of 62 fruits. Food Chem 2011; 129: 345-50.
198. Da delen A, Tümen G, Özcan MM, Dündar E. Phenolics profiles of olive fruits (Olea europaea L.) and oils from Ayval k, Domat and Gemlik varieties at different ripening stages. Food Chem 2013; 136: 41-5.
199. Füzfai Z, Molnár-Perl I. Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: Analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits. J Chromatogr A 2007; 1149: 88-101.
200. Arts IC, van de Putte B, Hollman PC. Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. J Agric Food Chem 2000; 48: 1746-51.
201. Tsanova-Savova S, Ribarova F, Gerova M. (+)-Catechin and ()-epicatechin in Bulgarian fruits. J Food Composit Anal 2005; 18: 691-8.
202. Suzuki T, Someya S, Hu F, Tanokura M. Comparative study of catechin compositions in five Japanese persimmons (Diospyros kaki). Food Chem 2005; 93: 149-52.
203. Sultana B, Anwar F. Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. Food Chem 2008; 108: 879-84.
204. Olszewska M. Separation of quercetin, sexangularetin, kaempferol and isorhamnetin for simultaneous HPLC determination of flavonoid aglycones in inflorescences, leaves and fruits of three Sorbus species. J Pharm Biomed Anal 2008; 48: 629-35.
205. Ozga JA, Saeed A, Wismer W, Reinecke DM. Characterization of cyanidin-and quercetin-derived flavonoids and other phenolics in mature saskatoon fruits (Amelanchier alnifolia Nutt.). J Agric Food Chem 2007; 55: 10414-24.
206. Pastrana-Bonilla E, Akoh CC, Sellappan S, Krewer G. Phenolic content and antioxidant capacity of muscadine grapes. J Agric Food Chem 2003; 51: 5497-503.
207. Wang SY, Chen CT, Wang CY, Chen P. Resveratrol content in strawberry fruit is affected by preharvest conditions. J Agric Food Chem 2007; 55: 8269-74.
208. Ehala S, Vaher M, Kaljurand M. Characterization of phenolic profiles of Northern European berries by capillary electrophoresis and determination of their antioxidant activity. J Agric Food Chem 2005; 53: 6484-90.
209. Huang X, Mazza G. Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry. J Chromatogr 2011; 1218: 3890-9.
210. Atanassova M, Bagdassarian V. Rutin content in plant products. J Univ Chem Technol Metallurgy 2009; 44: 201-3.
211. ata B, Trampczynska A, Paczesna J. Cultivar variation in apple peel and whole fruit phenolic composition. Sci Horticulture 2009; 121: 176-81.
212. Marín FR, Del Río JA. Selection of hybrids and edible Citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents. J Agric Food Chem 2001; 49: 3356-62.
213. Kumazawa S, Ikenaga M, USUI Y, et al. Comprehensive analysis of polyphenols in fruits consumed in Japan. Food Sci Technol Res 2007; 13: 404-13.
214. Matsui T, Ebuchi S, Kobayashi M, et al. Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the -glucosidase inhibitory action. J Agric Food Chem 2002; 50: 7244-8.
215. Llorach R, Martínez-Sánchez A, Tomás-Barberán FA, Gil MI, Ferreres F. Characterisation of polyphenols and antioxidant proper- ties of five lettuce varieties and escarole. Food Chem 2008; 108: 1028-38.
216. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 2006; 54: 4069-4075.
217. Li H, Deng Z, Zhu H, et al. Highly pigmented vegetables: Anthocyanin compositions and their role in antioxidant activities. Food Res Int 2012; 46: 250-9.
218. Handa SS. Indian herbal pharmacopoeia. Reg Res Lab 1998.
219. Rizvi SI, Mishra N. Anti oxidant effect of quercetin on type 2 diabetic erythrocytes. J Food Biochem 2009; 33: 404-15.
220. Murota K, Hotta A, Ido H, et al. Antioxidant capacity of albuminbound quercetin metabolites after onion consumption in humans. J Med Invest 2007; 54: 370-374.
221. Gupta R, Mathur M, Bajaj VK, et al. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes 2012; 4: 164-71.
222. Kumar A, Malik AK, Tewary DK. A new method for determination of myricetin and quercetin using solid phase microextraction- high performance liquid chromatography-ultra violet/visible system in grapes, vegetables and red wine samples. Anal Chim Acta 2009; 631: 177-81.
223. Tokuolu Ö, Ünal M, Yldrm Z. HPLC-UV and GC-MS characterization of the flavonol aglycons quercetin, kaempferol, and myricetin in tomato pastes and other tomato-based products. Acta Chromatogr 2003; 13: 196-207.
224. Lugasi A, Hóvári J, Sági KV, Bíró L. The role of antioxidant phytonutrients in the prevention of diseases. Acta Biol Szegediensis 2003; 47: 119-25.
225. Horcajada Molteni MN, Crespy V, Coxam V, Davicco MJ, Rémésy C, Barlet JP. Rutin inhibits ovariectomy induced osteopenia in rats. J Bone Mineral Res 2000; 15: 2251-8.
226. Stevenson A. Rutin content of asparagus. J Food Science 1950; 15: 150-4.
227. Li P, Wang X, Wang H, Wu Y-N. High performance liquid chromatographic determination of phenolic acids in fruits and vegetables. Biomed Environ Sci 1993; 6: 389-98.
228. Kowalski R, Kowalska G. Phenolic acid contents in fruits of auber- gine (Solanum melongena L.). Polish J Food Nutr Sci 2005; 14: 37-41.
229. Martínez Valverde I, Periago MJ, Provan G, Chesson A. Phenolic compounds, lycopene and antioxidant activity in commercial varieties of tomato (Lycopersicum esculentum). J Sci Food Agric 2002; 82: 323-30.
230. Alasalvar C, Grigor JM, Zhang D, Quantick PC, Shahidi F. Comparison of volatiles, phenolics, sugars, antioxidant vitamins, and sensory quality of different colored carrot varieties. J Agric Food Chem 2001; 49: 1410-6.
231. Rossetto M, Lante A, Vanzani P, Spettoli P, Scarpa M, Rigo A. Red chicories as potent scavengers of highly reactive radicals: a study on their phenolic composition and peroxyl radical trapping capacity and efficiency. J Agric Food Chem 2005; 53: 8169-75.
232. Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem 2001; 49: 3106-12.
233. Karadeniz F, Burdurlu HS, Nuray K, Soyer Y. Antioxidant activity of selected fruits and vegetables grown in Turkey. Turkish J Agric Forestry 2005; 29: 297-303.
234. Hokayem M, Blond E, Vidal H, et al. Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in firstdegree relatives of type 2 diabetic patients. Diabetes care 2013; 36: 1454-61.
235. Fenercioglu AK, Saler T, Genc E, Sabuncu H, Altuntas Y. The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications. J Endocrinol Invest 2010; 33: 118-24.
236. Wilson T, Luebke JL, Morcomb EF, et al. Glycemic responses to sweetened dried and raw cranberries in humans with type 2 diabetes. J Food Sci 2010; 75: H218-23.
237. Fukino Y, Ikeda A, Maruyama K, Aoki N, Okubo T, Iso H. Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities. Eur J Clin Nutr 2008; 62: 953-60.
238. Panlasigui LN, Thompson LU. Blood glucose lowering effects of brown rice in normal and diabetic subjects. Int J Food Sci Nutr 2006; 57: 151-8.
239. Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006; 187: 363-71.
240. Banini AE, Boyd LC, Allen JC, Allen HG, Sauls DL. Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Nutrition 2006; 22: 1137-45.
241. Fukino Y, Shimbo M, Aoki N, Okubo T, Iso H. Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers. J Nutr Sci Vitaminol 2005; 51: 335-42.