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Volumn 1852, Issue 6, 2014, Pages 1202-1208

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

Author keywords

Alzheimer's disease; Polyphenol; Resveratrol; SIRT1

Indexed keywords

AMYLOID; POLYPHENOL; RESVERATROL; STILBENE DERIVATIVE;

EID: 85003047354     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.10.006     Document Type: Review
Times cited : (210)

References (83)
  • 1
    • 33746764998 scopus 로고    scopus 로고
    • Distribution of [3H]trans-resveratrol in rat tissues following oral administration
    • Abd El-Mohsen M., et al. Distribution of [3H]trans-resveratrol in rat tissues following oral administration. Br. J. Nutr. 2006, 96(1):62-70.
    • (2006) Br. J. Nutr. , vol.96 , Issue.1 , pp. 62-70
    • Abd El-Mohsen, M.1
  • 2
    • 77649208936 scopus 로고    scopus 로고
    • Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice
    • Abraham J., Johnson R.W. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res. 2009, 12(6):445-453.
    • (2009) Rejuvenation Res. , vol.12 , Issue.6 , pp. 445-453
    • Abraham, J.1    Johnson, R.W.2
  • 3
    • 84885995574 scopus 로고    scopus 로고
    • Implications of rising prediabetes prevalence
    • Abraham T.M., Fox C.S. Implications of rising prediabetes prevalence. Diabetes Care 2013, 36(8):2139-2141.
    • (2013) Diabetes Care , vol.36 , Issue.8 , pp. 2139-2141
    • Abraham, T.M.1    Fox, C.S.2
  • 4
    • 79952273819 scopus 로고    scopus 로고
    • Long-term effects of intensive glucose lowering on cardiovascular outcomes
    • ACCORD Study Group, et al Long-term effects of intensive glucose lowering on cardiovascular outcomes. N. Engl. J. Med. 2011, 364(9):818-828.
    • (2011) N. Engl. J. Med. , vol.364 , Issue.9 , pp. 818-828
  • 5
    • 79956084514 scopus 로고    scopus 로고
    • The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Albert M.S., et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7(3):270-279.
    • (2011) Alzheimers Dement. , vol.7 , Issue.3 , pp. 270-279
    • Albert, M.S.1
  • 6
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur J.A., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444(7117):337-342.
    • (2006) Nature , vol.444 , Issue.7117 , pp. 337-342
    • Baur, J.A.1
  • 7
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5(6):493-506.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.6 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 8
    • 70350524083 scopus 로고    scopus 로고
    • Resveratrol is not a direct activator of SIRT1 enzyme activity
    • Beher D., et al. Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem. Biol. Drug Des. 2009, 74(6):619-624.
    • (2009) Chem. Biol. Drug Des. , vol.74 , Issue.6 , pp. 619-624
    • Beher, D.1
  • 9
    • 20444444649 scopus 로고    scopus 로고
    • Mechanism of human SIRT1 activation by resveratrol
    • Borra M.T., Smith B.C., Denu J.M. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 2005, 280(17):17187-17195.
    • (2005) J. Biol. Chem. , vol.280 , Issue.17 , pp. 17187-17195
    • Borra, M.T.1    Smith, B.C.2    Denu, J.M.3
  • 10
    • 0037157069 scopus 로고    scopus 로고
    • Plant foods and herbal sources of resveratrol
    • Burns J., et al. Plant foods and herbal sources of resveratrol. J. Agric. Food Chem. 2002, 50(11):3337-3340.
    • (2002) J. Agric. Food Chem. , vol.50 , Issue.11 , pp. 3337-3340
    • Burns, J.1
  • 11
    • 69849107217 scopus 로고    scopus 로고
    • Caloric restriction, SIRT1 and longevity
    • Cantó C., Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol. Metab. 2009, 20(7):325-331.
    • (2009) Trends Endocrinol. Metab. , vol.20 , Issue.7 , pp. 325-331
    • Cantó, C.1    Auwerx, J.2
  • 12
    • 64549127790 scopus 로고    scopus 로고
    • PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    • Cantó C., Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol. 2009, 20(2):98-105.
    • (2009) Curr. Opin. Lipidol. , vol.20 , Issue.2 , pp. 98-105
    • Cantó, C.1    Auwerx, J.2
  • 13
    • 84906978168 scopus 로고    scopus 로고
    • National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014
    • GA: US Department of Health and Human Services, Atlanta
    • Centers for Disease Control and Prevention National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014 2014, GA: US Department of Health and Human Services, Atlanta.
    • (2014)
  • 14
    • 50049105823 scopus 로고    scopus 로고
    • The regulation of AMP-activated protein kinase by upstream kinases
    • Carling D., Sanders M.J., Woods A. The regulation of AMP-activated protein kinase by upstream kinases. Int. J. Obes. (Lond.) 2008, 32(Suppl. 4):S55-S59.
    • (2008) Int. J. Obes. (Lond.) , vol.32 , pp. S55-S59
    • Carling, D.1    Sanders, M.J.2    Woods, A.3
  • 15
    • 67650061723 scopus 로고    scopus 로고
    • Impaired PGC-1alpha function in muscle in Huntington's disease
    • Chaturvedi R.K., et al. Impaired PGC-1alpha function in muscle in Huntington's disease. Hum. Mol. Genet. 2009, 18(16):3048-3065.
    • (2009) Hum. Mol. Genet. , vol.18 , Issue.16 , pp. 3048-3065
    • Chaturvedi, R.K.1
  • 16
    • 77955017449 scopus 로고    scopus 로고
    • Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    • Chaturvedi R.K., et al. Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation. Hum. Mol. Genet. 2010, 19(16):3190-3205.
    • (2010) Hum. Mol. Genet. , vol.19 , Issue.16 , pp. 3190-3205
    • Chaturvedi, R.K.1
  • 17
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer's disease: strategies for disease modification
    • Citron M. Alzheimer's disease: strategies for disease modification. Nat. Rev. Drug Discov. 2010, 9(5):387-398.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.5 , pp. 387-398
    • Citron, M.1
  • 18
    • 84855613853 scopus 로고    scopus 로고
    • Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
    • Craft S., et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch. Neurol. 2012, 69(1):29-38.
    • (2012) Arch. Neurol. , vol.69 , Issue.1 , pp. 29-38
    • Craft, S.1
  • 19
    • 34249846128 scopus 로고    scopus 로고
    • Resveratrol stimulates AMP kinase activity in neurons
    • Dasgupta B., Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(17):7217-7222.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.17 , pp. 7217-7222
    • Dasgupta, B.1    Milbrandt, J.2
  • 20
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
    • Donmez G., Wang D., Cohen D.E., Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010, 142(2):320-332.
    • (2010) Cell , vol.142 , Issue.2 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 21
    • 70349094526 scopus 로고    scopus 로고
    • Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts
    • Farias S.T., et al. Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts. Arch. Neurol. 2009, 66(9):1151-1157.
    • (2009) Arch. Neurol. , vol.66 , Issue.9 , pp. 1151-1157
    • Farias, S.T.1
  • 22
    • 70349106346 scopus 로고    scopus 로고
    • Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease
    • Ferruzzi M.G., et al. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J. Alzheimers Dis. 2009, 18(1):113-124.
    • (2009) J. Alzheimers Dis. , vol.18 , Issue.1 , pp. 113-124
    • Ferruzzi, M.G.1
  • 23
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T., Deng C.X., Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009, 460(7255):587-591.
    • (2009) Nature , vol.460 , Issue.7255 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 24
    • 76549089547 scopus 로고    scopus 로고
    • 2+ and AMP
    • 2+ and AMP. Biochem. J. 2010, 426(1):109-117.
    • (2010) Biochem. J. , vol.426 , Issue.1 , pp. 109-117
    • Fogarty, S.1
  • 25
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • Greet E.L., Brunet A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 2009, 8(2):113-127.
    • (2009) Aging Cell , vol.8 , Issue.2 , pp. 113-127
    • Greet, E.L.1    Brunet, A.2
  • 26
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    • Hardie D.G. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 2007, 8(10):774-785.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , Issue.10 , pp. 774-785
    • Hardie, D.G.1
  • 27
    • 77956410464 scopus 로고    scopus 로고
    • Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
    • Hawley S.A., et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab. 2010, 11(6):554-565.
    • (2010) Cell Metab. , vol.11 , Issue.6 , pp. 554-565
    • Hawley, S.A.1
  • 28
    • 77955660387 scopus 로고    scopus 로고
    • Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease
    • Ho D.J., et al. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Exp. Neurol. 2010, 225(1):74-84.
    • (2010) Exp. Neurol. , vol.225 , Issue.1 , pp. 74-84
    • Ho, D.J.1
  • 29
    • 58849097075 scopus 로고    scopus 로고
    • Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration
    • Ho L., et al. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. J. Alzheimers Dis. 2009, 16(1):59-72.
    • (2009) J. Alzheimers Dis. , vol.16 , Issue.1 , pp. 59-72
    • Ho, L.1
  • 30
    • 84873455519 scopus 로고    scopus 로고
    • Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease
    • Ho L., et al. Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease. FASEB J. 2013, 27(2):769-781.
    • (2013) FASEB J. , vol.27 , Issue.2 , pp. 769-781
    • Ho, L.1
  • 31
    • 77954968915 scopus 로고    scopus 로고
    • Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding
    • Ho L., Pasinetti G.M. Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding. Expert Rev. Proteomics 2010, 7(4):579-589.
    • (2010) Expert Rev. Proteomics , vol.7 , Issue.4 , pp. 579-589
    • Ho, L.1    Pasinetti, G.M.2
  • 32
    • 60349096854 scopus 로고    scopus 로고
    • Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies
    • Ho L., Yemul S., Wang J., Pasinetti G.M. Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies. J. Alzheimers Dis. 2009, 16(2):433-439.
    • (2009) J. Alzheimers Dis. , vol.16 , Issue.2 , pp. 433-439
    • Ho, L.1    Yemul, S.2    Wang, J.3    Pasinetti, G.M.4
  • 33
    • 80052572943 scopus 로고    scopus 로고
    • Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics
    • Howells L.M., et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics. Cancer Prev. Res. 2011, 4(9):1419-1425.
    • (2011) Cancer Prev. Res. , vol.4 , Issue.9 , pp. 1419-1425
    • Howells, L.M.1
  • 34
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz K.T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425(6954):191-196.
    • (2003) Nature , vol.425 , Issue.6954 , pp. 191-196
    • Howitz, K.T.1
  • 35
    • 84885597030 scopus 로고    scopus 로고
    • Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging
    • Johnson K.A., et al. Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement. 2013, 9(5 Suppl):S72-S83.
    • (2013) Alzheimers Dement. , vol.9 , Issue.5 , pp. S72-S83
    • Johnson, K.A.1
  • 36
    • 60249098801 scopus 로고    scopus 로고
    • Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
    • Karuppagounder S.S., et al. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem. Int. 2009, 54(2):111-118.
    • (2009) Neurochem. Int. , vol.54 , Issue.2 , pp. 111-118
    • Karuppagounder, S.S.1
  • 37
    • 77949501544 scopus 로고    scopus 로고
    • Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment
    • Krikorian R., et al. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br. J. Nutr. 2010, 103(5):730-734.
    • (2010) Br. J. Nutr. , vol.103 , Issue.5 , pp. 730-734
    • Krikorian, R.1
  • 38
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
    • Lagouge M., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 2006, 127(6):1109-1122.
    • (2006) Cell , vol.127 , Issue.6 , pp. 1109-1122
    • Lagouge, M.1
  • 39
    • 80054748660 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
    • Launer L.J., et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 2011, 10(11):969-977.
    • (2011) Lancet Neurol. , vol.10 , Issue.11 , pp. 969-977
    • Launer, L.J.1
  • 40
    • 77956373209 scopus 로고    scopus 로고
    • Insulin resistance, type 2 diabetes, and AD: cerebrovascular disease or neurodegeneration?
    • Luchsinger J.A. Insulin resistance, type 2 diabetes, and AD: cerebrovascular disease or neurodegeneration?. Neurology 2010, 75(9):758-759.
    • (2010) Neurology , vol.75 , Issue.9 , pp. 758-759
    • Luchsinger, J.A.1
  • 41
    • 0026864956 scopus 로고
    • The Huntington's disease candidate region exhibits many different haplotypes
    • MacDonald M.E., et al. The Huntington's disease candidate region exhibits many different haplotypes. Nat. Genet. 1992, 1(2):99-103.
    • (1992) Nat. Genet. , vol.1 , Issue.2 , pp. 99-103
    • MacDonald, M.E.1
  • 42
    • 78650525484 scopus 로고    scopus 로고
    • ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease
    • Maher P., et al. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum. Mol. Genet. 2011, 20(2):261-270.
    • (2011) Hum. Mol. Genet. , vol.20 , Issue.2 , pp. 261-270
    • Maher, P.1
  • 43
    • 27844497059 scopus 로고    scopus 로고
    • Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides
    • Marambaud P., Zhao H., Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J. Biol. Chem. 2005, 280(45):37377-37382.
    • (2005) J. Biol. Chem. , vol.280 , Issue.45 , pp. 37377-37382
    • Marambaud, P.1    Zhao, H.2    Davies, P.3
  • 44
    • 61849113222 scopus 로고    scopus 로고
    • Rate of progression of mild cognitive impairment to dementia-meta-analysis of 41 robust inception cohort studies
    • Mitchell A.J., Shiri-Feshki M. Rate of progression of mild cognitive impairment to dementia-meta-analysis of 41 robust inception cohort studies. Acta Psychiatr. Scand. 2009, 119(4):252-265.
    • (2009) Acta Psychiatr. Scand. , vol.119 , Issue.4 , pp. 252-265
    • Mitchell, A.J.1    Shiri-Feshki, M.2
  • 45
    • 57749112087 scopus 로고    scopus 로고
    • Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity
    • Ono K., et al. Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J. Biol. Chem. 2008, 283(47):32176-32187.
    • (2008) J. Biol. Chem. , vol.283 , Issue.47 , pp. 32176-32187
    • Ono, K.1
  • 46
    • 33750853036 scopus 로고    scopus 로고
    • The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta
    • Ono K., Naiki H., Yamada M. The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta. Curr. Pharm. Des. 2006, 12(33):4357-4375.
    • (2006) Curr. Pharm. Des. , vol.12 , Issue.33 , pp. 4357-4375
    • Ono, K.1    Naiki, H.2    Yamada, M.3
  • 47
    • 0030977937 scopus 로고    scopus 로고
    • Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area
    • Orgogozo J.M., et al. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev. Neurol. (Paris) 1997, 153(3):185-192.
    • (1997) Rev. Neurol. (Paris) , vol.153 , Issue.3 , pp. 185-192
    • Orgogozo, J.M.1
  • 48
    • 77950246109 scopus 로고    scopus 로고
    • SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
    • Pacholec M., et al. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 2010, 285(11):8340-8351.
    • (2010) J. Biol. Chem. , vol.285 , Issue.11 , pp. 8340-8351
    • Pacholec, M.1
  • 49
    • 80053937926 scopus 로고    scopus 로고
    • Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders
    • Pasinetti G.M., et al. Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders. Exp. Neurol. 2011, 232(1):1-6.
    • (2011) Exp. Neurol. , vol.232 , Issue.1 , pp. 1-6
    • Pasinetti, G.M.1
  • 50
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • Petersen R.C. Mild cognitive impairment as a diagnostic entity. J. Intern. Med. 2004, 256(3):183-194.
    • (2004) J. Intern. Med. , vol.256 , Issue.3 , pp. 183-194
    • Petersen, R.C.1
  • 51
    • 84880394491 scopus 로고    scopus 로고
    • Resveratrol in metabolic health: an overview of the current evidence and perspectives
    • Poulsen M.M., et al. Resveratrol in metabolic health: an overview of the current evidence and perspectives. Ann. N. Y. Acad. Sci. 2013, 74-82.
    • (2013) Ann. N. Y. Acad. Sci. , pp. 74-82
    • Poulsen, M.M.1
  • 52
    • 33846959101 scopus 로고    scopus 로고
    • Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)
    • Qin W., et al. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J. Alzheimers Dis. 2006, 10(4):417-422.
    • (2006) J. Alzheimers Dis. , vol.10 , Issue.4 , pp. 417-422
    • Qin, W.1
  • 53
    • 33746824192 scopus 로고    scopus 로고
    • Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    • Qin W., et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 2006, 281(31):21745-21754.
    • (2006) J. Biol. Chem. , vol.281 , Issue.31 , pp. 21745-21754
    • Qin, W.1
  • 54
    • 68449083925 scopus 로고    scopus 로고
    • Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol
    • Ranney A., Petro M.S. Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol. Behav. Pharmacol. 2009, 20(4):330-336.
    • (2009) Behav. Pharmacol. , vol.20 , Issue.4 , pp. 330-336
    • Ranney, A.1    Petro, M.S.2
  • 55
    • 36849078870 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials
    • Raschetti R., Albanese E., Vanacore N., Maggini M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Med. 2007, 4(11):e338.
    • (2007) PLoS Med. , vol.4 , Issue.11 , pp. e338
    • Raschetti, R.1    Albanese, E.2    Vanacore, N.3    Maggini, M.4
  • 56
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    • Reger M.A., et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 2008, 70(6):440-448.
    • (2008) Neurology , vol.70 , Issue.6 , pp. 440-448
    • Reger, M.A.1
  • 57
    • 3242803476 scopus 로고    scopus 로고
    • Resveratrol, pterostilbene, and piceatannol in vaccinium berries
    • Rimando A.M., et al. Resveratrol, pterostilbene, and piceatannol in vaccinium berries. J. Agric. Food Chem. 2004, 52(15):4713-4719.
    • (2004) J. Agric. Food Chem. , vol.52 , Issue.15 , pp. 4713-4719
    • Rimando, A.M.1
  • 58
    • 49749083488 scopus 로고    scopus 로고
    • Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases
    • Rocha-González H.I., Ambriz-Tututi M., Granados-Soto V. Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases. CNS Neurosci. Ther. 2008, 14(3):234-247.
    • (2008) CNS Neurosci. Ther. , vol.14 , Issue.3 , pp. 234-247
    • Rocha-González, H.I.1    Ambriz-Tututi, M.2    Granados-Soto, V.3
  • 59
    • 77949817711 scopus 로고    scopus 로고
    • AMPK and SIRT1: a long-standing partnership?
    • Ruderman N.B., et al. AMPK and SIRT1: a long-standing partnership?. Am. J. Physiol. Endocrinol. Metab. 2010, 298(4):751-760.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , Issue.4 , pp. 751-760
    • Ruderman, N.B.1
  • 61
    • 0035949487 scopus 로고    scopus 로고
    • Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
    • Selkoe D.J. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(20):11039-11041.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , Issue.20 , pp. 11039-11041
    • Selkoe, D.J.1
  • 62
    • 77950348878 scopus 로고    scopus 로고
    • AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    • Um J.H., et al. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010, 59(3):554-563.
    • (2010) Diabetes , vol.59 , Issue.3 , pp. 554-563
    • Um, J.H.1
  • 63
    • 77952180745 scopus 로고    scopus 로고
    • SirT1 in muscle physiology and disease: lessons from mouse models
    • Vinciguerra M., et al. SirT1 in muscle physiology and disease: lessons from mouse models. Dis. Model Mech. 2010, 3(6):298-303.
    • (2010) Dis. Model Mech. , vol.3 , Issue.6 , pp. 298-303
    • Vinciguerra, M.1
  • 64
    • 79952135316 scopus 로고    scopus 로고
    • AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies
    • Vingtdeux V., Davies P., Dickson D.W., Marambaud P. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol. 2011, 121(3):337-349.
    • (2011) Acta Neuropathol. , vol.121 , Issue.3 , pp. 337-349
    • Vingtdeux, V.1    Davies, P.2    Dickson, D.W.3    Marambaud, P.4
  • 65
    • 57449120637 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol in Alzheimer's disease
    • Vingtdeux V., et al. Therapeutic potential of resveratrol in Alzheimer's disease. BMC Neurosci. 2008, 9(Suppl. 2):S6.
    • (2008) BMC Neurosci. , vol.9 , pp. S6
    • Vingtdeux, V.1
  • 66
    • 77950575506 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism
    • Vingtdeux V., et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J. Biol. Chem. 2010, 285(12):9100-9113.
    • (2010) J. Biol. Chem. , vol.285 , Issue.12 , pp. 9100-9113
    • Vingtdeux, V.1
  • 67
    • 63849085094 scopus 로고    scopus 로고
    • Targeting the AMPK pathway for the treatment of Type 2 diabetes
    • Viollet B., et al. Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front. Biosci. (Landmark Ed.) 2009, 14:3380-3400.
    • (2009) Front. Biosci. (Landmark Ed.) , vol.14 , pp. 3380-3400
    • Viollet, B.1
  • 68
    • 78851469101 scopus 로고    scopus 로고
    • Bioavailability of resveratrol
    • Walle T. Bioavailability of resveratrol. Ann. N. Y. Acad. Sci. 2011, 1215:9-15.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1215 , pp. 9-15
    • Walle, T.1
  • 69
    • 84898025679 scopus 로고    scopus 로고
    • Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications
    • Wang J., et al. Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications. Front. Aging Neurosci. 2014, 6(42).
    • (2014) Front. Aging Neurosci. , vol.6 , Issue.42
    • Wang, J.1
  • 70
    • 84859542836 scopus 로고    scopus 로고
    • Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment
    • Wang J., et al. Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. J. Neurosci. 2012, 32(15):5144-5150.
    • (2012) J. Neurosci. , vol.32 , Issue.15 , pp. 5144-5150
    • Wang, J.1
  • 71
    • 77953421120 scopus 로고    scopus 로고
    • The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology
    • Wang J., et al. The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology. Biochim. Biophys. Acta 2010, 1804(8):1690-1694.
    • (2010) Biochim. Biophys. Acta , vol.1804 , Issue.8 , pp. 1690-1694
    • Wang, J.1
  • 72
    • 20144386977 scopus 로고    scopus 로고
    • Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease
    • Wang J., et al. Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2005, 19(6):659-661.
    • (2005) FASEB J. , vol.19 , Issue.6 , pp. 659-661
    • Wang, J.1
  • 73
    • 46749123053 scopus 로고    scopus 로고
    • Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
    • Wang J., et al. Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J. Neurosci. 2008, 28(25):6388-6392.
    • (2008) J. Neurosci. , vol.28 , Issue.25 , pp. 6388-6392
    • Wang, J.1
  • 74
    • 33845620279 scopus 로고    scopus 로고
    • Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease
    • Wang J., et al. Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006, 20(13):2313-2320.
    • (2006) FASEB J. , vol.20 , Issue.13 , pp. 2313-2320
    • Wang, J.1
  • 75
    • 79952338055 scopus 로고    scopus 로고
    • Potential application of grape derived polyphenols in Huntington's disease
    • Wang J., et al. Potential application of grape derived polyphenols in Huntington's disease. Transl. Neurosci. 2010, 1(2):95-100.
    • (2010) Transl. Neurosci. , vol.1 , Issue.2 , pp. 95-100
    • Wang, J.1
  • 76
    • 78650816787 scopus 로고    scopus 로고
    • Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease
    • Wang J., et al. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease. J. Alzheimers Dis. 2010, 22(2):653-661.
    • (2010) J. Alzheimers Dis. , vol.22 , Issue.2 , pp. 653-661
    • Wang, J.1
  • 77
    • 84889030836 scopus 로고    scopus 로고
    • Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model
    • Wang J., et al. Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model. Mol. Nutr. Food Res. 2013, 57(12):2091-2102.
    • (2013) Mol. Nutr. Food Res. , vol.57 , Issue.12 , pp. 2091-2102
    • Wang, J.1
  • 78
    • 20344371723 scopus 로고    scopus 로고
    • Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
    • Wenzel E., Soldo T., Erbersdobler H., Somoza V. Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol. Nutr. Food Res. 2005, 49(5):482-494.
    • (2005) Mol. Nutr. Food Res. , vol.49 , Issue.5 , pp. 482-494
    • Wenzel, E.1    Soldo, T.2    Erbersdobler, H.3    Somoza, V.4
  • 79
    • 33750437278 scopus 로고    scopus 로고
    • Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration
    • Weydt P., et al. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metab. 2006, 4(5):349-362.
    • (2006) Cell Metab. , vol.4 , Issue.5 , pp. 349-362
    • Weydt, P.1
  • 80
    • 84901810516 scopus 로고    scopus 로고
    • Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults
    • Witte A.V., Kerti L., Margulies D.S., Flöel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neurosci. 2014, 34(23):7862-7870.
    • (2014) J. Neurosci. , vol.34 , Issue.23 , pp. 7862-7870
    • Witte, A.V.1    Kerti, L.2    Margulies, D.S.3    Flöel, A.4
  • 81
    • 78049274928 scopus 로고    scopus 로고
    • Accelerated progression from mild cognitive impairment to dementia in people with diabetes
    • Xu W., et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes 2010, 59(11):2928-2935.
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2928-2935
    • Xu, W.1
  • 82
    • 4143119982 scopus 로고    scopus 로고
    • Diabetes, impaired fasting glucose, and development of cognitive impairment in older women
    • Yaffe K., et al. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology 2004, 63(4):658-663.
    • (2004) Neurology , vol.63 , Issue.4 , pp. 658-663
    • Yaffe, K.1
  • 83
    • 0034737299 scopus 로고    scopus 로고
    • Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    • Yamamoto A., Lucas J.J., Hen R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 2000, 101(1):57-66.
    • (2000) Cell , vol.101 , Issue.1 , pp. 57-66
    • Yamamoto, A.1    Lucas, J.J.2    Hen, R.3


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