Nutrient-secretion coupling in the pancreatic islet β-cell: Recent advances

Molecular Aspects of Medicine

Volumn 22, Issue 6, 2001, Pages 247-284

  Rutter, Guy A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

cell; ATP; Ca2+; Exocytosis; Glucose; Insulin; Islet; KATPchannel; Mitochondria; Pancreas; Secretion

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE MAGNESIUM; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP PHOSPHODIESTERASE; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 3; HEXANOIC ACID DERIVATIVE; INSULIN; LUCIFERASE; MALONYL COENZYME A; OXOISOCAPROIC ACID; PHOSPHOENOLPYRUVATE; POTASSIUM CHANNEL; POTASSIUM ION; PROPIDIUM IODIDE; PROTEIN KINASE B; PROTEIN KINASE C; PYRIDINE NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SULFONYLUREA; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR A; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANION TRANSPORT; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE; CELL VACUOLE; CHIMERA; DECARBOXYLATION; DEPOLARIZATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; EXOCYTOSIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; MITOCHONDRIAL RESPIRATION; MOLECULAR MECHANICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; OSCILLATION; PANCREAS ISLET BETA CELL; PHOSPHORYLATION; PROTEIN EXPRESSION; REVIEW;

ADENOSINE TRIPHOSPHATE; ANIMALS; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS;

EID: 0035570732     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0098-2997(01)00013-9     Document Type: Review

References (270)

1. Cloning of the beta cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
2. + channel in the beta-cell?
3. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice
4. 2+ oscillations and insulin secretion in pancreatic islets
5. 2+-dependent mechanism
6. Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion
7. Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene
8. Glucose action 'beyond ionic events' in the pancreatic beta cell
9. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells
10. Role of sterol response element binding protein-1 (SREBP1) in the regulation of insulin production by pancreatic islets
11. Metabolic engineering with recombinant adenoviruses
12. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion - A re-evaluation of the long-chain acyl-CoA hypothesis
13. Insulin suppresses its own secretion in vivo
14. 2+ channels
15. Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic beta-cells
16. Mechanisms of insulin secretion
17. Glucose induces closure of single potassium channels in isolated rat pancratic B-cells
18. 2+ ions
19. Insulin-stimulated insulin secretion in single pancreatic beta cells
20. 2+ stores in insulin-stimulated insulin secretion in β-cells
21. Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library - Identification of PFK-2/FBPase-2 as a novel interaction partner
22. Molecular biology of mammalian glucose transporters
23. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach
24. Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets
25. Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase
26. Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression
27. Effects of lactate on pancreatic islets. Lactate efflux as a possible determinant of islet-cell depolarization by glucose
28. 2+-regulated exocytosis
29. 2+ from permeabilized insulin-secreting cells
30. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells
31. 86Rb permeability in cultured neonatal and adult rat islets
32. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein
33. The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: Studies with a phorbol ester
34. ir6.2) of the ATP-regulated potassium channel
35. Glucose regulates acetyl CoA carboxylase gene expression in a pancreatic β-cell line (INS-1)
36. The ABCs of ATP-sensitive potassium channels: More pieces of the puzzle
37. i and contractile activity
38. Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays
39. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
40. Glucose repression in yeast
41. Insulin secretion in diabetes mellitus
42. Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
43. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
44. CyclicAMP dependent protein phosphorylation and insulin secretion in intact islets of Langerhans
45. Bioluminescent indicators in living mammals
46. + channels in pancreatic B-cells
47. Inhibition of glucose phosphorylation by mannoheptulose
48. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells
49. Collaborative study of estimates by radioimmunoassay of insulin concentrations in plasma samples examined in groups of five or six laboratories
50. Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT)
51. Dynamics of insulin secretion by the perfused rat pancreas
52. Levels of ketoglutarate and glutamate in stimulated pancreatic beta-cells
53. Role of AMP-activated protein kinase in the regulation by glucose of islet beta-cell gene expression
54. ′ kinase
55. Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin secreting cells (HIT T-15 and NMRI beta-cells)
56. Pathogenesis of NIDDM. A balanced overview
57. 2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria
58. A cytoplasmic inhibitor of the JNK signal transduction pathway
59. Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1 alpha-deficient mice
60. ′-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits
61. Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets
62. Effects of insulin secretagogues on protein kinase C-catalyzed phosphorylation of an endogenous substrate in isolated pancreatic islets
63. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: Studies with the antagonist extend in 9-39
64. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion
65. Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity
66. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells
67. 2+] changes at the secretory vesicle surface with a recombinant targeted cameleon
68. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
69. 2+ concentration elevation in glucose-induced insulin secretion
70. Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells - Possible implication of a pyruvate/citrate shuttle in insulin secretion
71. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
72. Cyclic ADP-ribose: A new way to control calcium
73. Glucose-induced translocation of protein kinase C in rat pancreatic islets
74. The mitochondrial KATP channel as a receptor for potassium channel openers
75. + channels in mouse B cells
76. + channels in mouse B cells
77. Response to glucose of transcription factor binding to the rat insulin-1 gene promoter
78. Rapid reduction and return of surface insulin receptors after exposure to brief pulses of insulin in perifused rat hepatocytes
79. Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys
80. 2+ of individual pancreatic beta-cells recorded by two procedures for dual-wavelength fluorometry
81. Novel method for measurement of submembrane ATP concentration
82. Pharmacological modulation of KATP channels
83. 2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell
84. No decrease of the beta-cell mass in type 2 diabetic patients
85. Mitochondria and cell death
86. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
87. Atypical isoforms of PKC and insulin secretion from pancreatic beta-cells: Evidence using Go 6976 and Ro 31-8220 as PKC inhibitors
88. + channels in rat CRI-G1, insulin secreting cells
89. Maturity-onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity
90. Mechanisms of glucose-induced insulin secretion
91. Triggering and amplifying pathways of regulation of insulin secretion by glucose
92. Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells
93. Kinesin and dynein superfamily proteins and the mechanism of organelle transport
94. Detection of exocytosis at individual pancreatic beta cells by amperometry at a chemically modified microelectrode
95. Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release
96. Myosin light-chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade
97. Reconstitution of I(KATP): An inward rectifier subunit plus the sulfonylurea receptor
98. Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells
99. Cyclic ADP-ribose and pancreatic beta cells
100. In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation
101. Evidence for a feedback inhibition of insulin on insulin secretion in the isolated, perfused canine pancreas
102. Mammalian glucokinase and its gene
103. Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans
104. 2+ in mouse pancreatic beta-cells
105. Protein kinase C and the regulation of insulin secretion from pancreatic B-cells
106. 2+ triggered, mitochondrial activation
107. Oxygen microsensor and its application to single cells and mouse pancreatic islets
108. 2+ in single islets of Langerhans
109. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
110. Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria
111. Dealing with energy demand: The AMP-activated protein kinase
112. Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells
113. Imaging glucose-induced increases in ATP in single living islet beta-cells
114. 2+ in aequorin-expressing INS-1 cells
115. Glucose-induced ATP microdomains in single islet beta-cells
116. +) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway
117. 2+ concentration in human pancreatic islets and insulinoma cells
118. 2+ in rat pancreatic islets
119. + channel of heart mitochondria
120. Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell
121. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
122. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man
123. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
124. 2+ concentration in the pancreatic beta cell
125. AMP- and stress activated protein kinases: Key regulators of gene transcription in mammalian cells
126. AMP-activated protein kinase (AMPK) is expressed at different levels in the endocrine and exocrine pancreas in rodents and humans
127. AMP-activated protein kinase in signal transduction to the nucleus
128. 2+](i) in insulin secreting cells
129. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
130. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor PI-3 kinase p70 s6 kinase and CaM kinase pathways
131. Diazoxide inhibits ATP production in isolated beta cell mitochondria only in the presence of extramitochondrial Mg nucleotides
132. Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets
133. Glucose metabolism and insulin release in mouse betaHC9 cells, as model for wild-type pancreatic beta-cells
134. Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels
135. 2+ oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets
136. 2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells
137. Lack of feedback inhibition of insulin secretion in denervated human pancreas
138. High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide
139. Glucose enters mitochondrial metabolism via both carboxylation and decarboxylation of pyruvate in pancreatic islets
140. Estimates of glycolysis, pyruvate (de)carboxylation, pentose phosphate pathway, and methyl succinate metabolism in incapacitated pancreatic islets
141. Glutamate is not a messenger in insulin secretion
142. Lack of glyconeogenesis in pancreatic islets: Expression of gluconeogenic enzyme genes in islets
143. Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells - Studies in aequorin-expressing intact and permeabilized INS-1 cells
144. Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase
145. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
146. Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell
147. Calmodulin and calbindin in pancreatic islet cells
148. Cyclic ADP-ribose measurements in rat pancreatic islets
149. Insulin secretion by isolated islets in presence of glucose, insulin and anti-insulin serum
150. The independence of insulin release and ambient insulin in vitro
151. Metabolism of glucose in the islets of Langerhans
152. Biochemical design features of the pancreatic islet cell glucose-sensory system
153. Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets
154. Role of calcium ions in regulation of mammalian intramitochondrial metabolism
155. Fatty acids, lipotoxicity and insulin secretion
156. Evidence that calcium release-activated current mediates the biphasic electrical activity of mouse pancreatic beta-cells
157. Pancreatic islet glucose metabolism and regulation of insulin secretion
158. The extended protein kinase C superfamily
159. Molecular structure of the glibenclamide binding site of the beta-cell K(ATP) channel
160. 2+ store in neuroendocrine cells with a VAMP2. Aequorin chimaera
161. 2+-induced diminution of the adenine nucleotide translocator
162. Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport
163. Mammalian sweet taste receptors
164. Biphasic insulin release as the expression of combined inhibitory and potentiating effects of glucose
165. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
166. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
167. Different expression of protein kinase C isozymes in pancreatic islet cells
168. Oscillations in oxygen tension and insulin release of individual pancreatic ob/ob mouse islets
169. Abnormal responsiveness of insulin release to exogenous pyruvate in patients with physical exercise-induced hyperinsulinemic hypoglycemia
170. Effect of carbohydrates upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets
171. 2 consumption by isolated pancreatic islets, as measured in a microincubation system with a Clark-type electrode
172. Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: Contributions of types III and IV to the modulation of insulin secretion
173. Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells
174. Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus
175. Purification of aldehyde dehydrogenase from rat liver mitochondria by alpha-cyanocinnamate affinity chromatography
176. Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and cluster analysis
177. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting
178. Secretory granule dynamics visualised in vivo with a phogrin-green fluorescent protein chimaera
179. 2+ in the vicinity of secretory granules
180. 2+ and secretion
181. 2+ by isolated organelles from a rat insulinoma
182. Signal transduction mechanisms in nutrient-induced insulin secretion
183. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
184. 2+, diacylglycerol, and protein kinase C activity
185. Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: Comparison with the effect of Rab3AL peptide
186. Cyclic AMP stimulates insulin exocytosis by modification of granules already present at the release sites
187. Integrating cytosolic calcium signals into mitochondrial metabolic responses
188. Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1)
189. A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: A study in hormone-sensitive lipase-deficient mice
190. The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint
191. The cell physiology of biphasic insulin secretion
192. 2+-binding to citrate cycle enzymes
193. Insulin secretion: Feed-forward control of insulin biosynthesis
194. 2+ with recombinant targeted aequorin: Significance for the regulation of pyruvate dehydrogenase activity
195. 2+ release: An intimate connection
196. Regulation of gene expression by glucose
197. 2+ to supramicromolar levels in a pancreatic β-cell line: Possible role in glucose and agonist-induced insulin secretion
198. 2+ stores in insulin-secreting cells: Lack of effect of cADP ribose
199. L-type calcium channels in insulin-secreting cells: Biochemical characterization and phosphorylation in RINm5F cells
200. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release
201. Effects of adrenaline and noradrenaline on glucose-induced electrical activity of mouse pancreatic B-cell
202. Release of immunoreactive and radioactively prelabelled endogenous (pro)-insulin from isolated islets of rat pancreas in the presence of exogenous insulin
203. 2+ depletion from granules inhibits exocytosis - A study with insulin-secreting cells
204. Characterization of the cyclic nucleotide phosphodiesterase isoenzymes present in rat epididymal fat cells
205. Metabolic fate of glucose in purified islet cells - Glucose-regulated anaplerosis in beta cells
206. Is GLUT2 required for glucose sensing?
207. Voltage-dependent potentiation of the activity of cardiac L-type calcium channel alpha1 subunits due to phosphorylation by cAMP-dependent protein kinase
208. SUR1 knockout mice - A model for K-ATP channel-independent regulation of insulin secretion
209. Interrelationship between chloride fluxes in pancreatic islets and insulin release
210. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogease in pancreatic β-cell. Potential role in nutrient sensing
211. The stimulus-secretion coupling of glucose-induced insulin release: Effect of endogenous pyruvate on islet function
212. 2+-dependent activation of the glycerol phosphate shuttle by nutrient secretagogues
213. Familial hyperinsulinism and pancreatic beta-cell ATP-sensitive potassium channels
214. Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion
215. Membrane phospholipid control of nucleotide sensitivity of KATP channels
216. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes
217. 2+ and exocytosis in pancreatic beta-cells
218. Molecular machinery mediating vesicle budding, docking and fusion
219. Lack of direct inhibition of insulin secretion by exogenous insulin in the canine pancreas
220. Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration
221. Tracking single secretory granules in live chromaffin cells by evanescent-field fluorescence microscopy
222. Hyperinsulinism of infancy: The regulated release of insulin by KATP channel-independent pathways
223. The synaptic vesicle cycle revisited
224. A synaptic vesicle membrane protein is conserved from mammals to Drosophila
225. Phosphoenolpyruvate in rat pancreatic islets: A possible intracellular trigger of insulin release?
226. Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium
227. Post-priming actions of ATP on Ca2-dependent exocytosis in pancreatic beta cells
228. Cyclic ADP-ribose in insulin secretion from pancreatic B-cells
229. Calcium-activated, phospholipid-dependent protein kinase in rat pancreas islets of langerhans. Its possible role in glucose-induced insulin release
230. 2+ in the endoplasmic reticulum of mouse pancreatic beta cells
231. 2+ in pancreatic β-cells stimulated by glucose, carbachol, and ATP
232. Cloning and functional expression in bacteria of a novel glucose transporter present in liver intestine kidney and B-pancreatic islet cells
233. Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C
234. Protein kinase C in beta-cells: Expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion
235. Motor proteins: Myosin V - The multi-purpose transport motor
236. From genome to aetiology in a multifactorial disease, type 1 diabetes
237. Are metabolic oscillations responsible for normal oscillatory insulin secretion?
238. Regulation of glucose metabolism in pancreatic islets
239. Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event
240. 2+-induced insulin secretion in permeabilized HIT-T15 cells
241. Mutation in mitochondrial tRNA(Leu(UUR)) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
242. Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors
243. Regulation of secretory vesicle movement in insulin secreting cells
244. 2+)-transport ATPase 3 gene (SERCA3) in Caucasian type II diabetic patients (UK Prospective Diabetes Study 48)
245. 2+] in MIN6-cells using recombinant cameleons: Roles of SERCA2 and ryanodine receptors
246. 2+ imaging
247. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
248. 2+
249. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
250. Expression profiling of pancreatic beta cells: Glucose regulation of secretory and metabolic pathway genes
251. Effects of forskolin on insulin release and cyclic AMP content in rat pancreatic islets
252. 2+-dependent threonine phosphorylation of myosin heavy chain in rat pancreatic islets and RINm5F cells
253. Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans
254. ++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture
255. The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
256. Adiposity signals and the control of energy homeostasis
257. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
258. Inhibition of SNARE complex assembly differentially affects kinetic components of exocytosis
259. Insulin receptor substrate-1 induced inhibition of endoplasmic reticulum calcium uptake in beta cells
260. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells
261. Characterization of kinectin, a kinesin-binding protein: Primary sequence and N-terminal topogenic signal analysis
262. Synergism of protein kinase A, protein kinase C, and myosin light-chain kinase in the secretory cascade of the pancreatic beta-cell
263. 2+ concentration and insulin secretion as evidenced from measurements in mouse single pancreatic islets
264. Insulin secretion: Combined effects of phorbol ester and A23187
265. 2+, cAMP and diacylglycerol
266. Effects of protein kinase C inhibitors on insulin secretory responses from rodent pancreatic islets
267. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
268. Expression and distribution of lactate/monocarboxylate transporter (MCT) isoforms in pancreatic islets and the exocrine pancreas
269. Overexpression of lactate dehydrogenase A attenuates glucose-induced insulin secretion in stable MIN-6 beta- cell lines
270. Role of AMP-activated protein kinase in mechanism of metformin action