Proinsulin binds with high affinity the insulin receptor isoform a and predominantly activates the mitogenic pathway

Endocrinology

Volumn 153, Issue 5, 2012, Pages 2152-2163

  Malaguarnera, Roberta ^a   Sacco, Antonella ^a   Voci, Concetta ^a   Pandini, Giuseppe ^b   Vigneri, Riccardo ^b   Belfiore, Antonino ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; INSULIN I 125; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROINSULIN; S6 KINASE; SOMATOMEDIN B; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STABLE TRANSFECTION;

APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROINSULIN; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN;

EID: 84860340287     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1843     Document Type: Article

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