메뉴 건너뛰기




Volumn 23, Issue 3, 2013, Pages 266-280

Diabetes and beta cell function: From mechanisms to evaluation and clinical implications

Author keywords

Diabetes mellitus; Hyperglycemia; Pancreatic beta cells

Indexed keywords

ACETYLSALICYLIC ACID; ADIPOCYTOKINE; AMYLIN; ANGIOTENSIN RECEPTOR ANTAGONIST; CASPASE 3; CXCL1 CHEMOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EXENDIN 4; FAS LIGAND; FATTY ACID; FIBRIC ACID DERIVATIVE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INCRETIN; INTERLEUKIN 6; LEPTIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PREPROINSULIN; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; SPHINGOSINE 1 PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 84885063145     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: 10.11613/BM.2013.033     Document Type: Review
Times cited : (155)

References (100)
  • 1
    • 0035130272 scopus 로고    scopus 로고
    • Beta-cell adaptation and decompensation during the progression of diabetes
    • Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A. Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 2001;50(Suppl 1):8154-9. http://dx.doi.org/10.2337/diabetes.50.2007.S154.
    • (2001) Diabetes , vol.50 , Issue.1 SUPPL. , pp. 8154-8159
    • Weir, G.C.1    Laybutt, D.R.2    Kaneto, H.3    Bonner-Weir, S.4    Sharma, A.5
  • 2
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965;14:619-33.
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 3
    • 35948950219 scopus 로고    scopus 로고
    • Clinical presentation and treatment of type 2 diabetes in children
    • Pinhas-Hamiel O, Zeitler P. Clinical presentation and treatment of type 2 diabetes in children. Pediatr Diabetes 2007;8 Suppl 9:16-27. http://dx.doi.org/10.1111/j.1399-5448.2007.00330.x.
    • (2007) Pediatr Diabetes , vol.8 , Issue.9 SUPPL. , pp. 16-27
    • Pinhas-Hamiel, O.1    Zeitler, P.2
  • 4
    • 79551479691 scopus 로고    scopus 로고
    • Is diabetes mellitus a continuous spectrum?
    • Brooks-Worrell B, Palmer JP. Is diabetes mellitus a continuous spectrum? Clin Chem 2011;57:158-61. http://dx.doi.org/10.1373/clinchem.2010.148270.
    • (2011) Clin Chem , vol.57 , pp. 158-161
    • Brooks-Worrell, B.1    Palmer, J.P.2
  • 5
    • 31844443691 scopus 로고    scopus 로고
    • Natural history of beta-cell function in type 1 diabetes
    • Sherry NA, Tsai EB, Herold KC. Natural history of beta-cell function in type 1 diabetes. Diabetes 2005;54 Suppl 2:S32-9. http://dx.doi.org/10.2337/diabetes.54.suppl_2.S32.
    • (2005) Diabetes , vol.54 , Issue.2 SUPPL.
    • Sherry, N.A.1    Tsai, E.B.2    Herold, K.C.3
  • 6
    • 55249120245 scopus 로고    scopus 로고
    • The accelerator hypothesis and increasing incidence of type 1 diabetes
    • Fourlanos S, Harrison LC, Colman PG. The accelerator hypothesis and increasing incidence of type 1 diabetes. Curr Opin Endocrinol Diabetes Obes 2008;15:321-5. http://dx.doi.org/10.1097/MED.0b013e3283073a5a.
    • (2008) Curr Opin Endocrinol Diabetes Obes , vol.15 , pp. 321-325
    • Fourlanos, S.1    Harrison, L.C.2    Colman, P.G.3
  • 7
    • 67650450153 scopus 로고    scopus 로고
    • The accelerator hypothesis: A review of the evidence for insulin resistance as the basis for type I as well as type II diabetes
    • Wilkin TJ. The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes. Int J Obes (Lond) 2009;33:716-26. http://dx.doi.org/10.1038/ijo.2009.97.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 716-726
    • Wilkin, T.J.1
  • 8
    • 84862258384 scopus 로고    scopus 로고
    • The interplay of autoimmunity and insulin resistance in type 1 diabetes
    • Nokoff NJ, Rewers M, Cree Green M. The interplay of autoimmunity and insulin resistance in type 1 diabetes. Discov Med 2012;13:115-22.
    • (2012) Discov Med , vol.13 , pp. 115-122
    • Nokoff, N.J.1    Rewers, M.2    Cree, G.M.3
  • 9
    • 84864025055 scopus 로고    scopus 로고
    • Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes
    • Schofield CJ, Sutherland S. Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes. Diabet Med 2012;29:972-9. http://dx.doi.org/10.1111/j.1464-5491.2012.03655.x.
    • (2012) Diabet Med , vol.29 , pp. 972-979
    • Schofield, C.J.1    Sutherland, S.2
  • 10
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005;54 Suppl 2:S97-107. http://dx.doi.org/10.2337/diabetes.54.suppl_2.S97
    • (2005) Diabetes , vol.54 , Issue.2 SUPPL.
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jörns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 11
    • 34249682591 scopus 로고    scopus 로고
    • Beta-cell failure in diabetes and preservation by clinical treatment
    • Wajchenberg B. Beta-cell failure in diabetes and preservation by clinical treatment. Endocrine Rev 2007;28:187-218. http://dx.doi.org/10.1210/10.1210/er.2006-0038.
    • (2007) Endocrine Rev , vol.28 , pp. 187-218
    • Wajchenberg, B.1
  • 12
    • 0842284799 scopus 로고    scopus 로고
    • Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • Robertson RP, Harmon J, Tran PO, Poitout V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004;53 Suppl 1:S119-24. http://dx.doi.org/10.2337/diabetes.53.2007.S119.
    • (2004) Diabetes , vol.53 , Issue.1 SUPPL.
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Poitout, V.4
  • 13
    • 84860390432 scopus 로고    scopus 로고
    • Glucolipotoxicity and beta cells in type 2 diabetes mellitus: Target for durable therapy
    • van Raalte DH, Diamant M. Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy? Diabetes Res Clin Pract 2011;93 Suppl 1:S37-46. http://dx.doi.org/10.1016/S0168-8227(11)70012-2.
    • (2011) Diabetes Res Clin Pract , vol.93 , Issue.1 SUPPL.
    • van Raalte, D.H.1    Diamant, M.2
  • 14
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
    • Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003;52:581-7. http://dx.doi.org/10.2337/diabetes.52.3.581.
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 15
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and β-cell dysfunction
    • Poitout V, Robertson RP. Glucolipotoxicity: Fuel excess and β-cell dysfunction. Endocr Rev 2008;29:351-66. http://dx.doi.org/10.1210/er.2007-0023.
    • (2008) Endocr Rev , vol.29 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 16
    • 84862809326 scopus 로고    scopus 로고
    • Glucolipotoxicity in pancreatic β-Cells
    • Kim JW, Yoon KH. Glucolipotoxicity in pancreatic β-Cells. Diabetes Metab J 2011;35:444-50. http://dx.doi.org/10.4093/dmj.2011.35.5.444.
    • (2011) Diabetes Metab J , vol.35 , pp. 444-450
    • Kim, J.W.1    Yoon, K.H.2
  • 17
    • 0029664752 scopus 로고    scopus 로고
    • Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator
    • Poitout V, Olson LK, Robertson RP. Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. J Clin Invest 1996;97:1041-6. http://dx.doi.org/10.1172/JCI118496.
    • (1996) J Clin Invest , vol.97 , pp. 1041-1046
    • Poitout, V.1    Olson, L.K.2    Robertson, R.P.3
  • 18
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006;116:1802-12. http://dx.doi.org/10.1172/JCI29103.
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 19
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008;29:42-61. http://dx.doi.org/10.1210/er.2007-0015.
    • (2008) Endocr Rev , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 20
    • 0034831112 scopus 로고    scopus 로고
    • Serum 8 hydroxy-guanine levels are increased in diabetic patients
    • Shin CS, Moon BS, Park KS, Kim SY, Park SJ, Chung MH, et al. Serum 8 hydroxy-guanine levels are increased in diabetic patients. Diabetes Care 2001;24:733-7. http://dx.doi.org/10.2337/diacare.24.4.733.
    • (2001) Diabetes Care , vol.24 , pp. 733-737
    • Shin, C.S.1    Moon, B.S.2    Park, K.S.3    Kim, S.Y.4    Park, S.J.5    Chung, M.H.6
  • 21
    • 0036163156 scopus 로고    scopus 로고
    • Reduced β-cell mass and expression of oxidative stress related DNA damage in the islet of Japanese type II diabetic patients
    • Sakuaba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced β-cell mass and expression of oxidative stress related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 2002;45:85-96. http://dx.doi.org/10.1007/s125-002-8248-z.
    • (2002) Diabetologia , vol.45 , pp. 85-96
    • Sakuaba, H.1    Mizukami, H.2    Yagihashi, N.3    Wada, R.4    Hanyu, C.5    Yagihashi, S.6
  • 22
    • 20044390365 scopus 로고    scopus 로고
    • Functional and molecular defects of pancreatic islets in human type 2 diabetes
    • Del Guerra S, Lupi R, Marselli L, Masini M, Bugliani M, Sbrana S, et al. Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes 2005;54:727-35. http://dx.doi.org/10.2337/diabetes.54.3.727.
    • (2005) Diabetes , vol.54 , pp. 727-735
    • Del Guerra, S.1    Lupi, R.2    Marselli, L.3    Masini, M.4    Bugliani, M.5    Sbrana, S.6
  • 23
    • 70449713491 scopus 로고    scopus 로고
    • Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress
    • Kawahito S, Kitahata H, Oshita S. Problems associated with glucose toxicity: role of hyperglycemia-induced oxidative stress. World J Gastroenterol 2009;15:4137-42. http://dx.doi.org/10.3748/wjg.15.4137.
    • (2009) World J Gastroenterol , vol.15 , pp. 4137-4142
    • Kawahito, S.1    Kitahata, H.2    Oshita, S.3
  • 24
    • 77957037030 scopus 로고    scopus 로고
    • Islets and their antioxidant defense
    • Acharya JD, Ghaskadbi SS. Islets and their antioxidant defense. Islets 2010;2:225-35. http://dx.doi.org/10.4161/isl.2.4.12219.
    • (2010) Islets , vol.2 , pp. 225-235
    • Acharya, J.D.1    Ghaskadbi, S.S.2
  • 26
    • 77957311822 scopus 로고    scopus 로고
    • The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells
    • Kaufman RJ, Back SH, Song B, Han J, Hassler J. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab 2010;12 Suppl 2:99-107. http://dx.doi.org/10.1111/j.1463-1326.2010.01281.x.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.2 SUPPL. , pp. 99-107
    • Kaufman, R.J.1    Back, S.H.2    Song, B.3    Han, J.4    Hassler, J.5
  • 27
    • 34447625413 scopus 로고    scopus 로고
    • Metabolic stress in insulin's target cells leads to ROS accumulation-a hypothetical common pathway causing insulin resistance
    • Eriksson JW. Metabolic stress in insulin's target cells leads to ROS accumulation-a hypothetical common pathway causing insulin resistance. FEBS Lett 2007;581:3734-42. http://dx.doi.org/10.1016/j.febslet.2007.06.044.
    • (2007) FEBS Lett , vol.581 , pp. 3734-3742
    • Eriksson, J.W.1
  • 28
    • 77449154126 scopus 로고    scopus 로고
    • Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes
    • Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB. Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes. Diabetes 2010;59:448-59. http://dx.doi.org/10.2337/db09-0129.
    • (2010) Diabetes , vol.59 , pp. 448-459
    • Lu, H.1    Koshkin, V.2    Allister, E.M.3    Gyulkhandanyan, A.V.4    Wheeler, M.B.5
  • 29
    • 84864397721 scopus 로고    scopus 로고
    • Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are re-producible by high glucose in vitro with attendant dysfunction
    • Ma Z, Wirström T, Borg LA, Larsson-Nyrén G, Hals I, Bondo-Hansen J, et al. Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are re-producible by high glucose in vitro with attendant dysfunction. Islets 2012;4:233-42. http://dx.doi.org/10.4161/isl.20516.
    • (2012) Islets , vol.4 , pp. 233-242
    • Ma, Z.1    Wirström, T.2    Borg, L.A.3    Larsson-Nyrén, G.4    Hals, I.5    Bondo-Hansen, J.6
  • 31
    • 0036738398 scopus 로고    scopus 로고
    • Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    • Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002;110:851-60.
    • (2002) J Clin Invest , vol.110 , pp. 851-860
    • Maedler, K.1    Sergeev, P.2    Ris, F.3    Oberholzer, J.4    Joller-Jemelka, H.I.5    Spinas, G.A.6
  • 32
    • 10344228731 scopus 로고    scopus 로고
    • Dysfunctional fat cells, lipotoxicity and type 2 diabetes
    • DeFronzo RA. Dysfunctional fat cells, lipotoxicity and type 2 diabetes. Int J Clin Pract Suppl 2004;143:9-21. http://dx.doi.org/10.1111/j.1368-504X.2004.00389.x.
    • (2004) Int J Clin Pract , vol.143 , pp. 9-21
    • Defronzo, R.A.1
  • 33
    • 79751486464 scopus 로고    scopus 로고
    • Modulation of lipid-induced ER stress by fatty acid shape
    • Deguil J, Pineau L, Rowland Snyder EC, Dupont S, Beney L, Gil A, et al. Modulation of lipid-induced ER stress by fatty acid shape. Traffic 2011;12:349-362. http://dx.doi.org/10.1111/j.1600-0854.2010.01150.x.
    • (2011) Traffic , vol.12 , pp. 349-362
    • Deguil, J.1    Pineau, L.2    Rowland, S.E.C.3    Dupont, S.4    Beney, L.5    Gil, A.6
  • 34
    • 0036896505 scopus 로고    scopus 로고
    • Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: Role in beta-cell adaptation and failure in the etiology of diabetes
    • Prentki M, Joly E, El-Assaad W, Roduit R. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 2002;51 Suppl 3:S405-13. http://dx.doi.org/10.2337/diabetes.51.2007.S405.
    • (2002) Diabetes , vol.51 , Issue.3 SUPPL.
    • Prentki, M.1    Joly, E.2    El-Assaad, W.3    Roduit, R.4
  • 35
    • 0142093526 scopus 로고    scopus 로고
    • Fatty acid metabolism and insulin secretion in pancreatic beta cells
    • Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia 2003;46:1297-312. http://dx.doi.org/10.1007/s00125-003-1207-4.
    • (2003) Diabetologia , vol.46 , pp. 1297-1312
    • Yaney, G.C.1    Corkey, B.E.2
  • 36
    • 0036721312 scopus 로고    scopus 로고
    • Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification
    • Cnop M, Hannaert JC, Grupping AY, Pipeleers DG. Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification. Endocrinology 2002;143:3449-53. http://dx.doi.org/10.1210/en.2002-220273.
    • (2002) Endocrinology , vol.143 , pp. 3449-3453
    • Cnop, M.1    Hannaert, J.C.2    Grupping, A.Y.3    Pipeleers, D.G.4
  • 37
    • 34247866358 scopus 로고    scopus 로고
    • Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells
    • Abderrahmani A, Niederhauser G, Favre D, Abdelli S, Ferdaoussi M, Yang JY, et al. Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells. Diabetologia 2007;50:1304-14. http://dx.doi.org/10.1007/s00125-007-0642-z.
    • (2007) Diabetologia , vol.50 , pp. 1304-1314
    • Abderrahmani, A.1    Niederhauser, G.2    Favre, D.3    Abdelli, S.4    Ferdaoussi, M.5    Yang, J.Y.6
  • 38
    • 84863172064 scopus 로고    scopus 로고
    • Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function
    • Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, et al. Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function. Diabetes 2012;61:659-64. http://dx.doi.org/10.2337/db11-1341.
    • (2012) Diabetes , vol.61 , pp. 659-664
    • Kruit, J.K.1    Wijesekara, N.2    Westwell-Roper, C.3    Vanmierlo, T.4    de Haan, W.5    Bhattacharjee, A.6
  • 39
    • 70349320177 scopus 로고    scopus 로고
    • Low-and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells
    • Rütti S, Ehses JA, Sibler RA, Prazak R, Rohrer L, Georgopoulos S, et al. Low-and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. Endocrinology 2009;150:4521-30. http://dx.doi.org/10.1210/en.2009-0252.
    • (2009) Endocrinology , vol.150 , pp. 4521-4530
    • Rütti, S.1    Ehses, J.A.2    Sibler, R.A.3    Prazak, R.4    Rohrer, L.5    Georgopoulos, S.6
  • 40
    • 82655171679 scopus 로고    scopus 로고
    • Immunology in the Clinic Review Series; focus on metabolic diseases: Development of islet autoimmune disease in type 2 diabetes patients: Potential sequelae of chronic inflammation
    • Brooks-Worrell B, Palmer JP. Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation. Clin Exp Immunol 2012;167:40-6. http://dx.doi.org/10.1111/j.1365-2249.2011.04501.x.
    • (2012) Clin Exp Immunol , vol.167 , pp. 40-46
    • Brooks-Worrell, B.1    Palmer, J.P.2
  • 41
    • 79951689303 scopus 로고    scopus 로고
    • Identification of autoantibody-negative autoimmune type 2 diabetes patients
    • Brooks-Worrell BM, Reichow JL, Goel A, Ismail H, Palmer JPP. Identification of autoantibody-negative autoimmune type 2 diabetes patients. Diabetes Care 2011;34:168-73. http://dx.doi.org/10.2337/dc10-0579.
    • (2011) Diabetes Care , vol.34 , pp. 168-173
    • Brooks-Worrell, B.M.1    Reichow, J.L.2    Goel, A.3    Ismail, H.4    Palmer, J.P.P.5
  • 42
    • 33645223308 scopus 로고    scopus 로고
    • Clinical phenotype and beta-cell autoimmunity in Italian patients with adult-onset diabetes
    • Genovese S, Bazzigaluppi E, Gonçalves D, Ciucci A, Cavallo MG, Purrello F, et al. Clinical phenotype and beta-cell autoimmunity in Italian patients with adult-onset diabetes. Eur J Endocrinol 2006;154:441-7. http://dx.doi.org/10.1530/eje.1.02115.
    • (2006) Eur J Endocrinol , vol.154 , pp. 441-447
    • Genovese, S.1    Bazzigaluppi, E.2    Gonçalves, D.3    Ciucci, A.4    Cavallo, M.G.5    Purrello, F.6
  • 44
    • 0034932098 scopus 로고    scopus 로고
    • The accelerator hypothesis: Weight gain as the missing link between Type I and Type II diabetes
    • Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 2001;44:914-22. http://dx.doi.org/10.1007/s001250100548.
    • (2001) Diabetologia , vol.44 , pp. 914-922
    • Wilkin, T.J.1
  • 45
    • 73949126369 scopus 로고    scopus 로고
    • Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes
    • Donath MY, Böni-Schnetzler M, Ellingsgaard H, Ehses JA. Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 2009;24:325-31. http://dx.doi.org/10.1152/physiol.00032.2009.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 325-331
    • Donath, M.Y.1    Böni-Schnetzler, M.2    Ellingsgaard, H.3    Ehses, J.A.4
  • 46
    • 79953320718 scopus 로고    scopus 로고
    • CXCL10a path to β-cell death
    • Paroni F, Domsgen E, Maedler K. CXCL10a path to β-cell death. Islets 2009;1:256-9. http://dx.doi.org/10.4161/isl.1.3.9110.
    • (2009) Islets , vol.1 , pp. 256-259
    • Paroni, F.1    Domsgen, E.2    Maedler, K.3
  • 47
    • 69949093803 scopus 로고    scopus 로고
    • Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications
    • Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab 2009;94:3171-82. http://dx.doi.org/10.1210/jc.2008-2534.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3171-3182
    • Goldberg, R.B.1
  • 48
    • 77957127882 scopus 로고    scopus 로고
    • Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling
    • Dula SB, Jecmenica M, Wu R, Jahanshahi P, Verrilli GM, Carter JD, et al. Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium 2010;48:133-42. http://dx.doi.org/10.1016/j.ceca.2010.07.007.
    • (2010) Cell Calcium , vol.48 , pp. 133-142
    • Dula, S.B.1    Jecmenica, M.2    Wu, R.3    Jahanshahi, P.4    Verrilli, G.M.5    Carter, J.D.6
  • 49
    • 84874406712 scopus 로고    scopus 로고
    • The role of adipokines in β-cell failure of type 2 diabetes
    • Dunmore SJ, Brown JE. The role of adipokines in β-cell failure of type 2 diabetes. J Endocrinol 2013;216:T37-45. http://dx.doi.org/10.1530/JOE-12-0278.
    • (2013) J Endocrinol , vol.216
    • Dunmore, S.J.1    Brown, J.E.2
  • 50
    • 79953736759 scopus 로고    scopus 로고
    • TNF-α acutely upregulates amylin expression in murine pancreatic beta cells
    • Cai K, Qi D, Wang O, Chen J, Liu X, Deng B, et al. TNF-α acutely upregulates amylin expression in murine pancreatic beta cells. Diabetologia 2011;54:617-26. http://dx.doi.org/10.1007/s00125-010-1972-9.
    • (2011) Diabetologia , vol.54 , pp. 617-626
    • Cai, K.1    Qi, D.2    Wang, O.3    Chen, J.4    Liu, X.5    Deng, B.6
  • 51
    • 84866133825 scopus 로고    scopus 로고
    • Adiponectin: Mechanistic insights and clinical implications
    • Turer AT, Scherer PE. Adiponectin: mechanistic insights and clinical implications. Diabetologia 2012;55:2319-26. http://dx.doi.org/10.1007/s00125-012-2598-x.
    • (2012) Diabetologia , vol.55 , pp. 2319-2326
    • Turer, A.T.1    Scherer, P.E.2
  • 52
    • 77958568034 scopus 로고    scopus 로고
    • Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion
    • Wijesekara N, Krishnamurthy M, Bhattacharjee A, Suhail A, Sweeney G, Wheeler MB. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. J Biol Chem 2010;285:33623-31. http://dx.doi.org/10.1074/jbc.M109.085084.
    • (2010) J Biol Chem , vol.285 , pp. 33623-33631
    • Wijesekara, N.1    Krishnamurthy, M.2    Bhattacharjee, A.3    Suhail, A.4    Sweeney, G.5    Wheeler, M.B.6
  • 53
    • 78651260799 scopus 로고    scopus 로고
    • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    • Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med 2011;17:55-63. http://dx.doi.org/10.1038/nm.2277.
    • (2011) Nat Med , vol.17 , pp. 55-63
    • Holland, W.L.1    Miller, R.A.2    Wang, Z.V.3    Sun, K.4    Barth, B.M.5    Bui, H.H.6
  • 54
    • 4043171124 scopus 로고    scopus 로고
    • Islet amyloid: A critical entity in the pathogenesis of type 2 diabetes
    • Hull RL, Westermark GT, Westermark P, Kahn SE. Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocrinol Metab 2004;89:3629-43. http://dx.doi.org/10.1210/jc.2004-0405.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3629-3643
    • Hull, R.L.1    Westermark, G.T.2    Westermark, P.3    Kahn, S.E.4
  • 55
    • 79954535899 scopus 로고    scopus 로고
    • Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
    • Westermark P, Andersson A, Westermark GT. Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. Physiol Rev 2011;91:795-826. http://dx.doi.org/10.1152/physrev.00042.2009.
    • (2011) Physiol Rev , vol.91 , pp. 795-826
    • Westermark, P.1    Andersson, A.2    Westermark, G.T.3
  • 56
    • 1542375103 scopus 로고    scopus 로고
    • Islet amyloid: A complication of islet dysfunction or an aetiological factor in Type 2 diabetes?
    • Clark A, Nilsson MR. Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes? Diabetologia 2004;47:157-69. http://dx.doi.org/10.1007/s00125-003-1304-4.
    • (2004) Diabetologia , vol.47 , pp. 157-169
    • Clark, A.1    Nilsson, M.R.2
  • 57
    • 0037167613 scopus 로고    scopus 로고
    • Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes
    • Anguiano M, Nowak RJ, Lansbury PT Jr. Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes. Biochemistry 2002;41:11338-43. http://dx.doi.org/10.1021/bi020314u.
    • (2002) Biochemistry , vol.41 , pp. 11338-11343
    • Anguiano, M.1    Nowak, R.J.2    Lansbury, P.T.3
  • 58
    • 77956958947 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    • Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol 2010;11:897-904. http://dx.doi.org/10.1038/ni.1935.
    • (2010) Nat Immunol , vol.11 , pp. 897-904
    • Masters, S.L.1    Dunne, A.2    Subramanian, S.L.3    Hull, R.L.4    Tannahill, G.M.5    Sharp, F.A.6
  • 59
    • 79954543511 scopus 로고    scopus 로고
    • β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition
    • Jurgens CA, Toukatly MN, Fligner CL, Udayasankar J, Subramanian SL, Zraika S, et al. β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol 2011;178:2632-40. http://dx.doi.org/10.1016/j.ajpath.2011.02.036.
    • (2011) Am J Pathol , vol.178 , pp. 2632-2640
    • Jurgens, C.A.1    Toukatly, M.N.2    Fligner, C.L.3    Udayasankar, J.4    Subramanian, S.L.5    Zraika, S.6
  • 60
    • 73349106529 scopus 로고    scopus 로고
    • The effects of glucagon-like peptide-1 on the beta cell
    • Vilsbøll T. The effects of glucagon-like peptide-1 on the beta cell. Diabetes Obes Metab 2009;11(Suppl 3):11-8. http://dx.doi.org/10.1111/j.1463-1326.2009.01073.x.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.3 SUPPL. , pp. 11-18
    • Vilsbøll, T.1
  • 61
    • 79959774265 scopus 로고    scopus 로고
    • Therapy in the early stage: Incretins
    • Cernea S, Raz I. Therapy in the early stage: incretins. Diabetes Care 2011;34 Suppl 2:S264-71. http://dx.doi.org/10.2337/dc11-s223.
    • (2011) Diabetes Care , vol.34 , Issue.2 SUPPL.
    • Cernea, S.1    Raz, I.2
  • 62
    • 0043169338 scopus 로고    scopus 로고
    • Differential effects of acute and extended infusions of glucagon-like peptide-1 on first-and second-phase insulin secretion in diabetic and nondiabetic humans
    • Quddusi S, Vahl TP, Hanson K, Prigeon RL, D'Alessio DA. Differential effects of acute and extended infusions of glucagon-like peptide-1 on first-and second-phase insulin secretion in diabetic and nondiabetic humans. Diabetes Care 2003;26:791-8. http://dx.doi.org/10.2337/diacare.26.3.791.
    • (2003) Diabetes Care , vol.26 , pp. 791-798
    • Quddusi, S.1    Vahl, T.P.2    Hanson, K.3    Prigeon, R.L.4    D'Alessio, D.A.5
  • 63
    • 27744541052 scopus 로고    scopus 로고
    • Exenatide augments first-and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes
    • Fehse F, Trautmann M, Holst JJ, Halseth AE, Nanayakkara N, Nielsen LL, et al. Exenatide augments first-and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab 2005;90:5991-7. http://dx.doi.org/10.1210/jc.2005-1093.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5991-5997
    • Fehse, F.1    Trautmann, M.2    Holst, J.J.3    Halseth, A.E.4    Nanayakkara, N.5    Nielsen, L.L.6
  • 64
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-5. http://dx.doi.org/10.1016/j.cmet.2006.01.004.
    • (2006) Cell Metab , vol.3 , pp. 153-155
    • Drucker, D.J.1
  • 65
    • 0344357096 scopus 로고
    • Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
    • Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A 1987;84:3434-8. http://dx.doi.org/10.1073/pnas.84.10.3434.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 3434-3438
    • Drucker, D.J.1    Philippe, J.2    Mojsov, S.3    Chick, W.L.4    Habener, J.F.5
  • 67
    • 0036323269 scopus 로고    scopus 로고
    • Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
    • Abraham EJ, Leech CA, Lin JC, Zulewski H, Habener JF. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 2002;143:3152-61. http://dx.doi.org/10.1210/en.143.8.3152.
    • (2002) Endocrinology , vol.143 , pp. 3152-3161
    • Abraham, E.J.1    Leech, C.A.2    Lin, J.C.3    Zulewski, H.4    Habener, J.F.5
  • 68
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 2003;144:5149-58. http://dx.doi.org/10.1210/en.2003-0323.
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3    Li Calzi, S.4    Khoury, N.5    Noushmehr, H.6
  • 69
    • 80052766495 scopus 로고    scopus 로고
    • Activation of the GLP-1 receptor signalling pathway: A relevant strategy to repair a deficient beta-cell mass
    • Portha B, Tourrel-Cuzin C, Movassat J. Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass. Exp Diabetes Res 2011;2011:376509.
    • (2011) Exp Diabetes Res , vol.2011 , pp. 376509
    • Portha, B.1    Tourrel-Cuzin, C.2    Movassat, J.3
  • 70
    • 77951793008 scopus 로고    scopus 로고
    • Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function
    • Meier JJ, Nauck MA. Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function? Diabetes 2010;59:1117-25. http://dx.doi.org/10.2337/db09-1899.
    • (2010) Diabetes , vol.59 , pp. 1117-1125
    • Meier, J.J.1    Nauck, M.A.2
  • 71
    • 1842855423 scopus 로고    scopus 로고
    • Incretins, insulin secretion and Type 2 diabetes mellitus
    • Vilsbøll T, Holst JJ. Incretins, insulin secretion and Type 2 diabetes mellitus. Diabetologia 2004;47:357-66. http://dx.doi.org/10.1007/s00125-004-1342-6.
    • (2004) Diabetologia , vol.47 , pp. 357-366
    • Vilsbøll, T.1    Holst, J.J.2
  • 72
    • 84856024160 scopus 로고    scopus 로고
    • The role of incretin therapy at different stages of diabetes
    • Cernea S. The role of incretin therapy at different stages of diabetes. Rev Diabet Stud 2011;8:323-38. http://dx.doi.org/10.1900/RDS.2011.8.323.
    • (2011) Rev Diabet Stud , vol.8 , pp. 323-338
    • Cernea, S.1
  • 73
    • 34249724553 scopus 로고    scopus 로고
    • Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: Possible contribution to impaired incretin effects in diabetes
    • Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, et al. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 2007;56:1551-8. http://dx.doi.org/10.2337/db06-1033.
    • (2007) Diabetes , vol.56 , pp. 1551-1558
    • Xu, G.1    Kaneto, H.2    Laybutt, D.R.3    Duvivier-Kali, V.F.4    Trivedi, N.5    Suzuma, K.6
  • 74
    • 10544249875 scopus 로고    scopus 로고
    • Identification of two missense mutations in the GIP receptor gene: A functional study and association analysis with NIDDM: No evidence of association with Japanese NIDDM subjects
    • Kubota A, Yamada Y, Hayami T, Yasuda K, Someya Y, Ihara Y, et al. Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects. Diabetes 1996;45:1701-5. http://dx.doi.org/10.2337/diabetes.45.12.1701.
    • (1996) Diabetes , vol.45 , pp. 1701-1705
    • Kubota, A.1    Yamada, Y.2    Hayami, T.3    Yasuda, K.4    Someya, Y.5    Ihara, Y.6
  • 75
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down?
    • Nauck MA, Vardarli I, Deacon CF, Holst JJ, Meier JJ. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia 2011;54:10-8. http://dx.doi.org/10.1007/s00125-010-1896-4.
    • (2011) Diabetologia , vol.54 , pp. 10-18
    • Nauck, M.A.1    Vardarli, I.2    Deacon, C.F.3    Holst, J.J.4    Meier, J.J.5
  • 76
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009;58:773-95. http://dx.doi.org/10.2337/db09-9028.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 77
    • 78751486038 scopus 로고    scopus 로고
    • Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 Diabetes. The CACTI Study
    • Schauer IE, Snell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, et al. Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 Diabetes. The CACTI Study. Diabetes 2011;60:306-14. http://dx.doi.org/10.2337/db10-0328.
    • (2011) Diabetes , vol.60 , pp. 306-314
    • Schauer, I.E.1    Snell-Bergeon, J.K.2    Bergman, B.C.3    Maahs, D.M.4    Kretowski, A.5    Eckel, R.H.6
  • 78
    • 34547109615 scopus 로고    scopus 로고
    • Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests
    • Cobelli C, Toffolo GM, Dalla Man C, Campioni M, Denti P, Caumo A, et al. Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab 2007;293:E1-15. http://dx.doi.org/10.1152/ajpendo.00421.2006.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Cobelli, C.1    Toffolo, G.M.2    Dalla Man, C.3    Campioni, M.4    Denti, P.5    Caumo, A.6
  • 79
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003;46:3-19.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 80
    • 48749131707 scopus 로고    scopus 로고
    • Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test
    • Retnakaran R, Shen S, Hanley AJ, Vuksan V, Hamilton JK, Zinman B. Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test. Obesity (Silver Spring) 2008;16:1901-7. http://dx.doi.org/10.1038/oby.2008.307.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1901-1907
    • Retnakaran, R.1    Shen, S.2    Hanley, A.J.3    Vuksan, V.4    Hamilton, J.K.5    Zinman, B.6
  • 81
    • 0036318476 scopus 로고    scopus 로고
    • Accurate assessment of beta-cell function: The hyperbolic correction
    • Bergman RN, Ader M, Huecking K, Van Citters G. Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 2002;51 Suppl 1:S212-20. http://dx.doi.org/10.2337/diabetes.51.2007.S212.
    • (2002) Diabetes , vol.51 , Issue.1 SUPPL.
    • Bergman, R.N.1    Ader, M.2    Huecking, K.3    van Citters, G.4
  • 82
    • 1542270658 scopus 로고    scopus 로고
    • Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies
    • Ahrén B, Pacini G. Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies. Eur J Endocrinol 2004;150:97-104. http://dx.doi.org/10.1530/eje.0.1500097.
    • (2004) Eur J Endocrinol , vol.150 , pp. 97-104
    • Ahrén, B.1    Pacini, G.2
  • 83
    • 39749109332 scopus 로고    scopus 로고
    • Methods for the Assessment of β-cell Function in vivo
    • In Michael Roden ed, John Wiley & Sons Ltd
    • Mari A, Pacini G. Methods for the Assessment of β-cell Function in vivo. In Michael Roden ed. Clinical Diabetes and Research: Methods and Techniques. John Wiley & Sons Ltd.,2007.p. 7-27. http://dx.doi.org/10.1002/9780470513095.ch2.
    • (2007) Clinical Diabetes and Research: Methods and Techniques , pp. 7-27
    • Mari, A.1    Pacini, G.2
  • 84
    • 38349006256 scopus 로고    scopus 로고
    • Current approaches for assessing insulin sensitivity and resistance in vivo: Advantages, limitations, and appropriate usage
    • Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 2008;294:E15-26. http://dx.doi.org/10.1152/ajpendo.00645.2007.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Muniyappa, R.1    Lee, S.2    Chen, H.3    Quon, M.J.4
  • 86
    • 2942598368 scopus 로고    scopus 로고
    • Beta cell function and its relation to insulin action in humans: A critical appraisal
    • Ferrannini E, Mari A. Beta cell function and its relation to insulin action in humans: a critical appraisal. Diabetologia 2004;47:943-56. http://dx.doi.org/10.1007/s00125-004-1381-z.
    • (2004) Diabetologia , vol.47 , pp. 943-956
    • Ferrannini, E.1    Mari, A.2
  • 87
    • 84871995815 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2013
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes-2013. Diabetes Care 2013;36 Suppl 1:S11-66. http://dx.doi.org/10.2337/dc13-S011.
    • (2013) Diabetes Care , vol.36 , Issue.1 SUPPL.
  • 88
    • 34547646530 scopus 로고    scopus 로고
    • Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. Pilot study for the standardization of insulin immunoassays with isotope dilution liquid chromatography/tandem mass spectrometry
    • Rodríguez-Cabaleiro D, Van Uytfanghe K, Stove V, Fiers T, Thienpont LM. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. Pilot study for the standardization of insulin immunoassays with isotope dilution liquid chromatography/tandem mass spectrometry. Clin Chem 2007;53:1462-9. http://dx.doi.org/10.1373/clinchem.2007.088393.
    • (2007) Clin Chem , vol.53 , pp. 1462-1469
    • Rodríguez-Cabaleiro, D.1    van Uytfanghe, K.2    Stove, V.3    Fiers, T.4    Thienpont, L.M.5
  • 89
    • 84864285795 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012;55:1577-96. http://dx.doi.org/10.1007/s00125-012-2534-0.
    • (2012) Diabetologia , vol.55 , pp. 1577-1596
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6
  • 90
    • 0029921391 scopus 로고    scopus 로고
    • Small doses of subcutaneous insulin as a strategy for preventing slowly progressive beta-cell failure in islet cell antibody-positive patients with clinical features of NIDDM
    • Kobayashi T, Nakanishi K, Murase T, Kosaka K. Small doses of subcutaneous insulin as a strategy for preventing slowly progressive beta-cell failure in islet cell antibody-positive patients with clinical features of NIDDM. Diabetes 1996;45:622-6. http://dx.doi.org/10.2337/diabetes.45.5.622.
    • (1996) Diabetes , vol.45 , pp. 622-626
    • Kobayashi, T.1    Nakanishi, K.2    Murase, T.3    Kosaka, K.4
  • 91
    • 43849105857 scopus 로고    scopus 로고
    • Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: A multicentre randomised parallel-group trial
    • Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008;371:1753-60. http://dx.doi.org/10.1016/S0140-6736-(08)60762-X.
    • (2008) Lancet , vol.371 , pp. 1753-1760
    • Weng, J.1    Li, Y.2    Xu, W.3    Shi, L.4    Zhang, Q.5    Zhu, D.6
  • 92
    • 0023239175 scopus 로고
    • Insulin suppresses its own secretion in vivo
    • Argoud GM, Schade DS, Eaton RP. Insulin suppresses its own secretion in vivo. Diabetes 1987;36:959-62. http://dx.doi.org/10.2337/diabetes.36.8.959.
    • (1987) Diabetes , vol.36 , pp. 959-962
    • Argoud, G.M.1    Schade, D.S.2    Eaton, R.P.3
  • 93
    • 0013522709 scopus 로고    scopus 로고
    • Effect of prophylactic insulin treatment on the number of ER-MP23+ macrophages in the pancreas of NOD mice. Is the prevention of diabetes based on beta-cell rest?
    • Jansen A, Rosmalen JG, Homo-Delarche F, Dardenne M, Drexhage HA. Effect of prophylactic insulin treatment on the number of ER-MP23+ macrophages in the pancreas of NOD mice. Is the prevention of diabetes based on beta-cell rest? J Autoimmun 1996;9:341-8. http://dx.doi.org/10.1006/jaut.1996.0046.
    • (1996) J Autoimmun , vol.9 , pp. 341-348
    • Jansen, A.1    Rosmalen, J.G.2    Homo-Delarche, F.3    Dardenne, M.4    Drexhage, H.A.5
  • 94
    • 34347225572 scopus 로고    scopus 로고
    • Pioglitazone and sulfonylureas: Effectively treating type 2 diabetes
    • Hanefeld M. Pioglitazone and sulfonylureas: effectively treating type 2 diabetes. Int J Clin Pract Suppl 2007;61:20-7. http://dx.doi.org/10.1111/j.1742-1241.2007.01361.x.
    • (2007) Int J Clin Pract Suppl , vol.61 , pp. 20-27
    • Hanefeld, M.1
  • 96
    • 38149091696 scopus 로고    scopus 로고
    • A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications
    • Molavi B, Rassouli N, Bagwe S, Rasouli N. A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications. Vasc Health Risk Manag 2007;3:967-73.
    • (2007) Vasc Health Risk Manag , vol.3 , pp. 967-973
    • Molavi, B.1    Rassouli, N.2    Bagwe, S.3    Rasouli, N.4
  • 97
    • 33645299329 scopus 로고    scopus 로고
    • "Anti-inflammatory" drugs and their effects on type 2 diabetes
    • Deans KA, Sattar N. "Anti-inflammatory" drugs and their effects on type 2 diabetes. Diabetes Technol Ther 2006;8:18-27. http://dx.doi.org/10.1089/dia.2006.8.18.
    • (2006) Diabetes Technol Ther , vol.8 , pp. 18-27
    • Deans, K.A.1    Sattar, N.2
  • 98
    • 84858013882 scopus 로고    scopus 로고
    • New and future immunomodulatory therapy in type 1 diabetes
    • Tooley JE, Waldron-Lynch F, Herold KC. New and future immunomodulatory therapy in type 1 diabetes. Trends Mol Med 2012;18:173-81. http://dx.doi.org/10.1016/j.molmed.2012.01.001.
    • (2012) Trends Mol Med , vol.18 , pp. 173-181
    • Tooley, J.E.1    Waldron-Lynch, F.2    Herold, K.C.3
  • 99
    • 79959740380 scopus 로고    scopus 로고
    • Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets
    • Aston-Mourney K, Hull RL, Zraika S, Udayasankar J, Subramanian SL, Kahn SE. Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets. Diabetologia 2011;54:1756-65. http://dx.doi.org/10.1007/s00125011-2143-3.
    • (2011) Diabetologia , vol.54 , pp. 1756-1765
    • Aston-Mourney, K.1    Hull, R.L.2    Zraika, S.3    Udayasankar, J.4    Subramanian, S.L.5    Kahn, S.E.6
  • 100
    • 78751559992 scopus 로고    scopus 로고
    • Beta cell function after weight loss: A clinical trial comparing gastric bypass surgery and intensive lifestyle intervention
    • Hofsø D, Jenssen T, Bollerslev J, Ueland T, Godang K, Stumvoll M, et al. Beta cell function after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention. Eur J Endocrinol 2011;164:231-8. http://dx.doi.org/10.1530/EJE-10-0804.
    • (2011) Eur J Endocrinol , vol.164 , pp. 231-238
    • Hofsø, D.1    Jenssen, T.2    Bollerslev, J.3    Ueland, T.4    Godang, K.5    Stumvoll, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.