The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia

Annals of the New York Academy of Sciences

Volumn 1202, Issue , 2010, Pages 10-16

  Fibach, Eitan ^a   Rachmilewitz, Eliezer A ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b WOLFSON MEDICAL CENTER   (Israel)

Author keywords

antioxidants; iron overload, iron chelators; oxidative stress; thalassemia

Indexed keywords

4 HYDROXYNONENAL; ALPHA TOCOPHEROL; ASCORBIC ACID; CARICA PAPAYA EXTRACT; CURCUMIN; DEFERASIROX; DEFEROXAMINE; HEPCIDIN; HYDROGEN PEROXIDE; IRON; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE; THIOREDOXIN;

ANTIOXIDANT ACTIVITY; BETA THALASSEMIA; CATALYSIS; CLINICAL TRIAL; CONFERENCE PAPER; DRUG MEGADOSE; FERMENTATION; FLOW CYTOMETRY; HEMOLYTIC ANEMIA; HUMAN; IRON CHELATION; IRON OVERLOAD; OXIDATIVE STRESS; THALASSEMIA;

EID: 77955905915     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05577.x     Document Type: Conference Paper

References (39)

1. Gu, X. & Y. Zeng. 2002. A review of the molecular diagnosis of thalassemia. Hematology 7: 203-209.
2. Rund,D.&E. Rachmilewitz. 2005. Beta-thalassemia.NEngl. J. Med. 353: 1135-1146.
3. Fibach, E. & E. Rachmilewitz. 2008. The role of oxidative stress in hemolytic anemia. Curr. Mol. Med. 8: 609-619.
4. Rachmilewitz, E.A., O. Weizer-Stern, K. Adamsky, et al. 2005. Role of iron in inducing oxidative stress in thalassemia: Can it be prevented by inhibition of absorption and by antioxidants? Ann. N.Y. Acad. Sci. 1054: 118-123.
5. Halliwell, B. & J. Gutteridge. 1999. Free Radicals in Biology and Medicine (3rd ed.). Oxford University Press. Midsomer Norton, Avon, England.
6. Awasthi, Y.C., Y. Yang, N.K. Tiwari, et al. 2004. Regulation of 4-hydroxynonenal-mediated signaling by glutathione Stransferases. Free Radic. Biol. Med. 37: 607-619.
7. Jones, D.P., J.L. Carlson, V.C. Mody, et al. 2000. Redox state of glutathione in human plasma. Free Radic. Biol. Med. 28: 625-635.
8. Kushner, J.P., J.P. Porter & N.F. Olivieri. 2001. Secondary iron overload. Hematol. Am. Soc. Hematol. Educ. Program. 47-61.
9. Park, C.H., E.V. Valore, A.J. Waring & T. Ganz. 2001. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276: 7806-7810.
10. Ganz, T. 2003. Hepcidin, a key regulator of ironmetabolism and mediator of anemia of inflammation. Blood 102: 783-788.
11. Nemeth, E., M.S. Tuttle, J. Powelson, et al. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093.
12. Pigeon, C., G. Ilyin, B. Courselaud, et al. 2001. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276: 7811-7819.
13. Adamsky, K., O. Weizer, N. Amariglio, et al. 2004. Decreased hepcidin mRNA expression in thalassemic mice. Br. J. Haematol. 124: 123-124.
14. Nicolas, G., L. Viatte, M. Bennoun, et al. 2002. Hepcidin, a new iron regulatory peptide. Blood Cells Mol. Dis. 29: 327-335.
15. Tanno, T., N.V. Bhanu, P.A. Oneal, et al. 2007. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med. 13: 1096-1101.
16. Weizer-Stern, O., K. Adamsky, N. Amariglio, et al. 2006. Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br. J. Haematol. 135: 129-138.
17. Prus, E. & E. Fibach. 2008. The labile iron pool in human erythroid cells. Br. J. Haematol. 142: 301-307.
18. Freikman, I., J. Amer, J.S. Cohen, et al. 2008. Oxidative stress causes membrane phospholipid rearrangement and shedding from RBC membranes-an NMR study. Biochim. Biophys. Acta. 1778: 2388-2394.
19. Taher, A., H. Isma'eel, G. Mehio, et al. 2006. Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in theMediterranean area and Iran. Thromb. Haemost. 96: 488-491.
20. Amer, J., A. Goldfarb & E. Fibach. 2004. Flow cytometric analysis of the oxidative status of normal and thalassemic red blood cells. Cytometry 60: 73-80.
21. Prus, E. & E. Fibach. 2008. Flow cytometry measurement of the labile ironpool inhumanhematopoietic cells. Cytometry A. 73: 22-27.
22. Keston, A.S. & R. Brandt. 1965. The fluorometric analysis of ultramicro quantities of hydrogen peroxide. Anal. Biochem. 11: 1-5.
23. Freikman, I., J. Amer, I. Ringel & E. Fibach. 2009. A flow cytometry approach for quantitative analysis of cellular phosphatidylserine distribution and shedding. Anal. Biochem. 393: 111-116.
24. Odame & D. Rund. 2008. Evidence-based treatment of ThalassemiaMajor. In Evidence-BasesHematology. A.Mark, J.G. Crowther, J. Ginsberg, H.J. Schunemann, R.M. Meyer & R. Lottenberg, Eds. Blackwell Publishing. Hoboken, New Jersey.
25. Prus, E. & E. Fibach. 2009. Effect of iron chelators on labile iron and oxidative status of thalassaemic erythroid cells. Acta Haematol. 123: 14-20.
26. Ghoti, H., E. Fibach, D. Merkel, et al. 2010. Changes in parameters of oxidative stress and free iron biomarkers during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndromes. Haematologica. In press. doi:10.3324/haematol.2010.024992.
27. Chan, A.C., C.K. Chow & D. Chiu. 1999. Interaction of antioxidants and their implication in genetic anemia. Proc. Soc. Exp. Biol. Med. 222: 274-282.
28. Modell, B., M. Khan & M. Darlison. 2000. Survival in betathalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet 355: 2051-2052.
29. Miniero, R., E. Canducci, D. Ghigo, et al. 1982. Vitamin E in beta-thalassemia. Acta Vitaminol. Enzymol. 4: 21-25.
30. Tesoriere, L., D. D'Arpa, D. Butera, et al. 2001. Oral supplements of vitamin E improve measures of oxidative stress in plasma and reduce oxidative damage to LDL and erythrocytes in beta-thalassemia intermedia patients. Free Radic. Res. 34: 529-540.
31. Kahane, I. & E.A. Rachmilewitz. 1976. Alterations in the red blood cell membrane and the effect of vitamin E on osmotic fragility in beta-thalassemiamajor. Isr. J.Med. Sci. 12: 11-15.
32. Giardini, O., A. Cantani, A. Donfrancesco, et al. 1985. Biochemical and clinical effects of vitamin E administration in homozygous beta-thalassemia. Acta Vitaminol. Enzymol. 7: 55-60.
33. Kalpravidh, R., N. Siritanaratkul, P. Insain, et al. 2010. Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoid. Clin. Biochem. 43: 423-429.
34. Grinberg, L., O. Shalev, H. Tonnesen & E. Rachmilewitz. 1996. Studies on curcumin and curcuminoids: XXVI. Antioxidant effects of curcumin on the red blood cell membrane. Int. J. Pharmaceutics 132: 251-257.
35. Srichairatanakool, S., C. Thephinlap, C. Phisalaphong, et al. 2007. Curcumin contributes to in vitro removal of nontransferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma. Med. Chem. 3: 469-474.
36. Amer, J., A. Goldfarb, E.A. Rachmilewitz & E. Fibach. 2008. Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients. Phytother. Res. 22: 820-828.
37. Fibach, E., E. Tan, S. Jamuar, et al. 2010. Amelioration of oxidative stress in RBC from patients with beta thalassemia major and intermedia and E-beta thalassemia following administration of fermented papaya preparation. Phytotherapy Res. In press. doi: 10.1002/ptr.3116.
38. Droge,W. 2002. Free radicals in the physiological control of cell function. Physiol. Rev. 82: 47-95.
39. Engelhardt, J.F. 1999. Redox-mediated gene therapies for environmental injury: approaches and concepts. Antioxid. Redox Signal. 1: 5-27.