메뉴 건너뛰기




Volumn 73, Issue 2, 2016, Pages 377-392

Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

Author keywords

Amino acid; Cancer; Fatty acid; Glucose; Metabolism

Indexed keywords

AMINO ACID; FATTY ACID; GLUCOSE;

EID: 84954044571     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-2070-4     Document Type: Review
Times cited : (563)

References (165)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 21376230 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646-674
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • 13298683 1:STN:280:DyaG28%2FltV2ktQ%3D%3D
    • Warburg O (1956) On the origin of cancer cells. Science 123(3191):309-314
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 3
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • 13351639 1:STN:280:DyaG287gsVeksA%3D%3D
    • Warburg O (1956) On respiratory impairment in cancer cells. Science 124(3215):269-270
    • (1956) Science , vol.124 , Issue.3215 , pp. 269-270
    • Warburg, O.1
  • 4
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
    • 21985671 1:CAS:528:DC%2BC3MXhsFyqtbfN
    • Lunt SY, Vander Heiden MG (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 27:441-464
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 5
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • 19460998 1:CAS:528:DC%2BD1MXmtVKlsbg%3D 2849637
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324(5930):1029-1033
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 6
    • 78650181190 scopus 로고    scopus 로고
    • The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
    • 21106670 1:CAS:528:DC%2BC3MXltVKn 3003197
    • Wellen KE et al (2010) The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev 24(24):2784-2799
    • (2010) Genes Dev , vol.24 , Issue.24 , pp. 2784-2799
    • Wellen, K.E.1
  • 7
    • 84864573730 scopus 로고    scopus 로고
    • MicroRNAs and the Warburg effect: New players in an old arena
    • 22856603 1:CAS:528:DC%2BC38XhtlWns7fM
    • Gao P, Sun L, He X, Cao Y, Zhang H (2012) MicroRNAs and the Warburg effect: new players in an old arena. Curr Gene Ther 12(4):285-291
    • (2012) Curr Gene Ther , vol.12 , Issue.4 , pp. 285-291
    • Gao, P.1    Sun, L.2    He, X.3    Cao, Y.4    Zhang, H.5
  • 8
    • 2942701935 scopus 로고    scopus 로고
    • Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
    • 15199147 1:CAS:528:DC%2BD2cXls1aqt7k%3D 480875
    • Kim JW et al (2004) Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol 24(13):5923-5936
    • (2004) Mol Cell Biol , vol.24 , Issue.13 , pp. 5923-5936
    • Kim, J.W.1
  • 9
    • 84931835248 scopus 로고    scopus 로고
    • Dysregulated glycolysis as an oncogenic event
    • 25609364 1:CAS:528:DC%2BC2MXht1Onsr8%3D
    • Mikawa T et al (2015) Dysregulated glycolysis as an oncogenic event. Cell Mol Life Sci 72(10):1881-1892
    • (2015) Cell Mol Life Sci , vol.72 , Issue.10 , pp. 1881-1892
    • Mikawa, T.1
  • 10
    • 21744442902 scopus 로고    scopus 로고
    • Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
    • 15988031 1:CAS:528:DC%2BD2MXmvVeiur0%3D 1168798
    • Li F et al (2005) Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 25(14):6225-6234
    • (2005) Mol Cell Biol , vol.25 , Issue.14 , pp. 6225-6234
    • Li, F.1
  • 11
    • 84926520380 scopus 로고    scopus 로고
    • CMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
    • 25793315 1:CAS:528:DC%2BC2MXkvVynsLg%3D
    • Sun L et al (2015) cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res 25(4):429-444
    • (2015) Cell Res , vol.25 , Issue.4 , pp. 429-444
    • Sun, L.1
  • 12
    • 0032741858 scopus 로고    scopus 로고
    • Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene
    • 10542317 1:CAS:528:DyaK1MXntVGksLs%3D
    • Graven KK, Yu Q, Pan D, Roncarati JS, Farber HW (1999) Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim Biophys Acta 1447(2-3):208-218
    • (1999) Biochim Biophys Acta , vol.1447 , Issue.2-3 , pp. 208-218
    • Graven, K.K.1    Yu, Q.2    Pan, D.3    Roncarati, J.S.4    Farber, H.W.5
  • 13
    • 84926637320 scopus 로고    scopus 로고
    • Critical protein GAPDH and its regulatory mechanisms in cancer cells
    • 25859407 4383849
    • Zhang JY et al (2015) Critical protein GAPDH and its regulatory mechanisms in cancer cells. Cancer Biol Med 12(1):10-22
    • (2015) Cancer Biol Med , vol.12 , Issue.1 , pp. 10-22
    • Zhang, J.Y.1
  • 14
    • 0031875003 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible genes in tumor cells
    • 9692838 1:CAS:528:DyaK1cXlslOjurk%3D
    • Kress S et al (1998) Expression of hypoxia-inducible genes in tumor cells. J Cancer Res Clin Oncol 124(6):315-320
    • (1998) J Cancer Res Clin Oncol , vol.124 , Issue.6 , pp. 315-320
    • Kress, S.1
  • 15
    • 84897708817 scopus 로고    scopus 로고
    • Hypoxia and cancer cell metabolism
    • 24389642 1:CAS:528:DC%2BC2cXjsFyisbk%3D
    • Huang D, Li C, Zhang H (2014) Hypoxia and cancer cell metabolism. Acta Biochim Biophys Sin 46(3):214-219
    • (2014) Acta Biochim Biophys Sin , vol.46 , Issue.3 , pp. 214-219
    • Huang, D.1    Li, C.2    Zhang, H.3
  • 16
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • 15059920 1:CAS:528:DC%2BD2cXis1yju7o%3D
    • Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E (2004) The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 64(7):2627-2633
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2627-2633
    • Schwartzenberg-Bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 17
    • 84906237532 scopus 로고    scopus 로고
    • Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD
    • 25114038 4170611
    • Zhang C et al (2014) Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget 5(14):5535-5546
    • (2014) Oncotarget , vol.5 , Issue.14 , pp. 5535-5546
    • Zhang, C.1
  • 18
    • 84895763135 scopus 로고    scopus 로고
    • Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
    • 24567357 1:CAS:528:DC%2BC2cXkt1eit7c%3D 3941061
    • Mikawa T et al (2014) Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J Cell Biol 204(5):729-745
    • (2014) J Cell Biol , vol.204 , Issue.5 , pp. 729-745
    • Mikawa, T.1
  • 19
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • 16839880 1:CAS:528:DC%2BD28Xns1Cgt78%3D
    • Bensaad K et al (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126(1):107-120
    • (2006) Cell , vol.126 , Issue.1 , pp. 107-120
    • Bensaad, K.1
  • 20
    • 84886904734 scopus 로고    scopus 로고
    • The emerging and diverse roles of sirtuins in cancer: A clinical perspective
    • 24133372 1:CAS:528:DC%2BC2cXjslart70%3D 3797239
    • Yuan H, Su L, Chen WY (2013) The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther 6:1399-1416
    • (2013) Onco Targets Ther , vol.6 , pp. 1399-1416
    • Yuan, H.1    Su, L.2    Chen, W.Y.3
  • 21
    • 84937397484 scopus 로고    scopus 로고
    • Sirtuins and the Metabolic Hurdles in Cancer
    • 26126285 1:CAS:528:DC%2BC2MXht1agsbjO
    • German NJ, Haigis MC (2015) Sirtuins and the Metabolic Hurdles in Cancer. Curr Biol 25(13):R569-R583
    • (2015) Curr Biol , vol.25 , Issue.13 , pp. R569-R583
    • German, N.J.1    Haigis, M.C.2
  • 22
    • 84907202296 scopus 로고    scopus 로고
    • Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
    • 25085992 1:CAS:528:DC%2BC2cXhvFKgurzM 4142723
    • Zwaans BM, Lombard DB (2014) Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. Dis Model Mech 7(9):1023-1032
    • (2014) Dis Model Mech , vol.7 , Issue.9 , pp. 1023-1032
    • Zwaans, B.M.1    Lombard, D.B.2
  • 23
    • 84856742769 scopus 로고    scopus 로고
    • Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation
    • 22157007 1:CAS:528:DC%2BC38XhvVSjt70%3D 3281715
    • Hallows WC, Yu W, Denu JM (2012) Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. J Biol Chem 287(6):3850-3858
    • (2012) J Biol Chem , vol.287 , Issue.6 , pp. 3850-3858
    • Hallows, W.C.1    Yu, W.2    Denu, J.M.3
  • 24
    • 84908243726 scopus 로고    scopus 로고
    • Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity
    • 25195573 1:CAS:528:DC%2BC2cXhs1SqtrrK
    • Tsusaka T et al (2014) Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity. Genes Cells 19(10):766-777
    • (2014) Genes Cells , vol.19 , Issue.10 , pp. 766-777
    • Tsusaka, T.1
  • 25
    • 84904052542 scopus 로고    scopus 로고
    • Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase
    • 24786789 1:CAS:528:DC%2BC2cXhtVKlurbO 4303242
    • Xu Y et al (2014) Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Res 74(13):3630-3642
    • (2014) Cancer Res , vol.74 , Issue.13 , pp. 3630-3642
    • Xu, Y.1
  • 26
    • 84858797950 scopus 로고    scopus 로고
    • Sirtuins as regulators of metabolism and healthspan
    • 22395773 1:CAS:528:DC%2BC38XjtlOktbw%3D
    • Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13(4):225-238
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.4 , pp. 225-238
    • Houtkooper, R.H.1    Pirinen, E.2    Auwerx, J.3
  • 27
    • 84930460701 scopus 로고    scopus 로고
    • MicroRNAs and energy metabolism in cancer cells, chapter 4
    • S. Babashah (eds) Springer Switzerland
    • Sun L, He X, Cao Y, Gao P, Zhang H (2014) MicroRNAs and energy metabolism in cancer cells, chapter 4. In: Babashah S (ed) MicroRNAs: key regulators of oncogenesis. Springer, Switzerland, pp 84-95
    • (2014) MicroRNAs: Key Regulators of Oncogenesis , pp. 84-95
    • Sun, L.1    He, X.2    Cao, Y.3    Gao, P.4    Zhang, H.5
  • 28
    • 84924590390 scopus 로고    scopus 로고
    • A long noncoding RNA connects c-Myc to tumor metabolism
    • 25512540 1:CAS:528:DC%2BC2cXitFCrt7zN 4284533
    • Hung CL et al (2014) A long noncoding RNA connects c-Myc to tumor metabolism. Proc Natl Acad Sci USA 111(52):18697-18702
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.52 , pp. 18697-18702
    • Hung, C.L.1
  • 29
    • 84865169609 scopus 로고    scopus 로고
    • Metabolic pathway alterations that support cell proliferation
    • 22262476 1:CAS:528:DC%2BC38Xht1ChsbfM
    • Vander Heiden MG et al (2011) Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol 76:325-334
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 325-334
    • Vander Heiden, M.G.1
  • 30
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • 22549953 1:CAS:528:DC%2BC38XmslOgtrk%3D 3347786
    • Dang CV (2012) Links between metabolism and cancer. Genes Dev 26(9):877-890
    • (2012) Genes Dev , vol.26 , Issue.9 , pp. 877-890
    • Dang, C.V.1
  • 31
    • 84925969707 scopus 로고    scopus 로고
    • Metabolic pathways promoting cancer cell survival and growth
    • 25774832 1:CAS:528:DC%2BC2MXksF2htbc%3D
    • Boroughs LK, DeBerardinis RJ (2015) Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol 17(4):351-359
    • (2015) Nat Cell Biol , vol.17 , Issue.4 , pp. 351-359
    • Boroughs, L.K.1    DeBerardinis, R.J.2
  • 32
    • 84919460671 scopus 로고    scopus 로고
    • MiR-22 as a prognostic factor targets glucose transporter protein type 1 in breast cancer
    • 25304371 1:CAS:528:DC%2BC2cXhslCitr7M
    • Chen B et al (2015) miR-22 as a prognostic factor targets glucose transporter protein type 1 in breast cancer. Cancer Lett 356(2 pt B):410-417
    • (2015) Cancer Lett , vol.356 , Issue.2 , pp. 410-417
    • Chen, B.1
  • 33
    • 0141863388 scopus 로고    scopus 로고
    • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
    • 14517300 1:CAS:528:DC%2BD3sXotVSru70%3D 230333
    • Rathmell JC et al (2003) Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 23(20):7315-7328
    • (2003) Mol Cell Biol , vol.23 , Issue.20 , pp. 7315-7328
    • Rathmell, J.C.1
  • 34
    • 34247184208 scopus 로고    scopus 로고
    • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
    • 17301289 1:CAS:528:DC%2BD2sXktVSmtbo%3D 1838986
    • Wieman HL, Wofford JA, Rathmell JC (2007) Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell 18(4):1437-1446
    • (2007) Mol Biol Cell , vol.18 , Issue.4 , pp. 1437-1446
    • Wieman, H.L.1    Wofford, J.A.2    Rathmell, J.C.3
  • 35
    • 84908001650 scopus 로고    scopus 로고
    • PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells
    • 25125078 1:CAS:528:DC%2BC2cXhvFWru7vO
    • Morani F et al (2014) PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells. J Mol Endocrinol 53(2):247-258
    • (2014) J Mol Endocrinol , vol.53 , Issue.2 , pp. 247-258
    • Morani, F.1
  • 36
    • 84953839832 scopus 로고    scopus 로고
    • Glucose transporter 1 (SLC2A1) and vascular endothelial growth factor A (VEGFA) predict survival after resection of colorectal cancer liver metastasis
    • 10.1097/SLA.0000000000001109
    • Goos JA et al (2015) Glucose transporter 1 (SLC2A1) and vascular endothelial growth factor A (VEGFA) predict survival after resection of colorectal cancer liver metastasis. Ann Surg. doi: 10.1097/SLA.0000000000001109
    • (2015) Ann Surg
    • Goos, J.A.1
  • 37
    • 43049139541 scopus 로고    scopus 로고
    • P53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
    • 18391940 1:CAS:528:DC%2BD1cXltl2isL8%3D
    • Kawauchi K, Araki K, Tobiume K, Tanaka N (2008) p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol 10(5):611-618
    • (2008) Nat Cell Biol , vol.10 , Issue.5 , pp. 611-618
    • Kawauchi, K.1    Araki, K.2    Tobiume, K.3    Tanaka, N.4
  • 38
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • 16892090 1:CAS:528:DC%2BD28Xnsl2hsLo%3D 3385868
    • Mathupala SP, Ko YH, Pedersen PL (2006) Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25(34):4777-4786
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 40
    • 84873708461 scopus 로고    scopus 로고
    • MiR-143 regulates hexokinase 2 expression in cancer cells
    • 22469988 1:CAS:528:DC%2BC38XkvVGntLw%3D
    • Peschiaroli A et al (2013) miR-143 regulates hexokinase 2 expression in cancer cells. Oncogene 32(6):797-802
    • (2013) Oncogene , vol.32 , Issue.6 , pp. 797-802
    • Peschiaroli, A.1
  • 41
    • 84922503253 scopus 로고    scopus 로고
    • Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth
    • 25176644 1:CAS:528:DC%2BC2cXhsVOhtrbP 4360961
    • Wang L et al (2014) Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth. Cell Rep 8(5):1461-1474
    • (2014) Cell Rep , vol.8 , Issue.5 , pp. 1461-1474
    • Wang, L.1
  • 42
    • 84906538538 scopus 로고    scopus 로고
    • Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway
    • 24890811 1:CAS:528:DC%2BC2cXhsValsbfI 4317864
    • Li Z, Li X, Wu S, Xue M, Chen W (2014) Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway. Cancer Sci 105(8):951-955
    • (2014) Cancer Sci , vol.105 , Issue.8 , pp. 951-955
    • Li, Z.1    Li, X.2    Wu, S.3    Xue, M.4    Chen, W.5
  • 43
    • 84899823027 scopus 로고    scopus 로고
    • Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration
    • 24465716 3900443
    • Du S et al (2014) Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration. PLoS One 9(1):e85804
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e85804
    • Du, S.1
  • 44
    • 84907299343 scopus 로고    scopus 로고
    • Role of aldolase A in osteosarcoma progression and metastasis: In vitro and in vivo evidence
    • 25215901 1:CAS:528:DC%2BC2cXhvFGgs7nE
    • Long F, Cai X, Luo W, Chen L, Li K (2014) Role of aldolase A in osteosarcoma progression and metastasis: in vitro and in vivo evidence. Oncol Rep 32(5):2031-2037
    • (2014) Oncol Rep , vol.32 , Issue.5 , pp. 2031-2037
    • Long, F.1    Cai, X.2    Luo, W.3    Chen, L.4    Li, K.5
  • 45
    • 84901237608 scopus 로고    scopus 로고
    • Angiopoietin-like 4 promotes melanoma cell invasion and survival through aldolase A
    • 24959248 1:CAS:528:DC%2BC2cXhtlyktb3O 4063564
    • Sun Y, Long J, Zhou Y (2014) Angiopoietin-like 4 promotes melanoma cell invasion and survival through aldolase A. Oncol Lett 8(1):211-217
    • (2014) Oncol Lett , vol.8 , Issue.1 , pp. 211-217
    • Sun, Y.1    Long, J.2    Zhou, Y.3
  • 46
    • 84878567940 scopus 로고    scopus 로고
    • Novel insight into the role of GAPDH playing in tumor
    • 22911551 1:CAS:528:DC%2BC3sXivFCgsLc%3D
    • Guo C, Liu S, Sun MZ (2013) Novel insight into the role of GAPDH playing in tumor. Clin Transl Oncol 15(3):167-172
    • (2013) Clin Transl Oncol , vol.15 , Issue.3 , pp. 167-172
    • Guo, C.1    Liu, S.2    Sun, M.Z.3
  • 47
    • 84920426306 scopus 로고    scopus 로고
    • Deregulation of glyceraldehyde-3-phosphate dehydrogenase expression during tumor progression of human cutaneous melanoma
    • 25550585 1:CAS:528:DC%2BC2MXhtFGit7k%3D
    • Ramos D et al (2015) Deregulation of glyceraldehyde-3-phosphate dehydrogenase expression during tumor progression of human cutaneous melanoma. Anticancer Res 35(1):439-444
    • (2015) Anticancer Res , vol.35 , Issue.1 , pp. 439-444
    • Ramos, D.1
  • 48
    • 84893694995 scopus 로고    scopus 로고
    • Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal
    • 24362262 1:CAS:528:DC%2BC2cXitVyksrY%3D 3916574
    • Li T et al (2014) Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal. J Biol Chem 289(6):3775-3785
    • (2014) J Biol Chem , vol.289 , Issue.6 , pp. 3775-3785
    • Li, T.1
  • 49
    • 34249279169 scopus 로고    scopus 로고
    • GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation
    • 17540177 1:CAS:528:DC%2BD2sXmsl2qsb8%3D
    • Colell A et al (2007) GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 129(5):983-997
    • (2007) Cell , vol.129 , Issue.5 , pp. 983-997
    • Colell, A.1
  • 50
    • 84906223319 scopus 로고    scopus 로고
    • The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications
    • 24285383 1:CAS:528:DC%2BC3sXhvV2hsbbM
    • Jiang X, Sun Q, Li H, Li K, Ren X (2014) The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications. Int J Cancer 135(9):1991-1996
    • (2014) Int J Cancer , vol.135 , Issue.9 , pp. 1991-1996
    • Jiang, X.1    Sun, Q.2    Li, H.3    Li, K.4    Ren, X.5
  • 51
    • 84869077946 scopus 로고    scopus 로고
    • Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
    • 23153533 1:CAS:528:DC%2BC38Xhs1Kls73N 3500524
    • Hitosugi T et al (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 22(5):585-600
    • (2012) Cancer Cell , vol.22 , Issue.5 , pp. 585-600
    • Hitosugi, T.1
  • 52
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • 20133848 1:CAS:528:DC%2BC3cXhvFCit7g%3D 2836706
    • Le A et al (2010) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 107(5):2037-2042
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.5 , pp. 2037-2042
    • Le, A.1
  • 53
    • 84916238418 scopus 로고    scopus 로고
    • Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells
    • 25394466 1:CAS:528:DC%2BC2MXksVyju78%3D
    • Liu X et al (2015) Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells. Oncol Rep 33(1):157-162
    • (2015) Oncol Rep , vol.33 , Issue.1 , pp. 157-162
    • Liu, X.1
  • 54
    • 84916224736 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil
    • 25333573 1:CAS:528:DC%2BC2MXhtlyjsLk%3D
    • Li X, Zhao H, Zhou X, Song L (2015) Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil. Mol Med Rep 11(1):577-582
    • (2015) Mol Med Rep , vol.11 , Issue.1 , pp. 577-582
    • Li, X.1    Zhao, H.2    Zhou, X.3    Song, L.4
  • 55
    • 84869208957 scopus 로고    scopus 로고
    • An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer
    • 23139210 1:CAS:528:DC%2BC38Xhs1ynt7fM
    • McCleland ML et al (2012) An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer. Cancer Res 72(22):5812-5823
    • (2012) Cancer Res , vol.72 , Issue.22 , pp. 5812-5823
    • McCleland, M.L.1
  • 56
    • 84954398881 scopus 로고    scopus 로고
    • The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B
    • 10.1002/mc.22258 25620379
    • Tambe Y, Hasebe M, Kim CJ, Yamamoto A, Inoue H (2015) The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B. Mol Carcinog. doi: 10.1002/mc.22258
    • (2015) Mol Carcinog
    • Tambe, Y.1    Hasebe, M.2    Kim, C.J.3    Yamamoto, A.4    Inoue, H.5
  • 57
    • 84905187426 scopus 로고    scopus 로고
    • Regulation of the pentose phosphate pathway in cancer
    • 25015087 1:CAS:528:DC%2BC2cXhtF2ksrjJ 4112277
    • Jiang P, Du W, Wu M (2014) Regulation of the pentose phosphate pathway in cancer. Protein Cell 5(8):592-602
    • (2014) Protein Cell , vol.5 , Issue.8 , pp. 592-602
    • Jiang, P.1    Du, W.2    Wu, M.3
  • 58
    • 84882973107 scopus 로고    scopus 로고
    • Molecular pathways: Reactive oxygen species homeostasis in cancer cells and implications for cancer therapy
    • 23719265 1:CAS:528:DC%2BC3sXhtlSitr7J 3933310
    • Nogueira V, Hay N (2013) Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clin Cancer Res 19(16):4309-4314
    • (2013) Clin Cancer Res , vol.19 , Issue.16 , pp. 4309-4314
    • Nogueira, V.1    Hay, N.2
  • 59
    • 79952280229 scopus 로고    scopus 로고
    • P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • 21336310 1:CAS:528:DC%2BC3MXisFKntrs%3D 3110666
    • Jiang P et al (2011) p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 13(3):310-316
    • (2011) Nat Cell Biol , vol.13 , Issue.3 , pp. 310-316
    • Jiang, P.1
  • 60
    • 84908500698 scopus 로고    scopus 로고
    • PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis
    • 24352616 1:CAS:528:DC%2BC2cXitVyhs7vF
    • Hong X et al (2014) PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis. Gut 63(10):1635-1647
    • (2014) Gut , vol.63 , Issue.10 , pp. 1635-1647
    • Hong, X.1
  • 61
    • 84904969433 scopus 로고    scopus 로고
    • The pentose phosphate pathway and cancer
    • 25037503 1:CAS:528:DC%2BC2cXhtFGqu73N 4329227
    • Patra KC, Hay N (2014) The pentose phosphate pathway and cancer. Trends Biochem Sci 39(8):347-354
    • (2014) Trends Biochem Sci , vol.39 , Issue.8 , pp. 347-354
    • Patra, K.C.1    Hay, N.2
  • 62
    • 84881557242 scopus 로고    scopus 로고
    • Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
    • 23911236 1:CAS:528:DC%2BC3sXht1Wrur%2FL 3753022
    • Patra KC et al (2013) Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 24(2):213-228
    • (2013) Cancer Cell , vol.24 , Issue.2 , pp. 213-228
    • Patra, K.C.1
  • 63
    • 84865300414 scopus 로고    scopus 로고
    • Phosphofructokinase 1 glycosylation regulates cell growth and metabolism
    • 22923583 1:CAS:528:DC%2BC38Xht1ahu7jF 3534962
    • Yi W et al (2012) Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science 337(6097):975-980
    • (2012) Science , vol.337 , Issue.6097 , pp. 975-980
    • Yi, W.1
  • 64
    • 82755166890 scopus 로고    scopus 로고
    • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
    • 22052977 1:CAS:528:DC%2BC3MXhsFCms7jK 3471535
    • Anastasiou D et al (2011) Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334(6060):1278-1283
    • (2011) Science , vol.334 , Issue.6060 , pp. 1278-1283
    • Anastasiou, D.1
  • 65
    • 84952877403 scopus 로고    scopus 로고
    • Pyruvate kinase M2 modulates esophageal squamous cell carcinoma chemotherapy response by regulating the pentose phosphate pathway
    • 10.1245/s10434-015-4522-3
    • Fukuda S et al (2015) Pyruvate kinase M2 modulates esophageal squamous cell carcinoma chemotherapy response by regulating the pentose phosphate pathway. Ann Surg Oncol. doi: 10.1245/s10434-015-4522-3
    • (2015) Ann Surg Oncol
    • Fukuda, S.1
  • 66
    • 80052775587 scopus 로고    scopus 로고
    • Serine metabolism: Some tumors take the road less traveled
    • 21907134 1:CAS:528:DC%2BC3MXhtFGltbnO 3172581
    • DeBerardinis RJ (2011) Serine metabolism: some tumors take the road less traveled. Cell Metab 14(3):285-286
    • (2011) Cell Metab , vol.14 , Issue.3 , pp. 285-286
    • DeBerardinis, R.J.1
  • 68
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • 17482131 1:CAS:528:DC%2BD2sXlsVahu7Y%3D
    • Zhang H et al (2007) HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11(5):407-420
    • (2007) Cancer Cell , vol.11 , Issue.5 , pp. 407-420
    • Zhang, H.1
  • 69
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • 16517405
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3(3):177-185
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 70
    • 84923025327 scopus 로고    scopus 로고
    • Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1
    • 25301052 1:CAS:528:DC%2BC2cXitVShs7bM
    • Ma X et al (2014) Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nat Commun 5:5212
    • (2014) Nat Commun , vol.5 , pp. 5212
    • Ma, X.1
  • 71
    • 84895896123 scopus 로고    scopus 로고
    • Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
    • 24605027 3942833
    • Swierczynski J, Hebanowska A, Sledzinski T (2014) Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J Gastroenterol 20(9):2279-2303
    • (2014) World J Gastroenterol , vol.20 , Issue.9 , pp. 2279-2303
    • Swierczynski, J.1    Hebanowska, A.2    Sledzinski, T.3
  • 72
    • 84881372774 scopus 로고    scopus 로고
    • Cellular fatty acid metabolism and cancer
    • 23791484 1:CAS:528:DC%2BC3sXpvVyrsLY%3D 3742569
    • Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr (2013) Cellular fatty acid metabolism and cancer. Cell Metab 18(2):153-161
    • (2013) Cell Metab , vol.18 , Issue.2 , pp. 153-161
    • Currie, E.1    Schulze, A.2    Zechner, R.3    Walther, T.C.4    Farese, R.V.5
  • 73
    • 84870954169 scopus 로고    scopus 로고
    • The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis
    • 23100451 3717962
    • Catalina-Rodriguez O et al (2012) The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget 3(10):1220-1235
    • (2012) Oncotarget , vol.3 , Issue.10 , pp. 1220-1235
    • Catalina-Rodriguez, O.1
  • 74
    • 84930907834 scopus 로고    scopus 로고
    • Targeting mitochondrial citrate transport in breast cancer cell lines
    • 1:CAS:528:DC%2BC2MXks1ynt7s%3D
    • Ozkaya AB, Ak H, Atay S, Aydin HH (2015) Targeting mitochondrial citrate transport in breast cancer cell lines. Anti-Cancer Agents Med Chem 15(3):374-381
    • (2015) Anti-Cancer Agents Med Chem , vol.15 , Issue.3 , pp. 374-381
    • Ozkaya, A.B.1    Ak, H.2    Atay, S.3    Aydin, H.H.4
  • 75
    • 66249105703 scopus 로고    scopus 로고
    • ATP-citrate lyase links cellular metabolism to histone acetylation
    • 19461003 1:CAS:528:DC%2BD1MXmtVKlsb8%3D 2746744
    • Wellen KE et al (2009) ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324(5930):1076-1080
    • (2009) Science , vol.324 , Issue.5930 , pp. 1076-1080
    • Wellen, K.E.1
  • 76
    • 84890511382 scopus 로고    scopus 로고
    • ATP citrate lyase mediates resistance of colorectal cancer cells to SN38
    • 24132143 1:CAS:528:DC%2BC3sXhvVyqsrvO 4302275
    • Zhou Y et al (2013) ATP citrate lyase mediates resistance of colorectal cancer cells to SN38. Mol Cancer Ther 12(12):2782-2791
    • (2013) Mol Cancer Ther , vol.12 , Issue.12 , pp. 2782-2791
    • Zhou, Y.1
  • 77
    • 0018769394 scopus 로고
    • Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast
    • 444407 1:CAS:528:DyaL3cXitVaitA%3D%3D 2009996
    • Szutowicz A, Kwiatkowski J, Angielski S (1979) Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast. Br J Cancer 39(6):681-687
    • (1979) Br J Cancer , vol.39 , Issue.6 , pp. 681-687
    • Szutowicz, A.1    Kwiatkowski, J.2    Angielski, S.3
  • 78
    • 77951239243 scopus 로고    scopus 로고
    • Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas
    • 19795461 1:CAS:528:DC%2BC3cXjvFahtbo%3D 2847004
    • Beckner ME et al (2010) Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. Int J Cancer 126(10):2282-2295
    • (2010) Int J Cancer , vol.126 , Issue.10 , pp. 2282-2295
    • Beckner, M.E.1
  • 79
    • 84863071066 scopus 로고    scopus 로고
    • Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer
    • 22266777 1:CAS:528:DC%2BC38XlslKhtbs%3D 3583602
    • Wang Y et al (2012) Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer. Oncol Rep 27(4):1156-1162
    • (2012) Oncol Rep , vol.27 , Issue.4 , pp. 1156-1162
    • Wang, Y.1
  • 80
    • 84864858864 scopus 로고    scopus 로고
    • ATP-citrate lyase: A key player in cancer metabolism
    • 22787121 1:CAS:528:DC%2BC38XhtFant7zF
    • Zaidi N, Swinnen JV, Smans K (2012) ATP-citrate lyase: a key player in cancer metabolism. Cancer Res 72(15):3709-3714
    • (2012) Cancer Res , vol.72 , Issue.15 , pp. 3709-3714
    • Zaidi, N.1    Swinnen, J.V.2    Smans, K.3
  • 81
    • 84855743864 scopus 로고    scopus 로고
    • Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways
    • 21688263 1:CAS:528:DC%2BC38XlvVGjug%3D%3D 3407542
    • Hanai J et al (2012) Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. J Cell Physiol 227(4):1709-1720
    • (2012) J Cell Physiol , vol.227 , Issue.4 , pp. 1709-1720
    • Hanai, J.1
  • 82
    • 84923273462 scopus 로고    scopus 로고
    • Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer
    • 25701462
    • Zong H, Zhang Y, You Y, Cai T, Wang Y (2015) Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer. Med Oncol 32(3):85
    • (2015) Med Oncol , vol.32 , Issue.3 , pp. 85
    • Zong, H.1    Zhang, Y.2    You, Y.3    Cai, T.4    Wang, Y.5
  • 83
    • 84882605310 scopus 로고    scopus 로고
    • Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth
    • 23932781 1:CAS:528:DC%2BC3sXht1GmurfI 4180208
    • Lin R et al (2013) Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell 51(4):506-518
    • (2013) Mol Cell , vol.51 , Issue.4 , pp. 506-518
    • Lin, R.1
  • 84
    • 84923269003 scopus 로고    scopus 로고
    • ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway
    • 25367309 1:CAS:528:DC%2BC2MXhtFGjsro%3D
    • Lee JH et al (2015) ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway. FEBS J 282(2):361-371
    • (2015) FEBS J , vol.282 , Issue.2 , pp. 361-371
    • Lee, J.H.1
  • 85
    • 84921525633 scopus 로고    scopus 로고
    • Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease
    • 25333641 1:CAS:528:DC%2BC2cXhslOlurjN
    • Bourbeau MP, Bartberger MD (2015) Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease. J Med Chem 58(2):525-536
    • (2015) J Med Chem , vol.58 , Issue.2 , pp. 525-536
    • Bourbeau, M.P.1    Bartberger, M.D.2
  • 86
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • 14985505 1:CAS:528:DC%2BD2cXisFWmsrg%3D 373461
    • Shaw RJ et al (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101(10):3329-3335
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.10 , pp. 3329-3335
    • Shaw, R.J.1
  • 87
    • 0023642627 scopus 로고
    • A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
    • 2889619 1:CAS:528:DyaL1cXltFOksA%3D%3D
    • Carling D, Zammit VA, Hardie DG (1987) A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223(2):217-222
    • (1987) FEBS Lett , vol.223 , Issue.2 , pp. 217-222
    • Carling, D.1    Zammit, V.A.2    Hardie, D.G.3
  • 88
    • 84878891625 scopus 로고    scopus 로고
    • SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase
    • 23746352 1:CAS:528:DC%2BC3sXptFOmuro%3D 3721068
    • Laurent G et al (2013) SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell 50(5):686-698
    • (2013) Mol Cell , vol.50 , Issue.5 , pp. 686-698
    • Laurent, G.1
  • 89
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • 17882277 1:CAS:528:DC%2BD2sXhtVOnsr3P
    • Menendez JA, Lupu R (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7(10):763-777
    • (2007) Nat Rev Cancer , vol.7 , Issue.10 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 90
    • 84890859981 scopus 로고    scopus 로고
    • Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity
    • 24200503 1:CAS:528:DC%2BC3sXhvVSmu7nL
    • Hopperton KE, Duncan RE, Bazinet RP, Archer MC (2014) Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. Exp Cell Res 320(2):302-310
    • (2014) Exp Cell Res , vol.320 , Issue.2 , pp. 302-310
    • Hopperton, K.E.1    Duncan, R.E.2    Bazinet, R.P.3    Archer, M.C.4
  • 91
    • 84872169944 scopus 로고    scopus 로고
    • Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
    • 23201681 1:CAS:528:DC%2BC38XhslymtLjP 3587167
    • Knobloch M et al (2013) Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature 493(7431):226-230
    • (2013) Nature , vol.493 , Issue.7431 , pp. 226-230
    • Knobloch, M.1
  • 92
    • 84938972141 scopus 로고    scopus 로고
    • SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism
    • 25589463 1:CAS:528:DC%2BC2MXhtlCrt77K
    • Sun Y et al (2015) SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism. Tumour Biol 36(6):4133-4141
    • (2015) Tumour Biol , vol.36 , Issue.6 , pp. 4133-4141
    • Sun, Y.1
  • 93
    • 84884150671 scopus 로고    scopus 로고
    • Multiple regulatory layers of SREBP1/2 by SIRT6
    • 24012758 1:CAS:528:DC%2BC3sXhsVWis7zJ
    • Elhanati S et al (2013) Multiple regulatory layers of SREBP1/2 by SIRT6. Cell Rep 4(5):905-912
    • (2013) Cell Rep , vol.4 , Issue.5 , pp. 905-912
    • Elhanati, S.1
  • 94
    • 84914695549 scopus 로고    scopus 로고
    • SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis
    • 25270091 1:CAS:528:DC%2BC2cXitVGktL3I
    • Lin L et al (2014) SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncol Rep 32(6):2831-2835
    • (2014) Oncol Rep , vol.32 , Issue.6 , pp. 2831-2835
    • Lin, L.1
  • 95
    • 50049116472 scopus 로고    scopus 로고
    • SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    • 18762023 1:CAS:528:DC%2BD1cXhtFeju77J 2593919
    • Porstmann T et al (2008) SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8(3):224-236
    • (2008) Cell Metab , vol.8 , Issue.3 , pp. 224-236
    • Porstmann, T.1
  • 96
    • 84957427207 scopus 로고    scopus 로고
    • Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells
    • 10.1038/onc.2015.123
    • Li S, Oh YT, Yue P, Khuri FR, Sun SY (2015) Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells. Oncogene. doi: 10.1038/onc.2015.123
    • (2015) Oncogene
    • Li, S.1    Oh, Y.T.2    Yue, P.3    Khuri, F.R.4    Sun, S.Y.5
  • 97
    • 84919905682 scopus 로고    scopus 로고
    • Acetate fuels the cancer engine
    • 25525870 1:CAS:528:DC%2BC2MXnslKruw%3D%3D
    • Lyssiotis CA, Cantley LC (2014) Acetate fuels the cancer engine. Cell 159(7):1492-1494
    • (2014) Cell , vol.159 , Issue.7 , pp. 1492-1494
    • Lyssiotis, C.A.1    Cantley, L.C.2
  • 98
    • 84919936304 scopus 로고    scopus 로고
    • Acetate dependence of tumors
    • 25525877 1:CAS:528:DC%2BC2MXnslOjsA%3D%3D 4272450
    • Comerford SA et al (2014) Acetate dependence of tumors. Cell 159(7):1591-1602
    • (2014) Cell , vol.159 , Issue.7 , pp. 1591-1602
    • Comerford, S.A.1
  • 99
    • 84919903877 scopus 로고    scopus 로고
    • Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
    • 25525878 1:CAS:528:DC%2BC2MXnslKqug%3D%3D 4374602
    • Mashimo T et al (2014) Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 159(7):1603-1614
    • (2014) Cell , vol.159 , Issue.7 , pp. 1603-1614
    • Mashimo, T.1
  • 100
    • 84868117861 scopus 로고    scopus 로고
    • Metabolism of [U-13 C] glucose in human brain tumors in vivo
    • 22419606 1:CAS:528:DC%2BC38XhsFGqtLrO 3406255
    • Maher EA et al (2012) Metabolism of [U-13 C] glucose in human brain tumors in vivo. NMR Biomed 25(11):1234-1244
    • (2012) NMR Biomed , vol.25 , Issue.11 , pp. 1234-1244
    • Maher, E.A.1
  • 101
    • 84929472135 scopus 로고    scopus 로고
    • Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver
    • 25713102 1:CAS:528:DC%2BC2MXnsF2ntbY%3D
    • Zhang X et al (2015) Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver. J Lipid Res 56(5):963-971
    • (2015) J Lipid Res , vol.56 , Issue.5 , pp. 963-971
    • Zhang, X.1
  • 102
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • 11994399 1:CAS:528:DC%2BD38XjsFals7c%3D 150968
    • Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109(9):1125-1131
    • (2002) J Clin Invest , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 103
    • 63249089044 scopus 로고    scopus 로고
    • Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation
    • 19345325 1:CAS:528:DC%2BD1MXlsFyrt7c%3D
    • Shamma A et al (2009) Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation. Cancer Cell 15(4):255-269
    • (2009) Cancer Cell , vol.15 , Issue.4 , pp. 255-269
    • Shamma, A.1
  • 104
    • 84862908644 scopus 로고    scopus 로고
    • Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
    • 22265415 1:CAS:528:DC%2BC38XhtFKgsb8%3D 3511889
    • Freed-Pastor WA et al (2012) Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 148(1-2):244-258
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 244-258
    • Freed-Pastor, W.A.1
  • 105
    • 84859768059 scopus 로고    scopus 로고
    • Lipophagy: Connecting autophagy and lipid metabolism
    • 22536247 3320019
    • Singh R, Cuervo AM (2012) Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol 2012:282041
    • (2012) Int J Cell Biol , vol.2012 , pp. 282041
    • Singh, R.1    Cuervo, A.M.2
  • 106
    • 84926348375 scopus 로고    scopus 로고
    • Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update
    • 25834313 1:CAS:528:DC%2BC2MXntFOrur0%3D 4375570
    • Yan S et al (2015) Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: an update. World J Gastroenterol 21(12):3492-3498
    • (2015) World J Gastroenterol , vol.21 , Issue.12 , pp. 3492-3498
    • Yan, S.1
  • 107
    • 18944392165 scopus 로고    scopus 로고
    • Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: Roles of cyclic AMP and p38 mitogen-activated protein kinase
    • 15849811 1:CAS:528:DC%2BD2MXlsFSis7k%3D 4305743
    • Liang YC et al (2005) Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase. World J Gastroenterol 11(17):2557-2563
    • (2005) World J Gastroenterol , vol.11 , Issue.17 , pp. 2557-2563
    • Liang, Y.C.1
  • 108
    • 84885395288 scopus 로고    scopus 로고
    • Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer
    • 24155918 1:CAS:528:DC%2BC3sXhs1KiurvF 3796543
    • Wu X et al (2013) Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer. PLoS One 8(10):e77060
    • (2013) PLoS One , vol.8 , Issue.10 , pp. e77060
    • Wu, X.1
  • 109
    • 84907410130 scopus 로고    scopus 로고
    • HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression
    • 25242319 1:CAS:528:DC%2BC2cXhsFyltbfJ
    • Huang D et al (2014) HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Rep 8(6):1930-1942
    • (2014) Cell Rep , vol.8 , Issue.6 , pp. 1930-1942
    • Huang, D.1
  • 110
    • 84873363313 scopus 로고    scopus 로고
    • SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival
    • 23213057 1:CAS:528:DC%2BC3sXitVOht7s%3D 3697078
    • Hassanein M et al (2013) SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin Cancer Res 19(3):560-570
    • (2013) Clin Cancer Res , vol.19 , Issue.3 , pp. 560-570
    • Hassanein, M.1
  • 111
    • 84876728581 scopus 로고    scopus 로고
    • Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer
    • 22934847 1:CAS:528:DC%2BC3sXotFaht7o%3D
    • Mates JM et al (2013) Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer. Curr Mol Med 13(4):514-534
    • (2013) Curr Mol Med , vol.13 , Issue.4 , pp. 514-534
    • Mates, J.M.1
  • 112
    • 64749116346 scopus 로고    scopus 로고
    • C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • 19219026 1:CAS:528:DC%2BD1MXhvFKjtrY%3D 2729443
    • Gao P et al (2009) c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458(7239):762-765
    • (2009) Nature , vol.458 , Issue.7239 , pp. 762-765
    • Gao, P.1
  • 113
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • 19033189 1:CAS:528:DC%2BD1cXhsV2rtL%2FK 2596212
    • Wise DR et al (2008) Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 105(48):18782-18787
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.48 , pp. 18782-18787
    • Wise, D.R.1
  • 114
    • 77952227625 scopus 로고    scopus 로고
    • Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
    • 20351271 1:CAS:528:DC%2BC3cXlsFWhsbs%3D 2867754
    • Suzuki S et al (2010) Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci USA 107(16):7461-7466
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.16 , pp. 7461-7466
    • Suzuki, S.1
  • 115
    • 84875894714 scopus 로고    scopus 로고
    • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    • 23535601 1:CAS:528:DC%2BC3sXkvFyjsrc%3D 3656466
    • Son J et al (2013) Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496(7443):101-105
    • (2013) Nature , vol.496 , Issue.7443 , pp. 101-105
    • Son, J.1
  • 116
    • 84855453655 scopus 로고    scopus 로고
    • Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
    • 22225880 1:CAS:528:DC%2BC38XkvF2nsg%3D%3D 3345194
    • Le A et al (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 15(1):110-121
    • (2012) Cell Metab , vol.15 , Issue.1 , pp. 110-121
    • Le, A.1
  • 117
    • 84894359469 scopus 로고    scopus 로고
    • Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1alpha
    • 24550282 1:CAS:528:DC%2BC2cXivFantrg%3D 3932920
    • Faubert B et al (2014) Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1alpha. Proc Natl Acad Sci USA 111(7):2554-2559
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.7 , pp. 2554-2559
    • Faubert, B.1
  • 118
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • 18032601 1:CAS:528:DC%2BD1cXisVOjtQ%3D%3D 2148292
    • DeBerardinis RJ et al (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104(49):19345-19350
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.49 , pp. 19345-19350
    • DeBerardinis, R.J.1
  • 119
    • 84922468705 scopus 로고    scopus 로고
    • Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
    • 25458842 1:CAS:528:DC%2BC2cXhvVOnt77P 4268166
    • Yang C et al (2014) Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol Cell 56(3):414-424
    • (2014) Mol Cell , vol.56 , Issue.3 , pp. 414-424
    • Yang, C.1
  • 120
    • 0036316013 scopus 로고    scopus 로고
    • A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
    • 12138190 1:CAS:528:DC%2BD38XlslyjtLw%3D 133987
    • Nikiforov MA et al (2002) A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol 22(16):5793-5800
    • (2002) Mol Cell Biol , vol.22 , Issue.16 , pp. 5793-5800
    • Nikiforov, M.A.1
  • 121
    • 84901263663 scopus 로고    scopus 로고
    • Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
    • 24813884 1:CAS:528:DC%2BC2cXnslGqs78%3D
    • Labuschagne CF, van den Broek NJ, Mackay GM, Vousden KH, Maddocks OD (2014) Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep 7(4):1248-1258
    • (2014) Cell Rep , vol.7 , Issue.4 , pp. 1248-1258
    • Labuschagne, C.F.1    Van Den Broek, N.J.2    MacKay, G.M.3    Vousden, K.H.4    Maddocks, O.D.5
  • 122
    • 84916641049 scopus 로고    scopus 로고
    • Proline metabolism and cancer: Emerging links to glutamine and collagen
    • 25474014 1:CAS:528:DC%2BC2cXitVKrtrfE 4255759
    • Phang JM, Liu W, Hancock CN, Fischer JW (2015) Proline metabolism and cancer: emerging links to glutamine and collagen. Curr Opin Clin Nutr Metab Care 18(1):71-77
    • (2015) Curr Opin Clin Nutr Metab Care , vol.18 , Issue.1 , pp. 71-77
    • Phang, J.M.1    Liu, W.2    Hancock, C.N.3    Fischer, J.W.4
  • 124
    • 84902089967 scopus 로고    scopus 로고
    • Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production
    • 24930674 4102783
    • Togashi Y et al (2014) Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. Oncotarget 5(10):2962-2973
    • (2014) Oncotarget , vol.5 , Issue.10 , pp. 2962-2973
    • Togashi, Y.1
  • 125
    • 0033822017 scopus 로고    scopus 로고
    • Single amino acid (arginine) deprivation: Rapid and selective death of cultured transformed and malignant cells
    • 10952786 1:CAS:528:DC%2BD3cXntFOhsLw%3D 2363527
    • Scott L, Lamb J, Smith S, Wheatley DN (2000) Single amino acid (arginine) deprivation: rapid and selective death of cultured transformed and malignant cells. Br J Cancer 83(6):800-810
    • (2000) Br J Cancer , vol.83 , Issue.6 , pp. 800-810
    • Scott, L.1    Lamb, J.2    Smith, S.3    Wheatley, D.N.4
  • 126
    • 79954775922 scopus 로고    scopus 로고
    • Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
    • 21152246 2998341
    • Kuo MT, Savaraj N, Feun LG (2010) Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget 1(4):246-251
    • (2010) Oncotarget , vol.1 , Issue.4 , pp. 246-251
    • Kuo, M.T.1    Savaraj, N.2    Feun, L.G.3
  • 127
    • 84916624777 scopus 로고    scopus 로고
    • Arginine deprivation in cancer therapy
    • 25474015 1:CAS:528:DC%2BC2cXitVKrtrfF
    • Feun LG, Kuo MT, Savaraj N (2015) Arginine deprivation in cancer therapy. Curr Opin Clin Nutr Metab Care 18(1):78-82
    • (2015) Curr Opin Clin Nutr Metab Care , vol.18 , Issue.1 , pp. 78-82
    • Feun, L.G.1    Kuo, M.T.2    Savaraj, N.3
  • 128
    • 79551469518 scopus 로고    scopus 로고
    • Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells
    • 20958264 1:CAS:528:DC%2BC3cXhsFOhsr%2FJ
    • Moon JS et al (2011) Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells. Biochem J 433(1):225-233
    • (2011) Biochem J , vol.433 , Issue.1 , pp. 225-233
    • Moon, J.S.1
  • 129
    • 84856014884 scopus 로고    scopus 로고
    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    • 1:CAS:528:DC%2BC3MXhsV2gt7fP
    • Metallo CM et al (2012) Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481(7381):380-384
    • (2012) Nature , vol.481 , Issue.7381 , pp. 380-384
    • Metallo, C.M.1
  • 130
    • 84855987831 scopus 로고    scopus 로고
    • Reductive carboxylation supports growth in tumour cells with defective mitochondria
    • 1:CAS:528:DC%2BC3MXhsV2gt73F
    • Mullen AR et al (2012) Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481(7381):385-388
    • (2012) Nature , vol.481 , Issue.7381 , pp. 385-388
    • Mullen, A.R.1
  • 131
    • 84893465244 scopus 로고    scopus 로고
    • Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth
    • 24506869 1:CAS:528:DC%2BC2cXhvFGltLw%3D 3920584
    • Sun RC, Denko NC (2014) Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab 19(2):285-292
    • (2014) Cell Metab , vol.19 , Issue.2 , pp. 285-292
    • Sun, R.C.1    Denko, N.C.2
  • 132
    • 84869082905 scopus 로고    scopus 로고
    • Serine is a natural ligand and allosteric activator of pyruvate kinase M2
    • 23064226 1:CAS:528:DC%2BC38XhsV2rsL7K 3894725
    • Chaneton B et al (2012) Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491(7424):458-462
    • (2012) Nature , vol.491 , Issue.7424 , pp. 458-462
    • Chaneton, B.1
  • 133
    • 84860793042 scopus 로고    scopus 로고
    • Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
    • 22509023 1:CAS:528:DC%2BC38XntVWks7g%3D 3345000
    • Ye J et al (2012) Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci USA 109(18):6904-6909
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.18 , pp. 6904-6909
    • Ye, J.1
  • 134
    • 84928661134 scopus 로고    scopus 로고
    • Glycolytic flux controls d-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes
    • 25870284 1:CAS:528:DC%2BC2MXmsFShtLw%3D 4418896
    • Suzuki M et al (2015) Glycolytic flux controls d-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes. Proc Natl Acad Sci USA 112(17):E2217-E2224
    • (2015) Proc Natl Acad Sci USA , vol.112 , Issue.17 , pp. E2217-E2224
    • Suzuki, M.1
  • 135
    • 84920268667 scopus 로고    scopus 로고
    • A nexus for cellular homeostasis: The interplay between metabolic and signal transduction pathways
    • Gomes AP, Blenis J (2015) A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. Curr Opin Biotechnol 34C:110-117
    • (2015) Curr Opin Biotechnol , vol.34 , pp. 110-117
    • Gomes, A.P.1    Blenis, J.2
  • 136
    • 84904510627 scopus 로고    scopus 로고
    • Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts
    • 24780297 1:CAS:528:DC%2BC2cXhtlGgsbnL
    • Hu JW, Sun P, Zhang DX, Xiong WJ, Mi J (2014) Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts. Cell Signal 26(10):2210-2216
    • (2014) Cell Signal , vol.26 , Issue.10 , pp. 2210-2216
    • Hu, J.W.1    Sun, P.2    Zhang, D.X.3    Xiong, W.J.4    Mi, J.5
  • 137
    • 84912122526 scopus 로고    scopus 로고
    • Phosphofructokinase: A mediator of glycolytic flux in cancer progression
    • 24910089
    • Al Hasawi N, Alkandari MF, Luqmani YA (2014) Phosphofructokinase: a mediator of glycolytic flux in cancer progression. Crit Rev Oncol Hematol 92(3):312-321
    • (2014) Crit Rev Oncol Hematol , vol.92 , Issue.3 , pp. 312-321
    • Al Hasawi, N.1    Alkandari, M.F.2    Luqmani, Y.A.3
  • 138
    • 84929191992 scopus 로고    scopus 로고
    • Aerobic glycolysis tunes YAP/TAZ transcriptional activity
    • 25796446 1:CAS:528:DC%2BC2MXnslOqurs%3D
    • Enzo E et al (2015) Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J 34(10):1349-1370
    • (2015) EMBO J , vol.34 , Issue.10 , pp. 1349-1370
    • Enzo, E.1
  • 139
    • 79952749503 scopus 로고    scopus 로고
    • Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
    • 21325052 1:CAS:528:DC%2BC3MXjs1Wqur4%3D 3054028
    • Sun Q et al (2011) Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 108(10):4129-4134
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.10 , pp. 4129-4134
    • Sun, Q.1
  • 140
    • 77956674635 scopus 로고    scopus 로고
    • Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    • 20847263 1:CAS:528:DC%2BC3cXhtFGjtLrK
    • Vander Heiden MG et al (2010) Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 329(5998):1492-1499
    • (2010) Science , vol.329 , Issue.5998 , pp. 1492-1499
    • Vander Heiden, M.G.1
  • 141
    • 84866842363 scopus 로고    scopus 로고
    • Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
    • 22922757 1:CAS:528:DC%2BC38Xht1Ght7rM 3711671
    • Anastasiou D et al (2012) Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol 8(10):839-847
    • (2012) Nat Chem Biol , vol.8 , Issue.10 , pp. 839-847
    • Anastasiou, D.1
  • 142
    • 84885589840 scopus 로고    scopus 로고
    • PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
    • 24120138 1:CAS:528:DC%2BC3sXhs1Sktr%2FI
    • Israelsen WJ et al (2013) PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 155(2):397-409
    • (2013) Cell , vol.155 , Issue.2 , pp. 397-409
    • Israelsen, W.J.1
  • 143
    • 84920591180 scopus 로고    scopus 로고
    • Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages
    • 25565206 1:CAS:528:DC%2BC2MXlvFyntQ%3D%3D
    • Palsson-McDermott EM et al (2015) Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab 21(1):65-80
    • (2015) Cell Metab , vol.21 , Issue.1 , pp. 65-80
    • Palsson-McDermott, E.M.1
  • 144
    • 84922269698 scopus 로고    scopus 로고
    • Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1alpha and Bcl-xL in culture
    • 25661370 1:CAS:528:DC%2BC2MXhvVWqsr8%3D
    • Dong T et al (2015) Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1alpha and Bcl-xL in culture. Biomed Pharmacother 69:277-284
    • (2015) Biomed Pharmacother , vol.69 , pp. 277-284
    • Dong, T.1
  • 145
    • 84901831464 scopus 로고    scopus 로고
    • Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling
    • 24686087 1:CAS:528:DC%2BC2cXhtFGlsb%2FL
    • Yang P, Li Z, Fu R, Wu H, Li Z (2014) Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling. Cell Signal 26(9):1853-1862
    • (2014) Cell Signal , vol.26 , Issue.9 , pp. 1853-1862
    • Yang, P.1    Li, Z.2    Fu, R.3    Wu, H.4    Li, Z.5
  • 146
    • 84927128104 scopus 로고    scopus 로고
    • Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma
    • 25788265 4466635
    • Hu W et al (2015) Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma. Oncotarget 6(9):6570-6583
    • (2015) Oncotarget , vol.6 , Issue.9 , pp. 6570-6583
    • Hu, W.1
  • 147
    • 84925536036 scopus 로고    scopus 로고
    • Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/beta-catenin pathway in colon cancer cells
    • 25732087 1:CAS:528:DC%2BC2MXjvVOru78%3D
    • Yang P et al (2015) Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/beta-catenin pathway in colon cancer cells. Biochem Biophys Res Commun 459(2):327-332
    • (2015) Biochem Biophys Res Commun , vol.459 , Issue.2 , pp. 327-332
    • Yang, P.1
  • 148
    • 84871104206 scopus 로고    scopus 로고
    • Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism
    • 23093405 1:CAS:528:DC%2BC38XhvVeksbzI
    • Ritterson Lew C, Tolan DR (2012) Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism. J Biol Chem 287(51):42554-42563
    • (2012) J Biol Chem , vol.287 , Issue.51 , pp. 42554-42563
    • Ritterson Lew, C.1    Tolan, D.R.2
  • 149
    • 84904433506 scopus 로고    scopus 로고
    • Aldolase positively regulates of the canonical Wnt signaling pathway
    • 24993527 4094682
    • Caspi M et al (2014) Aldolase positively regulates of the canonical Wnt signaling pathway. Mol Cancer 13:164
    • (2014) Mol Cancer , vol.13 , pp. 164
    • Caspi, M.1
  • 150
    • 84928722326 scopus 로고    scopus 로고
    • Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway
    • 25887760 4359783
    • Fu QF et al (2015) Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway. J Hematol Oncol 8(1):22
    • (2015) J Hematol Oncol , vol.8 , Issue.1 , pp. 22
    • Fu, Q.F.1
  • 152
    • 84864875404 scopus 로고    scopus 로고
    • A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo
    • 22689530 1:CAS:528:DC%2BC38XhtFOisL3P
    • Liu Y et al (2012) A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther 11(8):1672-1682
    • (2012) Mol Cancer Ther , vol.11 , Issue.8 , pp. 1672-1682
    • Liu, Y.1
  • 153
    • 79951782239 scopus 로고    scopus 로고
    • Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins
    • 21328458 1:CAS:528:DC%2BC3MXhvFeltbo%3D
    • Zhan T, Digel M, Kuch EM, Stremmel W, Fullekrug J (2011) Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins. J Cell Biochem 112(3):849-859
    • (2011) J Cell Biochem , vol.112 , Issue.3 , pp. 849-859
    • Zhan, T.1    Digel, M.2    Kuch, E.M.3    Stremmel, W.4    Fullekrug, J.5
  • 154
    • 84867447062 scopus 로고    scopus 로고
    • Methyljasmonate displays in vitro and in vivo activity against multiple myeloma cells
    • 22970818 1:CAS:528:DC%2BC38XhsVyks7bO 4414399
    • Klippel S et al (2012) Methyljasmonate displays in vitro and in vivo activity against multiple myeloma cells. Br J Haematol 159(3):340-351
    • (2012) Br J Haematol , vol.159 , Issue.3 , pp. 340-351
    • Klippel, S.1
  • 155
    • 84882239565 scopus 로고    scopus 로고
    • Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer
    • 23674815 1:CAS:528:DC%2BC3sXht1Chur3J 3742633
    • Clem BF et al (2013) Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther 12(8):1461-1470
    • (2013) Mol Cancer Ther , vol.12 , Issue.8 , pp. 1461-1470
    • Clem, B.F.1
  • 156
    • 84908220531 scopus 로고    scopus 로고
    • 2-Deoxy-d-glucose targeting of glucose metabolism in cancer cells as a potential therapy
    • 25218591 1:CAS:528:DC%2BC2cXhsFKqurbJ
    • Zhang D et al (2014) 2-Deoxy-d-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett 355(2):176-183
    • (2014) Cancer Lett , vol.355 , Issue.2 , pp. 176-183
    • Zhang, D.1
  • 157
    • 84894465269 scopus 로고    scopus 로고
    • ATP citrate lyase knockdown impacts cancer stem cells in vitro
    • 23807225 1:CAS:528:DC%2BC3sXhtVykt7bE 3702307
    • Hanai JI, Doro N, Seth P, Sukhatme VP (2013) ATP citrate lyase knockdown impacts cancer stem cells in vitro. Cell Death Dis 4:e696
    • (2013) Cell Death Dis , vol.4 , pp. e696
    • Hanai, J.I.1    Doro, N.2    Seth, P.3    Sukhatme, V.P.4
  • 159
    • 84921473930 scopus 로고    scopus 로고
    • Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase
    • 25513712 1:CAS:528:DC%2BC2cXitFOhu7%2FN 4306520
    • Fako VE, Wu X, Pflug B, Liu JY, Zhang JT (2015) Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase. J Med Chem 58(2):778-784
    • (2015) J Med Chem , vol.58 , Issue.2 , pp. 778-784
    • Fako, V.E.1    Wu, X.2    Pflug, B.3    Liu, J.Y.4    Zhang, J.T.5
  • 160
    • 84927133194 scopus 로고    scopus 로고
    • Targeting mitochondria metabolism for cancer therapy
    • 25517383 1:CAS:528:DC%2BC2cXitFCqsr%2FN 4340667
    • Weinberg SE, Chandel NS (2015) Targeting mitochondria metabolism for cancer therapy. Nat Chem Biol 11(1):9-15
    • (2015) Nat Chem Biol , vol.11 , Issue.1 , pp. 9-15
    • Weinberg, S.E.1    Chandel, N.S.2
  • 161
    • 77957937428 scopus 로고    scopus 로고
    • Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
    • 20832749 1:CAS:528:DC%2BC3cXhtFGht7bO 3078749
    • Wang JB et al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18(3):207-219
    • (2010) Cancer Cell , vol.18 , Issue.3 , pp. 207-219
    • Wang, J.B.1
  • 162
    • 84942849765 scopus 로고    scopus 로고
    • Targeting glutamine metabolism in breast cancer with aminooxyacetate
    • 25813021 1:CAS:528:DC%2BC2MXht1SrsLnI 4696069
    • Korangath P et al (2015) Targeting glutamine metabolism in breast cancer with aminooxyacetate. Clin Cancer Res 21(14):3263-3273
    • (2015) Clin Cancer Res , vol.21 , Issue.14 , pp. 3263-3273
    • Korangath, P.1
  • 163
    • 84930482603 scopus 로고    scopus 로고
    • Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
    • 25693838 1:CAS:528:DC%2BC2MXpslOksb8%3D
    • Wang Q et al (2015) Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development. J Pathol 236(3):278-289
    • (2015) J Pathol , vol.236 , Issue.3 , pp. 278-289
    • Wang, Q.1
  • 164
    • 84861420588 scopus 로고    scopus 로고
    • Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
    • 22628656 1:CAS:528:DC%2BC38Xnt1KgtL8%3D 3526189
    • Jain M et al (2012) Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336(6084):1040-1044
    • (2012) Science , vol.336 , Issue.6084 , pp. 1040-1044
    • Jain, M.1
  • 165
    • 84879555144 scopus 로고    scopus 로고
    • Tumor regression with a combination of drugs interfering with the tumor metabolism: Efficacy of hydroxycitrate, lipoic acid and capsaicin
    • 22797854 1:CAS:528:DC%2BC3sXjsleisbo%3D
    • Schwartz L et al (2013) Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin. Invest New Drugs 31(2):256-264
    • (2013) Invest New Drugs , vol.31 , Issue.2 , pp. 256-264
    • Schwartz, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.