-
2
-
-
84863688356
-
Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer
-
Modesitt SC, Hsu JY, Chowbina SR, Lawrence RT and Hoehn KL: Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer. Int J Gycecol Cancer 22: 732-741, 2012.
-
(2012)
Int J Gycecol Cancer
, vol.22
, pp. 732-741
-
-
Modesitt, S.C.1
Hsu, J.Y.2
Chowbina, S.R.3
Lawrence, R.T.4
Hoehn, K.L.5
-
3
-
-
84863837081
-
Lipid metabolism in cancer
-
Santos CR and Schulze A: Lipid metabolism in cancer. FEBS J 279: 2610-2623, 2012.
-
(2012)
FEBS J
, vol.279
, pp. 2610-2623
-
-
Santos, C.R.1
Schulze, A.2
-
4
-
-
0035515789
-
The molecular mechanism of aging and longevity and the function of sir2 proteins
-
(In Japanese)
-
Imai S: The molecular mechanism of aging and longevity and the function of Sir2 proteins. Nihon Ronen Igakkai Zasshi 38: 735-739, 2001 (In Japanese).
-
(2001)
Nihon Ronen Igakkai Zasshi
, vol.38
, pp. 735-739
-
-
Imai, S.1
-
5
-
-
62449178216
-
The critical role of the class III histone deacetylase SIRT1 in cancer
-
Liu T, Liu PY and Marshall GM: The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Res 69: 1702-1705, 2009
-
(2009)
Cancer Res
, vol.69
, pp. 1702-1705
-
-
Liu, T.1
Liu, P.Y.2
Marshall, G.M.3
-
6
-
-
84892534814
-
Tran scription factor NFκB regulates the expression of the histone deacetylase SIRT1
-
Katto J, Engel N, Abbas W, Herbein G and Mahlknecht U: Tran scription factor NFκB regulates the expression of the histone deacetylase SIRT1. Clin Epigenetics 5: e11, 2013.
-
(2013)
Clin Epigenetics
, vol.5
, pp. e11
-
-
Katto, J.1
Engel, N.2
Abbas, W.3
Herbein, G.4
Mahlknecht, U.5
-
7
-
-
84867380741
-
Janus-faced role of SIRT1 in tumorigenesis
-
Song NY and Surh YJ: Janus-faced role of SIRT1 in tumorigenesis. Ann NY Acad Sci 1271: 10-19, 2012.
-
(2012)
Ann NY Acad Sci
, vol.1271
, pp. 10-19
-
-
Song, N.Y.1
Surh, Y.J.2
-
8
-
-
79955469653
-
Sirtuin 1 in malignant transformation: Friend or foe?
-
Fang Y and Nicholl MB: Sirtuin 1 in malignant transformation: friend or foe? Cancer Lett 306: 10-14, 2011.
-
(2011)
Cancer Lett
, vol.306
, pp. 10-14
-
-
Fang, Y.1
Nicholl, M.B.2
-
9
-
-
58449087372
-
SREBPs: Physiology and pathophysiology of the SREBP family
-
Shimano H: SREBPs: physiology and pathophysiology of the SREBP family. FEBS J 276: 616-621, 2009.
-
(2009)
FEBS J
, vol.276
, pp. 616-621
-
-
Shimano, H.1
-
11
-
-
34748912615
-
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
-
Menendez JA and Lupu R: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7: 763-777, 2007.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 763-777
-
-
Menendez, J.A.1
Lupu, R.2
-
12
-
-
0034715909
-
Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia
-
Li JN, Mahmoud MA, Han WF, Ripple M and Pizer ES: Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia. Exp Cell Res 261: 159-165, 2000.
-
(2000)
Exp Cell Res
, vol.261
, pp. 159-165
-
-
Li, J.N.1
Mahmoud, M.A.2
Han, W.F.3
Ripple, M.4
Pizer, E.S.5
-
13
-
-
0035225094
-
Increased lipogenesis in steroid-responsive cancer cells: Mechanisms of regulation, role in cancer cell biology and perspectives on clinical applications
-
Swinnen JV: Increased lipogenesis in steroid-responsive cancer cells: mechanisms of regulation, role in cancer cell biology and perspectives on clinical applications. Verh K Acad Geneeskd Belg 63: 321-333, 2001.
-
(2001)
Verh K Acad Geneeskd Belg
, vol.63
, pp. 321-333
-
-
Swinnen, J.V.1
-
14
-
-
0037440477
-
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
-
Yang YU, Morin PJ, Han WF, et al: Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp Cell Res 282: 132-137, 2003.
-
(2003)
Exp Cell Res
, vol.282
, pp. 132-137
-
-
Yang, Y.U.1
Morin, P.J.2
Han, W.F.3
-
15
-
-
20444467309
-
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma
-
Yahagi N, Shimano H, Hasegawa K, et al: Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma. Eur J Cancer 41: 1316-1322, 2005.
-
(2005)
Eur J Cancer
, vol.41
, pp. 1316-1322
-
-
Yahagi, N.1
Shimano, H.2
Hasegawa, K.3
-
16
-
-
84862837453
-
Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
-
Li W, Tai Y, Zhou J, et al: Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle 11: 2348-2358, 2012.
-
(2012)
Cell Cycle
, vol.11
, pp. 2348-2358
-
-
Li, W.1
Tai, Y.2
Zhou, J.3
-
17
-
-
84880621589
-
Sterol regulatory element-binding protein 1 is required for ovarian tumor growth
-
Nie LY, Lu QT, Li WH, et al: Sterol regulatory element-binding protein 1 is required for ovarian tumor growth. Oncol Rep 30: 1346-1354, 2013.
-
(2013)
Oncol Rep
, vol.30
, pp. 1346-1354
-
-
Nie, L.Y.1
Lu, Q.T.2
Li, W.H.3
-
18
-
-
80052065433
-
Inhibition of SREBP1 sensitizes cells to death ligands
-
Eberhard Y, Gronda M, Hurren R, et al: Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget 2: 186-196, 2011.
-
(2011)
Oncotarget
, vol.2
, pp. 186-196
-
-
Eberhard, Y.1
Gronda, M.2
Hurren, R.3
-
19
-
-
34547100073
-
SIRT1 is significantly elevated in mouse and human prostate cancer
-
Huffman DM, Grizzle WE, Bamman MM, et al: SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 67: 6612-6618, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 6612-6618
-
-
Huffman, D.M.1
Grizzle, W.E.2
Bamman, M.M.3
-
20
-
-
79958185807
-
Expression and role of SIRT1 in hepatocellular carcinoma
-
Choi HN, Bae JS, Jamiyandorj U, et al: Expression and role of SIRT1 in hepatocellular carcinoma. Oncol Rep 26: 503-510, 2011.
-
(2011)
Oncol Rep
, vol.26
, pp. 503-510
-
-
Choi, H.N.1
Bae, J.S.2
Jamiyandorj, U.3
-
21
-
-
77957684701
-
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
-
Kalle AM, Mallika A, Badiger J, Alinakhi and Talukdar P and Sachchidanand: Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun 401: 13-19, 2010.
-
(2010)
Biochem Biophys Res Commun
, vol.401
, pp. 13-19
-
-
Kalle, A.M.1
Mallika, A.2
Badiger, J.3
Alinakhi4
Talukdar, P.5
Sachchidanand6
-
22
-
-
67650348173
-
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma
-
Cha EJ, Noh SJ, Kwon KS, et al: Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 15: 4453-4459, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4453-4459
-
-
Cha, E.J.1
Noh, S.J.2
Kwon, K.S.3
-
23
-
-
80052600926
-
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
-
Zhao G, Cui J, Zhang JG, et al: SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. Gene Ther 18: 920-928, 2011.
-
(2011)
Gene Ther
, vol.18
, pp. 920-928
-
-
Zhao, G.1
Cui, J.2
Zhang, J.G.3
-
24
-
-
84855187981
-
Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer du145 cells
-
Nakane K, Fujita Y, Terazawa R, et al: Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer Du145 cells. Int J Urol 19: 71-79, 2012.
-
(2012)
Int J Urol
, vol.19
, pp. 71-79
-
-
Nakane, K.1
Fujita, Y.2
Terazawa, R.3
-
25
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein R, Blander G, Michan S, et al: The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3: e2020, 2008.
-
(2008)
PLoS One
, vol.3
-
-
Firestein, R.1
Blander, G.2
Michan, S.3
-
26
-
-
84878721346
-
Altered expression of SIRT gene family in head and neck squamous cell carcinoma
-
Lai CC, Lin PM, Lin SF, et al: Altered expression of SIRT gene family in head and neck squamous cell carcinoma. Tumour Biol 34: 1847-1854, 2013.
-
(2013)
Tumour Biol
, vol.34
, pp. 1847-1854
-
-
Lai, C.C.1
Lin, P.M.2
Lin, S.F.3
-
27
-
-
0012249041
-
Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
-
Medes G, Thomas A and Weinhouse S: Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res 13: 27-29, 1953.
-
(1953)
Cancer Res
, vol.13
, pp. 27-29
-
-
Medes, G.1
Thomas, A.2
Weinhouse, S.3
-
28
-
-
85027938576
-
SIRT1, metabolism and cancer
-
Knight JR and Milner J: SIRT1, metabolism and cancer. Curr Opin Oncol 24: 68-75, 2012.
-
(2012)
Curr Opin Oncol
, vol.24
, pp. 68-75
-
-
Knight, J.R.1
Milner, J.2
-
29
-
-
10044271037
-
SREBP transcription factors: Master regulators of lipid homeostasis
-
Eberlé D, Hegarty B, Bossard P, Ferré P and Foufelle F: SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86: 839-848, 2004.
-
(2004)
Biochimie
, vol.86
, pp. 839-848
-
-
Eberlé, D.1
Hegarty, B.2
Bossard, P.3
Ferré, P.4
Foufelle, F.5
-
30
-
-
23844495174
-
Hyperphosphorylation regulates the activity of SREBP1 during mitosis
-
Bengoechea-Alonso MT, Punga T and Ericsson J: Hyperphosphorylation regulates the activity of SREBP1 during mitosis. Proc Natl Acad Sci USA 102: 11681-11686, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 11681-11686
-
-
Bengoechea-Alonso, M.T.1
Punga, T.2
Ericsson, J.3
-
31
-
-
77958595135
-
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
-
Ponugoti B, Kim DH, Xiao Z, et al: SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem 285: 33959-33970, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 33959-33970
-
-
Ponugoti, B.1
Kim, D.H.2
Xiao, Z.3
-
32
-
-
77954488637
-
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
-
Walker AK, Yang F, Jiang K, et al: Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 24: 1403-1417, 2010.
-
(2010)
Genes Dev
, vol.24
, pp. 1403-1417
-
-
Walker, A.K.1
Yang, F.2
Jiang, K.3
-
33
-
-
84866289380
-
Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle
-
Defour A, Dessalle K, Castro Perez A, et al: Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle. PLoS One 7: e43490, 2012.
-
(2012)
PLoS One
, vol.7
-
-
Defour, A.1
Dessalle, K.2
Castro Perez, A.3
-
34
-
-
84862004148
-
FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors sp1 and SREBP-1c
-
Deng X, Zhang W, O-Sullivan I, et al: FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem 287: 20132-20143, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 20132-20143
-
-
Deng, X.1
Zhang, W.2
O-Sullivan, I.3
-
35
-
-
33744515637
-
FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression
-
Zhang W, Patil S, Chauhan B, et al: FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem 281: 10105-10117, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 10105-10117
-
-
Zhang, W.1
Patil, S.2
Chauhan, B.3
-
36
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, Divecha N, Lemieux M, et al: Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563, 2004.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
-
37
-
-
16344384026
-
Suppression of FOXO1 activity by FhL2 through SIRT1-mediated deacetylation
-
Yang Y, Hou H, Haller EM, Nicosia SV and Bai W: Suppression of FOXO1 activity by FhL2 through SIRT1-mediated deacetylation. EmBO J 24: 1021-1032, 2005.
-
(2005)
EmBO J
, vol.24
, pp. 1021-1032
-
-
Yang, Y.1
Hou, H.2
Haller, E.M.3
Nicosia, S.V.4
Bai, W.5
-
38
-
-
84870535749
-
The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1
-
Frampton G, Ueno Y, Quinn M, et al: The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1. Am J Physiol Gastrointest Liver Physiol 303: G1202-G1211, 2012.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.303
, pp. G1202-G1211
-
-
Frampton, G.1
Ueno, Y.2
Quinn, M.3
|