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Volumn 32, Issue 6, 2014, Pages 2831-2835

SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis

Author keywords

Endometrial cancer; SIRT1; SREBP1

Indexed keywords

MESSENGER RNA; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SIRT1 PROTEIN, HUMAN; SREBF1 PROTEIN, HUMAN;

EID: 84914695549     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3521     Document Type: Article
Times cited : (47)

References (38)
  • 2
    • 84863688356 scopus 로고    scopus 로고
    • Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer
    • Modesitt SC, Hsu JY, Chowbina SR, Lawrence RT and Hoehn KL: Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer. Int J Gycecol Cancer 22: 732-741, 2012.
    • (2012) Int J Gycecol Cancer , vol.22 , pp. 732-741
    • Modesitt, S.C.1    Hsu, J.Y.2    Chowbina, S.R.3    Lawrence, R.T.4    Hoehn, K.L.5
  • 3
    • 84863837081 scopus 로고    scopus 로고
    • Lipid metabolism in cancer
    • Santos CR and Schulze A: Lipid metabolism in cancer. FEBS J 279: 2610-2623, 2012.
    • (2012) FEBS J , vol.279 , pp. 2610-2623
    • Santos, C.R.1    Schulze, A.2
  • 4
    • 0035515789 scopus 로고    scopus 로고
    • The molecular mechanism of aging and longevity and the function of sir2 proteins
    • (In Japanese)
    • Imai S: The molecular mechanism of aging and longevity and the function of Sir2 proteins. Nihon Ronen Igakkai Zasshi 38: 735-739, 2001 (In Japanese).
    • (2001) Nihon Ronen Igakkai Zasshi , vol.38 , pp. 735-739
    • Imai, S.1
  • 5
    • 62449178216 scopus 로고    scopus 로고
    • The critical role of the class III histone deacetylase SIRT1 in cancer
    • Liu T, Liu PY and Marshall GM: The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Res 69: 1702-1705, 2009
    • (2009) Cancer Res , vol.69 , pp. 1702-1705
    • Liu, T.1    Liu, P.Y.2    Marshall, G.M.3
  • 6
    • 84892534814 scopus 로고    scopus 로고
    • Tran scription factor NFκB regulates the expression of the histone deacetylase SIRT1
    • Katto J, Engel N, Abbas W, Herbein G and Mahlknecht U: Tran scription factor NFκB regulates the expression of the histone deacetylase SIRT1. Clin Epigenetics 5: e11, 2013.
    • (2013) Clin Epigenetics , vol.5 , pp. e11
    • Katto, J.1    Engel, N.2    Abbas, W.3    Herbein, G.4    Mahlknecht, U.5
  • 7
    • 84867380741 scopus 로고    scopus 로고
    • Janus-faced role of SIRT1 in tumorigenesis
    • Song NY and Surh YJ: Janus-faced role of SIRT1 in tumorigenesis. Ann NY Acad Sci 1271: 10-19, 2012.
    • (2012) Ann NY Acad Sci , vol.1271 , pp. 10-19
    • Song, N.Y.1    Surh, Y.J.2
  • 8
    • 79955469653 scopus 로고    scopus 로고
    • Sirtuin 1 in malignant transformation: Friend or foe?
    • Fang Y and Nicholl MB: Sirtuin 1 in malignant transformation: friend or foe? Cancer Lett 306: 10-14, 2011.
    • (2011) Cancer Lett , vol.306 , pp. 10-14
    • Fang, Y.1    Nicholl, M.B.2
  • 9
    • 58449087372 scopus 로고    scopus 로고
    • SREBPs: Physiology and pathophysiology of the SREBP family
    • Shimano H: SREBPs: physiology and pathophysiology of the SREBP family. FEBS J 276: 616-621, 2009.
    • (2009) FEBS J , vol.276 , pp. 616-621
    • Shimano, H.1
  • 11
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • Menendez JA and Lupu R: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7: 763-777, 2007.
    • (2007) Nat Rev Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 12
    • 0034715909 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia
    • Li JN, Mahmoud MA, Han WF, Ripple M and Pizer ES: Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia. Exp Cell Res 261: 159-165, 2000.
    • (2000) Exp Cell Res , vol.261 , pp. 159-165
    • Li, J.N.1    Mahmoud, M.A.2    Han, W.F.3    Ripple, M.4    Pizer, E.S.5
  • 13
    • 0035225094 scopus 로고    scopus 로고
    • Increased lipogenesis in steroid-responsive cancer cells: Mechanisms of regulation, role in cancer cell biology and perspectives on clinical applications
    • Swinnen JV: Increased lipogenesis in steroid-responsive cancer cells: mechanisms of regulation, role in cancer cell biology and perspectives on clinical applications. Verh K Acad Geneeskd Belg 63: 321-333, 2001.
    • (2001) Verh K Acad Geneeskd Belg , vol.63 , pp. 321-333
    • Swinnen, J.V.1
  • 14
    • 0037440477 scopus 로고    scopus 로고
    • Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
    • Yang YU, Morin PJ, Han WF, et al: Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp Cell Res 282: 132-137, 2003.
    • (2003) Exp Cell Res , vol.282 , pp. 132-137
    • Yang, Y.U.1    Morin, P.J.2    Han, W.F.3
  • 15
    • 20444467309 scopus 로고    scopus 로고
    • Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma
    • Yahagi N, Shimano H, Hasegawa K, et al: Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma. Eur J Cancer 41: 1316-1322, 2005.
    • (2005) Eur J Cancer , vol.41 , pp. 1316-1322
    • Yahagi, N.1    Shimano, H.2    Hasegawa, K.3
  • 16
    • 84862837453 scopus 로고    scopus 로고
    • Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
    • Li W, Tai Y, Zhou J, et al: Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle 11: 2348-2358, 2012.
    • (2012) Cell Cycle , vol.11 , pp. 2348-2358
    • Li, W.1    Tai, Y.2    Zhou, J.3
  • 17
    • 84880621589 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein 1 is required for ovarian tumor growth
    • Nie LY, Lu QT, Li WH, et al: Sterol regulatory element-binding protein 1 is required for ovarian tumor growth. Oncol Rep 30: 1346-1354, 2013.
    • (2013) Oncol Rep , vol.30 , pp. 1346-1354
    • Nie, L.Y.1    Lu, Q.T.2    Li, W.H.3
  • 18
    • 80052065433 scopus 로고    scopus 로고
    • Inhibition of SREBP1 sensitizes cells to death ligands
    • Eberhard Y, Gronda M, Hurren R, et al: Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget 2: 186-196, 2011.
    • (2011) Oncotarget , vol.2 , pp. 186-196
    • Eberhard, Y.1    Gronda, M.2    Hurren, R.3
  • 19
    • 34547100073 scopus 로고    scopus 로고
    • SIRT1 is significantly elevated in mouse and human prostate cancer
    • Huffman DM, Grizzle WE, Bamman MM, et al: SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 67: 6612-6618, 2007.
    • (2007) Cancer Res , vol.67 , pp. 6612-6618
    • Huffman, D.M.1    Grizzle, W.E.2    Bamman, M.M.3
  • 20
    • 79958185807 scopus 로고    scopus 로고
    • Expression and role of SIRT1 in hepatocellular carcinoma
    • Choi HN, Bae JS, Jamiyandorj U, et al: Expression and role of SIRT1 in hepatocellular carcinoma. Oncol Rep 26: 503-510, 2011.
    • (2011) Oncol Rep , vol.26 , pp. 503-510
    • Choi, H.N.1    Bae, J.S.2    Jamiyandorj, U.3
  • 22
    • 67650348173 scopus 로고    scopus 로고
    • Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma
    • Cha EJ, Noh SJ, Kwon KS, et al: Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 15: 4453-4459, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 4453-4459
    • Cha, E.J.1    Noh, S.J.2    Kwon, K.S.3
  • 23
    • 80052600926 scopus 로고    scopus 로고
    • SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
    • Zhao G, Cui J, Zhang JG, et al: SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. Gene Ther 18: 920-928, 2011.
    • (2011) Gene Ther , vol.18 , pp. 920-928
    • Zhao, G.1    Cui, J.2    Zhang, J.G.3
  • 24
    • 84855187981 scopus 로고    scopus 로고
    • Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer du145 cells
    • Nakane K, Fujita Y, Terazawa R, et al: Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer Du145 cells. Int J Urol 19: 71-79, 2012.
    • (2012) Int J Urol , vol.19 , pp. 71-79
    • Nakane, K.1    Fujita, Y.2    Terazawa, R.3
  • 25
    • 44849096876 scopus 로고    scopus 로고
    • The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    • Firestein R, Blander G, Michan S, et al: The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3: e2020, 2008.
    • (2008) PLoS One , vol.3
    • Firestein, R.1    Blander, G.2    Michan, S.3
  • 26
    • 84878721346 scopus 로고    scopus 로고
    • Altered expression of SIRT gene family in head and neck squamous cell carcinoma
    • Lai CC, Lin PM, Lin SF, et al: Altered expression of SIRT gene family in head and neck squamous cell carcinoma. Tumour Biol 34: 1847-1854, 2013.
    • (2013) Tumour Biol , vol.34 , pp. 1847-1854
    • Lai, C.C.1    Lin, P.M.2    Lin, S.F.3
  • 27
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • Medes G, Thomas A and Weinhouse S: Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res 13: 27-29, 1953.
    • (1953) Cancer Res , vol.13 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 28
    • 85027938576 scopus 로고    scopus 로고
    • SIRT1, metabolism and cancer
    • Knight JR and Milner J: SIRT1, metabolism and cancer. Curr Opin Oncol 24: 68-75, 2012.
    • (2012) Curr Opin Oncol , vol.24 , pp. 68-75
    • Knight, J.R.1    Milner, J.2
  • 29
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: Master regulators of lipid homeostasis
    • Eberlé D, Hegarty B, Bossard P, Ferré P and Foufelle F: SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86: 839-848, 2004.
    • (2004) Biochimie , vol.86 , pp. 839-848
    • Eberlé, D.1    Hegarty, B.2    Bossard, P.3    Ferré, P.4    Foufelle, F.5
  • 30
    • 23844495174 scopus 로고    scopus 로고
    • Hyperphosphorylation regulates the activity of SREBP1 during mitosis
    • Bengoechea-Alonso MT, Punga T and Ericsson J: Hyperphosphorylation regulates the activity of SREBP1 during mitosis. Proc Natl Acad Sci USA 102: 11681-11686, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11681-11686
    • Bengoechea-Alonso, M.T.1    Punga, T.2    Ericsson, J.3
  • 31
    • 77958595135 scopus 로고    scopus 로고
    • SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
    • Ponugoti B, Kim DH, Xiao Z, et al: SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem 285: 33959-33970, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 33959-33970
    • Ponugoti, B.1    Kim, D.H.2    Xiao, Z.3
  • 32
    • 77954488637 scopus 로고    scopus 로고
    • Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
    • Walker AK, Yang F, Jiang K, et al: Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 24: 1403-1417, 2010.
    • (2010) Genes Dev , vol.24 , pp. 1403-1417
    • Walker, A.K.1    Yang, F.2    Jiang, K.3
  • 33
    • 84866289380 scopus 로고    scopus 로고
    • Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle
    • Defour A, Dessalle K, Castro Perez A, et al: Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle. PLoS One 7: e43490, 2012.
    • (2012) PLoS One , vol.7
    • Defour, A.1    Dessalle, K.2    Castro Perez, A.3
  • 34
    • 84862004148 scopus 로고    scopus 로고
    • FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors sp1 and SREBP-1c
    • Deng X, Zhang W, O-Sullivan I, et al: FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem 287: 20132-20143, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 20132-20143
    • Deng, X.1    Zhang, W.2    O-Sullivan, I.3
  • 35
    • 33744515637 scopus 로고    scopus 로고
    • FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression
    • Zhang W, Patil S, Chauhan B, et al: FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem 281: 10105-10117, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 10105-10117
    • Zhang, W.1    Patil, S.2    Chauhan, B.3
  • 36
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta MC, Divecha N, Lemieux M, et al: Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563, 2004.
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3
  • 37
    • 16344384026 scopus 로고    scopus 로고
    • Suppression of FOXO1 activity by FhL2 through SIRT1-mediated deacetylation
    • Yang Y, Hou H, Haller EM, Nicosia SV and Bai W: Suppression of FOXO1 activity by FhL2 through SIRT1-mediated deacetylation. EmBO J 24: 1021-1032, 2005.
    • (2005) EmBO J , vol.24 , pp. 1021-1032
    • Yang, Y.1    Hou, H.2    Haller, E.M.3    Nicosia, S.V.4    Bai, W.5
  • 38
    • 84870535749 scopus 로고    scopus 로고
    • The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1
    • Frampton G, Ueno Y, Quinn M, et al: The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1. Am J Physiol Gastrointest Liver Physiol 303: G1202-G1211, 2012.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , pp. G1202-G1211
    • Frampton, G.1    Ueno, Y.2    Quinn, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.