Frequent amplification of oraov1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ros production

Oncotarget

Volumn 5, Issue 10, 2014, Pages 2962-2973

  Togashi, Yosuke ^a   Arao, Tokuzo ^a   Kato, Hiroaki ^a   Matsumoto, Kazuko ^a   Terashima, Masato ^a   Hayashi, Hidetoshi ^a   de Velasco, Marco A ^a   Fujita, Yoshihiko ^a   Kimura, Hideharu ^a   Yasuda, Takushi ^a   Shiozaki, Hitoshi ^a   Nishio, Kazuto ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Esophageal squamous cell cancer; Oral cancer overexpressed 1; Proline metabolism; Pyrroline 5 carboxylate reductase; Reactive oxygen species

Indexed keywords

MESSENGER RNA; PROLINE; PYRROLINE 5 CARBOXYLATE REDUCTASE; REACTIVE OXYGEN METABOLITE; ORAOV1 PROTEIN, HUMAN; SMALL INTERFERING RNA; TUMOR PROTEIN;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL LINE; CANCER STAGING; CANCER SURVIVAL; CARCINOGENICITY; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL FEATURE; COLONY FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; EMBRYO; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE; GENE AMPLIFICATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ORAOV1 GENE; PHENOTYPE; SURVIVAL TIME; TUMOR LOCALIZATION; TUMOR VOLUME; ANIMAL; CELL MOTION; ESOPHAGUS TUMOR; GENE DOSAGE; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KAPLAN MEIER METHOD; MALE; METABOLISM; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL MOVEMENT; ESOPHAGEAL NEOPLASMS; FEMALE; GENE AMPLIFICATION; GENE DOSAGE; HETEROGRAFTS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KAPLAN-MEIER ESTIMATE; MALE; MICE; MICE, NUDE; NEOPLASM PROTEINS; PHENOTYPE; PROLINE; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84902089967     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1561     Document Type: Article

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