메뉴 건너뛰기




Volumn 21, Issue 14, 2015, Pages 3263-3273

Targeting glutamine metabolism in breast cancer with aminooxyacetate

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINOOXYACETIC ACID; ASPARTIC ACID; BROXURIDINE; CARBOPLATIN; DOXORUBICIN; GLUCOSE REGULATED PROTEIN 78; GLUTAMINE; MYC PROTEIN; PACLITAXEL; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR;

EID: 84942849765     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-1200     Document Type: Article
Times cited : (135)

References (39)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-14.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 3
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 4
    • 79955961530 scopus 로고    scopus 로고
    • Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo
    • Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell 2011; 19: 613-28.
    • (2011) Cancer Cell , vol.19 , pp. 613-628
    • Sheen, J.H.1    Zoncu, R.2    Kim, D.3    Sabatini, D.M.4
  • 5
    • 80051923932 scopus 로고    scopus 로고
    • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    • Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011; 476: 346-50.
    • (2011) Nature , vol.476 , pp. 346-350
    • Possemato, R.1    Marks, K.M.2    Shaul, Y.D.3    Pacold, M.E.4    Kim, D.5    Birsoy, K.6
  • 6
    • 64749116346 scopus 로고    scopus 로고
    • c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009; 458: 762-5.
    • (2009) Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5    Ochi, T.6
  • 7
    • 84872905650 scopus 로고    scopus 로고
    • Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
    • Maddocks OD, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 2013; 493: 542-6.
    • (2013) Nature , vol.493 , pp. 542-546
    • Maddocks, O.D.1    Berkers, C.R.2    Mason, S.M.3    Zheng, L.4    Blyth, K.5    Gottlieb, E.6
  • 8
    • 80053539605 scopus 로고    scopus 로고
    • NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
    • Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, et al. NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol 2011; 13: 1272-9.
    • (2011) Nat Cell Biol , vol.13 , pp. 1272-1279
    • Mauro, C.1    Leow, S.C.2    Anso, E.3    Rocha, S.4    Thotakura, A.K.5    Tornatore, L.6
  • 9
    • 62749199200 scopus 로고    scopus 로고
    • Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the "basal" breast cancer subgroup
    • Alles MC, Gardiner-Garden M, Nott DJ, Wang Y, Foekens JA, Sutherland RL, et al. Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the "basal" breast cancer subgroup. PLoS ONE 2009; 4: e4710.
    • (2009) PLoS ONE , vol.4
    • Alles, M.C.1    Gardiner-Garden, M.2    Nott, D.J.3    Wang, Y.4    Foekens, J.A.5    Sutherland, R.L.6
  • 11
    • 84867424108 scopus 로고    scopus 로고
    • Therapeutic targeting of Myc-reprogrammed cancer cell metabolism
    • Dang CV Therapeutic targeting of Myc-reprogrammed cancer cell metabolism. Cold Spring Harb Symp Quant Biol 2011; 76: 369-74.
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 369-374
    • Dang, C.V.1
  • 12
    • 84869027086 scopus 로고    scopus 로고
    • ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation
    • Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, et al. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell 2012; 22: 631-44.
    • (2012) Cancer Cell , vol.22 , pp. 631-644
    • Qing, G.1    Li, B.2    Vu, A.3    Skuli, N.4    Walton, Z.E.5    Liu, X.6
  • 17
    • 84883387793 scopus 로고    scopus 로고
    • Targeting the unfolded protein response in disease
    • Hetz C, Chevet E, Harding HP. Targeting the unfolded protein response in disease. Nat Rev Drug Discov 2013; 12: 703-19.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 703-719
    • Hetz, C.1    Chevet, E.2    Harding, H.P.3
  • 18
    • 33748789479 scopus 로고    scopus 로고
    • Mediators of endoplasmic reticulum stress-induced apoptosis
    • Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006; 7: 880-5.
    • (2006) EMBO Rep , vol.7 , pp. 880-885
    • Szegezdi, E.1    Logue, S.E.2    Gorman, A.M.3    Samali, A.4
  • 19
    • 0028087602 scopus 로고
    • A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia
    • van de Loosdrecht AA, Beelen RH, Ossenkoppele GJ, Broekhoven MG, Langenhuijsen MM. A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia. J Immunol Methods 1994; 174: 311-20.
    • (1994) J Immunol Methods , vol.174 , pp. 311-320
    • Van De Loosdrecht, A.A.1    Beelen, R.H.2    Ossenkoppele, G.J.3    Broekhoven, M.G.4    Langenhuijsen, M.M.5
  • 21
    • 28244464886 scopus 로고    scopus 로고
    • RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation
    • Glunde K, Raman V, Mori N, Bhujwalla ZM. RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. Cancer Res 2005; 65: 11034-43.
    • (2005) Cancer Res , vol.65 , pp. 11034-11043
    • Glunde, K.1    Raman, V.2    Mori, N.3    Bhujwalla, Z.M.4
  • 22
    • 0029945204 scopus 로고    scopus 로고
    • A novel assaytomeasure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture
    • van Engeland M, Ramaekers FC, Schutte B, Reutelingsperger CP. A novel assaytomeasure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry 1996; 24: 131-9.
    • (1996) Cytometry , vol.24 , pp. 131-139
    • Van Engeland, M.1    Ramaekers, F.C.2    Schutte, B.3    Reutelingsperger, C.P.4
  • 23
    • 0023838811 scopus 로고
    • Double and triple staining methods for studying the proliferative activity ofhuman B and T lymphoid cells
    • Campana D, Coustan-Smith E, Janossy G. Double and triple staining methods for studying the proliferative activity ofhuman B and T lymphoid cells. J Immunol Methods 1988; 107: 79-88.
    • (1988) J Immunol Methods , vol.107 , pp. 79-88
    • Campana, D.1    Coustan-Smith, E.2    Janossy, G.3
  • 24
    • 0035126052 scopus 로고    scopus 로고
    • c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
    • D'Cruz CM, Gunther EJ, Boxer RB, Hartman JL, Sintasath L, Moody SE, et al. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med 2001; 7: 235-9.
    • (2001) Nat Med , vol.7 , pp. 235-239
    • D'Cruz, C.M.1    Gunther, E.J.2    Boxer, R.B.3    Hartman, J.L.4    Sintasath, L.5    Moody, S.E.6
  • 25
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-33.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 27
    • 84861891911 scopus 로고    scopus 로고
    • Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
    • Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, et al. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci U S A 2012; 109: 8983-8.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8983-8988
    • Liu, W.1    Le, A.2    Hancock, C.3    Lane, A.N.4    Dang, C.V.5    Fan, T.W.6
  • 28
    • 76249110471 scopus 로고    scopus 로고
    • Rethinking the Warburg effect with Myc micromanaging glutamine metabolism
    • Dang CV Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 2010; 70: 859-62.
    • (2010) Cancer Res , vol.70 , pp. 859-862
    • Dang, C.V.1
  • 29
    • 21744442902 scopus 로고    scopus 로고
    • Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
    • Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, et al. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 2005; 25: 6225-34.
    • (2005) Mol Cell Biol , vol.25 , pp. 6225-6234
    • Li, F.1    Wang, Y.2    Zeller, K.I.3    Potter, J.J.4    Wonsey, D.R.5    O'Donnell, K.A.6
  • 30
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 2008; 105: 18782-7.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18782-18787
    • Wise, D.R.1    DeBerardinis, R.J.2    Mancuso, A.3    Sayed, N.4    Zhang, X.Y.5    Pfeiffer, H.K.6
  • 31
    • 0030741163 scopus 로고    scopus 로고
    • Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy
    • Kinoshita Y, Yokota A. Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy. NMR Biomed 1997; 10: 2-12.
    • (1997) NMR Biomed , vol.10 , pp. 2-12
    • Kinoshita, Y.1    Yokota, A.2
  • 32
    • 3042562283 scopus 로고    scopus 로고
    • Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
    • Glunde K, Jie C, Bhujwalla ZM. Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res 2004; 64: 4270-6.
    • (2004) Cancer Res , vol.64 , pp. 4270-4276
    • Glunde, K.1    Jie, C.2    Bhujwalla, Z.M.3
  • 33
    • 54949098894 scopus 로고    scopus 로고
    • Nucleoside analogs: Molecular mechanisms signaling cell death
    • Ewald B, Sampath D, Plunkett W. Nucleoside analogs: molecular mechanisms signaling cell death. Oncogene 2008; 27: 6522-37.
    • (2008) Oncogene , vol.27 , pp. 6522-6537
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 34
    • 84901487313 scopus 로고    scopus 로고
    • Targeting metabolic changes in cancer: Novel therapeutic approaches
    • Bobrovnikova-Marjon E, Hurov JB. Targeting metabolic changes in cancer: novel therapeutic approaches. Annu Rev Med 2014; 65: 157-70.
    • (2014) Annu Rev Med , vol.65 , pp. 157-170
    • Bobrovnikova-Marjon, E.1    Hurov, J.B.2
  • 35
  • 36
    • 84884819157 scopus 로고    scopus 로고
    • Autophagosome formation - The role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage
    • Wirth M, Joachim J, Tooze SA. Autophagosome formation - the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage. Semin Cancer Biol 2013; 23: 301-9.
    • (2013) Semin Cancer Biol , vol.23 , pp. 301-309
    • Wirth, M.1    Joachim, J.2    Tooze, S.A.3
  • 37
    • 84880648722 scopus 로고    scopus 로고
    • Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
    • Jordheim LP, Durantel D, Zoulim F, Dumontet C. Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases. Nat Rev Drug Discov 2013; 12: 447-64.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 447-464
    • Jordheim, L.P.1    Durantel, D.2    Zoulim, F.3    Dumontet, C.4
  • 39
    • 33745241069 scopus 로고    scopus 로고
    • Quantification of choline-containing compounds in malignant breast tumors by 1H MR spectroscopy using water as an internal reference at 1.5 T
    • Baik HM, Su MY, Yu H, Mehta R, Nalcioglu O. Quantification of choline-containing compounds in malignant breast tumors by 1H MR spectroscopy using water as an internal reference at 1.5 T. MAGMA 2006; 19: 96-104.
    • (2006) MAGMA , vol.19 , pp. 96-104
    • Baik, H.M.1    Su, M.Y.2    Yu, H.3    Mehta, R.4    Nalcioglu, O.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.