-
1
-
-
84863980291
-
Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. from discovery to disease
-
A.K. Agarwal Lysophospholipid acyltransferases: 1-acylglycerol-3- phosphate O-acyltransferases. From discovery to disease Curr. Opin. Lipidol. 23 2012 290 302
-
(2012)
Curr. Opin. Lipidol.
, vol.23
, pp. 290-302
-
-
Agarwal, A.K.1
-
2
-
-
77954579285
-
Decrease in membrane phospholipid unsaturation induces unfolded protein response
-
H. Ariyama, N. Kono, S. Matsuda, T. Inoue, and H. Arai Decrease in membrane phospholipid unsaturation induces unfolded protein response J. Biol. Chem. 285 2010 22027 22035
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 22027-22035
-
-
Ariyama, H.1
Kono, N.2
Matsuda, S.3
Inoue, T.4
Arai, H.5
-
3
-
-
0347993103
-
Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts
-
C. Bagnato, and R.A. Igal Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts J. Biol. Chem. 278 2003 52203 52211
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52203-52211
-
-
Bagnato, C.1
Igal, R.A.2
-
4
-
-
30544433533
-
ATP citrate lyase is an important component of cell growth and transformation
-
D.E. Bauer, G. Hatzivassiliou, F. Zhao, C. Andreadis, and C.B. Thompson ATP citrate lyase is an important component of cell growth and transformation Oncogene 24 2005 6314 6322
-
(2005)
Oncogene
, vol.24
, pp. 6314-6322
-
-
Bauer, D.E.1
Hatzivassiliou, G.2
Zhao, F.3
Andreadis, C.4
Thompson, C.B.5
-
5
-
-
34548580317
-
Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
-
A. Beckers, S. Organe, L. Timmermans, K. Scheys, A. Peeters, K. Brusselmans, G. Verhoeven, and J.V. Swinnen Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells Cancer Res. 67 2007 8180 8187
-
(2007)
Cancer Res.
, vol.67
, pp. 8180-8187
-
-
Beckers, A.1
Organe, S.2
Timmermans, L.3
Scheys, K.4
Peeters, A.5
Brusselmans, K.6
Verhoeven, G.7
Swinnen, J.V.8
-
7
-
-
23044482013
-
RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells
-
K. Brusselmans, E. De Schrijver, G. Verhoeven, and J.V. Swinnen RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells Cancer Res. 65 2005 6719 6725
-
(2005)
Cancer Res.
, vol.65
, pp. 6719-6725
-
-
Brusselmans, K.1
De Schrijver, E.2
Verhoeven, G.3
Swinnen, J.V.4
-
8
-
-
0034633638
-
Intracellular unesterified arachidonic acid signals apoptosis
-
Y. Cao, A.T. Pearman, G.A. Zimmerman, T.M. McIntyre, and S.M. Prescott Intracellular unesterified arachidonic acid signals apoptosis Proc. Natl. Acad. Sci. USA 97 2000 11280 11285
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11280-11285
-
-
Cao, Y.1
Pearman, A.T.2
Zimmerman, G.A.3
McIntyre, T.M.4
Prescott, S.M.5
-
9
-
-
84870954169
-
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis
-
O. Catalina-Rodriguez, V.K. Kolukula, Y. Tomita, A. Preet, F. Palmieri, A. Wellstein, S. Byers, A.J. Giaccia, E. Glasgow, C. Albanese, and M.L. Avantaggiati The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis Oncotarget 3 2012 1220 1235
-
(2012)
Oncotarget
, vol.3
, pp. 1220-1235
-
-
Catalina-Rodriguez, O.1
Kolukula, V.K.2
Tomita, Y.3
Preet, A.4
Palmieri, F.5
Wellstein, A.6
Byers, S.7
Giaccia, A.J.8
Glasgow, E.9
Albanese, C.10
Avantaggiati, M.L.11
-
10
-
-
33744808464
-
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival
-
V. Chajès, M. Cambot, K. Moreau, G.M. Lenoir, and V. Joulin Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival Cancer Res. 66 2006 5287 5294
-
(2006)
Cancer Res.
, vol.66
, pp. 5287-5294
-
-
Chajès, V.1
Cambot, M.2
Moreau, K.3
Lenoir, G.M.4
Joulin, V.5
-
11
-
-
79960091939
-
Adipose triglyceride lipase contributes to cancer-associated cachexia
-
S.K. Das, S. Eder, S. Schauer, C. Diwoky, H. Temmel, B. Guertl, G. Gorkiewicz, K.P. Tamilarasan, P. Kumari, and M. Trauner Adipose triglyceride lipase contributes to cancer-associated cachexia Science 333 2011 233 238
-
(2011)
Science
, vol.333
, pp. 233-238
-
-
Das, S.K.1
Eder, S.2
Schauer, S.3
Diwoky, C.4
Temmel, H.5
Guertl, B.6
Gorkiewicz, G.7
Tamilarasan, K.P.8
Kumari, P.9
Trauner, M.10
-
12
-
-
0038418257
-
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
-
E. De Schrijver, K. Brusselmans, W. Heyns, G. Verhoeven, and J.V. Swinnen RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells Cancer Res. 63 2003 3799 3804
-
(2003)
Cancer Res.
, vol.63
, pp. 3799-3804
-
-
De Schrijver, E.1
Brusselmans, K.2
Heyns, W.3
Verhoeven, G.4
Swinnen, J.V.5
-
13
-
-
84858414020
-
Cellular metabolism and disease: What do metabolic outliers teach us?
-
R.J. DeBerardinis, and C.B. Thompson Cellular metabolism and disease: what do metabolic outliers teach us? Cell 148 2012 1132 1144
-
(2012)
Cell
, vol.148
, pp. 1132-1144
-
-
Deberardinis, R.J.1
Thompson, C.B.2
-
14
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
R.J. DeBerardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, and C.B. Thompson Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis Proc. Natl. Acad. Sci. USA 104 2007 19345 19350
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19345-19350
-
-
Deberardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
15
-
-
84866312491
-
CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues
-
R.A. DeFilippis, H. Chang, N. Dumont, J.T. Rabban, Y.Y. Chen, G.V. Fontenay, H.K. Berman, M.L. Gauthier, J. Zhao, and D. Hu CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues Cancer Discov 2 2012 826 839
-
(2012)
Cancer Discov
, vol.2
, pp. 826-839
-
-
Defilippis, R.A.1
Chang, H.2
Dumont, N.3
Rabban, J.T.4
Chen, Y.Y.5
Fontenay, G.V.6
Berman, H.K.7
Gauthier, M.L.8
Zhao, J.9
Hu, D.10
-
16
-
-
1542615071
-
Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence
-
S.L. Ettinger, R. Sobel, T.G. Whitmore, M. Akbari, D.R. Bradley, M.E. Gleave, and C.C. Nelson Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence Cancer Res. 64 2004 2212 2221
-
(2004)
Cancer Res.
, vol.64
, pp. 2212-2221
-
-
Ettinger, S.L.1
Sobel, R.2
Whitmore, T.G.3
Akbari, M.4
Bradley, D.R.5
Gleave, M.E.6
Nelson, C.C.7
-
17
-
-
70449769682
-
Lipid droplets finally get a little R-E-S-P-E-C-T
-
R.V. Farese Jr., and T.C. Walther Lipid droplets finally get a little R-E-S-P-E-C-T Cell 139 2009 855 860
-
(2009)
Cell
, vol.139
, pp. 855-860
-
-
Farese, Jr.R.V.1
Walther, T.C.2
-
18
-
-
77953471622
-
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice
-
V. Fritz, Z. Benfodda, G. Rodier, C. Henriquet, F. Iborra, C. Avancès, Y. Allory, A. de la Taille, S. Culine, and H. Blancou Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice Mol. Cancer Ther. 9 2010 1740 1754
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 1740-1754
-
-
Fritz, V.1
Benfodda, Z.2
Rodier, G.3
Henriquet, C.4
Iborra, F.5
Avancès, C.6
Allory, Y.7
De La Taille, A.8
Culine, S.9
Blancou, H.10
-
20
-
-
36348998521
-
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
-
O. Göransson, A. McBride, S.A. Hawley, F.A. Ross, N. Shpiro, M. Foretz, B. Viollet, D.G. Hardie, and K. Sakamoto Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase J. Biol. Chem. 282 2007 32549 32560
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 32549-32560
-
-
Göransson, O.1
McBride, A.2
Hawley, S.A.3
Ross, F.A.4
Shpiro, N.5
Foretz, M.6
Viollet, B.7
Hardie, D.G.8
Sakamoto, K.9
-
21
-
-
84877961669
-
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
-
10.1186/2049-3002-1-3 Published online January 23, 2013
-
B. Griffiths, C.A. Lewis, K. Bensaad, S. Ros, Q. Zhang, E.C. Ferber, S. Konisti, B. Peck, H. Miess, P. East, M. Wakelam, A.L. Harris, and A. Schulze Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth Cancer & Metabolism 1 2013 10.1186/2049-3002-1-3 Published online January 23, 2013
-
(2013)
Cancer & Metabolism
, vol.1
-
-
Griffiths, B.1
Lewis, C.A.2
Bensaad, K.3
Ros, S.4
Zhang, Q.5
Ferber, E.C.6
Konisti, S.7
Peck, B.8
Miess, H.9
East, P.10
Wakelam, M.11
Harris, A.L.12
Schulze, A.13
-
22
-
-
69149097363
-
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
-
D. Guo, I.J. Hildebrandt, R.M. Prins, H. Soto, M.M. Mazzotta, J. Dang, J. Czernin, J.Y. Shyy, A.D. Watson, and M. Phelps The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis Proc. Natl. Acad. Sci. USA 106 2009 12932 12937
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12932-12937
-
-
Guo, D.1
Hildebrandt, I.J.2
Prins, R.M.3
Soto, H.4
Mazzotta, M.M.5
Dang, J.6
Czernin, J.7
Shyy, J.Y.8
Watson, A.D.9
Phelps, M.10
-
23
-
-
77649216053
-
EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
-
D. Guo, R.M. Prins, J. Dang, D. Kuga, A. Iwanami, H. Soto, K.Y. Lin, T.T. Huang, D. Akhavan, and M.B. Hock EGFR signaling through an Akt-SREBP-1- dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy Sci. Signal. 2 2009 ra82
-
(2009)
Sci. Signal.
, vol.2
, pp. 82
-
-
Guo, D.1
Prins, R.M.2
Dang, J.3
Kuga, D.4
Iwanami, A.5
Soto, H.6
Lin, K.Y.7
Huang, T.T.8
Akhavan, D.9
Hock, M.B.10
-
24
-
-
79959370167
-
Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation
-
I. Hapala, E. Marza, and T. Ferreira Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation Biol. Cell 103 2011 271 285
-
(2011)
Biol. Cell
, vol.103
, pp. 271-285
-
-
Hapala, I.1
Marza, E.2
Ferreira, T.3
-
25
-
-
26644441651
-
ATP citrate lyase inhibition can suppress tumor cell growth
-
G. Hatzivassiliou, F. Zhao, D.E. Bauer, C. Andreadis, A.N. Shaw, D. Dhanak, S.R. Hingorani, D.A. Tuveson, and C.B. Thompson ATP citrate lyase inhibition can suppress tumor cell growth Cancer Cell 8 2005 311 321
-
(2005)
Cancer Cell
, vol.8
, pp. 311-321
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
Andreadis, C.4
Shaw, A.N.5
Dhanak, D.6
Hingorani, S.R.7
Tuveson, D.A.8
Thompson, C.B.9
-
26
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
27
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
P.P. Hsu, and D.M. Sabatini Cancer cell metabolism: Warburg and beyond Cell 134 2008 703 707
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
28
-
-
77956290719
-
Stearoyl-CoA desaturase-1: A novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer
-
R.A. Igal Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer Carcinogenesis 31 2010 1509 1515
-
(2010)
Carcinogenesis
, vol.31
, pp. 1509-1515
-
-
Igal, R.A.1
-
29
-
-
69249084006
-
Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells
-
K. Ishimoto, H. Nakamura, K. Tachibana, D. Yamasaki, A. Ota, K. Hirano, T. Tanaka, T. Hamakubo, J. Sakai, T. Kodama, and T. Doi Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells J. Biol. Chem. 284 2009 22195 22205
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 22195-22205
-
-
Ishimoto, K.1
Nakamura, H.2
Tachibana, K.3
Yamasaki, D.4
Ota, A.5
Hirano, K.6
Tanaka, T.7
Hamakubo, T.8
Sakai, J.9
Kodama, T.10
Doi, T.11
-
30
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
S.M. Jeon, N.S. Chandel, and N. Hay AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress Nature 485 2012 661 665
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
31
-
-
79955623949
-
AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation
-
C. Jose, E. Hébert-Chatelain, N. Bellance, A. Larendra, M. Su, K. Nouette-Gaulain, and R. Rossignol AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation Biochim. Biophys. Acta 1807 2011 707 718
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 707-718
-
-
Jose, C.1
Hébert-Chatelain, E.2
Bellance, N.3
Larendra, A.4
Su, M.5
Nouette-Gaulain, K.6
Rossignol, R.7
-
32
-
-
79960181626
-
Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins
-
S. Kamisuki, T. Shirakawa, A. Kugimiya, L. Abu-Elheiga, H.Y. Choo, K. Yamada, H. Shimogawa, S.J. Wakil, and M. Uesugi Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins J. Med. Chem. 54 2011 4923 4927
-
(2011)
J. Med. Chem.
, vol.54
, pp. 4923-4927
-
-
Kamisuki, S.1
Shirakawa, T.2
Kugimiya, A.3
Abu-Elheiga, L.4
Choo, H.Y.5
Yamada, K.6
Shimogawa, H.7
Wakil, S.J.8
Uesugi, M.9
-
33
-
-
0035816590
-
Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones
-
J.H. Kim, T.M. Lewin, and R.A. Coleman Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones J. Biol. Chem. 276 2001 24667 24673
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24667-24673
-
-
Kim, J.H.1
Lewin, T.M.2
Coleman, R.A.3
-
34
-
-
84872169944
-
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
-
M. Knobloch, S.M. Braun, L. Zurkirchen, C. von Schoultz, N. Zamboni, M.J. Araúzo-Bravo, W.J. Kovacs, O. Karalay, U. Suter, and R.A. Machado Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis Nature 493 2013 226 230
-
(2013)
Nature
, vol.493
, pp. 226-230
-
-
Knobloch, M.1
Braun, S.M.2
Zurkirchen, L.3
Von Schoultz, C.4
Zamboni, N.5
Araúzo-Bravo, M.J.6
Kovacs, W.J.7
Karalay, O.8
Suter, U.9
Machado, R.A.10
-
35
-
-
0037226462
-
Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis
-
C. Kumar-Sinha, K.W. Ignatoski, M.E. Lippman, S.P. Ethier, and A.M. Chinnaiyan Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis Cancer Res. 63 2003 132 139
-
(2003)
Cancer Res.
, vol.63
, pp. 132-139
-
-
Kumar-Sinha, C.1
Ignatoski, K.W.2
Lippman, M.E.3
Ethier, S.P.4
Chinnaiyan, A.M.5
-
36
-
-
70450204007
-
An emerging role of mTOR in lipid biosynthesis
-
M. Laplante, and D.M. Sabatini An emerging role of mTOR in lipid biosynthesis Curr. Biol. 19 2009 R1046 R1052
-
(2009)
Curr. Biol.
, vol.19
-
-
Laplante, M.1
Sabatini, D.M.2
-
37
-
-
79953165787
-
Regulation of the SREBP transcription factors by mTORC1
-
C.A. Lewis, B. Griffiths, C.R. Santos, M. Pende, and A. Schulze Regulation of the SREBP transcription factors by mTORC1 Biochem. Soc. Trans. 39 2011 495 499
-
(2011)
Biochem. Soc. Trans.
, vol.39
, pp. 495-499
-
-
Lewis, C.A.1
Griffiths, B.2
Santos, C.R.3
Pende, M.4
Schulze, A.5
-
38
-
-
0037088683
-
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
-
G. Liang, J. Yang, J.D. Horton, R.E. Hammer, J.L. Goldstein, and M.S. Brown Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c J. Biol. Chem. 277 2002 9520 9528
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 9520-9528
-
-
Liang, G.1
Yang, J.2
Horton, J.D.3
Hammer, R.E.4
Goldstein, J.L.5
Brown, M.S.6
-
39
-
-
0034733730
-
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
-
T.M. Loftus, D.E. Jaworsky, G.L. Frehywot, C.A. Townsend, G.V. Ronnett, M.D. Lane, and F.P. Kuhajda Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors Science 288 2000 2379 2381
-
(2000)
Science
, vol.288
, pp. 2379-2381
-
-
Loftus, T.M.1
Jaworsky, D.E.2
Frehywot, G.L.3
Townsend, C.A.4
Ronnett, G.V.5
Lane, M.D.6
Kuhajda, F.P.7
-
40
-
-
33845909566
-
Pharmacological inhibitors of Fatty Acid Synthase (FASN) - Catalyzed endogenous fatty acid biogenesis: A new family of anti-cancer agents?
-
R. Lupu, and J.A. Menendez Pharmacological inhibitors of Fatty Acid Synthase (FASN) - catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr. Pharm. Biotechnol. 7 2006 483 493
-
(2006)
Curr. Pharm. Biotechnol.
, vol.7
, pp. 483-493
-
-
Lupu, R.1
Menendez, J.A.2
-
41
-
-
33748752324
-
Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet
-
D.G. Mashek, L.O. Li, and R.A. Coleman Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet J. Lipid Res. 47 2006 2004 2010
-
(2006)
J. Lipid Res.
, vol.47
, pp. 2004-2010
-
-
Mashek, D.G.1
Li, L.O.2
Coleman, R.A.3
-
42
-
-
20544432048
-
P53-defective tumors with a functional apoptosome-mediated pathway: A new therapeutic target
-
T. Mashima, T. Oh-hara, S. Sato, M. Mochizuki, Y. Sugimoto, K. Yamazaki, J. Hamada, M. Tada, T. Moriuchi, and Y. Ishikawa p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target J. Natl. Cancer Inst. 97 2005 765 777
-
(2005)
J. Natl. Cancer Inst.
, vol.97
, pp. 765-777
-
-
Mashima, T.1
Oh-Hara, T.2
Sato, S.3
Mochizuki, M.4
Sugimoto, Y.5
Yamazaki, K.6
Hamada, J.7
Tada, M.8
Moriuchi, T.9
Ishikawa, Y.10
-
43
-
-
0012249041
-
Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
-
G. Medes, A. Thomas, and S. Weinhouse Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro Cancer Res. 13 1953 27 29
-
(1953)
Cancer Res.
, vol.13
, pp. 27-29
-
-
Medes, G.1
Thomas, A.2
Weinhouse, S.3
-
44
-
-
34748912615
-
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
-
J.A. Menendez, and R. Lupu Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat. Rev. Cancer 7 2007 763 777
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 763-777
-
-
Menendez, J.A.1
Lupu, R.2
-
45
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
C.M. Metallo, P.A. Gameiro, E.L. Bell, K.R. Mattaini, J. Yang, K. Hiller, C.M. Jewell, Z.R. Johnson, D.J. Irvine, and L. Guarente Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature 481 2012 380 384
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
Jewell, C.M.7
Johnson, Z.R.8
Irvine, D.J.9
Guarente, L.10
-
46
-
-
0347753697
-
Peroxisome-proliferator-activated receptors and cancers: Complex stories
-
L. Michalik, B. Desvergne, and W. Wahli Peroxisome-proliferator-activated receptors and cancers: complex stories Nat. Rev. Cancer 4 2004 61 70
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 61-70
-
-
Michalik, L.1
Desvergne, B.2
Wahli, W.3
-
47
-
-
54249161009
-
ATP citrate lyase: Activation and therapeutic implications in non-small cell lung cancer
-
T. Migita, T. Narita, K. Nomura, E. Miyagi, F. Inazuka, M. Matsuura, M. Ushijima, T. Mashima, H. Seimiya, and Y. Satoh ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer Cancer Res. 68 2008 8547 8554
-
(2008)
Cancer Res.
, vol.68
, pp. 8547-8554
-
-
Migita, T.1
Narita, T.2
Nomura, K.3
Miyagi, E.4
Inazuka, F.5
Matsuura, M.6
Ushijima, M.7
Mashima, T.8
Seimiya, H.9
Satoh, Y.10
-
48
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
A.R. Mullen, W.W. Wheaton, E.S. Jin, P.H. Chen, L.B. Sullivan, T. Cheng, Y. Yang, W.M. Linehan, N.S. Chandel, and R.J. DeBerardinis Reductive carboxylation supports growth in tumour cells with defective mitochondria Nature 481 2012 385 388
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
Yang, Y.7
Linehan, W.M.8
Chandel, N.S.9
Deberardinis, R.J.10
-
49
-
-
81255157465
-
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
-
K.M. Nieman, H.A. Kenny, C.V. Penicka, A. Ladanyi, R. Buell-Gutbrod, M.R. Zillhardt, I.L. Romero, M.S. Carey, G.B. Mills, and G.S. Hotamisligil Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth Nat. Med. 17 2011 1498 1503
-
(2011)
Nat. Med.
, vol.17
, pp. 1498-1503
-
-
Nieman, K.M.1
Kenny, H.A.2
Penicka, C.V.3
Ladanyi, A.4
Buell-Gutbrod, R.5
Zillhardt, M.R.6
Romero, I.L.7
Carey, M.S.8
Mills, G.B.9
Hotamisligil, G.S.10
-
50
-
-
73149109062
-
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
-
D.K. Nomura, J.Z. Long, S. Niessen, H.S. Hoover, S.W. Ng, and B.F. Cravatt Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis Cell 140 2010 49 61
-
(2010)
Cell
, vol.140
, pp. 49-61
-
-
Nomura, D.K.1
Long, J.Z.2
Niessen, S.3
Hoover, H.S.4
Ng, S.W.5
Cravatt, B.F.6
-
51
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
B. Ogretmen, and Y.A. Hannun Biologically active sphingolipids in cancer pathogenesis and treatment Nat. Rev. Cancer 4 2004 604 616
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
52
-
-
0021466891
-
Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor
-
M. Ookhtens, R. Kannan, I. Lyon, and N. Baker Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor Am. J. Physiol. 247 1984 R146 R153
-
(1984)
Am. J. Physiol.
, vol.247
-
-
Ookhtens, M.1
Kannan, R.2
Lyon, I.3
Baker, N.4
-
53
-
-
67650088283
-
Biochemical and physiological function of stearoyl-CoA desaturase
-
C.M. Paton, and J.M. Ntambi Biochemical and physiological function of stearoyl-CoA desaturase Am. J. Physiol. Endocrinol. Metab. 297 2009 E28 E37
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
-
-
Paton, C.M.1
Ntambi, J.M.2
-
54
-
-
79961165137
-
MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
T.R. Peterson, S.S. Sengupta, T.E. Harris, A.E. Carmack, S.A. Kang, E. Balderas, D.A. Guertin, K.L. Madden, A.E. Carpenter, B.N. Finck, and D.M. Sabatini mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway Cell 146 2011 408 420
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
Sabatini, D.M.11
-
55
-
-
79955601028
-
Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
-
L.S. Pike, A.L. Smift, N.J. Croteau, D.A. Ferrick, and M. Wu Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells Biochim. Biophys. Acta 1807 2011 726 734
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 726-734
-
-
Pike, L.S.1
Smift, A.L.2
Croteau, N.J.3
Ferrick, D.A.4
Wu, M.5
-
56
-
-
0034650757
-
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
-
E.S. Pizer, J. Thupari, W.F. Han, M.L. Pinn, F.J. Chrest, G.L. Frehywot, C.A. Townsend, and F.P. Kuhajda Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts Cancer Res. 60 2000 213 218
-
(2000)
Cancer Res.
, vol.60
, pp. 213-218
-
-
Pizer, E.S.1
Thupari, J.2
Han, W.F.3
Pinn, M.L.4
Chrest, F.J.5
Frehywot, G.L.6
Townsend, C.A.7
Kuhajda, F.P.8
-
57
-
-
84866322945
-
Investigating metformin for cancer prevention and treatment: The end of the beginning
-
M.N. Pollak Investigating metformin for cancer prevention and treatment: the end of the beginning Cancer Discov 2 2012 778 790
-
(2012)
Cancer Discov
, vol.2
, pp. 778-790
-
-
Pollak, M.N.1
-
58
-
-
84859341928
-
Targeting protein lipidation in disease
-
M.D. Resh Targeting protein lipidation in disease Trends Mol. Med. 18 2012 206 214
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 206-214
-
-
Resh, M.D.1
-
59
-
-
81755173915
-
Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
-
U.V. Roongta, J.G. Pabalan, X. Wang, R.P. Ryseck, J. Fargnoli, B.J. Henley, W.P. Yang, J. Zhu, M.T. Madireddi, and R.M. Lawrence Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy Mol. Cancer Res. 9 2011 1551 1561
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 1551-1561
-
-
Roongta, U.V.1
Pabalan, J.G.2
Wang, X.3
Ryseck, R.P.4
Fargnoli, J.5
Henley, B.J.6
Yang, W.P.7
Zhu, J.8
Madireddi, M.T.9
Lawrence, R.M.10
-
60
-
-
84864767268
-
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose- 2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
-
S. Ros, C.R. Santos, S. Moco, F. Baenke, G. Kelly, M. Howell, N. Zamboni, and A. Schulze Functional metabolic screen identifies 6-phosphofructo-2-kinase/ fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival Cancer Discov 2 2012 328 343
-
(2012)
Cancer Discov
, vol.2
, pp. 328-343
-
-
Ros, S.1
Santos, C.R.2
Moco, S.3
Baenke, F.4
Kelly, G.5
Howell, M.6
Zamboni, N.7
Schulze, A.8
-
61
-
-
74949089659
-
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
-
I. Samudio, R. Harmancey, M. Fiegl, H. Kantarjian, M. Konopleva, B. Korchin, K. Kaluarachchi, W. Bornmann, S. Duvvuri, H. Taegtmeyer, and M. Andreeff Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction J. Clin. Invest. 120 2010 142 156
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 142-156
-
-
Samudio, I.1
Harmancey, R.2
Fiegl, M.3
Kantarjian, H.4
Konopleva, M.5
Korchin, B.6
Kaluarachchi, K.7
Bornmann, W.8
Duvvuri, S.9
Taegtmeyer, H.10
Andreeff, M.11
-
62
-
-
84863837081
-
Lipid metabolism in cancer
-
C.R. Santos, and A. Schulze Lipid metabolism in cancer FEBS J. 279 2012 2610 2623
-
(2012)
FEBS J.
, vol.279
, pp. 2610-2623
-
-
Santos, C.R.1
Schulze, A.2
-
63
-
-
84869009687
-
How cancer metabolism is tuned for proliferation and vulnerable to disruption
-
A. Schulze, and A.L. Harris How cancer metabolism is tuned for proliferation and vulnerable to disruption Nature 491 2012 364 373
-
(2012)
Nature
, vol.491
, pp. 364-373
-
-
Schulze, A.1
Harris, A.L.2
-
64
-
-
84867099976
-
Expanding roles for SREBP in metabolism
-
W. Shao, and P.J. Espenshade Expanding roles for SREBP in metabolism Cell Metab. 16 2012 414 419
-
(2012)
Cell Metab.
, vol.16
, pp. 414-419
-
-
Shao, W.1
Espenshade, P.J.2
-
65
-
-
20144387628
-
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
-
J.V. Swinnen, A. Beckers, K. Brusselmans, S. Organe, J. Segers, L. Timmermans, F. Vanderhoydonc, L. Deboel, R. Derua, and E. Waelkens Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype Cancer Res. 65 2005 2441 2448
-
(2005)
Cancer Res.
, vol.65
, pp. 2441-2448
-
-
Swinnen, J.V.1
Beckers, A.2
Brusselmans, K.3
Organe, S.4
Segers, J.5
Timmermans, L.6
Vanderhoydonc, F.7
Deboel, L.8
Derua, R.9
Waelkens, E.10
-
67
-
-
66849089697
-
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
-
K. Takeuchi, and K. Reue Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis Am. J. Physiol. Endocrinol. Metab. 296 2009 E1195 E1209
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Takeuchi, K.1
Reue, K.2
-
68
-
-
13444306413
-
Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: Identification of a novel variant of isoform 6
-
C.G. Van Horn, J.M. Caviglia, L.O. Li, S. Wang, D.A. Granger, and R.A. Coleman Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6 Biochemistry 44 2005 1635 1642
-
(2005)
Biochemistry
, vol.44
, pp. 1635-1642
-
-
Van Horn, C.G.1
Caviglia, J.M.2
Li, L.O.3
Wang, S.4
Granger, D.A.5
Coleman, R.A.6
-
69
-
-
84857139806
-
Selective liver X receptor modulators (SLiMs): What use in human health?
-
E. Viennois, K. Mouzat, J. Dufour, L. Morel, J.M. Lobaccaro, and S. Baron Selective liver X receptor modulators (SLiMs): what use in human health? Mol. Cell. Endocrinol. 351 2012 129 141
-
(2012)
Mol. Cell. Endocrinol.
, vol.351
, pp. 129-141
-
-
Viennois, E.1
Mouzat, K.2
Dufour, J.3
Morel, L.4
Lobaccaro, J.M.5
Baron, S.6
-
70
-
-
66349099340
-
Fatty acid metabolism: Target for metabolic syndrome
-
S.J. Wakil, and L.A. Abu-Elheiga Fatty acid metabolism: target for metabolic syndrome J. Lipid Res. 50 Suppl 2009 S138 S143
-
(2009)
J. Lipid Res.
, vol.50
, Issue.SUPPL.
-
-
Wakil, S.J.1
Abu-Elheiga, L.A.2
-
71
-
-
12444279265
-
On the origin of cancer cells
-
O. Warburg On the origin of cancer cells Science 123 1956 309 314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
72
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
K.E. Wellen, G. Hatzivassiliou, U.M. Sachdeva, T.V. Bui, J.R. Cross, and C.B. Thompson ATP-citrate lyase links cellular metabolism to histone acetylation Science 324 2009 1076 1080
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
Hatzivassiliou, G.2
Sachdeva, U.M.3
Bui, T.V.4
Cross, J.R.5
Thompson, C.B.6
-
73
-
-
33745113772
-
Beyond peroxisome proliferator-activated receptor gamma signaling: The multi-facets of the antitumor effect of thiazolidinediones
-
J.R. Weng, C.Y. Chen, J.J. Pinzone, M.D. Ringel, and C.S. Chen Beyond peroxisome proliferator-activated receptor gamma signaling: the multi-facets of the antitumor effect of thiazolidinediones Endocr. Relat. Cancer 13 2006 401 413
-
(2006)
Endocr. Relat. Cancer
, vol.13
, pp. 401-413
-
-
Weng, J.R.1
Chen, C.Y.2
Pinzone, J.J.3
Ringel, M.D.4
Chen, C.S.5
-
74
-
-
84877731629
-
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity
-
K.J. Williams, J.P. Argus, Y. Zhu, M.Q. Wilks, B.N. Marbois, A.G. York, Y. Kidani, A.L. Pourzia, D. Akhavan, and D.N. Lisiero An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity Cancer Res. 73 2013 2850 2862
-
(2013)
Cancer Res.
, vol.73
, pp. 2850-2862
-
-
Williams, K.J.1
Argus, J.P.2
Zhu, Y.3
Wilks, M.Q.4
Marbois, B.N.5
York, A.G.6
Kidani, Y.7
Pourzia, A.L.8
Akhavan, D.9
Lisiero, D.N.10
-
75
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
D.R. Wise, R.J. DeBerardinis, A. Mancuso, N. Sayed, X.Y. Zhang, H.K. Pfeiffer, I. Nissim, E. Daikhin, M. Yudkoff, S.B. McMahon, and C.B. Thompson Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction Proc. Natl. Acad. Sci. USA 105 2008 18782 18787
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
Deberardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
Thompson, C.B.11
-
77
-
-
0034735894
-
Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas
-
Y. Yamashita, T. Kumabe, Y.Y. Cho, M. Watanabe, J. Kawagishi, T. Yoshimoto, T. Fujino, M.J. Kang, and T.T. Yamamoto Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas Oncogene 19 2000 5919 5925
-
(2000)
Oncogene
, vol.19
, pp. 5919-5925
-
-
Yamashita, Y.1
Kumabe, T.2
Cho, Y.Y.3
Watanabe, M.4
Kawagishi, J.5
Yoshimoto, T.6
Fujino, T.7
Kang, M.J.8
Yamamoto, T.T.9
-
78
-
-
78751478209
-
Peroxisome proliferator-activated receptor and epithelial ovarian cancer
-
Y. Yokoyama, and H. Mizunuma Peroxisome proliferator-activated receptor and epithelial ovarian cancer Eur. J. Gynaecol. Oncol. 31 2010 612 615
-
(2010)
Eur. J. Gynaecol. Oncol.
, vol.31
, pp. 612-615
-
-
Yokoyama, Y.1
Mizunuma, H.2
-
79
-
-
79956326256
-
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
-
K. Zaugg, Y. Yao, P.T. Reilly, K. Kannan, R. Kiarash, J. Mason, P. Huang, S.K. Sawyer, B. Fuerth, and B. Faubert Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress Genes Dev. 25 2011 1041 1051
-
(2011)
Genes Dev.
, vol.25
, pp. 1041-1051
-
-
Zaugg, K.1
Yao, Y.2
Reilly, P.T.3
Kannan, K.4
Kiarash, R.5
Mason, J.6
Huang, P.7
Sawyer, S.K.8
Fuerth, B.9
Faubert, B.10
-
80
-
-
69249202281
-
Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells
-
W. Zhou, Y. Tu, P.J. Simpson, and F.P. Kuhajda Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells Oncogene 28 2009 2979 2987
-
(2009)
Oncogene
, vol.28
, pp. 2979-2987
-
-
Zhou, W.1
Tu, Y.2
Simpson, P.J.3
Kuhajda, F.P.4
|