Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway

Cancer Science

Volumn 105, Issue 8, 2014, Pages 951-955

  Li, Zhengkun ^a   Li, Xu ^a   Wu, Shouzhen ^a   Xue, Mei ^a   Chen, Wei ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Aerobic glycolysis; Cancer metabolism; LncRNA; UCA1; Warburg effect

Indexed keywords

GLUCOSE; HEXOKINASE; HEXOKINASE 2; LONG UNTRANSLATED RNA; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA 143; ONCOPROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; UROTHELIAL CANCER ASSOCIATED 1 PROTEIN;

AEROBIC METABOLISM; ARTICLE; BLADDER CANCER CELL LINE; CONTROLLED STUDY; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; METABOLIC REGULATION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; UPREGULATION;

AEROBIC GLYCOLYSIS; CANCER METABOLISM; LNCRNA; UCA1; WARBURG EFFECT;

BLOTTING, WESTERN; CELL LINE, TUMOR; GLUCOSE; GLYCOLYSIS; HEXOKINASE; HUMANS; MICRORNAS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES; UP-REGULATION; URINARY BLADDER NEOPLASMS;

EID: 84906538538     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12461     Document Type: Article

References (29)

1. Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006; 18: 598-608.
2. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11: 85-95.
3. Kroemer G, Pouyssegur J. Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell 2008; 13: 472-82.
4. Vander Heiden MG. Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 2011; 10: 671-84.
5. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
6. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell 2009; 136: 629-41.
7. Hu WQ, Alvarez-Dominguez JR, Lodish HF. Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep 2012; 13: 971-83.
8. Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet 2009; 10: 155-9.
9. Gupta RA, Shah N, Wang KC et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464: 1071-6.
10. Guttman M, Donaghey J, Carey BW et al. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 2011; 477: 295-300.
11. Wang F, Li X, Xie XJ, Zhao L, Chen W. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett 2008; 582: 1919-27.
12. Wang XS, Zhang Z, Wang HC et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res 2006; 12: 4851-8.
13. Yang C, Li X, Wang Y, Zhao L, Chen W. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through P13-K dependent pathway in bladder carcinoma cells. Gene 2012; 496: 8-16.
14. Wang Y, Chen W, Yang C et al. Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. Int J Oncol 2012; 41: 276-84.
15. Vander Heiden MG, Cantley LC, Thompson CB. Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-33.
16. Robey RB, Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 2006; 25: 4683-96.
17. Mathupala SP, Ko YH, Pedersen PL. Hexokinase-2 bound to mitochondria: Cancer's stygian link to the "Warburg effect" and a pivotal target for effective therapy. Semin Cancer Biol 2009; 19: 17-24.
18. Sun QA, Chen XX, Ma JH et al. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 2011; 108: 4129-34.
19. Efeyan A, Sabatini DM. mTOR and cancer: many loops in one pathway. Curr Opin Cell Biol 2010; 22: 169-76.
20. Salmena L, Carracedo A. Pandolfi PP. Tenets of PTEN tumor suppression. Cell 2008; 133: 403-14.
21. Jiang S, Zhang LF, Zhang HW et al. A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J 2012; 31: 1985-98.
22. Yokogami K, Wakisaka S, Avruch J, Reeves SA. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol 2000; 10: 47-50.
23. Wen ZL, Zhong Z, Darnell JE. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995; 82: 241-50.
24. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-97.
25. Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell 2009; 136: 586-91.
26. Bensinger SJ, Christofk HR. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol 2012; 23: 352-61.
27. Fang R, Xiao T, Fang ZY et al. MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem 2012; 287: 23227-35.
28. Yang F, Zhang HF, Mei YD, Wu M. Reciprocal regulation of HIF-1 alpha and LincRNA-p21 modulates the Warburg effect. Mol Cell 2014; 53: 88-100.
29. Ellis BC, Graham LD, Molloy PL. CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta 2014; 1843: 372-86.