Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update

World Journal of Gastroenterology

Volumn 21, Issue 12, 2015, Pages 3492-3498

  Yan, Sheng ^a   Yang, Xue Feng ^a   Liu, Hao Lei ^a   Fu, Nian ^a   Ouyang, Yan ^b   Qing, Kai ^b  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Fatty acid; Liver diseases; Long chain acyl CoA synthetase; Metabolic diseases; Pathways; Proliferation

Indexed keywords

LONG CHAIN FATTY ACID COENZYME A LIGASE; LONG CHAIN FATTY ACID COENZYME A LIGASE 1; LONG CHAIN FATTY ACID COENZYME A LIGASE 3; LONG CHAIN FATTY ACID COENZYME A LIGASE 4; LONG CHAIN FATTY ACID COENZYME A LIGASE 5; LONG CHAIN FATTY ACID COENZYME A LIGASE 6; UNCLASSIFIED DRUG; COENZYME A LIGASE; FATTY ACID; ISOENZYME; LONG-CHAIN-FATTY-ACID-COA LIGASE;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; DIABETES MELLITUS; DISEASE CLASSIFICATION; FATTY ACID METABOLISM; FATTY LIVER; HUMAN; LIVER CELL; LIVER DISEASE; METABOLIC DISORDER; NEUROLOGIC DISEASE; NONHUMAN; OBESITY; SEQUENCE HOMOLOGY; TISSUE SPECIFICITY; ANIMAL; ENZYMOLOGY; LIVER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; COENZYME A LIGASES; FATTY ACIDS; HUMANS; ISOENZYMES; LIVER; LIVER DISEASES; METABOLIC DISEASES; NERVOUS SYSTEM DISEASES; SIGNAL TRANSDUCTION;

EID: 84926348375     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i12.3492     Document Type: Article

References (57)

1. Soupene E, Kuypers FA. Mammalian long-chain acyl-CoA synthetases. Exp Biol Med (Maywood) 2008; 233: 507-521 [PMID: 18375835 DOI: 10.3181/0710-MR-287]
2. Suzuki H, Kawarabayasi Y, Kondo J, Abe T, Nishikawa K, Kimura S, Hashimoto T, Yamamoto T. Structure and regulation of rat longchain acyl-CoA synthetase. J Biol Chem 1990; 265: 8681-8685 [PMID: 2341402]
3. Oikawa E, Iijima H, Suzuki T, Sasano H, Sato H, Kamataki A, Nagura H, Kang MJ, Fujino T, Suzuki H, Yamamoto TT. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes. J Biochem 1998; 124: 679-685 [PMID: 9722683]
4. Kang MJ, Fujino T, Sasano H, Minekura H, Yabuki N, Nagura H, Iijima H, Yamamoto TT. A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis. Proc Natl Acad Sci USA 1997; 94: 2880-2884 [PMID: 9096315]
5. Fujino T, Yamamoto T. Cloning and functional expression of a novel long-chain acyl-CoA synthetase expressed in brain. J Biochem 1992; 111: 197-203 [PMID: 1569043]
6. Wu M, Liu H, Chen W, Fujimoto Y, Liu J. Hepatic expression of long-chain acyl-CoA synthetase 3 is upregulated in hyperlipidemic hamsters. Lipids 2009; 44: 989-998 [PMID: 19756806 DOI: 10.1007/s11745-009-3341-3]
7. Mashek DG, McKenzie MA, Van Horn CG, Coleman RA. Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells. J Biol Chem 2006; 281: 945-950 [PMID: 16263710 DOI: 10.1074/jbc.M507646200]
8. Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA. Liver-specific loss of long chain acyl- CoA synthetase-1 decreases triacylglycerol synthesis and betaoxidation and alters phospholipid fatty acid composition. J Biol Chem 2009; 284: 27816-27826 [PMID: 19648649 DOI: 10.1074/jbc.M109.022467]
9. Li LO, Mashek DG, An J, Doughman SD, Newgard CB, Coleman RA. Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes. J Biol Chem 2006; 281: 37246-37255 [PMID: 17028193 DOI: 10.1074/jbc.M604427200]
10. Ellis JM, Li LO, Wu PC, Koves TR, Ilkayeva O, Stevens RD, Watkins SM, Muoio DM, Coleman RA. Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab 2010; 12: 53-64 [PMID: 20620995 DOI: 10.1016/j.cmet.2010.05.012]
11. Parkes HA, Preston E, Wilks D, Ballesteros M, Carpenter L, Wood L, Kraegen EW, Furler SM, Cooney GJ. Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo. Am J Physiol Endocrinol Metab 2006; 291: E737-E744 [PMID: 16705061 DOI: 10.1152/ajpendo.00112.2006]
12. Wang Z, Yang YX, Wang GD, Bian LH, Yang JM, Men JH, Yao H, Li Y, Lu Ying. Starch digestion and glycemic indexes. Weisheng Yanjiu 2003; 32: 622-624
13. Liu Y, Shi WR, Hong ZF, Zheng HY, Li Y. Effect of free fatty acids on long-chain acyl-CoA synthetase 1 expression level and lipid metabolism in liver cells. Yingyang Xuebao 2013; 35: 232-235, 240
14. Fujino T, Kang MJ, Suzuki H, Iijima H, Yamamoto T. Molecular characterization and expression of rat acyl-CoA synthetase 3. J Biol Chem 1996; 271: 16748-16752 [PMID: 8663269]
15. Murphy DJ. The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res 2001; 40: 325-438 [PMID: 11470496]
16. Fujimoto Y, Itabe H, Kinoshita T, Homma KJ, Onoduka J, Mori M, Yamaguchi S, Makita M, Higashi Y, Yamashita A, Takano T. Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7. J Lipid Res 2007; 48: 1280-1292 [PMID: 17379924 DOI: 10.1194/jlr.M700050-JLR200]
17. Yao H, Ye J. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. J Biol Chem 2008; 283: 849-854 [PMID: 18003621 DOI: 10.1074/jbc.M706160200]
18. Poppelreuther M, Rudolph B, Du C, Großmann R, Becker M, Thiele C, Ehehalt R, Füllekrug J. The N-terminal region of acyl- CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake. J Lipid Res 2012; 53: 888-900 [PMID: 22357706 DOI: 10.1194/jlr.M024562]
19. Schroeder F, Petrescu AD, Huang H, Atshaves BP, McIntosh AL, Martin GG, Hostetler HA, Vespa A, Landrock D, Landrock KK, Payne HR, Kier AB. Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription. Lipids 2008; 43: 1-17 [PMID: 17882463 DOI: 10.1007/s11745-007-3111-z]
20. Mashek DG, Li LO, Coleman RA. Long-chain acyl-CoA synthetases and fatty acid channeling. Future Lipidol 2007; 2: 465-476 [PMID: 20354580 DOI: 10.2217/17460875.2.4.465]
21. Wu X, Li Y, Wang J, Wen X, Marcus MT, Daniels G, Zhang DY, Ye F, Wang LH, Du X, Adams S, Singh B, Zavadil J, Lee P, Monaco ME. Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer. PLoS One 2013; 8: e77060 [PMID: 24155918 DOI: 10.1371/journal.pone.0077060]
22. Maloberti P, Castilla R, Castillo F, Cornejo Maciel F, Mendez CF, Paz C, Podestá EJ. Silencing the expression of mitochondrial acyl- CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormoneinduced steroidogenesis. FEBS J 2005; 272: 1804-1814 [PMID: 15794766 DOI: 10.1111/j.1742-4658.2005.04616.x]
23. Golej DL, Askari B, Kramer F, Barnhart S, Vivekanandan-Giri A, Pennathur S, Bornfeldt KE. Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2 release from human arterial smooth muscle cells. J Lipid Res 2011; 52: 782-793 [PMID: 21242590 DOI: 10.1194/jlr.M013292]
24. Cooke M, Orlando U, Maloberti P, Podestá EJ, Cornejo Maciel F. Tyrosine phosphatase SHP2 regulates the expression of acyl- CoA synthetase ACSL4. J Lipid Res 2011; 52: 1936-1948 [PMID: 21903867 DOI: 10.1194/jlr.M015552]
25. Bu SY, Mashek MT, Mashek DG. Suppression of long chain acyl- CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity. J Biol Chem 2009; 284: 30474-30483 [PMID: 19737935 DOI: 10.1074/jbc.M109.036665]
26. Meller N, Morgan ME, Wong WP, Altemus JB, Sehayek E. Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption. Lipids Health Dis 2013; 12: 88 [PMID: 23767941 DOI: 10.1186/1476-511X-12-88]
27. Bu SY, Mashek DG. Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways. J Lipid Res 2010; 51: 3270-3280 [PMID: 20798351 DOI: 10.1194/jlr.M009407]
28. Marszalek JR, Kitidis C, Dirusso CC, Lodish HF. Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. J Biol Chem 2005; 280: 10817-10826 [PMID: 15655248 DOI: 10.1074/jbc.M411750200]
29. Klaus C, Jeon MK, Kaemmerer E, Gassler N. Intestinal acyl-CoA synthetase 5: activation of long chain fatty acids and behind. World J Gastroenterol 2013; 19: 7369-7373 [PMID: 24259967 DOI: 10.3748/wjg.v19.i42.7369]
30. Schoonjans K, Staels B, Grimaldi P, Auwerx J. Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation. Eur J Biochem 1993; 216: 615-622 [PMID: 8375397]
31. Monaco ME, Creighton CJ, Lee P, Zou X, Topham MK, Stafforini DM. Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity. Transl Oncol 2010; 3: 91-98 [PMID: 20360933]
32. Liang YC, Wu CH, Chu JS, Wang CK, Hung LF, Wang YJ, Ho YS, Chang JG, Lin SY. Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase. World J Gastroenterol 2005; 11: 2557-2563 [PMID: 15849811]
33. Cao Y, Dave KB, Doan TP, Prescott SM. Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. Cancer Res 2001; 61: 8429-8434 [PMID: 11731423]
34. Xu C, Wang G, Hao Y, Zhi J, Zhang L, Chang C. Correlation analysis between gene expression profile of rat liver tissues and high-fat emulsion-induced nonalcoholic fatty liver. Dig Dis Sci 2011; 56: 2299-2308 [PMID: 21327921 DOI: 10.1007/s10620-011-1599-9]
35. Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJ, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, Zentgraf H, Erb P, Alonso A, Autschbach F, Schirmacher P, Knüchel R, Kopitz J. Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. Gastroenterology 2007; 133: 587-598 [PMID: 17681178 DOI: 10.1053/j.gastro.2007.06.005]
36. Catalá-Rabasa A, Ndagire D, Sabio JM, Fedetz M, Matesanz F, Alcina A. High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells. PLoS One 2011; 6: e28591 [PMID: 22163040 DOI: 10.1371/journal.pone.0028591]
37. Li X, Gonzalez O, Shen X, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Tsuchiya K, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JE, Bornfeldt KE. Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment. Arterioscler Thromb Vasc Biol 2013; 33: 232-240 [PMID: 23241406 DOI: 10.1161/ATVBAHA.112.252239]
38. Filip-Ciubotaru F, Foia L, Manciuc C, Grigore C. [PPARs: structure, mechanisms of action and control. Note I]. Rev Med Chir Soc Med Nat Iasi 2011; 115: 477-484 [PMID: 21870744]
39. Xin X, Yan HZ, Li WQ, Yu HY. Studies on PPAR α and γ participating in progression of liver fibrosis by regulating ACSL1. Linchuang Gandanbing Zazhi 2014; 30: 700-702
40. Reinartz A, Ehling J, Leue A, Liedtke C, Schneider U, Kopitz J, Weiss T, Hellerbrand C, Weiskirchen R, Knüchel R, Gassler N. Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis. Biochim Biophys Acta 2010; 1801: 1025-1035 [PMID: 20470896 DOI: 10.1016/ j.bbalip.2010.04.010]
41. Stepanova M, Hossain N, Afendy A, Perry K, Goodman ZD, Baranova A, Younossi Z. Hepatic gene expression of Caucasian and African-American patients with obesity-related non-alcoholic fatty liver disease. Obes Surg 2010; 20: 640-650 [PMID: 20119733 DOI: 10.1007/s11695-010-0078-2]
42. Pyper SR, Viswakarma N, Yu S, Reddy JK. PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. Nucl Recept Signal 2010; 8: e002 [PMID: 20414453 DOI: 10.1621/nrs.08002]
43. Uto H, Nakanishi C, Ido A, Hasuike S, Kusumoto K, Abe H, Numata M, Nagata K, Hayashi K, Tsubouchi H. The peroxisome proliferator-activated receptor-gamma agonist, pioglitazone, inhibits fat accumulation and fibrosis in the livers of rats fed a choline-deficient, l-amino acid-defined diet. Hepatol Res 2005; 32: 235-242 [PMID: 16085455 DOI: 10.1016/j.hepres.2005.05.008]
44. Dong B, Kan CF, Singh AB, Liu J. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. J Lipid Res 2013; 54: 1241-1254 [PMID: 23427282 DOI: 10.1194/jlr.M032599]
45. Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, Defoort C, Lovegrove JA, Drevon CA, Gibney MJ, Blaak EE, Kiec-Wilk B, Karlstrom B, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM. Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. J Lipid Res 2010; 51: 1793-1800 [PMID: 20176858 DOI: 10.1194/jlr.M003046]
46. Moller DE, Kaufman KD. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 2005; 56: 45-62 [PMID: 15660501 DOI: 10.1146/annurev.med.56.082103.104751]
47. Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan- Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KE. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci USA 2012; 109: E715-E724 [PMID: 22308341 DOI: 10.1073/pnas.1111600109]
48. Kim HC, Lee SW, Cho YY, Lim JM, Ryoo ZY, Lee EJ. RNA interference of long-chain acyl-CoA synthetase 6 suppresses the neurite outgrowth of mouse neuroblastoma NB41A3 cells. Mol Med Rep 2009; 2: 669-674 [PMID: 21475884 DOI: 10.3892/mmr-00000155]
49. Soreq H, Seidman S. Acetylcholinesterase - new roles for an old actor. Nat Rev Neurosci 2001; 2: 294-302 [PMID: 11283752 DOI: 10.1038/35067589]
50. Meloni I, Parri V, De Filippis R, Ariani F, Artuso R, Bruttini M, Katzaki E, Longo I, Mari F, Bellan C, Dotti CG, Renieri A. The XLMR gene ACSL4 plays a role in dendritic spine architecture. Neuroscience 2009; 159: 657-669 [PMID: 19166906 DOI: 10.1016/j.neuroscience.2008.11.056]
51. Perera F, Tang WY, Herbstman J, Tang D, Levin L, Miller R, Ho SM. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One 2009; 4: e4488 [PMID: 19221603 DOI: 10.1371/journal.pone.0004488]
52. Yuan XZ, Jin H, Bao YB, Piao MY. Advance of research on polycyclic aromatic hydrocarbons associated with asthma. Yanbing Daxue Yixue Zazhi 2012; 35: 70-74
53. Wang M, Song WL, Cheng Y, Fitzgerald GA. Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease. J Intern Med 2008; 263: 500-505 [PMID: 18410593 DOI: 10.1111/j.1365-2796.2008.01938.x]
54. Mandelbaum M, Kolega J, Dolan JM, Siddiqui AH, Meng H. A critical role for proinflammatory behavior of smooth muscle cells in hemodynamic initiation of intracranial aneurysm. PLoS One 2013; 8: e74357 [PMID: 24023941 DOI: 10.1371/journal. pone.0074357]
55. Cho YY, Kang MJ, Sone H, Suzuki T, Abe M, Igarashi M, Tokunaga T, Ogawa S, Takei YA, Miyazawa T, Sasano H, Fujino T, Yamamoto TT. Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency. Biochem Biophys Res Commun 2001; 284: 993-997 [PMID: 11409893 DOI: 10.1006/bbrc.2001.5065]
56. Piccini M, Vitelli F, Bruttini M, Pober BR, Jonsson JJ, Villanova M, Zollo M, Borsani G, Ballabio A, Renieri A. FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation. Genomics 1998; 47: 350-358 [PMID: 9480748 DOI: 10.1006/ geno.1997.5104]
57. Heimerl S, Moehle C, Zahn A, Boettcher A, Stremmel W, Langmann T, Schmitz G. Alterations in intestinal fatty acid metabolism in inflammatory bowel disease. Biochim Biophys Acta 2006; 1762: 341-350 [PMID: 16439103 DOI: 10.1016/j.bbadis.2005.12.006]