Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

Molecular Cell

Volumn 56, Issue 3, 2014, Pages 414-424

  Yang, Chendong ^a   Ko, Bookyung ^a   Hensley, Christopher T ^a   Jiang, Lei ^a   Wasti, Ajla T ^a,b   Kim, Jiyeon ^a   Sudderth, Jessica ^a   Calvaruso, MariaAntonietta ^a   Lumata, Lloyd ^a   Mitsche, Matthew ^a   Rutter, Jared ^c   Merritt, Matthew E ^a   DeBerardinis, Ralph J ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3 (1 PHENYLINDOL 3 YL)ACRYLIC ACID; ACETYL COENZYME A; ASPARTIC ACID; CARBON 13; CITRIC ACID; FUMARIC ACID; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; LACTIC ACID; MALIC ACID; MONOCARBOXYLATE TRANSPORTER; OXALOACETIC ACID; PALMITIC ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN BCL XL; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; SUCCINIC ACID; TRICARBOXYLIC ACID; ALDEHYDE REDUCTASE; ALPHA-CYANO-4-HYDROXYCINNAMATE; ANTINEOPLASTIC AGENT; CATECHIN; COUMARIC ACID; EPIGALLOCATECHIN GALLATE; GALACTITOL 2-DEHYDROGENASE;

ARTICLE; CARBOXYLATION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CITRIC ACID CYCLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FIBROBLAST; GLIOBLASTOMA; GLIOMA CELL; GLUCOSE OXIDATION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMPAIRED MITOCHONDRIAL PYRUVATE TRANSPORT; MASS SPECTROMETRY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATION; TUMOR GROWTH; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; DRUG SCREENING; LIPID METABOLISM; MALE; METABOLISM; NUDE MOUSE; OXIDATION REDUCTION REACTION; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; TUMOR VOLUME;

ACETYL COENZYME A; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CATECHIN; CELL LINE, TUMOR; CELL SURVIVAL; CITRIC ACID; CITRIC ACID CYCLE; COUMARIC ACIDS; GLUCOSE; GLUTAMINE; HUMANS; LIPID METABOLISM; MALE; MICE, NUDE; MITOCHONDRIA; OXIDATION-REDUCTION; PYRUVIC ACID; SUGAR ALCOHOL DEHYDROGENASES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84922468705     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.09.025     Document Type: Article

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