ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway

FEBS Journal

Volumn 282, Issue 2, 2015, Pages 361-371

  Lee, Jong Hyuk ^a   Jang, Hyonchol ^b   Lee, Soon Min ^a   Lee, Ji Eun ^a,d   Choi, Jinmi ^a   Kim, Tae Wan ^a   Cho, Eun Jung ^c   Youn, Hong Duk ^a  

^a Seoul National University   (South Korea)

^b National Cancer Center   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

AMP activated protein kinase (AMPK); ATP citrate lyase (ACLY); p53; senescence; tumor

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; PROTEIN P53; RECOMBINANT PROTEIN; TP53 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CELL AGING; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; HCT116 CELL LINE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PURIFICATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CARCINOGENESIS; CYTOSOL; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; SIGNAL TRANSDUCTION;

ACETYL COENZYME A; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ATP CITRATE (PRO-S)-LYASE; CARCINOGENESIS; CELL AGING; CYTOSOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; NEOPLASMS; RATS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84923269003     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13139     Document Type: Article

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