A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo

Molecular Cancer Therapeutics

Volumn 11, Issue 8, 2012, Pages 1672-1682

  Liu, Yi ^a   Cao, Yanyan ^a   Zhang, Weihe ^a   Bergmeier, Stephen ^a   Qian, Yanrong ^a   Akbar, Huzoor ^a   Colvin, Robert ^a   Ding, Juan ^a   Tong, Lingying ^a   Wu, Shiyong ^a   Hines, Jennifer ^a   Chen, Xiaozhuo ^a  

^a OHIO UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CYCLIN E2; CYCLINE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 1 INHIBITOR; GLYCOLYTIC ENZYME; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; WZB 117;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL DEATH; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ERYTHROCYTE; GLUCOSE TRANSPORT; GLYCOLYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SENESCENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLYCOLYSIS; HUMANS; HYDROXYBENZOATES; MALE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MOLECULAR DOCKING SIMULATION; NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR BURDEN;

EID: 84864875404     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0131     Document Type: Article

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