A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

Molecular and Cellular Biology

Volumn 22, Issue 16, 2002, Pages 5793-5800

  Nikiforov, Mikhail A ^a   Chandriani, Sanjay ^a   O'Connell, Brenda ^a   Petrenko, Oleksi ^a   Kotenko, Iulia ^a   Beavis, Andrew ^a   Sedivy, John M ^a   Cole, Michael D ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLYCINE HYDROXYMETHYLTRANSFERASE;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL METABOLISM; CONTROLLED STUDY; DNA LIBRARY; FIBROBLAST; FOLATE METABOLISM; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE METABOLISM; ONCOGENE C MYB; ONCOGENE C MYC; PHENOTYPE; PRIORITY JOURNAL; RAT;

ANIMALS; CARBON; CELL PHYSIOLOGY; CELL SEPARATION; CELLS, CULTURED; FIBROBLASTS; FLOW CYTOMETRY; GENE LIBRARY; GENES, MYC; GLYCINE HYDROXYMETHYLTRANSFERASE; HUMANS; MITOCHONDRIA; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, MUTANT STRAINS;

ANIMALIA;

EID: 0036316013     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.16.5793-5800.2002     Document Type: Article

References (46)

1. The ornithine decarboxylase gene is a transcriptional target of c-Myc
2. A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts
3. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
4. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter
5. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
6. c-myc null cells misregulate cad and gadd45 but not other proposed c-myc targets
7. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
8. c-Myc target genes involved in cell growth, apoptosis, and metabolism
9. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice
10. Analysis of C-MYC function in normal cells via contitional gene-targeted mutation
11. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation
12. 13C NMR
13. Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization
14. Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene
15. The Myc/Max/Mad network and the transcriptional control of cell behavior
16. Identification of c-myc responsive genes using rat cDNA microarray
17. MARX: An approach to genetics in mammalian cells
18. Identification of CDK4 as a target of c-MYC
19. c-Myc enhances protein synthesis and cell size during B lymphocyte development
20. Drosophila myc regulates cellular growth during development
21. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae
22. In vivo cross-linking and immunoprecipitation for studying dynamic protein: DNA associations in a chromatin environment
23. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
24. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
25. Phenotypes of Myc-deficient rat fibroblasts isolated by targeted homologous recombination
26. The c-Myc cofactor TRRAP recruits the histone acetylase hGCN5
27. 1/S-phase boundary is suppressed by inhibitory c-Myc mutants
28. Genetic dissection of c-myc apoptotic pathways
29. Complementation of Myc-dependent cell proliferation by cDNA expression library screening
30. Myc-enhanced expression of Cull promotes ubiquitin-dependent proteolysis and cell cycle progression
31. Production of high titer helper-free retroviruses by transient transfection
32. The molecular characterization of the fetal stem cell marker AA4
33. The metabolism of serine and glycine in mutant lines of Chinese hamster ovary cells
34. Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk9 fusion gene
35. Control of cell growth by c-Myc in the absence of cell division
36. The transcriptional program of a human B cell line in response to Myc
37. c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
38. Enzymes of serine metabolism in normal and neoplastic rat tissues
39. Liver enzymes of serine metabolism during neonatal development of the rat
40. The genetic organization and protein crystallographic structure of human serine hydroxymethyltransferase
41. Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators
42. Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene
43. Serine hydroxymethyltransferase activity and serine incorporation in leukocytes
44. c-Myc regulates mammalian body size by controlling cell number but not cell size
45. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC
46. Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis