-
1
-
-
84858796367
-
A two-way street: reciprocal regulation of metabolism and signalling
-
Wellen K.E., Thompson C.B. A two-way street: reciprocal regulation of metabolism and signalling. Nat Rev Mol Cell Biol 2012, 13:270-276.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 270-276
-
-
Wellen, K.E.1
Thompson, C.B.2
-
2
-
-
84863534997
-
Metabolic regulation of epigenetics
-
Lu C., Thompson C.B. Metabolic regulation of epigenetics. Cell Metab 2012, 16:9-17.
-
(2012)
Cell Metab
, vol.16
, pp. 9-17
-
-
Lu, C.1
Thompson, C.B.2
-
6
-
-
33846120108
-
The involvement of phosphatidylinositol 3-kinase /akt signaling in high glucose-induced downregulation of glut-1 expression in arpe cells
-
Kim D.I., Lim S.K., Park M.J., Han H.J., Kim G.Y., Park S.H. The involvement of phosphatidylinositol 3-kinase /akt signaling in high glucose-induced downregulation of glut-1 expression in arpe cells. Life Sci 2007, 80:626-632.
-
(2007)
Life Sci
, vol.80
, pp. 626-632
-
-
Kim, D.I.1
Lim, S.K.2
Park, M.J.3
Han, H.J.4
Kim, G.Y.5
Park, S.H.6
-
7
-
-
84882321254
-
Akt phosphorylates hk-ii at thr-473 and increases mitochondrial hk-ii association to protect cardiomyocytes
-
Roberts D.J., Tan-Sah V.P., Smith J.M., Miyamoto S. Akt phosphorylates hk-ii at thr-473 and increases mitochondrial hk-ii association to protect cardiomyocytes. J Biol Chem 2013, 288:23798-23806.
-
(2013)
J Biol Chem
, vol.288
, pp. 23798-23806
-
-
Roberts, D.J.1
Tan-Sah, V.P.2
Smith, J.M.3
Miyamoto, S.4
-
8
-
-
0030748651
-
Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase b and other protein kinases of the insulin signaling cascades
-
Deprez J., Vertommen D., Alessi D.R., Hue L., Rider M.H. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase b and other protein kinases of the insulin signaling cascades. J Biol Chem 1997, 272:17269-17275.
-
(1997)
J Biol Chem
, vol.272
, pp. 17269-17275
-
-
Deprez, J.1
Vertommen, D.2
Alessi, D.R.3
Hue, L.4
Rider, M.H.5
-
9
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by akt is required to inhibit apoptosis in the presence or absence of bax and bak
-
Majewski N., Nogueira V., Bhaskar P., Coy P.E., Skeen J.E., Gottlob K., Chandel N.S., Thompson C.B., Robey R.B., Hay N. Hexokinase-mitochondria interaction mediated by akt is required to inhibit apoptosis in the presence or absence of bax and bak. Mol Cell 2004, 16:819-830.
-
(2004)
Mol Cell
, vol.16
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
Chandel, N.S.7
Thompson, C.B.8
Robey, R.B.9
Hay, N.10
-
10
-
-
0037072780
-
The identification of atp-citrate lyase as a protein kinase b (akt) substrate in primary adipocytes
-
Berwick D.C., Hers I., Heesom K.J., Moule S.K., Tavare J.M. The identification of atp-citrate lyase as a protein kinase b (akt) substrate in primary adipocytes. J Biol Chem 2002, 277:33895-33900.
-
(2002)
J Biol Chem
, vol.277
, pp. 33895-33900
-
-
Berwick, D.C.1
Hers, I.2
Heesom, K.J.3
Moule, S.K.4
Tavare, J.M.5
-
11
-
-
84864858864
-
Atp-citrate lyase: a key player in cancer metabolism
-
Zaidi N., Swinnen J.V., Smans K. Atp-citrate lyase: a key player in cancer metabolism. Cancer Res 2012, 72:3709-3714.
-
(2012)
Cancer Res
, vol.72
, pp. 3709-3714
-
-
Zaidi, N.1
Swinnen, J.V.2
Smans, K.3
-
12
-
-
0347695988
-
Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization
-
Gregory M.A., Qi Y., Hann S.R. Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J Biol Chem 2003, 278:51606-51612.
-
(2003)
J Biol Chem
, vol.278
, pp. 51606-51612
-
-
Gregory, M.A.1
Qi, Y.2
Hann, S.R.3
-
14
-
-
80051866908
-
Oncogenic k-ras decouples glucose and glutamine metabolism to support cancer cell growth
-
Gaglio D., Metallo C.M., Gameiro P.A., Hiller K., Danna L.S., Balestrieri C., Alberghina L., Stephanopoulos G., Chiaradonna F. Oncogenic k-ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol 2011, 7.
-
(2011)
Mol Syst Biol
, vol.7
-
-
Gaglio, D.1
Metallo, C.M.2
Gameiro, P.A.3
Hiller, K.4
Danna, L.S.5
Balestrieri, C.6
Alberghina, L.7
Stephanopoulos, G.8
Chiaradonna, F.9
-
15
-
-
33748305738
-
Ras-dependent carbon metabolism and transformation in mouse fibroblasts
-
Chiaradonna F., Sacco E., Manzoni R., Giorgio M., Vanoni M., Alberghina L. Ras-dependent carbon metabolism and transformation in mouse fibroblasts. Oncogene 2006, 25:5391-5404.
-
(2006)
Oncogene
, vol.25
, pp. 5391-5404
-
-
Chiaradonna, F.1
Sacco, E.2
Manzoni, R.3
Giorgio, M.4
Vanoni, M.5
Alberghina, L.6
-
16
-
-
84860321700
-
Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H., Kimmelman A.C., Lyssiotis C.A., Hua S., Chu G.C., Fletcher-Sananikone E., Locasale J.W., Son J., Zhang H., Coloff J.L., et al. Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012, 149:656-670.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
Locasale, J.W.7
Son, J.8
Zhang, H.9
Coloff, J.L.10
-
17
-
-
84870598190
-
Erk1/2-dependent phosphorylation and nuclear translocation of pkm2 promotes the warburg effect
-
Yang W., Zheng Y., Xia Y., Ji H., Chen X., Guo F., Lyssiotis C.A., Aldape K., Cantley L.C., Lu Z. Erk1/2-dependent phosphorylation and nuclear translocation of pkm2 promotes the warburg effect. Nat Cell Biol 2012, 14:1295-1304.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1295-1304
-
-
Yang, W.1
Zheng, Y.2
Xia, Y.3
Ji, H.4
Chen, X.5
Guo, F.6
Lyssiotis, C.A.7
Aldape, K.8
Cantley, L.C.9
Lu, Z.10
-
18
-
-
84875894714
-
Glutamine supports pancreatic cancer growth through a kras-regulated metabolic pathway
-
Son J., Lyssiotis C.A., Ying H., Wang X., Hua S., Ligorio M., Perera R.M., Ferrone C.R., Mullarky E., Shyh-Chang N., et al. Glutamine supports pancreatic cancer growth through a kras-regulated metabolic pathway. Nature 2013, 496:101-105.
-
(2013)
Nature
, vol.496
, pp. 101-105
-
-
Son, J.1
Lyssiotis, C.A.2
Ying, H.3
Wang, X.4
Hua, S.5
Ligorio, M.6
Perera, R.M.7
Ferrone, C.R.8
Mullarky, E.9
Shyh-Chang, N.10
-
19
-
-
84859778293
-
Mtor signaling in growth control and disease
-
Laplante M., Sabatini D.M. Mtor signaling in growth control and disease. Cell 2012, 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
20
-
-
33646111903
-
Activity of tsc2 is inhibited by akt-mediated phosphorylation and membrane partitioning
-
Cai S.L., Tee A.R., Short J.D., Bergeron J.M., Kim J., Shen J., Guo R., Johnson C.L., Kiguchi K., Walker C.L. Activity of tsc2 is inhibited by akt-mediated phosphorylation and membrane partitioning. J Cell Biol 2006, 173:279-289.
-
(2006)
J Cell Biol
, vol.173
, pp. 279-289
-
-
Cai, S.L.1
Tee, A.R.2
Short, J.D.3
Bergeron, J.M.4
Kim, J.5
Shen, J.6
Guo, R.7
Johnson, C.L.8
Kiguchi, K.9
Walker, C.L.10
-
21
-
-
4544384577
-
Tumor-promoting phorbol esters and activated ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal s6 kinase
-
Roux P.P., Ballif B.A., Anjum R., Gygi S.P., Blenis J. Tumor-promoting phorbol esters and activated ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal s6 kinase. Proc Natl Acad Sci USA 2004, 101:13489-13494.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
22
-
-
44449161481
-
The tsc1-tsc2 complex: a molecular switchboard controlling cell growth
-
Huang J., Manning B.D. The tsc1-tsc2 complex: a molecular switchboard controlling cell growth. Biochem J 2008, 412:179-190.
-
(2008)
Biochem J
, vol.412
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
23
-
-
78650943298
-
Erk1/2 phosphorylate raptor to promote ras-dependent activation of mtor complex 1 (mtorc1)
-
Carriere A., Romeo Y., Acosta-Jaquez H.A., Moreau J., Bonneil E., Thibault P., Fingar D.C., Roux P.P. Erk1/2 phosphorylate raptor to promote ras-dependent activation of mtor complex 1 (mtorc1). J Biol Chem 2011, 286:567-577.
-
(2011)
J Biol Chem
, vol.286
, pp. 567-577
-
-
Carriere, A.1
Romeo, Y.2
Acosta-Jaquez, H.A.3
Moreau, J.4
Bonneil, E.5
Thibault, P.6
Fingar, D.C.7
Roux, P.P.8
-
24
-
-
51049083138
-
Oncogenic mapk signaling stimulates mtorc1 activity by promoting rsk-mediated raptor phosphorylation
-
Carriere A., Cargnello M., Julien L.A., Gao H., Bonneil E., Thibault P., Roux P.P. Oncogenic mapk signaling stimulates mtorc1 activity by promoting rsk-mediated raptor phosphorylation. Curr Biol CB 2008, 18:1269-1277.
-
(2008)
Curr Biol CB
, vol.18
, pp. 1269-1277
-
-
Carriere, A.1
Cargnello, M.2
Julien, L.A.3
Gao, H.4
Bonneil, E.5
Thibault, P.6
Roux, P.P.7
-
25
-
-
79952104568
-
Mtor couples cellular nutrient sensing to organismal metabolic homeostasis
-
Howell J.J., Manning B.D. Mtor couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab: TEM 2011, 22:94-102.
-
(2011)
Trends Endocrinol Metab: TEM
, vol.22
, pp. 94-102
-
-
Howell, J.J.1
Manning, B.D.2
-
26
-
-
84878532557
-
Signal integration by mtorc1 coordinates nutrient input with biosynthetic output
-
Dibble C.C., Manning B.D. Signal integration by mtorc1 coordinates nutrient input with biosynthetic output. Nat Cell Biol 2013, 15:555-564.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 555-564
-
-
Dibble, C.C.1
Manning, B.D.2
-
27
-
-
27744569843
-
Mtor and s6k1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
-
Holz M.K., Ballif B.A., Gygi S.P., Blenis J. Mtor and s6k1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005, 123:569-580.
-
(2005)
Cell
, vol.123
, pp. 569-580
-
-
Holz, M.K.1
Ballif, B.A.2
Gygi, S.P.3
Blenis, J.4
-
28
-
-
84893912480
-
Proteomic analysis of cap-dependent translation identifies larp1 as a key regulator of 5'top mrna translation
-
Tcherkezian J., Cargnello M., Romeo Y., Huttlin E.L., Lavoie G., Gygi S.P., Roux P.P. Proteomic analysis of cap-dependent translation identifies larp1 as a key regulator of 5'top mrna translation. Genes Dev 2014, 28:357-371.
-
(2014)
Genes Dev
, vol.28
, pp. 357-371
-
-
Tcherkezian, J.1
Cargnello, M.2
Romeo, Y.3
Huttlin, E.L.4
Lavoie, G.5
Gygi, S.P.6
Roux, P.P.7
-
29
-
-
67349217986
-
Molecular mechanisms of mtor-mediated translational control
-
Ma X.M., Blenis J. Molecular mechanisms of mtor-mediated translational control. Nat Rev Mol Cell Biol 2009, 10:307-318.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
30
-
-
84906898355
-
Coordinated regulation of protein synthesis and degradation by mtorc1
-
Zhang Y., Nicholatos J., Dreier J.R., Ricoult S.J., Widenmaier S.B., Hotamisligil G.S., Kwiatkowski D.J., Manning B.D. Coordinated regulation of protein synthesis and degradation by mtorc1. Nature 2014, 513(7518):440-443.
-
(2014)
Nature
, vol.513
, Issue.7518
, pp. 440-443
-
-
Zhang, Y.1
Nicholatos, J.2
Dreier, J.R.3
Ricoult, S.J.4
Widenmaier, S.B.5
Hotamisligil, G.S.6
Kwiatkowski, D.J.7
Manning, B.D.8
-
31
-
-
84880566446
-
A growing role for mtor in promoting anabolic metabolism
-
Howell J.J., Ricoult S.J.H., Ben-Sahra I., Manning B.D. A growing role for mtor in promoting anabolic metabolism. Biochem Soc Trans 2013, 41:906-912.
-
(2013)
Biochem Soc Trans
, vol.41
, pp. 906-912
-
-
Howell, J.J.1
Ricoult, S.J.H.2
Ben-Sahra, I.3
Manning, B.D.4
-
32
-
-
79954576972
-
Transcriptional control of cellular metabolism by mtor signaling
-
Yecies J.L., Manning B.D. Transcriptional control of cellular metabolism by mtor signaling. Cancer Res 2011, 71:2815-2820.
-
(2011)
Cancer Res
, vol.71
, pp. 2815-2820
-
-
Yecies, J.L.1
Manning, B.D.2
-
33
-
-
84874995247
-
Stimulation of de novo pyrimidine synthesis by growth signaling through mtor and s6k1
-
Ben-Sahra I., Howell J.J., Asara J.M., Manning B.D. Stimulation of de novo pyrimidine synthesis by growth signaling through mtor and s6k1. Science 2013, 339:1323-1328.
-
(2013)
Science
, vol.339
, pp. 1323-1328
-
-
Ben-Sahra, I.1
Howell, J.J.2
Asara, J.M.3
Manning, B.D.4
-
34
-
-
0032514376
-
Translational induction of the c-myc oncogene via activation of the frap/tor signalling pathway
-
West M.J., Stoneley M., Willis A.E. Translational induction of the c-myc oncogene via activation of the frap/tor signalling pathway. Oncogene 1998, 17:769-780.
-
(1998)
Oncogene
, vol.17
, pp. 769-780
-
-
West, M.J.1
Stoneley, M.2
Willis, A.E.3
-
35
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mtor complex 1
-
Duvel K., Yecies J.L., Menon S., Raman P., Lipovsky A.I., Souza A.L., Triantafellow E., Ma Q.C., Gorski R., Cleaver S., et al. Activation of a metabolic gene regulatory network downstream of mtor complex 1. Mol Cell 2010, 39:171-183.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.C.8
Gorski, R.9
Cleaver, S.10
-
36
-
-
84874961313
-
Quantitative phosphoproteomics reveal mtorc1 activates de novo pyrimidine synthesis
-
Robitaille A.M., Christen S., Shimobayashi M., Cornu M., Fava L.L., Moes S., Prescianotto-Baschong C., Sauer U., Jenoe P., Hall M.N. Quantitative phosphoproteomics reveal mtorc1 activates de novo pyrimidine synthesis. Science 2013, 339:1320-1323.
-
(2013)
Science
, vol.339
, pp. 1320-1323
-
-
Robitaille, A.M.1
Christen, S.2
Shimobayashi, M.3
Cornu, M.4
Fava, L.L.5
Moes, S.6
Prescianotto-Baschong, C.7
Sauer, U.8
Jenoe, P.9
Hall, M.N.10
-
37
-
-
84867540151
-
C-myc and cancer metabolism
-
Miller D.M., Thomas S.D., Islam A., Muench D., Sedoris K. C-myc and cancer metabolism. Clin Cancer Res 2012, 18:5546-5553.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5546-5553
-
-
Miller, D.M.1
Thomas, S.D.2
Islam, A.3
Muench, D.4
Sedoris, K.5
-
38
-
-
77952562382
-
Glucose addiction of tsc null cells is caused by failed mtorc1-dependent balancing of metabolic demand with supply
-
Choo A.Y., Kim S.G., Vander Heiden M.G., Mahoney S.J., Vu H., Yoon S.O., Cantley L.C., Blenis J. Glucose addiction of tsc null cells is caused by failed mtorc1-dependent balancing of metabolic demand with supply. Mol Cell 2010, 38:487-499.
-
(2010)
Mol Cell
, vol.38
, pp. 487-499
-
-
Choo, A.Y.1
Kim, S.G.2
Vander Heiden, M.G.3
Mahoney, S.J.4
Vu, H.5
Yoon, S.O.6
Cantley, L.C.7
Blenis, J.8
-
39
-
-
84908192544
-
The mtorc1/s6k1 pathway regulates glutamine metabolism through the eif4b-dependent control of c-myc translation
-
in press
-
Csibi A., Lee G., Yoon S.-O., Tong H., Ilter D., Elia I., Fendt S.-M., Roberts T.M., Blenis J. The mtorc1/s6k1 pathway regulates glutamine metabolism through the eif4b-dependent control of c-myc translation. Curr Biol 2014, 24(19):2274-2280. in press.
-
(2014)
Curr Biol
, vol.24
, Issue.19
, pp. 2274-2280
-
-
Csibi, A.1
Lee, G.2
Yoon, S.-O.3
Tong, H.4
Ilter, D.5
Elia, I.6
Fendt, S.-M.7
Roberts, T.M.8
Blenis, J.9
-
40
-
-
84877720366
-
The mtorc1 pathway stimulates glutamine metabolism and cell proliferation by repressing sirt4
-
Csibi A., Fendt S.M., Li C., Poulogiannis G., Choo A.Y., Chapski D.J., Jeong S.M., Dempsey J.M., Parkhitko A., Morrison T., et al. The mtorc1 pathway stimulates glutamine metabolism and cell proliferation by repressing sirt4. Cell 2013, 153:840-854.
-
(2013)
Cell
, vol.153
, pp. 840-854
-
-
Csibi, A.1
Fendt, S.M.2
Li, C.3
Poulogiannis, G.4
Choo, A.Y.5
Chapski, D.J.6
Jeong, S.M.7
Dempsey, J.M.8
Parkhitko, A.9
Morrison, T.10
-
41
-
-
10044271037
-
Srebp transcription factors: master regulators of lipid homeostasis
-
Eberle D., Hegarty B., Bossard P., Ferre P., Foufelle F. Srebp transcription factors: master regulators of lipid homeostasis. Biochimie 2004, 86:839-848.
-
(2004)
Biochimie
, vol.86
, pp. 839-848
-
-
Eberle, D.1
Hegarty, B.2
Bossard, P.3
Ferre, P.4
Foufelle, F.5
-
42
-
-
79961165137
-
Mtor complex 1 regulates lipin 1 localization to control the srebp pathway
-
Peterson T.R., Sengupta S.S., Harris T.E., Carmack A.E., Kang S.A., Balderas E., Guertin D.A., Madden K.L., Carpenter A.E., Finck B.N., Sabatini D.M. Mtor complex 1 regulates lipin 1 localization to control the srebp pathway. Cell 2011, 146:408-420.
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
Sabatini, D.M.11
-
43
-
-
84858782079
-
Ampk: a nutrient and energy sensor that maintains energy homeostasis
-
Hardie D.G., Ross F.A., Hawley S.A. Ampk: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012, 13:251-262.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
45
-
-
77949887506
-
Mammalian sirtuins: biological insights and disease relevance
-
Haigis M.C., Sinclair D.A. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 2010, 5:253-295.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
46
-
-
77949817711
-
Ampk and sirt1: a long-standing partnership?
-
Ruderman N.B., Xu X.J., Nelson L., Cacicedo J.M., Saha A.K., Lan F., Ido Y. Ampk and sirt1: a long-standing partnership?. Am J Physiol Endocrinol Metab 2010, 298:E751-E760.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
, pp. E751-E760
-
-
Ruderman, N.B.1
Xu, X.J.2
Nelson, L.3
Cacicedo, J.M.4
Saha, A.K.5
Lan, F.6
Ido, Y.7
-
47
-
-
77249156847
-
Interdependence of ampk and sirt1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Canto C., Jiang L.Q., Deshmukh A.S., Mataki C., Coste A., Lagouge M., Zierath J.R., Auwerx J. Interdependence of ampk and sirt1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab 2010, 11:213-219.
-
(2010)
Cell Metab
, vol.11
, pp. 213-219
-
-
Canto, C.1
Jiang, L.Q.2
Deshmukh, A.S.3
Mataki, C.4
Coste, A.5
Lagouge, M.6
Zierath, J.R.7
Auwerx, J.8
-
48
-
-
67349276169
-
Ampk regulates energy expenditure by modulating nad+ metabolism and sirt1 activity
-
Canto C., Gerhart-Hines Z., Feige J.N., Lagouge M., Noriega L., Milne J.C., Elliott P.J., Puigserver P., Auwerx J. Ampk regulates energy expenditure by modulating nad+ metabolism and sirt1 activity. Nature 2009, 458:1056-1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
49
-
-
64549127790
-
Pgc-1alpha, sirt1 and ampk, an energy sensing network that controls energy expenditure
-
Canto C., Auwerx J. Pgc-1alpha, sirt1 and ampk, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 2009, 20:98-105.
-
(2009)
Curr Opin Lipidol
, vol.20
, pp. 98-105
-
-
Canto, C.1
Auwerx, J.2
-
50
-
-
29244436681
-
Ampk activation increases fatty acid oxidation in skeletal muscle by activating pparalpha and pgc-1
-
Lee W.J., Kim M., Park H.S., Kim H.S., Jeon M.J., Oh K.S., Koh E.H., Won J.C., Kim M.S., Oh G.T., et al. Ampk activation increases fatty acid oxidation in skeletal muscle by activating pparalpha and pgc-1. Biochem Biophys Res Commun 2006, 340:291-295.
-
(2006)
Biochem Biophys Res Commun
, vol.340
, pp. 291-295
-
-
Lee, W.J.1
Kim, M.2
Park, H.S.3
Kim, H.S.4
Jeon, M.J.5
Oh, K.S.6
Koh, E.H.7
Won, J.C.8
Kim, M.S.9
Oh, G.T.10
-
51
-
-
0036864358
-
Regulation of fatty acid synthesis and oxidation by the amp-activated protein kinase
-
Hardie D.G., Pan D.A. Regulation of fatty acid synthesis and oxidation by the amp-activated protein kinase. Biochem Soc Transact 2002, 30(Pt 6):1064-1070.
-
(2002)
Biochem Soc Transact
, vol.30
, pp. 1064-1070
-
-
Hardie, D.G.1
Pan, D.A.2
-
52
-
-
79953755370
-
Ampk phosphorylates and inhibits srebp activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., Park O., Luo Z., Lefai E., Shyy J.Y., et al. Ampk phosphorylates and inhibits srebp activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011, 13:376-388.
-
(2011)
Cell Metab
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
Park, O.7
Luo, Z.8
Lefai, E.9
Shyy, J.Y.10
-
53
-
-
77958595135
-
Sirt1 deacetylates and inhibits srebp-1c activity in regulation of hepatic lipid metabolism
-
Ponugoti B., Kim D.H., Xiao Z., Smith Z., Miao J., Zang M., Wu S.Y., Chiang C.M., Veenstra T.D., Kemper J.K. Sirt1 deacetylates and inhibits srebp-1c activity in regulation of hepatic lipid metabolism. J Biol Chem 2010, 285:33959-33970.
-
(2010)
J Biol Chem
, vol.285
, pp. 33959-33970
-
-
Ponugoti, B.1
Kim, D.H.2
Xiao, Z.3
Smith, Z.4
Miao, J.5
Zang, M.6
Wu, S.Y.7
Chiang, C.M.8
Veenstra, T.D.9
Kemper, J.K.10
-
54
-
-
0034687210
-
Phosphorylation and activation of heart pfk-2 by ampk has a role in the stimulation of glycolysis during ischaemia
-
Marsin A.S., Bertrand L., Rider M.H., Deprez J., Beauloye C., Vincent M.F., Van den Berghe G., Carling D., Hue L. Phosphorylation and activation of heart pfk-2 by ampk has a role in the stimulation of glycolysis during ischaemia. Curr Biol: CB 2000, 10:1247-1255.
-
(2000)
Curr Biol: CB
, vol.10
, pp. 1247-1255
-
-
Marsin, A.S.1
Bertrand, L.2
Rider, M.H.3
Deprez, J.4
Beauloye, C.5
Vincent, M.F.6
Van den Berghe, G.7
Carling, D.8
Hue, L.9
-
55
-
-
0035798668
-
Stimulation of glucose transport by amp-activated protein kinase via activation of p38 mitogen-activated protein kinase
-
Xi X., Han J., Zhang J.Z. Stimulation of glucose transport by amp-activated protein kinase via activation of p38 mitogen-activated protein kinase. J Biol Chem 2001, 276:41029-41034.
-
(2001)
J Biol Chem
, vol.276
, pp. 41029-41034
-
-
Xi, X.1
Han, J.2
Zhang, J.Z.3
-
56
-
-
84875813063
-
Ampk-dependent degradation of txnip upon energy stress leads to enhanced glucose uptake via glut1
-
Wu N., Zheng B., Shaywitz A., Dagon Y., Tower C., Bellinger G., Shen C.H., Wen J., Asara J., McGraw T.E., et al. Ampk-dependent degradation of txnip upon energy stress leads to enhanced glucose uptake via glut1. Mol Cell 2013, 49:1167-1175.
-
(2013)
Mol Cell
, vol.49
, pp. 1167-1175
-
-
Wu, N.1
Zheng, B.2
Shaywitz, A.3
Dagon, Y.4
Tower, C.5
Bellinger, G.6
Shen, C.H.7
Wen, J.8
Asara, J.9
McGraw, T.E.10
-
57
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
-
Lim J.H., Lee Y.M., Chun Y.S., Chen J., Kim J.E., Park J.W. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 2010, 38:864-878.
-
(2010)
Mol Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
Lee, Y.M.2
Chun, Y.S.3
Chen, J.4
Kim, J.E.5
Park, J.W.6
-
58
-
-
84893442805
-
Declining nad(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes A.P., Price N.L., Ling A.J., Moslehi J.J., Montgomery M.K., Rajman L., White J.P., Teodoro J.S., Wrann C.D., Hubbard B.P., et al. Declining nad(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013, 155:1624-1638.
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
Price, N.L.2
Ling, A.J.3
Moslehi, J.J.4
Montgomery, M.K.5
Rajman, L.6
White, J.P.7
Teodoro, J.S.8
Wrann, C.D.9
Hubbard, B.P.10
-
59
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
-
Liu Y., Dentin R., Chen D., Hedrick S., Ravnskjaer K., Schenk S., Milne J., Meyers D.J., Cole P., Yates J., et al. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 2008, 456:269-273.
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
Dentin, R.2
Chen, D.3
Hedrick, S.4
Ravnskjaer, K.5
Schenk, S.6
Milne, J.7
Meyers, D.J.8
Cole, P.9
Yates, J.10
-
60
-
-
77957768686
-
Ampk-dependent repression of hepatic gluconeogenesis via disruption of creb.Crtc2 complex by orphan nuclear receptor small heterodimer partner
-
Lee J.M., Seo W.Y., Song K.H., Chanda D., Kim Y.D., Kim D.K., Lee M.W., Ryu D., Kim Y.H., Noh J.R., et al. Ampk-dependent repression of hepatic gluconeogenesis via disruption of creb.Crtc2 complex by orphan nuclear receptor small heterodimer partner. J Biol Chem 2010, 285:32182-32191.
-
(2010)
J Biol Chem
, vol.285
, pp. 32182-32191
-
-
Lee, J.M.1
Seo, W.Y.2
Song, K.H.3
Chanda, D.4
Kim, Y.D.5
Kim, D.K.6
Lee, M.W.7
Ryu, D.8
Kim, Y.H.9
Noh, J.R.10
-
61
-
-
84860477354
-
Sirt1 is required for ampk activation and the beneficial effects of resveratrol on mitochondrial function
-
Price N.L., Gomes A.P., Ling A.J., Duarte F.V., Martin-Montalvo A., North B.J., Agarwal B., Ye L., Ramadori G., Teodoro J.S., et al. Sirt1 is required for ampk activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 2012, 15:675-690.
-
(2012)
Cell Metab
, vol.15
, pp. 675-690
-
-
Price, N.L.1
Gomes, A.P.2
Ling, A.J.3
Duarte, F.V.4
Martin-Montalvo, A.5
North, B.J.6
Agarwal, B.7
Ye, L.8
Ramadori, G.9
Teodoro, J.S.10
-
62
-
-
79959819034
-
Sirt3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ros production
-
Bell E.L., Emerling B.M., Ricoult S.J., Guarente L. Sirt3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ros production. Oncogene 2011, 30:2986-2996.
-
(2011)
Oncogene
, vol.30
, pp. 2986-2996
-
-
Bell, E.L.1
Emerling, B.M.2
Ricoult, S.J.3
Guarente, L.4
-
63
-
-
79952501323
-
Sirt3 opposes reprogramming of cancer cell metabolism through hif1alpha destabilization
-
Finley L.W., Carracedo A., Lee J., Souza A., Egia A., Zhang J., Teruya-Feldstein J., Moreira P.I., Cardoso S.M., Clish C.B., et al. Sirt3 opposes reprogramming of cancer cell metabolism through hif1alpha destabilization. Cancer Cell 2011, 19:416-428.
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.1
Carracedo, A.2
Lee, J.3
Souza, A.4
Egia, A.5
Zhang, J.6
Teruya-Feldstein, J.7
Moreira, P.I.8
Cardoso, S.M.9
Clish, C.B.10
-
64
-
-
84870874690
-
The histone deacetylase sirt6 is a tumor suppressor that controls cancer metabolism
-
Sebastian C., Zwaans B.M., Silberman D.M., Gymrek M., Goren A., Zhong L., Ram O., Truelove J., Guimaraes A.R., Toiber D., et al. The histone deacetylase sirt6 is a tumor suppressor that controls cancer metabolism. Cell 2012, 151:1185-1199.
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastian, C.1
Zwaans, B.M.2
Silberman, D.M.3
Gymrek, M.4
Goren, A.5
Zhong, L.6
Ram, O.7
Truelove, J.8
Guimaraes, A.R.9
Toiber, D.10
-
65
-
-
84902670910
-
Sirt3 deacetylates atp synthase f1 complex proteins in response to nutrient- and exercise-induced stress
-
Vassilopoulos A., Pennington J.D., Andresson T., Rees D.M., Bosley A.D., Fearnley I.M., Ham A., Flynn C.R., Hill S., Rose K.L., et al. Sirt3 deacetylates atp synthase f1 complex proteins in response to nutrient- and exercise-induced stress. Antioxidants Redox Signal 2014, 21:551-564.
-
(2014)
Antioxidants Redox Signal
, vol.21
, pp. 551-564
-
-
Vassilopoulos, A.1
Pennington, J.D.2
Andresson, T.3
Rees, D.M.4
Bosley, A.D.5
Fearnley, I.M.6
Ham, A.7
Flynn, C.R.8
Hill, S.9
Rose, K.L.10
-
66
-
-
80051716282
-
Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity
-
Finley L.W., Haas W., Desquiret-Dumas V., Wallace D.C., Procaccio V., Gygi S.P., Haigis M.C. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PloS One 2011, 6:e23295.
-
(2011)
PloS One
, vol.6
, pp. e23295
-
-
Finley, L.W.1
Haas, W.2
Desquiret-Dumas, V.3
Wallace, D.C.4
Procaccio, V.5
Gygi, S.P.6
Haigis, M.C.7
-
67
-
-
84886993387
-
Sirt4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation
-
Laurent G., de Boer V.C., Finley L.W., Sweeney M., Lu H., Schug T.T., Cen Y., Jeong S.M., Li X., Sauve A.A., Haigis M.C. Sirt4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation. Mol Cell Biol 2013, 33:4552-4561.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4552-4561
-
-
Laurent, G.1
de Boer, V.C.2
Finley, L.W.3
Sweeney, M.4
Lu, H.5
Schug, T.T.6
Cen, Y.7
Jeong, S.M.8
Li, X.9
Sauve, A.A.10
Haigis, M.C.11
-
68
-
-
84878891625
-
Sirt4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl coa decarboxylase
-
Laurent G., German N.J., Saha A.K., de Boer V.C., Davies M., Koves T.R., Dephoure N., Fischer F., Boanca G., Vaitheesvaran B., et al. Sirt4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl coa decarboxylase. Mol Cell 2013, 50:686-698.
-
(2013)
Mol Cell
, vol.50
, pp. 686-698
-
-
Laurent, G.1
German, N.J.2
Saha, A.K.3
de Boer, V.C.4
Davies, M.5
Koves, T.R.6
Dephoure, N.7
Fischer, F.8
Boanca, G.9
Vaitheesvaran, B.10
-
69
-
-
0345167800
-
Tsc2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., Guan K.L. Tsc2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
70
-
-
42949139481
-
Ampk phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., Shaw R.J. Ampk phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008, 30:214-226.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
71
-
-
84872272443
-
Metabolic stress controls mtorc1 lysosomal localization and dimerization by regulating the ttt-ruvbl1/2 complex
-
Kim S.G., Hoffman G.R., Poulogiannis G., Buel G.R., Jang Y.J., Lee K.W., Kim B.Y., Erikson R.L., Cantley L.C., Choo A.Y., Blenis J. Metabolic stress controls mtorc1 lysosomal localization and dimerization by regulating the ttt-ruvbl1/2 complex. Mol Cell 2013, 49:172-185.
-
(2013)
Mol Cell
, vol.49
, pp. 172-185
-
-
Kim, S.G.1
Hoffman, G.R.2
Poulogiannis, G.3
Buel, G.R.4
Jang, Y.J.5
Lee, K.W.6
Kim, B.Y.7
Erikson, R.L.8
Cantley, L.C.9
Choo, A.Y.10
Blenis, J.11
|