Longevity effect of IGF-1R+/- mutation depends on genetic background-specific receptor activation

Aging Cell

Volumn 13, Issue 1, 2014, Pages 19-28

  Xu, Jie ^a,b   Gontier, Géraldine ^a,b   Chaker, Zayna ^a,c   Lacube, Philippe ^a,b   Dupont, Joëlle ^d,e,f   Holzenberger, Martin ^a,b  

^a HÔPITAL SAINT ANTOINE   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d CEMAGREF   (France)

^e UMR85 PHYSIOLOGIE DE LA REPRODUCTION ET DES COMPORTEMENTS   (France)

^f UNIVERSITÉ DE TOURS   (France)

Author keywords

Gene knockout; Genetic background; IGF I; IRS; Lifespan; Stress resistance

Indexed keywords

GROWTH HORMONE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; GLUCOSE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; IRS2 PROTEIN, MOUSE; PARAQUAT; PHOSPHOTYROSINE; SOMATOMEDIN;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; FEEDBACK SYSTEM; FEMALE; LIFE EXTENSION; LONGEVITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; STRESS; ANIMAL; BIOLOGICAL MODEL; BODY SIZE; C57BL MOUSE; DRUG EFFECTS; GENETICS; HETEROZYGOTE; KNOCKOUT MOUSE; METABOLISM; MUTATION; SIGNAL TRANSDUCTION; TOXICITY;

MUS;

ANIMALS; BODY SIZE; FEMALE; GLUCOSE; HETEROZYGOTE; INSULIN RECEPTOR SUBSTRATE PROTEINS; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUTATION; OXIDATIVE STRESS; PARAQUAT; PHOSPHOTYROSINE; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; SOMATOMEDINS;

EID: 84892530622     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12145     Document Type: Article

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