Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies

Cell Metabolism

Volumn 17, Issue 1, 2013, Pages 101-112

  Stenesen, Drew ^a   Suh, Jae Myoung ^a,b   Seo, Jin ^a   Yu, Kweon ^c   Lee, Kyu Sun ^c   Kim, Jong Seok ^d   Min, Kyung Jin ^d   Graff, Jonathan M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Inha University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLOSUCCINATE SYNTHASE; FAT; MUTANT PROTEIN;

ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DROSOPHILA; GENE EXPRESSION; LIFESPAN; MUSCLE; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; TRANSGENIC ANIMAL; TRANSGENICS;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLOSUCCINATE SYNTHASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CALORIC RESTRICTION; DROSOPHILA; FAT BODY; HETEROZYGOTE; LONGEVITY; MUTATION; RNA INTERFERENCE;

ANIMALIA;

EID: 84872137308     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2012.12.006     Document Type: Article

References (52)

1. M. Antosh, R. Whitaker, A. Kroll, S. Hosier, C. Chang, J. Bauer, L. Cooper, N. Neretti, and S.L. Helfand Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila Cell Cycle 10 2011 904 911
2. J. Apfeld, G. O'Connor, T. McDonagh, P.S. DiStefano, and R. Curtis The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans Genes Dev. 18 2004 3004 3009 (Pubitemid 39658169)
3. M. Artal-Sanz, and N. Tavernarakis Mechanisms of aging and energy metabolism in Caenorhabditis elegans IUBMB Life 60 2008 315 322
4. M. Blüher, B.B. Kahn, and C.R. Kahn Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 2003 572 574 (Pubitemid 36135156)
5. S.J. Broughton, M.D. Piper, T. Ikeya, T.M. Bass, J. Jacobson, Y. Driege, P. Martinez, E. Hafen, D.J. Withers, S.J. Leevers, and L. Partridge Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands Proc. Natl. Acad. Sci. USA 102 2005 3105 3110 (Pubitemid 40299923)
6. D. Carling The AMP-activated protein kinase cascade - a unifying system for energy control Trends Biochem. Sci. 29 2004 18 24 (Pubitemid 38068476)
7. T. Chapman, L.F. Liddle, J.M. Kalb, M.F. Wolfner, and L. Partridge Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products Nature 373 1995 241 244
8. D. Chen, and D.M. McKearin A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell Development 130 2003 1159 1170 (Pubitemid 36395697)
9. E. Cohen, J.F. Paulsson, P. Blinder, T. Burstyn-Cohen, D. Du, G. Estepa, A. Adame, H.M. Pham, M. Holzenberger, and J.W. Kelly Reduced IGF-1 signaling delays age-associated proteotoxicity in mice Cell 139 2009 1157 1169
10. R. Cordts, and L. Partridge Courtship reduces longevity of male Drosophila melanogaster Anim. Behav. 52 1996 269 278
11. R. Curtis, G. O'Connor, and P.S. DiStefano Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways Aging Cell 5 2006 119 126 (Pubitemid 44056503)
12. L. Fontana, L. Partridge, and V.D. Longo Extending healthy life span - from yeast to humans Science 328 2010 321 326
13. E.L. Greer, and A. Brunet Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans Aging Cell 8 2009 113 127
14. Z. Guo, F. Mitchell-Raymundo, H. Yang, Y. Ikeno, J. Nelson, V. Diaz, A. Richardson, and R. Reddick Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice Mech. Ageing Dev. 123 2002 1121 1131 (Pubitemid 34603096)
15. E.L. Greer, D. Dowlatshahi, M.R. Banko, J. Villen, K. Hoang, D. Blanchard, S.P. Gygi, and A. Brunet An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans Curr. Biol. 17 2007 1646 1656 (Pubitemid 47503807)
16. D.G. Hardie Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status Endocrinology 144 2003 5179 5183 (Pubitemid 37476044)
17. D.G. Hardie AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy Nat. Rev. Mol. Cell Biol. 8 2007 774 785 (Pubitemid 47462132)
18. D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, K. Flurkey, N.L. Nadon, J.E. Wilkinson, K. Frenkel, and C.S. Carter Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature 460 2009 392 395
19. R.H. Houtkooper, R.W. Williams, and J. Auwerx Metabolic networks of longevity Cell 142 2010 9 14
20. D.S. Hwangbo, B. Gershman, M.P. Tu, M. Palmer, and M. Tatar Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body Nature 429 2004 562 566 (Pubitemid 38737660)
21. E.C. Johnson, N. Kazgan, C.A. Bretz, L.J. Forsberg, C.E. Hector, R.J. Worthen, R. Onyenwoke, and J.E. Brenman Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila PLoS ONE 5 2010 5
22. B.B. Kahn, T. Alquier, D. Carling, and D.G. Hardie AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism Cell Metab. 1 2005 15 25 (Pubitemid 43960587)
23. Y. Kanfi, S. Naiman, G. Amir, V. Peshti, G. Zinman, L. Nahum, Z. Bar-Joseph, and H.Y. Cohen The sirtuin SIRT6 regulates lifespan in male mice Nature 483 2012 218 221
24. P. Kapahi, B.M. Zid, T. Harper, D. Koslover, V. Sapin, and S. Benzer Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr. Biol. 14 2004 885 890 (Pubitemid 38800910)
25. S.D. Katewa, F. Demontis, M. Kolipinski, A. Hubbard, M.S. Gill, N. Perrimon, S. Melov, and P. Kapahi Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster Cell Metab. 16 2012 97 103
26. J.H. Lee, H. Koh, M. Kim, Y. Kim, S.Y. Lee, R.E. Karess, S.H. Lee, M. Shong, J.M. Kim, J. Kim, and J. Chung Energy-dependent regulation of cell structure by AMP-activated protein kinase Nature 447 2007 1017 1020 (Pubitemid 46975745)
27. S. Libert, J. Zwiener, X. Chu, W. Vanvoorhies, G. Roman, and S.D. Pletcher Regulation of Drosophila life span by olfaction and food-derived odors Science 315 2007 1133 1137 (Pubitemid 46328025)
28. Y.J. Lin, L. Seroude, and S. Benzer Extended life-span and stress resistance in the Drosophila mutant methuselah Science 282 1998 943 946 (Pubitemid 28507527)
29. W. Mair, I. Morantte, A.P. Rodrigues, G. Manning, M. Montminy, R.J. Shaw, and A. Dillin Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB Nature 470 2011 404 408
30. M. Matecic, D.L. Smith, X. Pan, N. Maqani, S. Bekiranov, J.D. Boeke, and J.S. Smith A microarray-based genetic screen for yeast chronological aging factors PLoS Genet. 6 2010 e1000921
31. R.A. Miller, D.E. Harrison, C.M. Astle, J.A. Baur, A.R. Boyd, R. de Cabo, E. Fernandez, K. Flurkey, M.A. Javors, and J.F. Nelson Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice J. Gerontol. A Biol. Sci. Med. Sci. 66 2011 191 201
32. R.K. Minor, J.S. Allard, C.M. Younts, T.M. Ward, and R. de Cabo Dietary interventions to extend life span and health span based on calorie restriction J. Gerontol. A Biol. Sci. Med. Sci. 65 2010 695 703
33. R.K. Minor, J.A. Baur, A.P. Gomes, T.M. Ward, A. Csiszar, E.M. Mercken, K. Abdelmohsen, Y.-K. Shin, C. Canto, and M. Scheibye-Knudsen SRT1720 improves survival and healthspan of obese mice Sci. Rep. 1 2011 10.1038/srep00070
34. D. Omodei, and L. Fontana Calorie restriction and prevention of age-associated chronic disease FEBS Lett. 585 2011 1537 1542
35. T. Osterwalder, K.S. Yoon, B.H. White, and H. Keshishian A conditional tissue-specific transgene expression system using inducible GAL4 Proc. Natl. Acad. Sci. USA 98 2001 12596 12601 (Pubitemid 33019991)
36. D.A. Pan, and D.G. Hardie A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion Biochem. J. 367 2002 179 186 (Pubitemid 35176904)
37. M.D. Piper, and A. Bartke Diet and aging Cell Metab. 8 2008 99 104
38. S.C. Reed, and E.W. Reed Natural Selection in Laboratory Populations of Drosophila. II. Competition Between a White-Eye Gene and Its Wild Type Allele Evolution 4 1950 34 42
39. S.B. Roberts, and I. Rosenberg Nutrition and aging: changes in the regulation of energy metabolism with aging Physiol. Rev. 86 2006 651 667
40. B. Rogina, and S.L. Helfand Sir2 mediates longevity in the fly through a pathway related to calorie restriction Proc. Natl. Acad. Sci. USA 101 2004 15998 16003 (Pubitemid 39507916)
41. R.J. Rolfes Regulation of purine nucleotide biosynthesis: in yeast and beyond Biochem. Soc. Trans. 34 2006 786 790 (Pubitemid 44796421)
42. G. Roman, K. Endo, L. Zong, and R.L. Davis P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster Proc. Natl. Acad. Sci. USA 98 2001 12602 12607 (Pubitemid 33019992)
43. G.M. Rubin, and A.C. Spradling Genetic transformation of Drosophila with transposable element vectors Science 218 1982 348 353 (Pubitemid 12037603)
44. D.A. Sinclair Toward a unified theory of caloric restriction and longevity regulation Mech. Ageing Dev. 126 2005 987 1002 (Pubitemid 41033180)
45. S.R. Spindler Caloric restriction: from soup to nuts Ageing Res. Rev. 9 2010 324 353
46. M.M. Stayton, F.B. Rudolph, and H.J. Fromm Regulation, genetics, and properties of adenylosuccinate synthetase: a review Curr. Top. Cell. Regul. 22 1983 103 141
47. V. Stocchi, L. Cucchiarini, M. Magnani, L. Chiarantini, P. Palma, and G. Crescentini Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells Anal. Biochem. 146 1985 118 124 (Pubitemid 15093059)
48. J.M. Suh, D. Stenesen, J.M. Peters, A. Inoue, A. Cade, and J.M. Graff An RGS-containing sorting nexin controls Drosophila lifespan PLoS ONE 3 2008 e2152
49. E.A. Toth, and T.O. Yeates The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway Structure 8 2000 163 174 (Pubitemid 30097362)
50. M.C. Wang, D. Bohmann, and H. Jasper JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila Dev. Cell 5 2003 811 816 (Pubitemid 37362223)
51. B. Xiao, M.J. Sanders, E. Underwood, R. Heath, F.V. Mayer, D. Carmena, C. Jing, P.A. Walker, J.F. Eccleston, and L.F. Haire Structure of mammalian AMPK and its regulation by ADP Nature 472 2011 230 233
52. B.M. Zid, A.N. Rogers, S.D. Katewa, M.A. Vargas, M.C. Kolipinski, T.A. Lu, S. Benzer, and P. Kapahi 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila Cell 139 2009 149 160