Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 24, 2014, Pages

  De Haes, Wouter ^a   Frooninckx, Lotte ^a   Van Assche, Roel ^a   Smolders, Arne ^b   Depuydt, Geert ^a   Billen, Johan ^a   Braeckman, Bart P ^b   Schoofs, Liliane ^a   Temmerman, Liesbet ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN; MITOCHONDRIAL PROTEIN; PEROXIREDOXIN 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; GENETIC CONSERVATION; LIFE EXPECTANCY; LIFESPAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN UNFOLDING; PROTEOMICS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ACYL-COA DEHYDROGENASE; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HORMESIS; HOT TEMPERATURE; HYDROGEN PEROXIDE; HYPOGLYCEMIC AGENTS; LONGEVITY; METFORMIN; MITOCHONDRIA; MODELS, ANIMAL; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PEROXIREDOXINS; PROTEIN UNFOLDING; PROTEOMICS; REACTIVE OXYGEN SPECIES; ROTENONE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84902603273     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321776111     Document Type: Article

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