Caenorhabditis elegans pathways that surveil and defend mitochondria

Nature

Volumn 508, Issue 7496, 2014, Pages 406-410

  Liu, Ying ^a,b,c   Samuel, Buck S ^a,b   Breen, Peter C ^a,b   Ruvkun, Gary ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Peking University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; MITOCHONDRIAL TOXIN; TOXIN; UNCLASSIFIED DRUG;

GENETIC VARIATION; GROWTH RATE; METABOLISM; MICROBIAL ACTIVITY; MITOCHONDRION; PATHOGENICITY;

ARTICLE; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DETOXIFICATION; GENE; GENE ACTIVITY; GENE DISRUPTION; GENE INACTIVATION; GENE MAPPING; HABITAT; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CERAMIDES; GENOME; HOMEOSTASIS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; METABOLIC DETOXICATION, DRUG; MEVALONIC ACID; MITOCHONDRIA; RNA INTERFERENCE; SERINE C-PALMITOYLTRANSFERASE;

EID: 84898975844     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13204     Document Type: Article

References (24)

1. Melo, J. A. & Ruvkun, G. Inactivation of conserved C. elegans genes engages pathogen-And xenobiotic-Associated defenses. Cell 149, 452-466 (2012
2. Runkel, E. D., Liu, S., Baumeister, R. & Schulze, E. Surveillance-Activated defenses block the ROS-induced mitochondrial unfolded protein response. PLoS Genet. 9, e1003346 (2013
3. Benedetti, C., Haynes, C. M., Yang, Y., Harding, H. P. & Ron, D. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics 174, 229-239 (2006
4. Haynes, C. M., Petrova, K., Benedetti, C., Yang, Y.& Ron, D. ClpPmediates activation of a mitochondrial unfolded protein response in C. elegans. Dev. Cell 13, 467-480 (2007
5. Haynes, C. M., Yang, Y., Blais, S. P., Neubert, T. A. & Ron, D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol. Cell 37, 529-540 (2010
6. Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M. & Haynes, C. M. Mitochondrialimport efficiency ofATFS-1 regulates mitochondrialUPRactivation. Science 337, 587-590 (2012
7. Durieux, J., Wolff, S. & Dillin, A. The cell-non-Autonomous nature of electron transport chain-mediated longevity. Cell 144, 79-91 (2011
8. Pellegrino, M. W., Nargund, A. M. & Haynes, C. M. Signaling the mitochondrial unfolded protein response. Biochim. Biophys. Acta 1833, 410-416 (2013
9. Estes, K. A., Dunbar, T. L., Powell, J. R., Ausubel, F. M. & Troemel, E. R. bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infectioninCaenorhabditis elegans.Proc. Natl Acad.Sci.USA107,2153- 2158(2010
10. Félix, M. A. & Duveau, F. Population dynamics and habitat sharing of natural populations of Caenorhabditis elegans and C. briggsae. BMC Biol. 10, 59 (2012
11. Lee, S. S. et al. A systematicRNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genet. 33, 40-48 (2003
12. Menuz, V. et al. Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science 324, 381-384 (2009
13. Deng, X. et al. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science 322, 110-115 (2008
14. Sentelle, R. D. et al. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chem. Biol. 8, 831-838 (2012
15. Colombini, M. Ceramide channels and their role in mitochondria-mediated apoptosis. Biochim. Biophys. Acta 1797, 1239-1244 (2010
16. Wenner Moyer, M. The search beyond statins. Nature Med. 16, 150-153 (2010
17. Graham, D. J. et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. J. Am. Med. Assoc. 292, 2585-2590 (2004
18. Rauthan, M., Ranji, P., Aguilera Pradenas, N., Pitot, C.& Pilon, M. The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. Proc. Natl Acad. Sci. USA 110, 5981-5986 (2013
19. Hage-Sleiman, R., Esmerian, M. O., Kobeissy, H. & Dbaibo, G. p53 and ceramide as collaborators in the stress response. Int. J. Mol. Sci. 14, 4982-5012 (2013
20. Senkal, C. E. et al. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum(ER) stress and apoptosis via perturbation of cellular Ca21 and ER/Golgi membrane network. J. Biol. Chem. 286, 42446-42458 (2011
21. Breslow, D. K. & Weissman, J. S. Membranes in balance: Mechanisms of sphingolipid homeostasis. Mol. Cell 40, 267-279 (2010
22. Bookout,A. L.& Mangelsdorf, D. J.Quantitative real-TimePCRprotocol for analysis of nuclear receptor signaling pathways. Nucl. Recept. Signal. 1, e012 (2003
23. Phillips, C. M., McDonald, K. L. & Dernburg, A. F. Cytological analysis of meiosis in Caenorhabditis elegans. Methods Mol. Biol. 558, 171-195 (2009
24. Wagner, B. K. et al. Asmall-molecule screening strategy to identify suppressors of statin myopathy. ACS Chem. Biol. 6, 900-904 (2011