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Volumn 33, Issue 7, 2015, Pages 1420-1432

Rapid prototyping of microbial cell factories via genome-scale engineering

Author keywords

Genome synthesis; Genome scale engineering; High throughput technology; Homologous recombination; Microbial cell factory; Transcriptome engineering

Indexed keywords

BIOLOGICAL MATERIALS; GENES; SYNTHESIS (CHEMICAL); THROUGHPUT;

EID: 84947598027     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2014.11.007     Document Type: Review
Times cited : (37)

References (194)
  • 1
    • 0029278832 scopus 로고
    • Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome
    • Albert H., Dale E.C., Lee E., Ow D.W. Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome. Plant J 1995, 7:649-659.
    • (1995) Plant J , vol.7 , pp. 649-659
    • Albert, H.1    Dale, E.C.2    Lee, E.3    Ow, D.W.4
  • 2
    • 0029063381 scopus 로고
    • Mini-Tn10 transposon derivatives for insertion mutagenesis and gene delivery into the chromosome of Gram-negative bacteria
    • Alexeyev M.F., Shokolenko I.N. Mini-Tn10 transposon derivatives for insertion mutagenesis and gene delivery into the chromosome of Gram-negative bacteria. Gene 1995, 160:59-62.
    • (1995) Gene , vol.160 , pp. 59-62
    • Alexeyev, M.F.1    Shokolenko, I.N.2
  • 3
    • 33847083318 scopus 로고    scopus 로고
    • Global transcription machinery engineering: a new approach for improving cellular phenotype
    • Alper H., Stephanopoulos G. Global transcription machinery engineering: a new approach for improving cellular phenotype. Metab Eng 2007, 9:258-267.
    • (2007) Metab Eng , vol.9 , pp. 258-267
    • Alper, H.1    Stephanopoulos, G.2
  • 5
    • 33845442201 scopus 로고    scopus 로고
    • Engineering yeast transcription machinery for improved ethanol tolerance and production
    • Alper H., Moxley J., Nevoigt E., Fink G.R., Stephanopoulos G. Engineering yeast transcription machinery for improved ethanol tolerance and production. Science 2006, 314:1565-1568.
    • (2006) Science , vol.314 , pp. 1565-1568
    • Alper, H.1    Moxley, J.2    Nevoigt, E.3    Fink, G.R.4    Stephanopoulos, G.5
  • 7
    • 84899954929 scopus 로고    scopus 로고
    • Activities and specificities of homodimeric TALENs in Saccharomyces cerevisiae
    • Aouida M., Piatek M.J., Bangarusamy D.K., Mahfouz M.M. Activities and specificities of homodimeric TALENs in Saccharomyces cerevisiae. Curr Genet 2014, 60:61-74.
    • (2014) Curr Genet , vol.60 , pp. 61-74
    • Aouida, M.1    Piatek, M.J.2    Bangarusamy, D.K.3    Mahfouz, M.M.4
  • 8
    • 31544450286 scopus 로고    scopus 로고
    • Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection
    • Baba T., Ara T., Hasegawa M., Takai Y., Okumura Y., Baba M., et al. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol 2006, 2:0008.
    • (2006) Mol Syst Biol , vol.2 , pp. 0008
    • Baba, T.1    Ara, T.2    Hasegawa, M.3    Takai, Y.4    Okumura, Y.5    Baba, M.6
  • 10
  • 11
    • 84929572600 scopus 로고    scopus 로고
    • Homology-Integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae
    • Bao Z., Xiao H., Liang J., Zhang L., Xiong X., Sun N., et al. Homology-Integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. ACS Synth Biol 2014.
    • (2014) ACS Synth Biol
    • Bao, Z.1    Xiao, H.2    Liang, J.3    Zhang, L.4    Xiong, X.5    Sun, N.6
  • 12
    • 84882507458 scopus 로고    scopus 로고
    • 2,2-Diphenyl-1-picrylhydrazyl as a screening tool for recombinant monoterpene biosynthesis
    • Behrendorff J.B., Vickers C.E., Chrysanthopoulos P., Nielsen L.K. 2,2-Diphenyl-1-picrylhydrazyl as a screening tool for recombinant monoterpene biosynthesis. Microb Cell Fact 2013, 12:76.
    • (2013) Microb Cell Fact , vol.12 , pp. 76
    • Behrendorff, J.B.1    Vickers, C.E.2    Chrysanthopoulos, P.3    Nielsen, L.K.4
  • 13
    • 0034749283 scopus 로고    scopus 로고
    • Stimulation of homologous recombination through targeted cleavage by chimeric nucleases
    • Bibikova M., Carroll D., Segal D.J., Trautman J.K., Smith J., Kim Y.G., et al. Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Mol Cell Biol 2001, 21:289-297.
    • (2001) Mol Cell Biol , vol.21 , pp. 289-297
    • Bibikova, M.1    Carroll, D.2    Segal, D.J.3    Trautman, J.K.4    Smith, J.5    Kim, Y.G.6
  • 14
    • 84882986957 scopus 로고    scopus 로고
    • Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
    • Bikard D., Jiang W., Samai P., Hochschild A., Zhang F., Marraffini L.A. Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res 2013, 41:7429-7437.
    • (2013) Nucleic Acids Res , vol.41 , pp. 7429-7437
    • Bikard, D.1    Jiang, W.2    Samai, P.3    Hochschild, A.4    Zhang, F.5    Marraffini, L.A.6
  • 16
    • 83055177124 scopus 로고    scopus 로고
    • Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach
    • Blazeck J., Liu L., Redden H., Alper H. Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach. Appl Environ Microbiol 2011, 77:7905-7914.
    • (2011) Appl Environ Microbiol , vol.77 , pp. 7905-7914
    • Blazeck, J.1    Liu, L.2    Redden, H.3    Alper, H.4
  • 17
    • 84866744379 scopus 로고    scopus 로고
    • Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters
    • Blazeck J., Garg R., Reed B., Alper H.S. Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters. Biotechnol Bioeng 2012, 109:2884-2895.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2884-2895
    • Blazeck, J.1    Garg, R.2    Reed, B.3    Alper, H.S.4
  • 18
    • 84866944595 scopus 로고    scopus 로고
    • Genomic analysis of a key innovation in an experimental Escherichia coli population
    • Blount Z.D., Barrick J.E., Davidson C.J., Lenski R.E. Genomic analysis of a key innovation in an experimental Escherichia coli population. Nature 2012, 489:513-518.
    • (2012) Nature , vol.489 , pp. 513-518
    • Blount, Z.D.1    Barrick, J.E.2    Davidson, C.J.3    Lenski, R.E.4
  • 19
    • 0030994634 scopus 로고    scopus 로고
    • Yeast surface display for screening combinatorial polypeptide libraries
    • Boder E.T., Wittrup K.D. Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotechnol 1997, 15:553-557.
    • (1997) Nat Biotechnol , vol.15 , pp. 553-557
    • Boder, E.T.1    Wittrup, K.D.2
  • 21
    • 79952262678 scopus 로고    scopus 로고
    • Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae
    • Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H., Pretorius I.S., et al. Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae. PLoS Genet 2011, 7:e1001287.
    • (2011) PLoS Genet , vol.7 , pp. e1001287
    • Borneman, A.R.1    Desany, B.A.2    Riches, D.3    Affourtit, J.P.4    Forgan, A.H.5    Pretorius, I.S.6
  • 22
    • 84874990532 scopus 로고    scopus 로고
    • Comparative genomics: a revolutionary tool for wine yeast strain development
    • Borneman A.R., Pretorius I.S., Chambers P.J. Comparative genomics: a revolutionary tool for wine yeast strain development. Curr Opin Biotechnol 2013, 24:192-199.
    • (2013) Curr Opin Biotechnol , vol.24 , pp. 192-199
    • Borneman, A.R.1    Pretorius, I.S.2    Chambers, P.J.3
  • 23
    • 45549089565 scopus 로고    scopus 로고
    • The art and design of genetic screens: RNA interference
    • Boutros M., Ahringer J. The art and design of genetic screens: RNA interference. Nat Rev Genet 2008, 9:554-566.
    • (2008) Nat Rev Genet , vol.9 , pp. 554-566
    • Boutros, M.1    Ahringer, J.2
  • 24
    • 84877158197 scopus 로고    scopus 로고
    • Recombineering to homogeneity: extension of multiplex recombineering to large-scale genome editing
    • Boyle N.R., Reynolds T.S., Evans R., Lynch M., Gill R.T. Recombineering to homogeneity: extension of multiplex recombineering to large-scale genome editing. Biotechnol J 2013, 8:515-522.
    • (2013) Biotechnol J , vol.8 , pp. 515-522
    • Boyle, N.R.1    Reynolds, T.S.2    Evans, R.3    Lynch, M.4    Gill, R.T.5
  • 26
    • 84866879789 scopus 로고    scopus 로고
    • Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers
    • Briggs A.W., Rios X., Chari R., Yang L., Zhang F., Mali P., et al. Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res 2012, 40:e117.
    • (2012) Nucleic Acids Res , vol.40 , pp. e117
    • Briggs, A.W.1    Rios, X.2    Chari, R.3    Yang, L.4    Zhang, F.5    Mali, P.6
  • 27
    • 0034754491 scopus 로고    scopus 로고
    • Alteration of Cre recombinase site specificity by substrate-linked protein evolution
    • Buchholz F., Stewart A.F. Alteration of Cre recombinase site specificity by substrate-linked protein evolution. Nat Biotechnol 2001, 19:1047-1052.
    • (2001) Nat Biotechnol , vol.19 , pp. 1047-1052
    • Buchholz, F.1    Stewart, A.F.2
  • 31
    • 84866050528 scopus 로고    scopus 로고
    • Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection
    • Carr P.A., Wang H.H., Sterling B., Isaacs F.J., Lajoie M.J., Xu G., et al. Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection. Nucleic Acids Res 2012, 40:e132.
    • (2012) Nucleic Acids Res , vol.40 , pp. e132
    • Carr, P.A.1    Wang, H.H.2    Sterling, B.3    Isaacs, F.J.4    Lajoie, M.J.5    Xu, G.6
  • 32
    • 80051535219 scopus 로고    scopus 로고
    • Genome engineering with zinc-finger nucleases
    • Carroll D. Genome engineering with zinc-finger nucleases. Genetics 2011, 188:773-782.
    • (2011) Genetics , vol.188 , pp. 773-782
    • Carroll, D.1
  • 33
    • 0037047595 scopus 로고    scopus 로고
    • Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template
    • Cello J., Paul A.V., Wimmer E. Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template. Science 2002, 297:1016-1018.
    • (2002) Science , vol.297 , pp. 1016-1018
    • Cello, J.1    Paul, A.V.2    Wimmer, E.3
  • 35
    • 84943659921 scopus 로고    scopus 로고
    • Recent advances in DNA assembly technologies
    • Chao R., Yuan Y., Zhao H. Recent advances in DNA assembly technologies. FEMS Yeast Res 2014.
    • (2014) FEMS Yeast Res
    • Chao, R.1    Yuan, Y.2    Zhao, H.3
  • 36
    • 84891710947 scopus 로고    scopus 로고
    • Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
    • Cho S.W., Kim S., Kim Y., Kweon J., Kim H.S., Bae S., et al. Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. Genome Res 2014, 24:132-141.
    • (2014) Genome Res , vol.24 , pp. 132-141
    • Cho, S.W.1    Kim, S.2    Kim, Y.3    Kweon, J.4    Kim, H.S.5    Bae, S.6
  • 37
    • 77952265112 scopus 로고    scopus 로고
    • In silico identification of gene amplification targets for improvement of lycopene production
    • Choi H.S., Lee S.Y., Kim T.Y., Woo H.M. In silico identification of gene amplification targets for improvement of lycopene production. Appl Environ Microbiol 2010, 76:3097-3105.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 3097-3105
    • Choi, H.S.1    Lee, S.Y.2    Kim, T.Y.3    Woo, H.M.4
  • 38
    • 84886022252 scopus 로고    scopus 로고
    • Programming adaptive control to evolve increased metabolite production
    • Chou H.H., Keasling J.D. Programming adaptive control to evolve increased metabolite production. Nat Commun 2013, 4:2595.
    • (2013) Nat Commun , vol.4 , pp. 2595
    • Chou, H.H.1    Keasling, J.D.2
  • 39
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong L., Ran F.A., Cox D., Lin S.L., Barretto R., Habib N., et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013, 339:819-823.
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1    Ran, F.A.2    Cox, D.3    Lin, S.L.4    Barretto, R.5    Habib, N.6
  • 43
    • 84886101511 scopus 로고    scopus 로고
    • Model-based design of synthetic, biological systems
    • Crook N., Alper H.S. Model-based design of synthetic, biological systems. Chem Eng Sci 2013, 103:2-11.
    • (2013) Chem Eng Sci , vol.103 , pp. 2-11
    • Crook, N.1    Alper, H.S.2
  • 45
    • 40349101854 scopus 로고    scopus 로고
    • Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages
    • Datta S., Costantino N., Zhou X., Court D.L. Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages. Proc Natl Acad Sci U S A 2008, 105:1626-1631.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1626-1631
    • Datta, S.1    Costantino, N.2    Zhou, X.3    Court, D.L.4
  • 46
    • 84859616870 scopus 로고    scopus 로고
    • Laboratory evolution of new lactate transporter genes in a jen1Delta mutant of Saccharomyces cerevisiae and their identification as ADY2 alleles by whole-genome resequencing and transcriptome analysis
    • de Kok S., Nijkamp J.F., Oud B., Roque F.C., de Ridder D., Daran J.M., et al. Laboratory evolution of new lactate transporter genes in a jen1Delta mutant of Saccharomyces cerevisiae and their identification as ADY2 alleles by whole-genome resequencing and transcriptome analysis. FEMS Yeast Res 2012, 12:359-374.
    • (2012) FEMS Yeast Res , vol.12 , pp. 359-374
    • de Kok, S.1    Nijkamp, J.F.2    Oud, B.3    Roque, F.C.4    de Ridder, D.5    Daran, J.M.6
  • 47
    • 79953250082 scopus 로고    scopus 로고
    • CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
    • Deltcheva E., Chylinski K., Sharma C.M., Gonzales K., Chao Y., Pirzada Z.A., et al. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature 2011, 471:602-607.
    • (2011) Nature , vol.471 , pp. 602-607
    • Deltcheva, E.1    Chylinski, K.2    Sharma, C.M.3    Gonzales, K.4    Chao, Y.5    Pirzada, Z.A.6
  • 48
    • 84867823155 scopus 로고    scopus 로고
    • Design automation for synthetic biological systems
    • Densmore D., Hassoun S. Design automation for synthetic biological systems. Des Test Comput IEEE 2012, 29:7-20.
    • (2012) Des Test Comput IEEE , vol.29 , pp. 7-20
    • Densmore, D.1    Hassoun, S.2
  • 52
    • 77953642931 scopus 로고    scopus 로고
    • High-throughput metabolic engineering: advances in small-molecule screening and selection
    • Dietrich J.A., McKee A.E., Keasling J.D. High-throughput metabolic engineering: advances in small-molecule screening and selection. Annu Rev Biochem 2010, 79:563-590.
    • (2010) Annu Rev Biochem , vol.79 , pp. 563-590
    • Dietrich, J.A.1    McKee, A.E.2    Keasling, J.D.3
  • 53
    • 84875515904 scopus 로고    scopus 로고
    • Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis
    • Dietrich J.A., Shis D.L., Alikhani A., Keasling J.D. Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis. ACS Synth Biol 2013, 2:47-58.
    • (2013) ACS Synth Biol , vol.2 , pp. 47-58
    • Dietrich, J.A.1    Shis, D.L.2    Alikhani, A.3    Keasling, J.D.4
  • 55
    • 0029954688 scopus 로고    scopus 로고
    • Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
    • Dymecki S.M. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc Natl Acad Sci U S A 1996, 93:6191-6196.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6191-6196
    • Dymecki, S.M.1
  • 56
    • 80053132391 scopus 로고    scopus 로고
    • Synthetic chromosome arms function in yeast and generate phenotypic diversity by design
    • Dymond J.S., Richardson S.M., Coombes C.E., Babatz T., Muller H., Annaluru N., et al. Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature 2011, 477:471-476.
    • (2011) Nature , vol.477 , pp. 471-476
    • Dymond, J.S.1    Richardson, S.M.2    Coombes, C.E.3    Babatz, T.4    Muller, H.5    Annaluru, N.6
  • 57
    • 33646187810 scopus 로고    scopus 로고
    • High-throughput RNAi screening in cultured cells: a user's guide
    • Echeverri C.J., Perrimon N. High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet 2006, 7:373-384.
    • (2006) Nat Rev Genet , vol.7 , pp. 373-384
    • Echeverri, C.J.1    Perrimon, N.2
  • 58
    • 79952779354 scopus 로고    scopus 로고
    • Retrospective application of transposon-directed insertion site sequencing to a library of signature-tagged mini-Tn5Km2 mutants of Escherichia coli O157:H7 screened in cattle
    • Eckert S.E., Dziva F., Chaudhuri R.R., Langridge G.C., Turner D.J., Pickard D.J., et al. Retrospective application of transposon-directed insertion site sequencing to a library of signature-tagged mini-Tn5Km2 mutants of Escherichia coli O157:H7 screened in cattle. J Bacteriol 2011, 193:1771-1776.
    • (2011) J Bacteriol , vol.193 , pp. 1771-1776
    • Eckert, S.E.1    Dziva, F.2    Chaudhuri, R.R.3    Langridge, G.C.4    Turner, D.J.5    Pickard, D.J.6
  • 59
    • 0035810938 scopus 로고    scopus 로고
    • High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides
    • Ellis H.M., Yu D., DiTizio T., Court D.L. High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides. Proc Natl Acad Sci U S A 2001, 98:6742-6746.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6742-6746
    • Ellis, H.M.1    Yu, D.2    DiTizio, T.3    Court, D.L.4
  • 61
    • 84873800970 scopus 로고    scopus 로고
    • Genome-scale engineering for systems and synthetic biology
    • Esvelt K.M., Wang H.H. Genome-scale engineering for systems and synthetic biology. Mol Syst Biol 2013, 9:17.
    • (2013) Mol Syst Biol , vol.9 , pp. 17
    • Esvelt, K.M.1    Wang, H.H.2
  • 62
    • 79955534060 scopus 로고    scopus 로고
    • A system for the continuous directed evolution of biomolecules
    • Esvelt K.M., Carlson J.C., Liu D.R. A system for the continuous directed evolution of biomolecules. Nature 2011, 472:499-503.
    • (2011) Nature , vol.472 , pp. 499-503
    • Esvelt, K.M.1    Carlson, J.C.2    Liu, D.R.3
  • 63
    • 84886488970 scopus 로고    scopus 로고
    • Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas
    • Farzadfard F., Perli S.D., Lu T.K. Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas. ACS Synth Biol 2013, 2:604-613.
    • (2013) ACS Synth Biol , vol.2 , pp. 604-613
    • Farzadfard, F.1    Perli, S.D.2    Lu, T.K.3
  • 64
    • 84885181396 scopus 로고    scopus 로고
    • Efficient genome editing in plants using a CRISPR/Cas system
    • Feng Z., Zhang B., Ding W., Liu X., Yang D.L., Wei P., et al. Efficient genome editing in plants using a CRISPR/Cas system. Cell Res 2013, 23:1229-1232.
    • (2013) Cell Res , vol.23 , pp. 1229-1232
    • Feng, Z.1    Zhang, B.2    Ding, W.3    Liu, X.4    Yang, D.L.5    Wei, P.6
  • 65
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S.Q., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.Q.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 66
    • 0036271625 scopus 로고    scopus 로고
    • A genome-wide strategy for the identification of essential genes in Staphylococcus aureus
    • Forsyth R.A., Haselbeck R.J., Ohlsen K.L., Yamamoto R.T., Xu H., Trawick J.D., et al. A genome-wide strategy for the identification of essential genes in Staphylococcus aureus. Mol Microbiol 2002, 43:1387-1400.
    • (2002) Mol Microbiol , vol.43 , pp. 1387-1400
    • Forsyth, R.A.1    Haselbeck, R.J.2    Ohlsen, K.L.3    Yamamoto, R.T.4    Xu, H.5    Trawick, J.D.6
  • 67
    • 84860778298 scopus 로고    scopus 로고
    • Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting
    • Fu J., Bian X., Hu S., Wang H., Huang F., Seibert P.M., et al. Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol 2012, 30:440-446.
    • (2012) Nat Biotechnol , vol.30 , pp. 440-446
    • Fu, J.1    Bian, X.2    Hu, S.3    Wang, H.4    Huang, F.5    Seibert, P.M.6
  • 68
    • 84880570576 scopus 로고    scopus 로고
    • High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
    • Fu Y.F., Foden J.A., Khayter C., Maeder M.L., Reyon D., Joung J.K., et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol 2013, 31:822-826.
    • (2013) Nat Biotechnol , vol.31 , pp. 822-826
    • Fu, Y.F.1    Foden, J.A.2    Khayter, C.3    Maeder, M.L.4    Reyon, D.5    Joung, J.K.6
  • 69
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
    • Fu Y.F., Sander J.D., Reyon D., Cascio V.M., Joung J.K. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol 2014, 32:279-284.
    • (2014) Nat Biotechnol , vol.32 , pp. 279-284
    • Fu, Y.F.1    Sander, J.D.2    Reyon, D.3    Cascio, V.M.4    Joung, J.K.5
  • 70
    • 84886550456 scopus 로고    scopus 로고
    • Strategies for the multiplex mapping of genes to traits
    • Garst A., Lynch M., Evans R., Gill R.T. Strategies for the multiplex mapping of genes to traits. Microb Cell Fact 2013, 12:99.
    • (2013) Microb Cell Fact , vol.12 , pp. 99
    • Garst, A.1    Lynch, M.2    Evans, R.3    Gill, R.T.4
  • 71
    • 0037173615 scopus 로고    scopus 로고
    • Functional profiling of the Saccharomyces cerevisiae genome
    • Giaever G., Chu A.M., Ni L., Connelly C., Riles L., Veronneau S., et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 2002, 418:387-391.
    • (2002) Nature , vol.418 , pp. 387-391
    • Giaever, G.1    Chu, A.M.2    Ni, L.3    Connelly, C.4    Riles, L.5    Veronneau, S.6
  • 74
    • 84880571335 scopus 로고    scopus 로고
    • CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
    • Gilbert L.A., Larson M.H., Morsut L., Liu Z., Brar G.A., Torres S.E., et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 2013, 154:442-451.
    • (2013) Cell , vol.154 , pp. 442-451
    • Gilbert, L.A.1    Larson, M.H.2    Morsut, L.3    Liu, Z.4    Brar, G.A.5    Torres, S.E.6
  • 77
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon G.J. RNA interference. Nature 2002, 418:244-251.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 78
    • 64349112353 scopus 로고    scopus 로고
    • A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
    • Ho C.H., Magtanong L., Barker S.L., Gresham D., Nishimura S., Natarajan P., et al. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nat Biotechnol 2009, 27:369-377.
    • (2009) Nat Biotechnol , vol.27 , pp. 369-377
    • Ho, C.H.1    Magtanong, L.2    Barker, S.L.3    Gresham, D.4    Nishimura, S.5    Natarajan, P.6
  • 82
    • 67650476607 scopus 로고    scopus 로고
    • Synthetic lethality-a new direction in cancer-drug development
    • Iglehart J.D., Silver D.P. Synthetic lethality-a new direction in cancer-drug development. N Engl J Med 2009, 361:189-191.
    • (2009) N Engl J Med , vol.361 , pp. 189-191
    • Iglehart, J.D.1    Silver, D.P.2
  • 83
    • 79960502359 scopus 로고    scopus 로고
    • Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
    • Isaacs F.J., Carr P.A., Wang H.H., Lajoie M.J., Sterling B., Kraal L., et al. Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science 2011, 333:348-353.
    • (2011) Science , vol.333 , pp. 348-353
    • Isaacs, F.J.1    Carr, P.A.2    Wang, H.H.3    Lajoie, M.J.4    Sterling, B.5    Kraal, L.6
  • 84
    • 84882622697 scopus 로고    scopus 로고
    • Genome-scale genetic engineering in Escherichia coli
    • Jeong J., Cho N., Jung D., Bang D. Genome-scale genetic engineering in Escherichia coli. Biotechnol Adv 2013, 31:804-810.
    • (2013) Biotechnol Adv , vol.31 , pp. 804-810
    • Jeong, J.1    Cho, N.2    Jung, D.3    Bang, D.4
  • 85
    • 84874608929 scopus 로고    scopus 로고
    • RNA-guided editing of bacterial genomes using CRISPR-Cas systems
    • Jiang W., Bikard D., Cox D., Zhang F., Marraffini L.A. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol 2013, 31:233-239.
    • (2013) Nat Biotechnol , vol.31 , pp. 233-239
    • Jiang, W.1    Bikard, D.2    Cox, D.3    Zhang, F.4    Marraffini, L.A.5
  • 86
    • 84898913466 scopus 로고    scopus 로고
    • Small RNA regulators in bacteria: powerful tools for metabolic engineering and synthetic biology
    • Kang Z., Zhang C.Z., Zhang J.L., Jin P., Zhang J., Du G.C., et al. Small RNA regulators in bacteria: powerful tools for metabolic engineering and synthetic biology. Appl Microbiol Biotechnol 2014, 98:3413-3424.
    • (2014) Appl Microbiol Biotechnol , vol.98 , pp. 3413-3424
    • Kang, Z.1    Zhang, C.Z.2    Zhang, J.L.3    Jin, P.4    Zhang, J.5    Du, G.C.6
  • 87
    • 84868247020 scopus 로고    scopus 로고
    • Cloning the Acholeplasma laidlawii PG-8A genome in Saccharomyces cerevisiae as a yeast centromeric plasmid
    • Karas B.J., Tagwerker C., Yonemoto I.T., Hutchison C.A., Smith H.O. Cloning the Acholeplasma laidlawii PG-8A genome in Saccharomyces cerevisiae as a yeast centromeric plasmid. ACS Synth Biol 2012, 1:22-28.
    • (2012) ACS Synth Biol , vol.1 , pp. 22-28
    • Karas, B.J.1    Tagwerker, C.2    Yonemoto, I.T.3    Hutchison, C.A.4    Smith, H.O.5
  • 88
    • 0035199354 scopus 로고    scopus 로고
    • Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria
    • Karberg M., Guo H., Zhong J., Coon R., Perutka J., Lambowitz A.M. Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria. Nat Biotechnol 2001, 19:1162-1167.
    • (2001) Nat Biotechnol , vol.19 , pp. 1162-1167
    • Karberg, M.1    Guo, H.2    Zhong, J.3    Coon, R.4    Perutka, J.5    Lambowitz, A.M.6
  • 89
    • 80052459188 scopus 로고    scopus 로고
    • The therapeutic potential of PhiC31 integrase as a gene therapy system
    • Karow M., Calos M.P. The therapeutic potential of PhiC31 integrase as a gene therapy system. Expert Opin Biol Ther 2011, 11:1287-1296.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1287-1296
    • Karow, M.1    Calos, M.P.2
  • 90
    • 78649716727 scopus 로고    scopus 로고
    • Manufacturing molecules through metabolic engineering
    • Keasling J.D. Manufacturing molecules through metabolic engineering. Science 2010, 330:1355-1358.
    • (2010) Science , vol.330 , pp. 1355-1358
    • Keasling, J.D.1
  • 91
    • 78751556862 scopus 로고    scopus 로고
    • Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery
    • Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., et al. Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery. Mol Syst Biol 2011, 7:460.
    • (2011) Mol Syst Biol , vol.7 , pp. 460
    • Kim, H.U.1    Kim, S.Y.2    Jeong, H.3    Kim, T.Y.4    Kim, J.J.5    Choy, H.E.6
  • 92
    • 84861990434 scopus 로고    scopus 로고
    • Precision genome engineering with programmable DNA-nicking enzymes
    • Kim E., Kim S., Kim D.H., Choi B.S., Choi I.Y., Kim J.S. Precision genome engineering with programmable DNA-nicking enzymes. Genome Res 2012, 22:1327-1333.
    • (2012) Genome Res , vol.22 , pp. 1327-1333
    • Kim, E.1    Kim, S.2    Kim, D.H.3    Choi, B.S.4    Choi, I.Y.5    Kim, J.S.6
  • 93
    • 40649093316 scopus 로고    scopus 로고
    • Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains
    • Klein-Marcuschamer D., Stephanopoulos G. Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains. Proc Natl Acad Sci U S A 2008, 105:2319-2324.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2319-2324
    • Klein-Marcuschamer, D.1    Stephanopoulos, G.2
  • 94
    • 84871247687 scopus 로고    scopus 로고
    • Manipulating replisome dynamics to enhance lambda Red-mediated multiplex genome engineering
    • Lajoie M.J., Gregg C.J., Mosberg J.A., Washington G.C., Church G.M. Manipulating replisome dynamics to enhance lambda Red-mediated multiplex genome engineering. Nucleic Acids Res 2012, 40:e170.
    • (2012) Nucleic Acids Res , vol.40 , pp. e170
    • Lajoie, M.J.1    Gregg, C.J.2    Mosberg, J.A.3    Washington, G.C.4    Church, G.M.5
  • 95
    • 79952589723 scopus 로고    scopus 로고
    • Engineering butanol-tolerance in Escherichia coli with artificial transcription factor libraries
    • Lee J.Y., Yang K.S., Jang S.A., Sung B.H., Kim S.C. Engineering butanol-tolerance in Escherichia coli with artificial transcription factor libraries. Biotechnol Bioeng 2011, 108:742-749.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 742-749
    • Lee, J.Y.1    Yang, K.S.2    Jang, S.A.3    Sung, B.H.4    Kim, S.C.5
  • 96
    • 84861440312 scopus 로고    scopus 로고
    • Systems metabolic engineering of microorganisms for natural and non-natural chemicals
    • Lee J.W., Na D., Park J.M., Lee J., Choi S., Lee S.Y. Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Nat Chem Biol 2012, 8:536-546.
    • (2012) Nat Chem Biol , vol.8 , pp. 536-546
    • Lee, J.W.1    Na, D.2    Park, J.M.3    Lee, J.4    Choi, S.5    Lee, S.Y.6
  • 97
    • 68049085915 scopus 로고    scopus 로고
    • Directed evolution of enzymes: library screening strategies
    • Leemhuis H., Kelly R.M., Dijkhuizen L. Directed evolution of enzymes: library screening strategies. IUBMB Life 2009, 61:222-228.
    • (2009) IUBMB Life , vol.61 , pp. 222-228
    • Leemhuis, H.1    Kelly, R.M.2    Dijkhuizen, L.3
  • 98
    • 78650002545 scopus 로고    scopus 로고
    • Large-scale in silico modeling of metabolic interactions between cell types in the human brain
    • Lewis N.E., Schramm G., Bordbar A., Schellenberger J., Andersen M.P., Cheng J.K., et al. Large-scale in silico modeling of metabolic interactions between cell types in the human brain. Nat Biotechnol 2010, 28:1279-1285.
    • (2010) Nat Biotechnol , vol.28 , pp. 1279-1285
    • Lewis, N.E.1    Schramm, G.2    Bordbar, A.3    Schellenberger, J.4    Andersen, M.P.5    Cheng, J.K.6
  • 99
    • 0026511244 scopus 로고
    • Functional domains in Fok I restriction endonuclease
    • Li L., Wu L.P., Chandrasegaran S. Functional domains in Fok I restriction endonuclease. Proc Natl Acad Sci U S A 1992, 89:4275-4279.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 4275-4279
    • Li, L.1    Wu, L.P.2    Chandrasegaran, S.3
  • 100
    • 79960034141 scopus 로고    scopus 로고
    • Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
    • Li T., Huang S., Zhao X., Wright D.A., Carpenter S., Spalding M.H., et al. Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes. Nucleic Acids Res 2011, 39:6315-6325.
    • (2011) Nucleic Acids Res , vol.39 , pp. 6315-6325
    • Li, T.1    Huang, S.2    Zhao, X.3    Wright, D.A.4    Carpenter, S.5    Spalding, M.H.6
  • 101
    • 84896865972 scopus 로고    scopus 로고
    • Fairytale: a high-throughput TAL effector synthesis platform
    • Liang J., Chao R., Abil Z., Bao Z., Zhao H. Fairytale: a high-throughput TAL effector synthesis platform. ACS Synth Biol 2014, 3:67-73.
    • (2014) ACS Synth Biol , vol.3 , pp. 67-73
    • Liang, J.1    Chao, R.2    Abil, Z.3    Bao, Z.4    Zhao, H.5
  • 102
    • 84882565642 scopus 로고    scopus 로고
    • Engineering of transcriptional regulators enhances microbial stress tolerance
    • Lin Z., Zhang Y., Wang J. Engineering of transcriptional regulators enhances microbial stress tolerance. Biotechnol Adv 2013, 31:986-991.
    • (2013) Biotechnol Adv , vol.31 , pp. 986-991
    • Lin, Z.1    Zhang, Y.2    Wang, J.3
  • 104
    • 47649125318 scopus 로고    scopus 로고
    • Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
    • Lopez-Maury L., Marguerat S., Bahler J. Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nat Rev Genet 2008, 9:583-593.
    • (2008) Nat Rev Genet , vol.9 , pp. 583-593
    • Lopez-Maury, L.1    Marguerat, S.2    Bahler, J.3
  • 105
    • 3242671593 scopus 로고    scopus 로고
    • Mapping phenotypic landscapes using DNA micro-arrays
    • Lynch M.D., Gill R.T., Stephanopoulos G. Mapping phenotypic landscapes using DNA micro-arrays. Metab Eng 2004, 6:177-185.
    • (2004) Metab Eng , vol.6 , pp. 177-185
    • Lynch, M.D.1    Gill, R.T.2    Stephanopoulos, G.3
  • 106
    • 33845948161 scopus 로고    scopus 로고
    • SCALEs: multiscale analysis of library enrichment
    • Lynch M.D., Warnecke T., Gill R.T. SCALEs: multiscale analysis of library enrichment. Nat Methods 2007, 4:87-93.
    • (2007) Nat Methods , vol.4 , pp. 87-93
    • Lynch, M.D.1    Warnecke, T.2    Gill, R.T.3
  • 107
    • 49649118775 scopus 로고    scopus 로고
    • Methods for homologous recombination in Drosophila
    • Maggert K.A., Gong W.J., Golic K.G. Methods for homologous recombination in Drosophila. Methods Mol Biol 2008, 420:155-174.
    • (2008) Methods Mol Biol , vol.420 , pp. 155-174
    • Maggert, K.A.1    Gong, W.J.2    Golic, K.G.3
  • 109
    • 52949096084 scopus 로고    scopus 로고
    • Next-generation DNA, sequencing methods
    • Mardis E.R. Next-generation DNA, sequencing methods. Annu Rev Genomics Hum Genet 2008, 9:387-402.
    • (2008) Annu Rev Genomics Hum Genet , vol.9 , pp. 387-402
    • Mardis, E.R.1
  • 111
    • 78650023082 scopus 로고    scopus 로고
    • High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing
    • Matzas M., Stahler P.F., Kefer N., Siebelt N., Boisguerin V., Leonard J.T., et al. High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing. Nat Biotechnol 2010, 28:1291-1294.
    • (2010) Nat Biotechnol , vol.28 , pp. 1291-1294
    • Matzas, M.1    Stahler, P.F.2    Kefer, N.3    Siebelt, N.4    Boisguerin, V.5    Leonard, J.T.6
  • 112
    • 44949162060 scopus 로고    scopus 로고
    • Targeted gene inactivation in Zebrafish using engineered zinc-finger nucleases
    • Meng X., Noyes M.B., Zhu L.J., Lawson N.D., Wolfe S.A. Targeted gene inactivation in Zebrafish using engineered zinc-finger nucleases. Nat Biotechnol 2008, 26:695-701.
    • (2008) Nat Biotechnol , vol.26 , pp. 695-701
    • Meng, X.1    Noyes, M.B.2    Zhu, L.J.3    Lawson, N.D.4    Wolfe, S.A.5
  • 113
    • 84862785751 scopus 로고    scopus 로고
    • A genome-wide inducible phenotypic screen identifies antisense RNA constructs silencing Escherichia coli essential genes
    • Meng J., Kanzaki G., Meas D., Lam C.K., Crummer H., Tain J., et al. A genome-wide inducible phenotypic screen identifies antisense RNA constructs silencing Escherichia coli essential genes. FEMS Microbiol Lett 2012, 329:45-53.
    • (2012) FEMS Microbiol Lett , vol.329 , pp. 45-53
    • Meng, J.1    Kanzaki, G.2    Meas, D.3    Lam, C.K.4    Crummer, H.5    Tain, J.6
  • 114
    • 0034625266 scopus 로고    scopus 로고
    • Evidence for the adaptive evolution of mutation rates
    • Metzgar D., Wills C. Evidence for the adaptive evolution of mutation rates. Cell 2000, 101:581-584.
    • (2000) Cell , vol.101 , pp. 581-584
    • Metzgar, D.1    Wills, C.2
  • 115
    • 0029066770 scopus 로고
    • Structure and activities of group II introns
    • Michel F., Ferat J.L. Structure and activities of group II introns. Annu Rev Biochem 1995, 64:435-461.
    • (1995) Annu Rev Biochem , vol.64 , pp. 435-461
    • Michel, F.1    Ferat, J.L.2
  • 116
    • 84862167101 scopus 로고    scopus 로고
    • High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch
    • Michener J.K., Smolke C.D. High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch. Metab Eng 2012, 14:306-316.
    • (2012) Metab Eng , vol.14 , pp. 306-316
    • Michener, J.K.1    Smolke, C.D.2
  • 117
    • 0018931537 scopus 로고
    • Integrative recombination of bacteriophage lambda: extent of the DNA sequence involved in attachment site function
    • Mizuuchi M., Mizuuchi K. Integrative recombination of bacteriophage lambda: extent of the DNA sequence involved in attachment site function. Proc Natl Acad Sci U S A 1980, 77:3220-3224.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 3220-3224
    • Mizuuchi, M.1    Mizuuchi, K.2
  • 118
    • 45549091435 scopus 로고    scopus 로고
    • Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway
    • Moure C.M., Gimble F.S., Quiocho F.A. Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway. Nucleic Acids Res 2008, 36:3287-3296.
    • (2008) Nucleic Acids Res , vol.36 , pp. 3287-3296
    • Moure, C.M.1    Gimble, F.S.2    Quiocho, F.A.3
  • 119
    • 62649117859 scopus 로고    scopus 로고
    • Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis
    • Mueller S., Coleman J.R., Wimmer E. Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis. Chem Biol 2009, 16:337-347.
    • (2009) Chem Biol , vol.16 , pp. 337-347
    • Mueller, S.1    Coleman, J.R.2    Wimmer, E.3
  • 120
    • 0031924072 scopus 로고    scopus 로고
    • Use of bacteriophage lambda recombination functions to promote gene replacement in Escherichia coli
    • Murphy K.C. Use of bacteriophage lambda recombination functions to promote gene replacement in Escherichia coli. J Bacteriol 1998, 180:2063-2071.
    • (1998) J Bacteriol , vol.180 , pp. 2063-2071
    • Murphy, K.C.1
  • 121
    • 80053039555 scopus 로고    scopus 로고
    • A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
    • Mussolino C., Morbitzer R., Lutge F., Dannemann N., Lahaye T., Cathomen T. A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res 2011, 39:9283-9293.
    • (2011) Nucleic Acids Res , vol.39 , pp. 9283-9293
    • Mussolino, C.1    Morbitzer, R.2    Lutge, F.3    Dannemann, N.4    Lahaye, T.5    Cathomen, T.6
  • 123
    • 84873596341 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs
    • Na D., Yoo S.M., Chung H., Park H., Park J.H., Lee S.Y. Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs. Nat Biotechnol 2013, 31:170-174.
    • (2013) Nat Biotechnol , vol.31 , pp. 170-174
    • Na, D.1    Yoo, S.M.2    Chung, H.3    Park, H.4    Park, J.H.5    Lee, S.Y.6
  • 124
    • 0034059140 scopus 로고    scopus 로고
    • Cre recombinase: the universal reagent for genome tailoring
    • Nagy A. Cre recombinase: the universal reagent for genome tailoring. Genesis 2000, 26:99-109.
    • (2000) Genesis , vol.26 , pp. 99-109
    • Nagy, A.1
  • 125
    • 33845667323 scopus 로고    scopus 로고
    • Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli
    • Nakashima N., Tamura T., Good L. Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli. Nucleic Acids Res 2006, 34:e138.
    • (2006) Nucleic Acids Res , vol.34 , pp. e138
    • Nakashima, N.1    Tamura, T.2    Good, L.3
  • 126
    • 0036427644 scopus 로고    scopus 로고
    • Accelerating drug discovery by integrative implementation of laboratory automation in the work flow
    • Nettekoven M., Thomas A.W. Accelerating drug discovery by integrative implementation of laboratory automation in the work flow. Curr Med Chem 2002, 9:2179-2190.
    • (2002) Curr Med Chem , vol.9 , pp. 2179-2190
    • Nettekoven, M.1    Thomas, A.W.2
  • 127
    • 33747376106 scopus 로고    scopus 로고
    • Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae
    • Nevoigt E., Kohnke J., Fischer C.R., Alper H., Stahl U., Stephanopoulos G. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae. Appl Environ Microbiol 2006, 72:5266-5273.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 5266-5273
    • Nevoigt, E.1    Kohnke, J.2    Fischer, C.R.3    Alper, H.4    Stahl, U.5    Stephanopoulos, G.6
  • 128
    • 83755224308 scopus 로고    scopus 로고
    • Coexisting/Coexpressing Genomic Libraries (CoGeL) identify interactions among distantly located genetic loci for developing complex microbial phenotypes
    • Nicolaou S.A., Gaida S.M., Papoutsakis E.T. Coexisting/Coexpressing Genomic Libraries (CoGeL) identify interactions among distantly located genetic loci for developing complex microbial phenotypes. Nucleic Acids Res 2011, 39:e152.
    • (2011) Nucleic Acids Res , vol.39 , pp. e152
    • Nicolaou, S.A.1    Gaida, S.M.2    Papoutsakis, E.T.3
  • 129
    • 84857683425 scopus 로고    scopus 로고
    • Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis
    • Nicolas P., Mader U., Dervyn E., Rochat T., Leduc A., Pigeonneau N., et al. Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science 2012, 335:1103-1106.
    • (2012) Science , vol.335 , pp. 1103-1106
    • Nicolas, P.1    Mader, U.2    Dervyn, E.3    Rochat, T.4    Leduc, A.5    Pigeonneau, N.6
  • 130
  • 133
    • 10744225041 scopus 로고    scopus 로고
    • Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors
    • Park K.-S., Lee D.-K., Lee H., Lee Y., Jang Y.-S., Kim Y.H., et al. Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors. Nat Biotechnol 2003, 21:1208-1214.
    • (2003) Nat Biotechnol , vol.21 , pp. 1208-1214
    • Park, K.-S.1    Lee, D.-K.2    Lee, H.3    Lee, Y.4    Jang, Y.-S.5    Kim, Y.H.6
  • 134
    • 22544461606 scopus 로고    scopus 로고
    • Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells
    • Park K.S., Jang Y.S., Lee H., Kim J.S. Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells. J Bacteriol 2005, 187:5496-5499.
    • (2005) J Bacteriol , vol.187 , pp. 5496-5499
    • Park, K.S.1    Jang, Y.S.2    Lee, H.3    Kim, J.S.4
  • 135
    • 34249934691 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation
    • Park J.H., Lee K.H., Kim T.Y., Lee S.Y. Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation. Proc Natl Acad Sci U S A 2007, 104:7797-7802.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7797-7802
    • Park, J.H.1    Lee, K.H.2    Kim, T.Y.3    Lee, S.Y.4
  • 136
    • 0025773296 scopus 로고
    • Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1A
    • Pavletich N.P., Pabo C.O. Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1A. Science 1991, 252:809-817.
    • (1991) Science , vol.252 , pp. 809-817
    • Pavletich, N.P.1    Pabo, C.O.2
  • 137
    • 0742289608 scopus 로고    scopus 로고
    • Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes
    • Perutka J., Wang W., Goerlitz D., Lambowitz A.M. Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes. J Mol Biol 2004, 336:421-439.
    • (2004) J Mol Biol , vol.336 , pp. 421-439
    • Perutka, J.1    Wang, W.2    Goerlitz, D.3    Lambowitz, A.M.4
  • 138
    • 33747078696 scopus 로고    scopus 로고
    • Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes
    • Pfleger B.F., Pitera D.J., Smolke C.D., Keasling J.D. Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes. Nat Biotechnol 2006, 24:1027-1032.
    • (2006) Nat Biotechnol , vol.24 , pp. 1027-1032
    • Pfleger, B.F.1    Pitera, D.J.2    Smolke, C.D.3    Keasling, J.D.4
  • 140
    • 77956419824 scopus 로고    scopus 로고
    • Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network
    • Plata G., Hsiao T.L., Olszewski K.L., Llinas M., Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol 2010, 6:408.
    • (2010) Mol Syst Biol , vol.6 , pp. 408
    • Plata, G.1    Hsiao, T.L.2    Olszewski, K.L.3    Llinas, M.4    Vitkup, D.5
  • 141
    • 79960958091 scopus 로고    scopus 로고
    • Adaptive laboratory evolution - harnessing the power of biology for metabolic engineering
    • Portnoy V.A., Bezdan D., Zengler K. Adaptive laboratory evolution - harnessing the power of biology for metabolic engineering. Curr Opin Biotechnol 2011, 22:590-594.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 590-594
    • Portnoy, V.A.1    Bezdan, D.2    Zengler, K.3
  • 142
    • 84898878580 scopus 로고    scopus 로고
    • A versatile framework for microbial engineering using synthetic non-coding RNAs
    • Qi L.S., Arkin A.P. A versatile framework for microbial engineering using synthetic non-coding RNAs. Nat Rev Microbiol 2014, 12:341-354.
    • (2014) Nat Rev Microbiol , vol.12 , pp. 341-354
    • Qi, L.S.1    Arkin, A.P.2
  • 143
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    • Qi L.S., Larson M.H., Gilbert L.A., Doudna J.A., Weissman J.S., Arkin A.P., et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 2013, 152:1173-1183.
    • (2013) Cell , vol.152 , pp. 1173-1183
    • Qi, L.S.1    Larson, M.H.2    Gilbert, L.A.3    Doudna, J.A.4    Weissman, J.S.5    Arkin, A.P.6
  • 144
    • 79955773387 scopus 로고    scopus 로고
    • Parallel on-chip gene synthesis and application to optimization of protein expression
    • Quan J.Y., Saaem I., Tang N., Ma S.M., Negre N., Gong H., et al. Parallel on-chip gene synthesis and application to optimization of protein expression. Nat Biotechnol 2011, 29:449.
    • (2011) Nat Biotechnol , vol.29 , pp. 449
    • Quan, J.Y.1    Saaem, I.2    Tang, N.3    Ma, S.M.4    Negre, N.5    Gong, H.6
  • 145
    • 84880084177 scopus 로고    scopus 로고
    • Synthetic biology and metabolic engineering approaches to produce biofuels
    • Rabinovitch-Deere C.A., Oliver J.W.K., Rodriguez G.M., Atsumi S. Synthetic biology and metabolic engineering approaches to produce biofuels. Chem Rev 2013, 113:4611-4632.
    • (2013) Chem Rev , vol.113 , pp. 4611-4632
    • Rabinovitch-Deere, C.A.1    Oliver, J.W.K.2    Rodriguez, G.M.3    Atsumi, S.4
  • 147
    • 70349964350 scopus 로고    scopus 로고
    • Automated design of synthetic ribosome binding sites to control protein expression
    • Salis H.M., Mirsky E.A., Voigt C.A. Automated design of synthetic ribosome binding sites to control protein expression. Nat Biotechnol 2009, 27:946-950.
    • (2009) Nat Biotechnol , vol.27 , pp. 946-950
    • Salis, H.M.1    Mirsky, E.A.2    Voigt, C.A.3
  • 149
    • 0037007010 scopus 로고    scopus 로고
    • Directed evolution of the site specificity of Cre recombinase
    • Santoro S.W., Schultz P.G. Directed evolution of the site specificity of Cre recombinase. Proc Natl Acad Sci U S A 2002, 99:4185-4190.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 4185-4190
    • Santoro, S.W.1    Schultz, P.G.2
  • 150
    • 43049136820 scopus 로고    scopus 로고
    • Combinatorial engineering of microbes for optimizing cellular phenotype
    • Santos C.N., Stephanopoulos G. Combinatorial engineering of microbes for optimizing cellular phenotype. Curr Opin Chem Biol 2008, 12:168-176.
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 168-176
    • Santos, C.N.1    Stephanopoulos, G.2
  • 152
    • 79952002951 scopus 로고    scopus 로고
    • Probing cellular processes with oligo-mediated recombination and using the knowledge gained to optimize recombineering
    • Sawitzke J.A., Costantino N., Li X.T., Thomason L.C., Bubunenko M., Court C., et al. Probing cellular processes with oligo-mediated recombination and using the knowledge gained to optimize recombineering. J Mol Biol 2011, 407:45-59.
    • (2011) J Mol Biol , vol.407 , pp. 45-59
    • Sawitzke, J.A.1    Costantino, N.2    Li, X.T.3    Thomason, L.C.4    Bubunenko, M.5    Court, C.6
  • 153
    • 0028109636 scopus 로고
    • Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci
    • Schlake T., Bode J. Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci. Biochemistry 1994, 33:12746-12751.
    • (1994) Biochemistry , vol.33 , pp. 12746-12751
    • Schlake, T.1    Bode, J.2
  • 154
    • 84884325112 scopus 로고    scopus 로고
    • Genome engineering at the dawn of the golden age
    • Segal D.J., Meckler J.F. Genome engineering at the dawn of the golden age. Annu Rev Genomics Hum Genet 2013, 14:135-158.
    • (2013) Annu Rev Genomics Hum Genet , vol.14 , pp. 135-158
    • Segal, D.J.1    Meckler, J.F.2
  • 155
    • 36248966555 scopus 로고    scopus 로고
    • Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum
    • Shao L., Hu S., Yang Y., Gu Y., Chen J., Jiang W., et al. Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum. Cell Res 2007, 17:963-965.
    • (2007) Cell Res , vol.17 , pp. 963-965
    • Shao, L.1    Hu, S.2    Yang, Y.3    Gu, Y.4    Chen, J.5    Jiang, W.6
  • 156
    • 84887870749 scopus 로고    scopus 로고
    • Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold
    • Shao Z., Rao G., Li C., Abil Z., Luo Y., Zhao H. Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold. ACS Synth Biol 2013, 2:662-669.
    • (2013) ACS Synth Biol , vol.2 , pp. 662-669
    • Shao, Z.1    Rao, G.2    Li, C.3    Abil, Z.4    Luo, Y.5    Zhao, H.6
  • 157
    • 59849119654 scopus 로고    scopus 로고
    • Recombineering: a homologous recombination-based method of genetic engineering
    • Sharan S.K., Thomason L.C., Kuznetsov S.G., Court D.L. Recombineering: a homologous recombination-based method of genetic engineering. Nat Protoc 2009, 4:206-223.
    • (2009) Nat Protoc , vol.4 , pp. 206-223
    • Sharan, S.K.1    Thomason, L.C.2    Kuznetsov, S.G.3    Court, D.L.4
  • 158
    • 84897954175 scopus 로고    scopus 로고
    • Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
    • Shen B., Zhang W., Zhang J., Zhou J., Wang J., Chen L., et al. Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods 2014, 11:399-402.
    • (2014) Nat Methods , vol.11 , pp. 399-402
    • Shen, B.1    Zhang, W.2    Zhang, J.3    Zhou, J.4    Wang, J.5    Chen, L.6
  • 159
    • 84902170377 scopus 로고    scopus 로고
    • RNAi-assisted genome evolution in Saccharomyces cerevisiae for complex phenotype engineering
    • Si T., Luo Y., Bao Z., Zhao H. RNAi-assisted genome evolution in Saccharomyces cerevisiae for complex phenotype engineering. ACS Synth Biol 2014.
    • (2014) ACS Synth Biol
    • Si, T.1    Luo, Y.2    Bao, Z.3    Zhao, H.4
  • 160
    • 79951694132 scopus 로고    scopus 로고
    • Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy
    • Silva G., Poirot L., Galetto R., Smith J., Montoya G., Duchateau P., et al. Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Curr Gene Ther 2011, 11:11-27.
    • (2011) Curr Gene Ther , vol.11 , pp. 11-27
    • Silva, G.1    Poirot, L.2    Galetto, R.3    Smith, J.4    Montoya, G.5    Duchateau, P.6
  • 161
    • 53549085971 scopus 로고    scopus 로고
    • Rapid whole-genome mutational profiling using next-generation sequencing technologies
    • Smith D.R., Quinlan A.R., Peckham H.E., Makowsky K., Tao W., Woolf B., et al. Rapid whole-genome mutational profiling using next-generation sequencing technologies. Genome Res 2008, 18:1638-1642.
    • (2008) Genome Res , vol.18 , pp. 1638-1642
    • Smith, D.R.1    Quinlan, A.R.2    Peckham, H.E.3    Makowsky, K.4    Tao, W.5    Woolf, B.6
  • 163
    • 0019888368 scopus 로고
    • Bacteriophage-p1 site-specific recombination.2. Recombination between loxp and the bacterial chromosome
    • Sternberg N., Hamilton D., Hoess R. Bacteriophage-p1 site-specific recombination.2. Recombination between loxp and the bacterial chromosome. J Mol Biol 1981, 150:487-507.
    • (1981) J Mol Biol , vol.150 , pp. 487-507
    • Sternberg, N.1    Hamilton, D.2    Hoess, R.3
  • 164
    • 84862817382 scopus 로고    scopus 로고
    • Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae
    • Sun J., Shao Z., Zhao H., Nair N., Wen F., Xu J.H., et al. Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae. Biotechnol Bioeng 2012, 109:2082-2092.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2082-2092
    • Sun, J.1    Shao, Z.2    Zhao, H.3    Nair, N.4    Wen, F.5    Xu, J.H.6
  • 165
    • 84866013226 scopus 로고    scopus 로고
    • Recent advances in targeted genome engineering in mammalian systems
    • Sun N., Abil Z., Zhao H. Recent advances in targeted genome engineering in mammalian systems. Biotechnol J 2012, 7:1074-1087.
    • (2012) Biotechnol J , vol.7 , pp. 1074-1087
    • Sun, N.1    Abil, Z.2    Zhao, H.3
  • 166
    • 84863297206 scopus 로고    scopus 로고
    • Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease
    • Sun N., Liang J., Abil Z., Zhao H. Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease. Mol Biosyst 2012, 8:1255-1263.
    • (2012) Mol Biosyst , vol.8 , pp. 1255-1263
    • Sun, N.1    Liang, J.2    Abil, Z.3    Zhao, H.4
  • 169
    • 0035861532 scopus 로고    scopus 로고
    • Systematic genetic analysis with ordered arrays of yeast deletion mutants
    • Tong A.H., Evangelista M., Parsons A.B., Xu H., Bader G.D., Page N., et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 2001, 294:2364-2368.
    • (2001) Science , vol.294 , pp. 2364-2368
    • Tong, A.H.1    Evangelista, M.2    Parsons, A.B.3    Xu, H.4    Bader, G.D.5    Page, N.6
  • 170
    • 66249093890 scopus 로고    scopus 로고
    • High-frequency modification of plant genes using engineered zinc-finger nucleases
    • Townsend J.A., Wright D.A., Winfrey R.J., Fu F., Maeder M.L., Joung J.K., et al. High-frequency modification of plant genes using engineered zinc-finger nucleases. Nature 2009, 459:442-445.
    • (2009) Nature , vol.459 , pp. 442-445
    • Townsend, J.A.1    Wright, D.A.2    Winfrey, R.J.3    Fu, F.4    Maeder, M.L.5    Joung, J.K.6
  • 171
    • 82655181514 scopus 로고    scopus 로고
    • Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications
    • Turan S., Bode J. Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications. FASEB J 2011, 25:4088-4107.
    • (2011) FASEB J , vol.25 , pp. 4088-4107
    • Turan, S.1    Bode, J.2
  • 172
    • 77956123402 scopus 로고    scopus 로고
    • Multiplexing RMCE: versatile extensions of the Flp-recombinase-mediated cassette-exchange technology
    • Turan S., Kuehle J., Schambach A., Baum C., Bode J. Multiplexing RMCE: versatile extensions of the Flp-recombinase-mediated cassette-exchange technology. J Mol Biol 2010, 402:52-69.
    • (2010) J Mol Biol , vol.402 , pp. 52-69
    • Turan, S.1    Kuehle, J.2    Schambach, A.3    Baum, C.4    Bode, J.5
  • 173
    • 79952310557 scopus 로고    scopus 로고
    • Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges
    • Turan S., Galla M., Ernst E., Qiao J., Voelkel C., Schiedlmeier B., et al. Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges. J Mol Biol 2011, 407:193-221.
    • (2011) J Mol Biol , vol.407 , pp. 193-221
    • Turan, S.1    Galla, M.2    Ernst, E.3    Qiao, J.4    Voelkel, C.5    Schiedlmeier, B.6
  • 174
    • 84872271412 scopus 로고    scopus 로고
    • Recombinase-mediated cassette exchange (RMCE) - a rapidly-expanding toolbox for targeted genomic modifications
    • Turan S., Zehe C., Kuehle J., Qiao J., Bode J. Recombinase-mediated cassette exchange (RMCE) - a rapidly-expanding toolbox for targeted genomic modifications. Gene 2013, 515:1-27.
    • (2013) Gene , vol.515 , pp. 1-27
    • Turan, S.1    Zehe, C.2    Kuehle, J.3    Qiao, J.4    Bode, J.5
  • 175
  • 176
    • 67650756698 scopus 로고    scopus 로고
    • Analysis of CRISPR in Streptococcus mutans suggests frequent occurrence of acquired immunity against infection by M102-like bacteriophages
    • van der Ploeg J.R. Analysis of CRISPR in Streptococcus mutans suggests frequent occurrence of acquired immunity against infection by M102-like bacteriophages. Microbiology 2009, 155:1966-1976.
    • (2009) Microbiology , vol.155 , pp. 1966-1976
    • van der Ploeg, J.R.1
  • 177
    • 0036575444 scopus 로고    scopus 로고
    • Antisense RNAs everywhere?
    • Wagner E.G., Flardh K. Antisense RNAs everywhere?. Trends Genet 2002, 18:223-226.
    • (2002) Trends Genet , vol.18 , pp. 223-226
    • Wagner, E.G.1    Flardh, K.2
  • 178
    • 19744372984 scopus 로고    scopus 로고
    • Inducible antisense RNA expression in the characterization of gene functions in Streptococcus mutans
    • Wang B., Kuramitsu H.K. Inducible antisense RNA expression in the characterization of gene functions in Streptococcus mutans. Infect Immun 2005, 73:3568-3576.
    • (2005) Infect Immun , vol.73 , pp. 3568-3576
    • Wang, B.1    Kuramitsu, H.K.2
  • 179
    • 68949161807 scopus 로고    scopus 로고
    • Programming cells by multiplex genome engineering and accelerated evolution
    • Wang H.H., Isaacs F.J., Carr P.A., Sun Z.Z., Xu G., Forest C.R., et al. Programming cells by multiplex genome engineering and accelerated evolution. Nature 2009, 460:894-898.
    • (2009) Nature , vol.460 , pp. 894-898
    • Wang, H.H.1    Isaacs, F.J.2    Carr, P.A.3    Sun, Z.Z.4    Xu, G.5    Forest, C.R.6
  • 180
    • 84863328748 scopus 로고    scopus 로고
    • Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis
    • Wang H.H., Huang P.Y., Xu G., Haas W., Marblestone A., Li J., et al. Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis. ACS Synth Biol 2012, 1:43-52.
    • (2012) ACS Synth Biol , vol.1 , pp. 43-52
    • Wang, H.H.1    Huang, P.Y.2    Xu, G.3    Haas, W.4    Marblestone, A.5    Li, J.6
  • 181
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang H., Yang H., Shivalila C.S., Dawlaty M.M., Cheng A.W., Zhang F., et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013, 153:910-918.
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3    Dawlaty, M.M.4    Cheng, A.W.5    Zhang, F.6
  • 182
    • 84879101651 scopus 로고    scopus 로고
    • Synthetic biology: advancing the design of diverse genetic systems
    • Wang Y.H., Wei K.Y., Smolke C.D. Synthetic biology: advancing the design of diverse genetic systems. Annu Rev Chem Biomol Eng 2013, 4:69-102.
    • (2013) Annu Rev Chem Biomol Eng , vol.4 , pp. 69-102
    • Wang, Y.H.1    Wei, K.Y.2    Smolke, C.D.3
  • 183
    • 84900315204 scopus 로고    scopus 로고
    • Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption
    • Wang B.L., Ghaderi A., Zhou H., Agresti J., Weitz D.A., Fink G.R., et al. Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption. Nat Biotechnol 2014, 32:473-478.
    • (2014) Nat Biotechnol , vol.32 , pp. 473-478
    • Wang, B.L.1    Ghaderi, A.2    Zhou, H.3    Agresti, J.4    Weitz, D.A.5    Fink, G.R.6
  • 185
    • 84897149238 scopus 로고    scopus 로고
    • Integrating biological redesign: where synthetic biology came from and where it needs to go
    • Way J.C., Collins J.J., Keasling J.D., Silver P.A. Integrating biological redesign: where synthetic biology came from and where it needs to go. Cell 2014, 157:151-161.
    • (2014) Cell , vol.157 , pp. 151-161
    • Way, J.C.1    Collins, J.J.2    Keasling, J.D.3    Silver, P.A.4
  • 186
    • 0033529707 scopus 로고    scopus 로고
    • Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
    • Winzeler E.A., Shoemaker D.D., Astromoff A., Liang H., Anderson K., Andre B., et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 1999, 285:901-906.
    • (1999) Science , vol.285 , pp. 901-906
    • Winzeler, E.A.1    Shoemaker, D.D.2    Astromoff, A.3    Liang, H.4    Anderson, K.5    Andre, B.6
  • 188
    • 84902164599 scopus 로고    scopus 로고
    • Genome-wide RNAi screen reveals the E3 SUMO-protein ligase gene SIZ1 as a novel determinant of furfural tolerance in Saccharomyces cerevisiae
    • Xiao H., Zhao H. Genome-wide RNAi screen reveals the E3 SUMO-protein ligase gene SIZ1 as a novel determinant of furfural tolerance in Saccharomyces cerevisiae. Biotechnol Biofuels 2014, 7:78.
    • (2014) Biotechnol Biofuels , vol.7 , pp. 78
    • Xiao, H.1    Zhao, H.2
  • 189
    • 79955569746 scopus 로고    scopus 로고
    • Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases
    • Young J.J., Cherone J.M., Doyon Y., Ankoudinova I., Faraji F.M., Lee A.H., et al. Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. Proc Natl Acad Sci U S A 2011, 108:7052-7057.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7052-7057
    • Young, J.J.1    Cherone, J.M.2    Doyon, Y.3    Ankoudinova, I.4    Faraji, F.M.5    Lee, A.H.6
  • 190
    • 33749514099 scopus 로고    scopus 로고
    • Genomic analysis of the hierarchical structure of regulatory networks
    • Yu H., Gerstein M. Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 2006, 103:14724-14731.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14724-14731
    • Yu, H.1    Gerstein, M.2
  • 191
    • 49249139249 scopus 로고    scopus 로고
    • Rapid and efficient construction of markerless deletions in the Escherichia coli genome
    • Yu B.J., Kang K.H., Lee J.H., Sung B.H., Kim M.S., Kim S.C. Rapid and efficient construction of markerless deletions in the Escherichia coli genome. Nucleic Acids Res 2008, 36:e84.
    • (2008) Nucleic Acids Res , vol.36 , pp. e84
    • Yu, B.J.1    Kang, K.H.2    Lee, J.H.3    Sung, B.H.4    Kim, M.S.5    Kim, S.C.6
  • 192
    • 33746415885 scopus 로고    scopus 로고
    • A comprehensive library of fluorescent transcriptional reporters for Escherichia coli
    • Zaslaver A., Bren A., Ronen M., Itzkovitz S., Kikoin I., Shavit S., et al. A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat Methods 2006, 3:623-628.
    • (2006) Nat Methods , vol.3 , pp. 623-628
    • Zaslaver, A.1    Bren, A.2    Ronen, M.3    Itzkovitz, S.4    Kikoin, I.5    Shavit, S.6
  • 193
    • 0031664853 scopus 로고    scopus 로고
    • A new logic for DNA engineering using recombination in Escherichia coli
    • Zhang Y., Buchholz F., Muyrers J.P., Stewart A.F. A new logic for DNA engineering using recombination in Escherichia coli. Nat Genet 1998, 20:123-128.
    • (1998) Nat Genet , vol.20 , pp. 123-128
    • Zhang, Y.1    Buchholz, F.2    Muyrers, J.P.3    Stewart, A.F.4


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