Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 19, 2007, Pages 7797-7802

  Jin, Hwan Park ^a,b   Kwang, Ho Lee ^a,b,d   Tae, Yong Kim ^a,b   Sang, Yup Lee ^a,b,c  

^a BioProcess Engineering Research Center   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^d CJ Corporation   (South Korea)

Author keywords

Exporter; Global regulator; In silico prediction; Systems biology

Indexed keywords

ACETOLACTATE SYNTHASE; GLUCOSE; SIGNAL PEPTIDE; TRANSCRIPTOME; VALINE; DIHYDROXYACID DEHYDRATASE; ESCHERICHIA COLI PROTEIN; HYDROLYASE; LEUCINE RESPONSIVE REGULATORY PROTEIN; LRP PROTEIN, E COLI; UNCLASSIFIED DRUG;

ACEF GENE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BATCH FERMENTATION; CONTROLLED STUDY; ENZYME INHIBITION; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE DELETION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; ILVA GENE; ILVBN GENE; IVLCED GENE; LEUA GENE; LRP GENE; MDH GENE; METABOLIC ENGINEERING; NEGATIVE FEEDBACK; NONHUMAN; OPERON; PANB GENE; PFKA GENE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SIMULATION; SITE DIRECTED MUTAGENESIS; YGAZH GENE; BIOSYNTHESIS; GENETIC ENGINEERING; GENETICS; METABOLISM;

ESCHERICHIA COLI;

ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE AMPLIFICATION; GENETIC ENGINEERING; HYDRO-LYASES; LEUCINE-RESPONSIVE REGULATORY PROTEIN; TRANSCRIPTION, GENETIC; VALINE;

EID: 34249934691     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702609104     Document Type: Article

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